RICERCA ITALIANA     

FIRB simili:

• 1 - Riconoscimento molecolare e funzionalità cellulare
• 2 - Sviluppo di molecole innovative in grado di curare malattie neurodegenerative e neuroinfiammatorie.
• 3 - Modelli transgenici per malattie ad eziologia complessa
• 4 - BILANCIO OSPITE-TUMORE NELLA TERAPIA MEDICA DELLE NEOPLASIE: RUOLO DI NF-kB
• 5 - GENOMICA FUNZIONALE DELLE MALATTIE MUSCOLARI E CARDIACHE. RICERCA DI NUOVI MARCATORI MOLECOLARI E DI NUOVI BERSAGLI PER LA TERAPIA
• 6 - Meccanismi molecolari della morte cellulare e loro implicazione in patologia umana
• 7 - PROTEASI NELLA RISPOSTA CELLULARE NORMALE E PATOLOGICA: IDENTIFICAZIONE DEI SUBSTRATI ENDOGENI E DEI MECCANISMI MOLECOLARI INDOTTI
• 8 - Uso di modelli animali per l'analisi proteomica dei complessi molecolari coinvolti nel traffico intracellulare e di proteine di membrana.
• 9 - GENOTOPO:Genomica funzionale del topo
• 10 - Identificazione e validazione di meccanismi genetico-molecolari coinvolti nel trasporto tubulare renale del sodio nell'ipertensione e nelle sue complicanze d'organo.

Classificazione scientifico-disciplinare

• Area scientifico disciplinare: Scienze mediche
  • MEDICINA INTERNA

Classificazione brevettuale

• CHEMISTRY; METALLURGY
  • BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF (biocides, pest repellants or attractants, or plant growth regulators, containing micro-organisms, viruses, microbial fungi, enzymes, fermentates or substances produced by or extracted from micro-organisms or animal material A01N63/00; food compositions A21, A23; medicinal preparations A61K; chemical aspects of, or use of materials for, bandages, dressings, absorbent pads or surgical articles A61L; fertilisers C05); PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS (preservation of living parts of humans or animals A01N1/02); MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (micro-biological testing media C12Q)
• HUMAN NECESSITIES
  • AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS

Classificazione geografica

• Regione: Piemonte

Bibliografia

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Aoki H and Izumo S. Signal transduction of cardiac myocyte hypertrophy. Heart Physiology and Pathophysiology, Fourth Edition, Capter 58 pages 1065-1086; Academic Press 2001.
Belkin AM, Retta SF, Pletjushkina OY, Balzac F, Silengo L, Fassler R, Koteliansky VE, Burridge K, Tarone G. Muscle beta1D integrin reinforces the cytoskeleton-matrix link: modulation of integrin adhesive function by alternative splicing. J Cell Biol 1997;139:1583-95
Belkin AM, Zhidkova NI, Balzac F, Altruda F, Tomatis D, Maier A, Tarone G, Koteliansky VE, Burridge K. Beta 1D integrin displaces the beta 1A isoform in striated muscles: localization at junctional structures and signaling potential in nonmuscle cells. J Cell Biol 1996;132:211-26
Brancaccio M, Guazzone S, Menini N, Sibona E, Hirsch E, De Andrea M, Rocchi M, Altruda F, Tarone G, Silengo L. J Biol Chem 1999; 274: 29282-8
Carson JA, Wei L. Integrin signaling's potential for mediating gene expression in hypertrophying skeletal muscle. J Appl Physiol. 2000, 88: 337-43
Chien KR, 1999, Cell 98; 555-558
Davis MJ, Wu X, Nurkiewicz TR, Kawasaki J, Davis GE, Hill MA, Meininger GA. Integrins and mechanotransduction of the vascular myogenic response. Am J Physiol Heart Circ Physiol. 2001, 280: H1427-33.
Hirsch E, Bosco O, Tropel P, Laffargue M, Calvez R, Altruda F, Wymann M, Montrucchio G. Resistance to thromboembolism in PI3Kgamma-deficient mice. FASEB J. 2001; 15:2019-21.
Hirsch E, Katanaev VL, Garlanda C, Azzolino O, Pirola L, Silengo L, Sozzani S, Mantovani A, Altruda F, Wymann MP. Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation. Science. 2000; 287:1049-53.
Hunter JJ, Chien KR. Signalingpathways for cardiac hypertrophy and failure. N Engl J Med 1999, 341:1276-83
Luft FC. Angiotensin, inflammation, hypertension, and cardiovascular disease. Curr Hypertens Rep. 2001;3:61-7.
Quignard JF, Mironneau J, Carricaburu V, Fournier B, Babich A, Nurnberg B, Mironneau C, Macrez N. Phosphoinositide 3-kinase gamma mediates angiotensin II-induced stimulation of L-type calcium channels in vascular myocytes. J Biol Chem. 2001;276:32545-51.
Ruiz-Ortega M, Lorenzo O, Suzuki Y, Ruperez M, Egido J. Proinflammatory actions of angiotensins. Curr Opin Nephrol Hypertens. 2001;10:321-9
Ruwhof C, van der Laarse A. Mechanical stress-induced cardiac hypertrophy: mechanisms and signal transduction pathways. Cardiovasc Res 2000, 47:23-37
Schawarz, M. Schaller, M. and Ginsberg M. Integrins: emerging paradigms of signal transduction. Ann.Rev. Cell Dev. Biol. 1995; 11: 549-599
Wakasaki H, Koya D, Schoen FJ, Jirousek MR, Ways DK, Hoit BD, Walsh RA, King GL.Targeted overexpression of protein kinase C beta2 isoform in myocardium causes cardiomyopathy. Proc Natl Acad Sci U S A 1997; 94:9320-5.

Parole Chiave

ipertensione; cardiopatia ipertrofica e dilatativa; infarto miocardico; fosfoinositide 3 chinasi; melusina; diabete