RICERCA ITALIANA     

FIRB simili:

• 1 - Identificazione ed analisi funzionale delle alterazioni molecolari e geniche che caratterizzano i tumori della mammella ormono-responsivi
• 2 - Caratterizzazione genetico-molecolare delle neoplasie umane: le leucemie mieloidi acute ed i sarcomi.
• 3 - Profili di espressione genica nell'iniziazione e progressione tumorale: correlazione con indicatori prognostici e terapeutici
• 4 - L'ingegneria dei tessuti per la rigenerazione dei tessuti connettivi con particolare riferimento al tessuto osseo
• 5 - Ottimizzazione dell' espansione ex-vivo di cellule staminali e progenitori emopoietici umani
• 6 - Cellule staminali adulte pluripotenti per la ricostituzione tissutale in modelli di malattie degenerative
• 7 - Identificazione, purificazione, transdifferenziazione e banking di cellule staminali indirizzate verso fenotipi propri e non propri da utilizzare per riparazione tissutale
• 8 - Studio dell'identità cellulare e dei meccanismi di differenziazione cellulare nell'era della postegnomica utilizzando tre situazioni paradigmatiche: la mammella, l'osso e i linfociti
• 9 - Identificazione di nuovi marcatori molecolari per la diagnosi e la prognosi del carcinoma renale con tecniche genomiche e proteomiche. (Possibile risultato atteso: Identificazione di nuovi marcatori diagnostici o prognostici di malattie).
• 10 - BILANCIO OSPITE-TUMORE NELLA TERAPIA MEDICA DELLE NEOPLASIE: RUOLO DI NF-kB

Classificazione scientifico-disciplinare

• Area scientifico disciplinare: Scienze mediche
  • GENETICA MEDICA
  • MALATTIE DEL SANGUE

Classificazione brevettuale

• CHEMISTRY; METALLURGY
  • BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS (immunoassay G01N33/53); COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
• HUMAN NECESSITIES
  • MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES (bringing into special physical form A61J [N: mechanical aspects]; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; compounds per se C01, C07, C08, C12N; soap compositions C11D; micro-organisms per se C12N) [C0203]

Classificazione geografica

• Regione: Lazio

Bibliografia

1) Catovsky D, Foa R: The Lymphoid Leukaemias. Butterworths, London, pp. 1-320,1990
2) Berger R: Cytogenetics in adult acute lymphoblastic leukemia. Rev Clin Exp Hematol, 5.4,68-84,1998
3) Mauro FR, Foa R, Giannarelli D, et al: Clinical characteristics and outcome of young chronic lymphocytic leukemia patients: A single institution study of 204 cases. Blood, 94,448-454, 1999
4) Hallek M: New concepts in the pathogenesis, diagnosis, prognostic factors and clinical presentation of chronic lymphocytic leukemia. Rev Clin Exp Hematol, 4.2,103-117,2000
5) Dohner H, Stilgenbauer S,Benner A, et al: Genomic aberrations and survival in chronic lymphocytic leukemia. N Engl J Med, 343,1910-1916,2000
6) Damle RN, Wasil RT, Fais F, et al: IgV gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia. Blood, 94,1840-1847,1999
7) Hamblin TJ, Davis Z, Gardiner A, et al: Unmutated Ig VH genes are associated with a more aggressive form of chronic lymphocytic leukemia. Blood 94,1848-1854,1999
8) Management of Chronic Lymphocytic Leukemia. Rev Clin Exp Hematol, 4.2,101-180,2000
9) Science, 16 February 2001.
10) Golup TR, Slonim DK, Tamayo P, et al: Molecular classification of cancer: class discovery and class prediction by gene expression monitoring. Science, 286,531-537,1999
11) Allzahed AA, Eisen MB, Davis RE, et al: Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature, 403,503-511,2000
12) Rozovskaia T, Feinstein E, Mor O, Foa R, et al: Upregulation of Meis1 and HoxA9 in acute lymphocytic leukemias with the t(4:11) abnormality. Oncogene, 20,874-878,2001
13) Zhang H, Yu C-Y, Singer B, Xiong M: Recursive partitioning for tumor classification with gene expression microarray data. Proc Natl Acad Sci USA, 98,6730-6735,2001
14) Semenzato G, Pizzolo G,…, Foa R,…: Binding of sheep erythrocytes in chronic lymphocytic leukaemias of B-cell origin. J Clin Immunol, 2,296-302,1982
15) Foa R, Catovsky D, …, Semenzato G: Chronic T-cell leukaemias. III. T-colonies, PHA response and correlation with membrane phenotype. Leuk Res, 6,809-814,1982
16) Semenzato G, Pezzutto A, Foa R, et al: T lymphocytes in B-cell chronic lymphocytic leukemia: characterization by monoclonal antibodies and correlation with Fc receptors. Clin Immunol Immunopathol, 26,155-161,1983
17) Pizzolo G, …, Foa R, …, Semenzato G: Rearrangement for the T-cell receptor gene and co-expression of immature T-cell markers and natural killer cell phenotype, in a patient with acute lymphoblastic leukaemia. Br J Haematol, 65,17-22,1987
18) Zambello R.,…, Foa R, Semenzato G: Cytotoxic in vitro function in the lymphoproliferative disease of granular lymphocytes. Clin Exp Immunol, 70,222-230,1987
19) Semenzato G, Foa R, Agostini C, et al: High serum levels of soluble interleukin 2 receptor in patients with B chronic lymphocytic leukemia. Blood, 70,396-400,1987
20) Semenzato G, Pandolfi F,…, Foa R: The lymphoproliferative disease of granular lymphocytes. A heterogeneous disorder ranging from indolent to aggressive conditions. Cancer, 60,2971-2978,1987
21) Pizzolo G,…, Semenzato G,…, Foa R: Increased levels of soluble interleukin-2 receptor in the serum of patients with human immunodeficiency virus infection. Diagn Clin Immunol, 5,180-183,1987
22) Agostini C, Semenzato G,…, Foa R,…: Increased levels of soluble CD8 molecule in the serum of patients with acquired immunodeficiency syndrome (AIDS) and AIDS-related disorders. Clin Immunol Immunopathol, 50,146-153,1989
23) Agostini C,…, Foa R,…, Semenzato G: Lymphoproliferative disease of granular lymphocytes in a patient with concomitant hepatitis B virus infection of CD4 lymphocytes. J Clin Immunol, 9,401-408,1989
24) Biondi A,…, Foa R, Migone N: High prevalence of T-cell receptor Vd2-(D)-Dd3 or Dd1/2-Dd3 rearrangements in B-precursor acute lymphoblastic leukemias. Blood, 75,1834-1840,1990
25) Roncella S,…, Foa R,…, Ferrarini M: Establishment of an EBV-positive lymphoblastoid cell line that grows as a lymphoma in nude mice and expresses membrane CD2 molecules. Int J Cancer, 45,299-307,1990
26) Roncella S,…, Foa R,…, Ferrarini M: Assessment of the potential malignancy of Epstein-Barr-Virus (EBV)-infected B cells in AIDS related disorders. Cancer Detect Prevent, 14,325-329,1990
27) Trentin L,…, Foa R, Semenzato G: Mechanisms accounting for lymphocytic alveolitis in hypersensitivity pneumonitis. J Immunol, 145,2147-2154,1990
28) Francia di Celle P,…, Semenzato G,…, Foa R Polyclonal nature of some granular T-cell expansions (CD3+, CD8+) based on the configuration of the Tcell receptor b and g chain gene regions. J Immunol Res, 2,144-150,1990
29) Pistoia V,…, Foa R, Ferrarini M: Emergence of a B-cell lymphoblastic lymphoma in a patient with B cell chronic lymphocytic leukemia: Evidence for the single cell origin of the two tumors.
Blood, 78,797-804,1991
30) Pandolfi F, Foa R,…, Semenzato G: Clonally expanded CD3+, CD4-, CD8- cells bearing the a/b or the g/d T-cell receptor in patients with the lymphoproliferative disease of granular lymphocytes. Clin Immunol Immunopathol, 60,371-383,1991
31) Biondi A,…, Foa R, Migone N: Unique genotypic features of infant acute lymphoblastic leukaemia at presentation and relapse. Br J Haematol, 80,472-479,1992
32) Foa R, Guarini A,…, Semenzato G: Constitutive production of tumor necrosis factor alpha in hairy cell leukemia: Possible role in the pathogenesis of the cytopenia(s) and effect of treatment with alpha-interferon. J Clin Oncol, 10,954-959,1992
33) Roncella S,…, Foa R,…, Ferrarini M: Cytogenetic rearrangement of c-myc oncogene occurs prior to infection with Epstein-barr virus in the monoclonal malignant B cells from an AIDS patient. Leuk Lymph, 9, 157-164,1993
34) Zambello R,…, Foa R, Semenzato G: Persistent polyclonal lymphocytosis in human immunodeficiency virus-1 infected patients. Blood, 81,3015-3021,1993
35) Adami F,…, Foa R, Semenzato G: Serum levels of tumour necrosis factor-a in patients with B-cell chronic lymphocytic leukaemia. Eur J Cancer, 30A,1259-1263,1994
36) Jain R,…, Foa R, Ferrarini M, Chiorazzi N: A potential role for antigen selection in the clonal evolution of Burkitt's lymphoma. J Immunol, 153,45-52,1994
37) Cimino G,…, Mecucci C,…, Foa R,…: A prospective study of residual-disease monitoring of the ALL1/AF4 transcript in patients with t(4;11) acute lymphoblastic leukemia. Blood, 95,96-101,2000
38) Mecucci C, La Starza R,…, Foa R: t(4;11)(q21;p15) translocation involving NUP98 and RAP1GDS1 genes. Characterisation of a new subset of T acute lymphoblastic leukemia. Br J Haematol, 109,788-793,2000
39) Mancini M,…, Mecucci C,…, Foa R: Detection of BCR/ABL rearrangements in adult acute lymphoblastic leukemia using a highly sensitive interphase fluorescence in situ hybridization method (D-FISH). The Hematol J, 2,54-60,2001
40) Cimino G,…, Foa R, Mecucci C,…: Molecular evaluation of the NUP98/RAP1GDS1 gene frequency in adults with T-acute lymphoblastic leukemia. Haematologica, 86,436-437,2001
41) La Starza R,…, Foa R, Mecucci C: Philadelphia positive acute lymphoblastic leukemia with multiple subclones including duplication of the Philadelphia chromosome and of the Abelson oncogene. Cancer Genet Cytogenet, 2001, in press
42) Testa U,…, Ritz J, Peschle C, Foa R: Human acute leukemia with stem cell phenotype and multilineage differentiation potential via cascade activation of growth factor receptors. Submitted
43) Chiaretti S,…, Ritz J, Foa R: Gene expression profiles of adult ALL reveal distinct genetic patterns that correlate with cell surface phenotype, chromosomal abnormalities and clinical outcome. ASH, 2001
44) Capello D, Fais F,…,Ferrarini M: Identification of three subgroups of B cell chronic lymphocytic leukemia based upon mutations of BCL-6 and IgV genes. Leukemia, 14,811-815,2000
45) Ziegler BL,…, Zanjani ED, Peschle C: KDR receptor: a key marker defining hematopoietic stem cells. Science, 285,1553-1558,1999

Parole Chiave

PROFILO GENOMICO; LEUCEMIE LINFOIDI ACUTE; DISORDINI LINFOPROLIFERATIVI CRONICI; CLASSIFICAZIONE DI MALATTIA; PROGNOSI; TERAPIE INNOVATIVE