RICERCA ITALIANA     

FIRB simili:

• 1 - Riconoscimento molecolare e funzionalità cellulare
• 2 - Molecole innovative ad attività antiflogistica ed antitumorale prodotte con metodologie chimiche avanzate
• 3 - Studio dell'identità cellulare e dei meccanismi di differenziazione cellulare nell'era della postegnomica utilizzando tre situazioni paradigmatiche: la mammella, l'osso e i linfociti
• 4 - Modelli transgenici per malattie ad eziologia complessa
• 5 - Meccanismi di regolazione dello sviluppo del sistema nervoso e del differenziamento neurale (PRONEURO)
• 6 - Meccanismi molecolari della morte cellulare e loro implicazione in patologia umana
• 7 - Approcci combinati di terapia genica nel trattamento del glioblastoma
• 8 - BILANCIO OSPITE-TUMORE NELLA TERAPIA MEDICA DELLE NEOPLASIE: RUOLO DI NF-kB
• 9 - Il sistema di trasduzione del segnale Ca2+: dalle molecole alle funzioni
• 10 - Interazioni funzionali tra proteine delle sinapsi: fisiopatologia e potenziali indicazioni terapeutiche

Classificazione scientifico-disciplinare

• Area scientifico disciplinare: Scienze mediche
  • PATOLOGIA GENERALE
  • MALATTIE DEL SANGUE

Classificazione brevettuale

• CHEMISTRY; METALLURGY
  • BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF (biocides, pest repellants or attractants, or plant growth regulators, containing micro-organisms, viruses, microbial fungi, enzymes, fermentates or substances produced by or extracted from micro-organisms or animal material A01N63/00; food compositions A21, A23; medicinal preparations A61K; chemical aspects of, or use of materials for, bandages, dressings, absorbent pads or surgical articles A61L; fertilisers C05); PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS (preservation of living parts of humans or animals A01N1/02); MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (micro-biological testing media C12Q)
  • ORGANIC CHEMISTRY (such compounds as the oxides, sulfides, or oxysulfides of carbon, cyanogen, phosgene, hydrocyanic acid or salts thereof C01; products obtained from layered base-exchange silicates by ion-exchange with organic compounds such as ammonium, phosphonium or sulfonium compounds or by intercalation of organic compounds C01B33/44; macromolecular compounds C08; dyes C09; fermentation products C12; fermentation or enzyme-using processes to synthesise a desired chemical compound or composition or to separate optical isomers from a racemic mixture C12P; production of organic compounds by electrolysis or electrophoresis C25B3/00, C25B7/00)
    • PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00)

Classificazione geografica

• Regione: Piemonte

Bibliografia

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2. Alessio, M., S. Roggero, A. Funaro, L. B. De Monte, L. Peruzzi, M. Geuna, and F. Malavasi. 1990. CD38 molecule: structural and biochemical analysis on human T lymphocytes, thymocytes, and plasma cells. J Immunol 145:878.
3. States, D. J., T. F. Walseth, and H. C. Lee. 1992. Similarities in amino acid sequences of Aplysia ADP-ribosyl cyclase and human lymphocyte antigen CD38. Trends Biochem Sci 17:495.
4. Howard, M., J. C. Grimaldi, J. F. Bazan, F. E. Lund, L. Santos-Argumedo, R. M. Parkhouse, T. F. Walseth, and H. C. Lee. 1993. Formation and hydrolysis of cyclic ADP-ribose catalyzed by lymphocyte antigen CD38. Science 262:1056.
5. Malavasi, F., A. Funaro, S. Roggero, A. Horenstein, L. Calosso, and K. Mehta. 1994. Human CD38: a glycoprotein in search of a function. Immunol Today 15:95.
6. Mehta, K., S. Umar, and F. Malavasi. 1996. Human CD38, a cell-surface protein with multiple functions. FASEB J 10:1408.
7. Deaglio, S., U. Dianzani, A. L. Horenstein, J. E. Fernandez, C. van Kooten, M. Bragardo, A. Funaro, G. Garbarino, F. Di Virgilio, J. Banchereau, and F. Malavasi. 1996. Human CD38 ligand. A 120-KDA protein predominantly expressed on endothelial cells. J Immunol 156:727.
8. Ferrero, E., and F. Malavasi. 1997. Human CD38, a leukocyte receptor and ectoenzyme, is a member of a novel eukaryotic gene family of nicotinamide adenine dinucleotide+-converting enzymes: extensive structural homology with the genes for murine bone marrow stromal cell antigen 1 and aplysian ADP-ribosyl cyclase. J Immunol 159:3858.
9. Funaro, A., M. Reinis, O. Trubiani, S. Santi, R. Di Primio, and F. Malavasi. 1998. CD38 functions are regulated through an internalization step. J Immunol 160:2238.
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Parole Chiave

ectoenzimi; marcatori diagnostici; marcatori prognostici; immunofarmaci; leucemie; diabete