RICERCA ITALIANA     

FIRB simili:

• 1 - PRIME: PRogetto Integrato Malattie Ereditarie
• 2 - Costituzione di una banca di DNA e cDNA per l'identificazione di nuovi marcatori diagnostici e prognostici della IgA nefropatia.
• 3 - GENOMICA FUNZIONALE DELLE MALATTIE MUSCOLARI E CARDIACHE. RICERCA DI NUOVI MARCATORI MOLECOLARI E DI NUOVI BERSAGLI PER LA TERAPIA
• 4 - Identificazione e validazione di meccanismi genetico-molecolari coinvolti nel trasporto tubulare renale del sodio nell'ipertensione e nelle sue complicanze d'organo.
• 5 - Identificazione di profili genomici nucleo-mitocondriali nella patogenesi di malattie comuni età-associate. Implicazioni diagnostiche e terapeutiche.
• 6 - Basi ereditarie della suscettibilità allo sviluppo dei tumori
• 7 - Decodificazione della complessità delle malattie genetiche "semplici"
• 8 - Sistemi di diagnostica molecolare per l'identificazione e l'analisi di determinanti genetici di rilevanza per l'agroindustria, la zootecnica e l'ambiente
• 9 - Identificazione e analisi dell'espressione dei geni nel suino per lo studio e il miglioramento della produzione e della qualità della carne
• 10 - Sviluppo di molecole innovative in grado di curare malattie neurodegenerative e neuroinfiammatorie.

Classificazione scientifico-disciplinare

• Area scientifico disciplinare: Scienze mediche
  • GENETICA MEDICA

Classificazione brevettuale

• CHEMISTRY; METALLURGY
  • BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS (immunoassay G01N33/53); COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES

Classificazione geografica

• Regione: Veneto

Bibliografia

· Almind K et al. Putting the genes for type 2 diabetes on the map. Nat Med 7:277-279, 2001.
· Bader JS. The relative power of SNPs and haplotype as genetic markers for association tests. Pharmacogenomics 2:11-24, 2001.
· Barker JN. Genetic aspects of psoriasis. Clin Exp Dermatol 26:321-325, 2001.
· Beaudet AL. 1998 ASHG Presidential Address. Making genomic medicine a reality. Am J Hum Genet 64:1-13, 1999.
· Becker KG, Diabetes 48:1353-1358, 1999.
· Bowcock AM, Hum Mol Genet 10:1793-1805, 2001
· Cardon LR, Bell JI. Association study designs for complex diseases. Nat Rev Genet 2:91-99, 2001.
· Cavanaugh J. International collaboration provides convincing linkage replication in complex disease through analysis of a large pooled data set: Crohn disease and chromosome 16. Am J Hum Genet 68: 1165-1171, 2001.
· Chanez P., Vignola A.M., Stenger R. et al. Platelet-derived growth factor in asthma. Allergy 50:878-883, 1995.
· Cheng S., Grow M.A., Pallaud C., et al.. A multilocus genotyping assay for candidate markers of cardiovascular disease risk. Genome Res 9: 936-949, 1999.
· Collins FS. Shattuck Lecture - Medical and societal consequences of the human genome project. N Engl J Med 341:28-37, 1999.
· Collins FS and McKusick VA. Implications of the human genome project for medical science. JAMA 285: 540-544, 2001.
· Cox NJ, Wapelhorst B, Morrison VA, et al. Seven regions of the genome show evidence of linkage to type 1 diabetes in a consensus analysis of 767 multiplex families. Am J Hum Genet 69:820-830, 2001.
· Giordano M., Mellai M., Hoogerdoon B., Momigliano-Richiardi P. Determination of SNP allele frequencies in pooled DNAs by primer extension genotyping and denaturing high performance liquid chromatography. J. Biochem Biophys Methods 47:101-110, 2001
· K.J. Holroyd, L.C. Martinati, E. Trabetti, et al. Asthma and bronchialhyperresponsiveness linked to the XY Long Arm Pseudosomal Region. Genomics, 52: 233-235, 1998.
· Heinzmann A, Deichmann. Genes for atopy and asthma. Current opinion Allergy Clin Immunol. 1:387-392, 2001
· Holloway JW, Lonjou C, Beghe B, et al. Linkage analysis of the 5q31-33 candidate region for asthma in 240 UK families. Genes Immun 2:20-24, 2001.
· Lander ES and Schork NJ. Genetic dissection of complex traits. Science 265:237-248, 1994.
· Lonjou C., Barnes K., Chen H. et al. A first trial of retrospective collaboration for positional cloning in complex inheritance: assay of the cytokine region on chromosome 5 by the Consortium on Asthma Genetics (COAG). PNAS 97:10942-10947, 2000.
· G. Malerba, E. Trabetti, C. Patuzzo, M.C. Lauciello, R. Galavotti, L. Pescollderungg, A.L. Boner, P.F. Pignatti. Candidate genes and a genome-wide search in Italian families with atopic asthmatic children. Clin Exp Allergy 29 Suppl.4:27-30, 1999.
· G. Malerba, M.C. Lauciello, T. Scherpbier, E. Trabetti, R. Galavotti, V. Cusin, L. Pescollderungg, G. Zanoni, L.C. Martinati, A.L. Boner, R.C. Levitt, P.F. Pignatti. Linkage analysis of chromosome 12 markers in Italian families with atopic asthmatic children. Am J Respir Crit Care Med 162:1587-1590, 2000.
· G. Malerba, C. Patuzzo, E. Trabetti, M.C. Lauciello, R. Galavotti, L.Pescollderungg, M.B. Whalen, G. Zanoni, L.C. Martinati, A.L. Boner, P.F. Pignatti. Chromosome 14 linkage analysis and mutation study of two serpin genes in allergic asthmatic families. J Allergy Clin Immunol 107: 654-658, 2001.
· Mathew C. Postgenomic technologies: hunting the genes for common disorders. B M J 322: 1031-1034, 2001.
· Palmer L.J., Lonjou C., Barnes K., et al. A retrospective collaboration on chromosome 5 by the International Consortium on Asthma Genetics (COAG). Clin Exp Allergy 31:152-154, 2001.
· C. Patuzzo, E. Trabetti, G. Malerba, L.C. Martinati, A.L. Boner, L. Pescollderungg, G. Zanoni, P.F. Pignatti.No linkage or association of the IL-4Ra gene Q576R mutation with atopic asthma in Italian families. J Med Genet 37:382-384, 2000.
· Peltonen L and McKusick VA. Dissecting human disease in the Postgenomic Era. Science 291: 1224-1229, 2001.
· Pritchard JK. Are rare variants responsible for susceptibility to complex diseases? Am J Hum Genet 69: 124-137, 2001.
· Reaven G. Role of insuline resiatnce in human disease. Diabetes 37:1595-1607, 1988.
· Riley JH, Allan CJ, Lai E, Roses A. The use of single nucleotide polymorphisms in the isolation of common disease genes. Pharmacogenomics 1:39-47, 2000.
· Risch N and Merikangas K. The future of genetic studies of complex human diseases. Sciences 273:1516-1517, 1996.
· Risch NJ. Searching for genetic determinants in the new millennium. Nature, 405: 847- 856, 2000.
· Stewart TL and Ralston SH. Role of genetic factors in the pathogenesis of osteoporosis. J Endocrinology 166:235-245, 2000.
· E.Trabetti, V. Cusin, G. Malerba, et al. Association of the FcepsilonRIbeta gene with bronchial hyper-responsiveness in an Italian population. J Med Genet, 35:680-681,1998.
· E. Trabetti, C. Patuzzo, G. Malerba, et al. Association of a Lymphotoxin alpha gene polymorphism and atopy in Italian Families. J Med Genet 36:323-325, 1999.
· Undlien DE, Trends Genet 17:93-100, 2001.
· S. Venanzi, G. Malerba, R. Galavotti, M.C. Lauciello, E. Trabetti, G. Zanoni, L. Pescollderungg, L.C. Martinati, A.L. Boner, P.F. Pignatti. Linkage to atopy on chromosome 19 in northern-eastern Italian families with allergic asthma. Clin Exp Allergy 31:1220-1224, 2001.
· Vignola A.M., Chanez P., Chiappara G. et al. Transforming growth factor-beta expression in mucosal biopsies in asthma and chronic bronchitis. Am J Respir Crit Care Med 156:591-599, 1997.
· Zhu F., Yan W., Zhao Z.L., Chai Y.B. et al. Improved PCR-based subtractive hybridization strategy for cloning differentially expressed genes. BioTechniques 29:310-313, 2000.

Parole Chiave

Malattie multifattoriali; Suscettibilita' genetica; Genomica funzionale