RICERCA ITALIANA     

FIRB simili:

• 1 - Riconoscimento molecolare e funzionalità cellulare
• 2 - BILANCIO OSPITE-TUMORE NELLA TERAPIA MEDICA DELLE NEOPLASIE: RUOLO DI NF-kB
• 3 - Il sistema di trasduzione del segnale Ca2+: dalle molecole alle funzioni
• 4 - Meccanismi di regolazione dello sviluppo del sistema nervoso e del differenziamento neurale (PRONEURO)
• 5 - Bersagli molecolari in complessi multiproteici che trasmettono segnali metabolici, proliferativi ed infiammatori
• 6 - Determinazione dei meccanismi molecolari di trasduzione del segnale implicati nel controllo della proliferazione e differenziamento in cellule emopoietiche
• 7 - Meccanismi molecolari della morte cellulare e loro implicazione in patologia umana
• 8 - Meccanismi di trasduzione del segnale e funzione sinaptica: sviluppo di modelli molecolari, cellulari ed animali
• 9 - Sviluppo di Tecnologie Avanzate per lo Studio della Proteomica Differenziale del Segnale (Segnalo-Proteomica)
• 10 - PROTEASI NELLA RISPOSTA CELLULARE NORMALE E PATOLOGICA: IDENTIFICAZIONE DEI SUBSTRATI ENDOGENI E DEI MECCANISMI MOLECOLARI INDOTTI

Classificazione scientifico-disciplinare

• Area scientifico disciplinare: Scienze biologiche
  • BIOLOGIA MOLECOLARE
  • BIOLOGIA APPLICATA

Classificazione brevettuale

• CHEMISTRY; METALLURGY
  • BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF (biocides, pest repellants or attractants, or plant growth regulators, containing micro-organisms, viruses, microbial fungi, enzymes, fermentates or substances produced by or extracted from micro-organisms or animal material A01N63/00; food compositions A21, A23; medicinal preparations A61K; chemical aspects of, or use of materials for, bandages, dressings, absorbent pads or surgical articles A61L; fertilisers C05); PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS (preservation of living parts of humans or animals A01N1/02); MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (micro-biological testing media C12Q)
  • ORGANIC CHEMISTRY (such compounds as the oxides, sulfides, or oxysulfides of carbon, cyanogen, phosgene, hydrocyanic acid or salts thereof C01; products obtained from layered base-exchange silicates by ion-exchange with organic compounds such as ammonium, phosphonium or sulfonium compounds or by intercalation of organic compounds C01B33/44; macromolecular compounds C08; dyes C09; fermentation products C12; fermentation or enzyme-using processes to synthesise a desired chemical compound or composition or to separate optical isomers from a racemic mixture C12P; production of organic compounds by electrolysis or electrophoresis C25B3/00, C25B7/00)
    • PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00)

Classificazione geografica

• Regione: Veneto

Bibliografia

1. Butcher, E. C. and L. J. Picker (1996). "Lymphocyte homing and homeostasis." Science 272(5258): 60-6.
2. Devalaraja, M. N. and A. Richmond (1999). "Multiple chemotactic factors: fine control or redundancy?" Trends Pharmacol Sci 20(4): 151-6.
3. Laudanna, C., J. J. Campbell, et al. (1996). "Role of Rho in chemoattractant-activated leukocyte adhesion through integrins." Science 271(5251): 981-3.
4. Laudanna, C., D. Mochly-Rosen, et al. (1998). "Evidence of zeta protein kinase C involvement in polymorphonuclear neutrophil integrin-dependent adhesion and chemotaxis." J Biol Chem 273(46): 30306-15.
5. Constantin, G., M. Majeed, et al. (2000). "Chemokines trigger immediate beta2 integrin affinity and mobility changes: differential regulation and roles in lymphocyte arrest under flow." Immunity 13(6): 759-69.
6. Hirsch, E., V. L. Katanaev, C. Garlanda, O. Azzolino, L. Pirola, L. Silengo, S. Sozzani, A. Mantovani, F. Altruda, and M. P. Wymann. 2000. Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation. Science 287:1049-53.
7. Wymann, M. P., S. Sozzani, F. Altruda, A. Mantovani, and E. Hirsch. 2000. Lipids on the move: phosphoinositide 3-kinases in leukocyte function. Immunol Today 21:260-4Defilippi P, 1.
8. Integrin signal transduction in myeloid leukocytes. C.A. Lowell and G. Berton. J. Leukoc. Biol. 65:313-320, 1999.
9. Deficiency of Scr family kinases p59/61hck and p58c-fgr results in defective adhesion-dependent neutrophil functions. C.A. Lowell, L. Fumagalli, G. Berton. J. Cell. Biol. 133, 895-910, 1996.
10. Adhesion-Dependent Degranulation of Neutrophils Requires the Src Family Kinases Fgr and Hck. A. Mócsai, E. Ligeti, C. A. Lowell, G.Berton. J. Immunol. 162:1120-1126, 1999.
11. Impaired integrin-mediated signal transduction, altered cytoskeletal structure and reduced motility in Hck/Fgr deficient macrophages. Suen, P. W., D. Ilic, E. Caveggion, G. Berton, C. H. Damsky, C. A. Lowell. J Cell Sci. 112: 4067-78, 1999.
12. Resistance to endotoxic shock and reduced neutrophil migration in mice deficient for the SRC-family kinases Hck and Fgr. C.A. Lowell, G. Berton. Proc. Natl.Acad.Sci USA 95: 7580-7584, 1998.
13. A beta1 integrin signaling pathway involving Src-family kinases, Cbl and PI-3 kinase is required for macrophage spreading and migration. Meng F., Lowell C.A. EMBO J. 17:4391-4403, 1998.
14. Gismondi A, Santoni A, Tarone G. (1997) Signal Transduction by Integrins. Molecular Biology Intelligence Unit, Landes Bioscience, Austin Texas.
15. Integrin signaling in neutrophils and macrophages. Berton, G. C.A. Lowell. 1999 Cell. Signal. 9: 621-635.
16. Giancotti FG and Ruoslahti E (1999) Integrin signaling. Science, 285, 1028-1032.
17. Howe, A., Aplin, A.E., Alahari, S.K., and Juliano, R.L. (1998) Integrin signaling and cell growth control. Curr. Opin. Cell Biol., 10, 220-231.
18. Roovers K, Davey G, Zhu X, Bottazzi ME, Assoian RK (1999) Alpha5beta1 integrin controls cyclin D1 expression by sustaining mitogen-activated protein kinase activity in growth factor-treated cells. Mol Biol Cell 10, 3197-3204.
19. Moro L, Venturino M, Bozzo C, Silengo L, Altruda F, Beguinot L, Tarone G, Defilippi P (1998) Integrins induce activation of EGF receptor: role in MAP kinase induction and adhesion-dependent cell survival. EMBO J 17, 6622-6632.
20. Schwartz MA and Baron V (1999) Interactions between mitogenic stimuli, or , a thousand and one connections. Curr opin in Cell Biol., 11, 197-202.

Parole Chiave

adesione cellulare; migrazione; trasduzione del segnale; integrine; sopravvivenza cellulare; proliferazione