RICERCA ITALIANA     

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Classificazione scientifico-disciplinare

• Area scientifico disciplinare: Scienze mediche
  • PATOLOGIA GENERALE

Classificazione brevettuale

• CHEMISTRY; METALLURGY
  • ORGANIC CHEMISTRY (such compounds as the oxides, sulfides, or oxysulfides of carbon, cyanogen, phosgene, hydrocyanic acid or salts thereof C01; products obtained from layered base-exchange silicates by ion-exchange with organic compounds such as ammonium, phosphonium or sulfonium compounds or by intercalation of organic compounds C01B33/44; macromolecular compounds C08; dyes C09; fermentation products C12; fermentation or enzyme-using processes to synthesise a desired chemical compound or composition or to separate optical isomers from a racemic mixture C12P; production of organic compounds by electrolysis or electrophoresis C25B3/00, C25B7/00)
    • PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00)
• HUMAN NECESSITIES
  • MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES (bringing into special physical form A61J [N: mechanical aspects]; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; compounds per se C01, C07, C08, C12N; soap compositions C11D; micro-organisms per se C12N) [C0203]

Classificazione geografica

• Regione: Liguria

Bibliografia

(1) Steinman L. Multiple sclerosis: a two-stage disease. Nat Immunol 2001; 2(9):762-764.
(2) Oksenberg JR, Baranzini SE, Barcellos LF, Hauser SL. Multiple sclerosis: genomic rewards. J Neuroimmunol 2001; 113(2):171-184.
(3) Prineas JW. The neuropathology of multiple sclerosis. JC Koetsier ed, editor. [Handbook of Clinical Neurology. Vol.3 (47):], 213-258. 1985. Amsterdam:Elsevier.
Ref Type: Serial (Book,Monograph)
(4) Tourtellotte WW, Baumhefner RW, Syndulko K, Shapshak P, Osborne M, Rubinshtein G et al. The long march of the cerebrospinal fluid profile indicative of clinical definite multiple sclerosis; and still marching. J Neuroimmunol 1988; 20(2-3):217-227.
(5) Interferon beta-1b in the treatment of multiple sclerosis: final outcome of the randomized controlled trial. The IFNB Multiple Sclerosis Study Group and The University of British Columbia MS/MRI Analysis Group. Neurology 1995; 45(7):1277-1285.
(6) Zamvil SS, Steinman L. The T lymphocyte in experimental allergic encephalomyelitis. Annu Rev Immunol 1990; 8:579-621.
(7) Gran B, Hemmer B, Vergelli M, McFarland HF, Martin R. Molecular mimicry and multiple sclerosis: degenerate T-cell recognition and the induction of autoimmunity. Ann Neurol 1999; 45(5):559-567.
(8) Genain CP, Lee-Parritz D, Nguyen MH, Massacesi L, Joshi N, Ferrante R et al. In healthy primates, circulating autoreactive T cells mediate autoimmune disease. J Clin Invest 1994; 94(3):1339-1345.
(9) Uccelli A, Ristori G, Giunti D, Seri M, Montesperelli C, Caroli F et al. Dynamics of the reactivity to MBP in multiple sclerosis. J Neurovirol 2000; 6:S52-S56.
(10) de Rosbo NK, Ben Nun A. T-cell responses to myelin antigens in multiple sclerosis; relevance of the predominant autoimmune reactivity to myelin oligodendrocyte glycoprotein. J Autoimmun 1998; 11(4):287-299.
(11) Tuohy VK, Yu M, Weinstock-Guttman B, Kinkel RP. Diversity and plasticity of self recognition during the development of multiple sclerosis. J Clin Invest 1997; 99(7):1682-1690.
(12) Ristori G, Salvetti M, Pesole G, Attimonelli M, Buttinelli C, Martin R et al. Compositional bias and mimicry toward the nonself proteome in immunodominant T cell epitopes of self and nonself antigens. FASEB J 2000; 14(3):431-438.
(13) Sun D, Wekerle H. Ia-restricted encephalitogenic T lymphocytes mediating EAE lyse autoantigen-presenting astrocytes. Nature 1986; 320(6057):70-72.
(14) Pashenkov M, Huang YM, Kostulas V, Haglund M, Soderstrom M, Link H. Two subsets of dendritic cells are present in human cerebrospinal fluid. Brain 2001; 124(Pt 3):480-492.
(15) Shevach EM. Regulatory T cells in autoimmmunity. Annu Rev Immunol 2000; 18:423-449.
(16) Olsson T. Critical influences of the cytokine orchestration on the outcome of myelin antigen-specific T-cell autoimmunity in experimental autoimmune encephalomyelitis and multiple sclerosis. Immunol Rev 1995; 144:245-268.
(17) Huang D, Han Y, Rani MR, Glabinski A, Trebst C, Sorensen T et al. Chemokines and chemokine receptors in inflammation of the nervous system: manifold roles and exquisite regulation. Immunol Rev 2000; 177:52-67.
(18) Sallusto F, Lanzavecchia A. Mobilizing dendritic cells for tolerance, priming, and chronic inflammation. J Exp Med 1999; 189(4):611-614.
(19) Colombo M, Dono M, Gazzola P, Roncella S, Valetto A, Chiorazzi N et al. Accumulation of clonally related B lymphocytes in the cerebrospinal fluid of multiple sclerosis patients. J Immunol 2000; 164(5):2782-2789.
(20) Genain CP, Cannella B, Hauser SL, Raine CS. Identification of autoantibodies associated with myelin damage in multiple sclerosis. Nat Med 1999; 5(2):170-175.

Parole Chiave

Sistema Nervoso Centrale; Sclerosi Multipla; Autoimmunità; Liquor cefalorachidiano