RICERCA ITALIANA     

FIRB simili:

• 1 - MALATTIE NEURODEGENERATIVE COME CONSEGUENZA DI UN ALTERATO PROCESSAMENTO DI PROTEINE NEURONALI. MODELLI ANIMALI E DI COLTURE CELLULARI IN VITRO.
• 2 - Sviluppo di molecole innovative in grado di curare malattie neurodegenerative e neuroinfiammatorie.
• 3 - PRIME: PRogetto Integrato Malattie Ereditarie
• 4 - Metabolismo e organizzazione degli sfingolipidi in modelli di neurodegenerazione cellulare: comprensione dei meccanismi molecolari di base e sviluppo di nuove strategie terapeutiche.
• 5 - Modelli transgenici per malattie ad eziologia complessa
• 6 - Meccanismi molecolari della morte cellulare e loro implicazione in patologia umana
• 7 - Misfolding di proteine e patologie umane: studio della conversione patologica di proteine globulari in aggregati fibrillari e sviluppo di farmaci che inibiscano i processi di misfolding e aggregazione
• 8 - GENOMICA FUNZIONALE DELLE MALATTIE MUSCOLARI E CARDIACHE. RICERCA DI NUOVI MARCATORI MOLECOLARI E DI NUOVI BERSAGLI PER LA TERAPIA
• 9 - Canalopatie genetiche: identificazione di marcatori molecolari e loro funzione, sviluppo di sistemi diagnostici avanzati e identificazione di bersagli farmacologici.
• 10 - Identificazione e validazione di meccanismi genetico-molecolari coinvolti nel trasporto tubulare renale del sodio nell'ipertensione e nelle sue complicanze d'organo.

Classificazione scientifico-disciplinare

• Area scientifico disciplinare: Scienze biologiche
  • FISIOLOGIA
  • FARMACOLOGIA
• Area scientifico disciplinare: Scienze mediche
  • NEUROLOGIA

Classificazione brevettuale

• CHEMISTRY; METALLURGY
  • BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF (biocides, pest repellants or attractants, or plant growth regulators, containing micro-organisms, viruses, microbial fungi, enzymes, fermentates or substances produced by or extracted from micro-organisms or animal material A01N63/00; food compositions A21, A23; medicinal preparations A61K; chemical aspects of, or use of materials for, bandages, dressings, absorbent pads or surgical articles A61L; fertilisers C05); PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS (preservation of living parts of humans or animals A01N1/02); MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (micro-biological testing media C12Q)

Classificazione geografica

• Regione: Lombardia

Bibliografia

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Brion JP, Tremp G, Octave JN (1999) Transegenic expression of the shortest human tau affects its compartmentalization and its phosphorylation as in pretangle stage of Alzheimer’s disease. Am J Pathol 154: 255-270

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Dickson DW (2001) Alfa-Synuclein and the Lewy body disorders. Curr Opinion Neurol 14: 423-432

Elliot JL (1999) Experimental Models of Amyotrophic Lateral Sclerosis. Neurobiol Dis 6: 310-320

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Monani UR, Sendtner M, Coovert DD, Parsons DW, Andreassi C, Le TT, Jablonka S, Schrank B, Rossol W, Prior TW, Morris GE, Burghes AH (2000) The human centromeric survival motor neuron gene (SMN2) rescues embryonic lethality in Smn(-/-) mice and results in a mouse with spinal muscular atrophy. Hum Mol Genet 9: 333-339

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Probst A, Gotz J, Wiederhold KH, Tolnay M, Mistl C, Jaton AL, Hong M, Ishihara T, Lee VM, Trojanowski JQ, Jakes R, Crowther RA, Spillantini MG, Burki K, Goedert M (2000) Axonopathy and amyotrophy in mice transgenic for human four-repeat tau protein. Acta Neuropathol (Berl) 99: 469-481

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Sturchler-Pierrat C, Abramowski D, Duke M, Wiederhold KH, Mistl C, Rothacher S, Ledermann B, Burki K, Frey P, Paganetti PA, Waridel C, Calhoun ME, Jucker M, Probst A, Staufenbiel M, Sommer B (1997) Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology. Proc Natl Acad Sci USA 94: 13287-13292

van der Putten H, Wiederhold KH, Probst A, Barbieri S, Mistl C, Danner S, Kauffmann S, Hofele K, Spooren WP, Ruegg MA, Lin S, Caroni P, Sommer B, Tolnay M, Bilbe G (2000) Neuropathology in mice expressing human alpha-synuclein. J Neurosci 20: 6021-6029

Parole Chiave

NEURODEGENERAZIONE; MALATTIE DEL MOTONEURONE; CITOSCHELETRO; PROTEINE MALCONFORMATE