RICERCA ITALIANA     

FIRB simili:

• 1 - Meccanismi di vulnerabilita' neuronale: identificazione di nuovi target biologici per lo sviluppo di terapie innovative
• 2 - BILANCIO OSPITE-TUMORE NELLA TERAPIA MEDICA DELLE NEOPLASIE: RUOLO DI NF-kB
• 3 - Meccanismi molecolari della morte cellulare e loro implicazione in patologia umana
• 4 - Sviluppo di molecole innovative in grado di curare malattie neurodegenerative e neuroinfiammatorie.
• 5 - Modelli transgenici per malattie ad eziologia complessa
• 6 - Modulazione razionale dell'attività antitumorale di farmaci "classici" tramite intervento selettivo su specifiche cascate regolatorie
• 7 - Approcci combinati di terapia genica nel trattamento del glioblastoma
• 8 - Meccanismi di regolazione dello sviluppo del sistema nervoso e del differenziamento neurale (PRONEURO)
• 9 - Identificazione delle vie di signaling implicate nella riparazione molecolare e nel recupero funzionale di cellule post-mitotiche (miocardiociti, miociti scheletrici e neuroni). Studio pre-clinico e clinico.
• 10 - Il sistema di trasduzione del segnale Ca2+: dalle molecole alle funzioni

Classificazione scientifico-disciplinare

• Area scientifico disciplinare: Scienze biologiche
  • FARMACOLOGIA
• Area scientifico disciplinare: Scienze mediche
  • PATOLOGIA GENERALE

Classificazione brevettuale

• CHEMISTRY; METALLURGY
  • BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF (biocides, pest repellants or attractants, or plant growth regulators, containing micro-organisms, viruses, microbial fungi, enzymes, fermentates or substances produced by or extracted from micro-organisms or animal material A01N63/00; food compositions A21, A23; medicinal preparations A61K; chemical aspects of, or use of materials for, bandages, dressings, absorbent pads or surgical articles A61L; fertilisers C05); PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS (preservation of living parts of humans or animals A01N1/02); MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (micro-biological testing media C12Q)

Classificazione geografica

• Regione: Lombardia

Bibliografia

-Abbracchio MP & Williams M eds (2001) "Purinergic and pyrimidinergic signalling I", Handbook of Experimental Pharmacology 151/1, Springer

-Abbracchio MP, Ongini E, Memo M (1999) Disclosing apoptosis in the CNS.
Trends Pharmacol. Sci., 20: 129-131

-Baldassarre D, Amato M, Bondioli A, Sirtori CR, Tremoli E. (2000) Carotid artery intima-media thickness measured by ultrasonography in normal clinical practice correlates well with atherosclerosis risk factors. Stroke. 31(10):2426-30

-Barone FC, Feuerstein GZ (1999) Inflammatory mediators and stroke: new opportunities for novel therapeutics. Journal of Cerebral Blood Flow & Metabolism. 19(8):819-34

-Bretillon L, Lutjohann D, Stahle L, Widhe T, Bindl L, Eggertsen G, Diczfalusy U, Bjorkhem I. (2000) Plasma levels of 24S-hydroxycholesterol reflect the balance between cerebral production and hepatic metabolism and are inversely related to body surface. J Lipid Res 41:840-845.

-Brambilla, R, Burnstock G, Bonazzi A, Ceruti S, Cattabeni F, Abbracchio MP (1999) Cyclo-oxygenase-2 mediates P2Y receptor-induced reactive astrogliosis. Br. J. Pharmacol. 126, 563-567

-Buccellati C, Folco GC, Sala A, Scelsi R, Masoero E, Poggi P, Govoni S, Favalli L Rozza A (1998) Inhibition of prostanoid synthesis protects against neuronal damage induced by focal ischemia in rat brain. Neuroscience Letters. 257(3):123-6

-Chabriat H, Pappata S, Poupon C, Clark CA, Vahedi K, Poupon F, Mangin JF, Pachot-Clouard M, Jobert A, Le Bihan D, Bousser MG (1999) Clinical severity in CADASIL related to ultrastructural damage in white matter: in vivo study with diffusion tensor MRI. Stroke. 30(12):2637-43

-Danysz W (2001) Neurotoxicity as a mechanism for neurodegenerative disorders: basic and clinical aspects. Expert Opin Investig Drugs 10:985-9.

-Danysz W, Parsons AC (1998)Glycine and N-methyl-D-aspartate receptors: physiological significance and possible therapeutic applications. Pharmacological Reviews. 50(4):597-664

-de Curtis M, Biella G, Buccellati C, Folco G (1998) Simultaneous investigation of the neuronal and vascular compartments in the guinea pig brain isolated in vitro. Brain Research. Brain Research Protocols. 3(2):221-8

-del Zoppo G, Ginis I, Hallenbeck JM, Iadecola C, Wang X, Feuerstein GZ (2000) Inflammation and stroke: putative role for cytokines, adhesion molecules and iNOS in brain response to ischemia. Brain Pathology. 10(1):95-112

-Dubal DB, Zhu H, Yu J, Rau SW, Shughrue PJ, Merchenthaler I, Kindy MS, Wise PM (2001) Estrogen receptor alpha, not beta, is a critical link in estradiol-mediated protection against brain injury. Proceedings of the National Academy of Sciences of the United States of America. 98(4):1952-7

-Eligini S, Colli S, Basso F, Sironi L, Tremoli E (1999) Oxidized low density lipoprotein suppresses expression of inducible cyclo-oxygenase in human macrophages. Artheriosclerosis, Thromb. Vasc. Biol. 19: 1719-1725

-Ellison JA, Barone FC, Feuerstein GZ (1999). Matrix remodeling after stroke. De novo expression of matrix proteins and integrin receptors. Annals of the New York Academy of Sciences. 890:204-22, 1999

-Fifth International Conference on Neuroprotective Agents (2001) Annals of the New
York Academy of Sciences 939.

-Freedman SB. Isner JM. (2001) Therapeutic angiogenesis for ischemic cardiovascular disease. Journal of Molecular & Cellular Cardiology. 33(3):379-93

-Galli C, Petroni A, Bertazzo A, Sarti S (1989). Arachidonic acid and its metabolites during cerebral ischemia and recirculation. Pharmacological interventions. Annals of the New York Academy of Sciences. 559:352-64

-Gottschall PE, Deb S (1996) Regulation of matrix metalloproteinase expressions in astrocytes, microglia and neurons. Neuroimmunomodulation. 3(2-3):69-75

-Govoni S, Masoero E, Favalli L, Rozza A, Scelsi R, Viappiani S, Buccellati C, Sala A, Folco G (2001) The Cycloxygenase-2 inhibitor SC58236 is neuroprotective in an in vivo model of focal ischemia in the rat. Neuroscience Letters. 303(2):91-4

-Guerrini U, Sironi L, Tremoli E, Cimino M. Pollo B, Calvio AM, Paoletti R, Asdente M. (2001) New insights into brain damage in stroke-prone rats: a nuclear magnetic imaging study. Stroke, in press.

-Harukuni I, Bhardwaj A, Shaivitz AB,. DeVries AC,. London ED,. Hurn PD,. Traystman RJ,. Kirsch JR,. Faraci FM (2000) . Sigma(1)-receptor ligand 4-phenyl-1-(4-phenylbutyl)-piperidine affords neuroprotection from focal ischemia with prolonged reperfusion. Stroke. 31(4):976-82

-Janowski BA, Grogan MJ, Jones SA, Wisely GB, Kliewer SA, Corey EJ, Mangelsdorf DJ (1999) Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta. Proc Natl Acad Sci U S A 96:266-271.

-Jonas S, Aiyagari V, Vieira D, Figueroa M (2001) The failure of neuronal protective agents versus the success of thrombolysis in the treatment of ischemic stroke. The predictive value of animal models. Annals of the New York Academy of Sciences 939: 257-267.

-Jonas S (2001) A brief and very personal review of the prevention and treatment of stroke with recommendations for the direction of future investigations. Annals of the New York Academy of Sciences 939: 465-468.

-McCulloch J, Dewar D (2001) A radical approach to stroke therapy. Proceedings of the National Academy of Sciences USA 98: 10989-10991.

-Mun-Bryce S. Rosenberg GA. (1998) Matrix metalloproteinases in cerebrovascular disease. Journal of Cerebral Blood Flow & Metabolism. 18(11):1163-72.

-Neary JT, Rathbone MP, Cattabeni F, Abbracchio MP, Burnstock G (1996) Trophic actions of extracellular nucleotides and nucleosides on glial and neuronal cells. Trends Neurosci. 19(1): 13-18

-Nicosia S, Capra V, Accomazzo MR, Ragnuni D, Ravasi S, Caiani A, Jommi L, Saponara R, Mezzetti M, Rovati GE (1999). Receptors for cysteinyl-leukotrienes in human cells. Advances in Experimental Medicine & Biology. 447:165-70

-Sala A, Aliev GM, Rossoni G, Buccellati C, Burnstock G, Folco GC, Maclouf J. (1996) Morphological and functional changes of coronary vasculature caused by transcellular biosynthesis of sulfido-peptide leukotrienese in isolated heart of rabbit. Blood 87:1924-1832.

-Schena M, Shalon D, Heller R, Chai A, Brown PO, Davis RW (1996) Parallel human genome analysis: microarray-based expression monitoring of 1000 genes. Proceedings of the National Academy of Sciences of the United States of America. 93(20):10614-9

-Semenza GL (1998) Transcription factors in human disease. Oxford Monographs on Medical Genetics No. 37.

-Sironi L, Tremoli E, Miller I, Guerrini U, Calvio AM, Eberini I, Gemeiner M, Asdente M, Paoletti R, Gianazza E (2001) Acute-phase proteins before cerebral ischemia in stroke-prone rats: identification by proteomics. Stroke. 32(3):753-60.

-Trapaidze N, Gomes I. Cvejic S. Bansinath M. Devi LA. (2000) Opioid receptor endocytosis and activation of MAP kinase pathway. Brain Research Molecular Brain Research 76(2):220-8.

-Viviani B, Marinovich M (1998) Neurotoxicity: an active role for glia? Neurosci. Res. Commun. 23: 1-13.

-Viviani B, Galli CL, Padovani A, Ciusani E, Marinovich M (2000) Dying neural cells activate glia through the release of a protease product. Glia, 32:84-90.

-Viviani B, Corsini E, Galli CL, Marinovich M (1998) Glia increase degeneration of hippocampal neurobs through the release of tumor necrosis factor-alpha. Toxicol. Appl. Pharmacol. 150: 271-276.

-Watters JJ. Chun TY. Kim YN. Bertics PJ. Gorski J (2000) Estrogen modulation of prolactin gene expression requires an intact mitogen-activated protein kinase signal transduction pathway in cultured rat pituitary cells. Molecular Endocrinology 14(11):1872-81

Parole Chiave

ischemia cerebrale; infiammazione; proteoma; risonanza magnetica per immagini; fattori di trascrizione; neuroprotezione