RICERCA ITALIANA     

FIRB simili:

• 1 - Meccanismi di regolazione dello sviluppo del sistema nervoso e del differenziamento neurale (PRONEURO)
• 2 - Modelli transgenici per malattie ad eziologia complessa
• 3 - Geni murini, fenotipi e malattie umane - MousePHD
• 4 - Metodologie per l'individuazione e lo sviluppo di molecole in grado di interferire specificamente con bersagli critici per la terapia di malattie
• 5 - Studio dell'identità cellulare e dei meccanismi di differenziazione cellulare nell'era della postegnomica utilizzando tre situazioni paradigmatiche: la mammella, l'osso e i linfociti
• 6 - Sviluppo di strategie per l'analisi funzionale del genoma
• 7 - Sviluppo di nuove tecnologie per la genomica funzionale basate su RNA
• 8 - BILANCIO OSPITE-TUMORE NELLA TERAPIA MEDICA DELLE NEOPLASIE: RUOLO DI NF-kB
• 9 - ESPRESSIONE GENICA ED ACCUMULO DI PROTEINE D'INTERESSE AGRONOMICO NELLA CELLULA VEGETALE: MECCANISMI TRASCRIZIONALI E POST-TRASCRIZIONALI
• 10 - Il sistema di trasduzione del segnale Ca2+: dalle molecole alle funzioni

Classificazione scientifico-disciplinare

• Area scientifico disciplinare: Scienze biologiche
  • BIOLOGIA MOLECOLARE
  • BIOLOGIA APPLICATA

Classificazione brevettuale

• CHEMISTRY; METALLURGY
  • BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF (biocides, pest repellants or attractants, or plant growth regulators, containing micro-organisms, viruses, microbial fungi, enzymes, fermentates or substances produced by or extracted from micro-organisms or animal material A01N63/00; food compositions A21, A23; medicinal preparations A61K; chemical aspects of, or use of materials for, bandages, dressings, absorbent pads or surgical articles A61L; fertilisers C05); PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS (preservation of living parts of humans or animals A01N1/02); MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (micro-biological testing media C12Q)

Classificazione geografica

• Regione: Campania

Bibliografia

1) Macchia PE, De Felice M, Di Lauro R. Molecular genetics of congenital hypothyroidism. Curr Opin Genet Dev. 1999, 9:289-94

2) Kimura S, Hara Y, Pineau T, Fernandez-Salguero P, Fox CH, Ward JM, Gonzalez FJ. The T/ebp null mouse: thyroid-specific enhancer-binding protein is essential for the organogenesis of the thyroid, lung, ventral forebrain, and pituitary. Genes Dev. 1996, 10:60-9.

3) Mansouri A, Chowdhury K, Gruss P. Follicular cells of the thyroid gland require Pax8 gene function.Nat Genet. 1998, 19:87-90.

4) De Felice M, Ovitt C, Biffali E, Rodriguez-Mallon A, Arra C, Anastassiadis K, Macchia PE, Mattei MG, Mariano A, Scholer H, Macchia V, Di Lauro R.
A mouse model for hereditary thyroid dysgenesis and cleft palate.
Nat Genet. 1998, 19:395-8.

5) Shen MMand Schier AF The EGF-CFC gene family in vertebrate development. Trends Genet. 2000, 16:303-09.

6) Reissmann E, Jornvall H, Blokzijl A, Andersson O, Chang C,
Minchiotti G, Persico MG, Ibanez CF, Brivanlou AH
The orphane receptor ALK7 and the Activin receptor ALK4 mediate signaling
by Nodal proteins during vertebrate development. Genes Dev. 2001, 15:2010-
22

7) Xu C, Liguori G, Persico MG, & Adamson ED. Abrogation of the Cripto gene in mouse leads to failure of postgastrulation morphogenesis and lack of differentiation of cardiomyocytes. Development 1999 ,126, 483-94.

8) Xu C, Liguori G, Adamson ED, & Persico MG. Specific arrest of cardiogenesis in cultured embryonic stem cells lacking Cripto-1. Dev. Biol. 1998, 196:237-47.

9) Hirsch E, Katanaev VL, Garlanda C, Azzolino O, Pirola L., Silengo L., Sozzani S, Mantovani A, Altruda ., Wymann MP. Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation. Science 2000, 287:1049-53.

10) Takeda K, Clausen BE, Kaisho T, Tsujimura T,Terada N, Forster I, Akira S.
Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils. Immunity 1999, 10:39-49.

11) Atreya R, Mudter J, Finotto S, Mullberg J, Jostock T, Wirtz S, Schutz M, Bartsch B, Holtmann M, Becker C, Strand D, Czaja J, Schlaak JF, Lehr HA, Autschbach F, Schurmann G, Nishimoto N, Yoshizaki K, Ito H, Kishimoto T, Galle PR, Rose-John S, Neurath MF.
Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in crohn disease and experimental colitis in vivo. Nat Med. 2000, 6:583-8.

12) Alonzi T, Maritano D, Gorgoni B, Rizzuto G, Libert C, Poli V. Essential role of STAT3 in the control of the acute-phase response as revealed by inducible gene inactivation [correction of activation] in the liver. Mol Cell Biol. 2001, 21:1621-32.

13) Sutrias-Grau M, Bianchi ME, Bernues J.
High mobility group protein 1 interacts specifically with the core domain of human TATA box-binding protein and interferes with transcription factor IIB within the pre-initiation complex. J Biol Chem. 1999, 274:1628-34.

14) Muller S, Scaffidi P, Degryse B, Bonaldi T, Ronfani L, Agresti A, Beltrame M, Bianchi ME. New EMBO members' review: the double life of HMGB1 chromatin protein: architectural factor and extracellular signal.
EMBO J. 2001, 20:4337-40.

15) Degryse B, Bonaldi T, Scaffidi P, Muller S, Resnati M, Sanvito F, Arrigoni G, Bianchi ME. The high mobility group (HMG) boxes of the nuclear protein HMG1 induce chemotaxis and cytoskeleton reorganization in rat smooth muscle cells. J Cell Biol. 2001,152:1197-206.

16) Calogero S, Grassi F, Aguzzi A, Voigtlander T, Ferrier P, Ferrari S, Bianchi ME. The lack of chromosomal protein Hmg1 does not disrupt cell growth but causes lethal hypoglycaemia in newborn mice. Nat Genet. 1999, 22:276-80.

17) Acampora D, Gulisano M, Simeone A. Otx genes and the genetic control of brain morphogenesis. Mol Cell Neurosci. 1999, 13:1-8

18) Acampora D, Postiglione MP, Avantaggiato V, Di Bonito M, Simeone A.
The role of Otx and Otp genes in brain development. Int J Dev Biol. 2000, 44:669-77

19) Boyl PP, Signore M, Acampora D, Martinez-Barbera JP, Ilengo C, Annino A, Corte G, Simeone A. Forebrain and midbrain development requires epiblast-restricted Otx2 translational control mediated by its 3' UTR.
Development. 2001, 128:2989-3000.

20) Colombatti A, Doliana R, Bot S, Canton A, Mongiat M, Mungiguerra G, Paron-Cilli S, Spessotto P. The EMILIN protein family. Matrix Biol. 2000, 19:289-301.

21) Skarnes, W.C. Gene trapping methods for the identification and functional analysis of cell surface proteins in mice. Methods Enzymol. 2000, 328:592-615.

22) Seibler, J., Schübeler, D., Fiering, S., Groudine, M. and Bode, J. DNA cassette exchange in ES cells mediated by Flp recombinase: an efficient strategy for repeated modification of tagged loci by marker-free constructs. Biochemistry 1998, 37:6229-6234.

23) Bonner RF, Emmert-Buck M, Cole K, Pohida T, Chuaqui R, Goldstein S, Liotta LA.Laser capture microdissection: molecular analysis of tissue. Science 1997, 278:1481-83.

24) Simone NL, Bonner RF, Gillespie JW, Emmert-Buck MR, Liotta LA.
Laser-capture microdissection: opening the microscopic frontier to molecular analysis. Trends Genet. 1998, 14:272-6.

25) Parlato R, Rosica A, Cuccurullo V, Mansi L, Macchia PE, De Felice M, Owens JD, Mushinski JF, Bonner RF, and Di Lauro R. A preservation method tha tallows recovery of intact RNA from tissues dissected by Laser Capture Microdissection. Anal.Biochem. (in press)

26) Migliaccio E, Giorgio M, Mele S, Pelicci G, Reboldi P, Pandolfi PP, Lanfrancone L, Pelicci PG. The p66shc adaptor protein controls oxidative stress response and lifespan in mammals. Nature. 1999, 402:309-13.

27) Finkel T, Holbrook NJ. Oxidants, oxidative stress and the biology of ageing.
Nature. 2000, 408:239-47.

28) Ronfani L, Ferraguti M, Croci L, Ovitt CE, Scholer HR, Consalez GG, Bianchi ME. Reduced fertility and spermatogenesis defects in mice lacking chromosomal protein Hmgb2. Development. 2001, 128:1265-73.

29)Sutrias-Grau M, Bianchi ME, Bernues J. High mobility group protein 1 interacts specifically with the core domain of human TATA box-binding protein and interferes with transcription factor IIB within the pre-initiation complex. J Biol Chem. 1999, 274:1628-34.

30) Baker JC, Beddington RS, Harland RM. Wnt signaling in Xenopus embryos inhibits bmp4 expression and activates neural development. Genes Dev. 1999, 13: 3149-59.

31) King RW, Lustig KD, Stukenberg PT, McGarry TJ, Kirschner MW. Expression cloning in the test tube. Science 1997, 277: 973-4.

32) Ko MS, Kitchen JR, Wang XT, Wang XH, Sun T, Grahovac MJ, Kargul GJ, Lim MK, Cui Y, Sano Y, Tanaka T, Liang Y, Mason S, Paonessa PD, Sauls AD, DePalma GE, Sharara R, Rowe LB, Eppig J, Morrell C, Doi H. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development 2000, 127:1737-49.

33) Zhang, J., Talbot, W. S., & Schier, A. F. Positional cloning identifies zebrafish one-eyed pinhead as a permissive EGF-related ligand required during gastrulation. Cell 1998, 92, 241-251.

34) Hickman-Davis JM, Fang FC, Nathan C, Shepherd VL, Voelker DR, Wright JR. Lung surfactant and reactive oxygen-nitrogen species: antimicrobial activity and host-pathogen interactions. Am J Physiol Lung Cell Mol Physiol. 2001, 281:L517-23.

Parole Chiave

Modelli animali; Genetica dell'infiammazione; Controllo genetico della durata della vita; Genetica dell'apparato cardiovascolare; Genomica funzionale; Genetica della migrazione cellulare