RICERCA ITALIANA     

FIRB simili:

• 1 - BILANCIO OSPITE-TUMORE NELLA TERAPIA MEDICA DELLE NEOPLASIE: RUOLO DI NF-kB
• 2 - Sviluppo di molecole innovative in grado di curare malattie neurodegenerative e neuroinfiammatorie.
• 3 - Il sistema di trasduzione del segnale Ca2+: dalle molecole alle funzioni
• 4 - Modelli transgenici per malattie ad eziologia complessa
• 5 - Approcci combinati di terapia genica nel trattamento del glioblastoma
• 6 - Riconoscimento molecolare e funzionalità cellulare
• 7 - Meccanismi di regolazione dello sviluppo del sistema nervoso e del differenziamento neurale (PRONEURO)
• 8 - Studio dell'identità cellulare e dei meccanismi di differenziazione cellulare nell'era della postegnomica utilizzando tre situazioni paradigmatiche: la mammella, l'osso e i linfociti
• 9 - Meccanismi di trasduzione del segnale e funzione sinaptica: sviluppo di modelli molecolari, cellulari ed animali
• 10 - ESPRESSIONE GENICA ED ACCUMULO DI PROTEINE D'INTERESSE AGRONOMICO NELLA CELLULA VEGETALE: MECCANISMI TRASCRIZIONALI E POST-TRASCRIZIONALI

Classificazione scientifico-disciplinare

• Area scientifico disciplinare: Scienze biologiche
  • BIOLOGIA MOLECOLARE

Classificazione brevettuale

• CHEMISTRY; METALLURGY
  • BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF (biocides, pest repellants or attractants, or plant growth regulators, containing micro-organisms, viruses, microbial fungi, enzymes, fermentates or substances produced by or extracted from micro-organisms or animal material A01N63/00; food compositions A21, A23; medicinal preparations A61K; chemical aspects of, or use of materials for, bandages, dressings, absorbent pads or surgical articles A61L; fertilisers C05); PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS (preservation of living parts of humans or animals A01N1/02); MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (micro-biological testing media C12Q)

Classificazione geografica

• Regione: Lazio

Bibliografia

Adrain C, Martin SJ. The mitochondrial apoptosome: a killer unleashed by the cytochrome seas. Trends Biochem Sci. 2001 26:390-7
Aznar S, Lacal JC. Searching new targets for anticancer drug design: the families of Ras and Rho GTPases and their effectors. Prog Nucleic Acid Res Mol Biol. 2001;67:193-234
Barber GN. Host defense, viruses and apoptosis. Cell Death Differ. 2001 Feb;8(2):113-26
Boya P, Roques B, Kroemer G. New EMBO members' review: viral and bacterial proteins regulating apoptosis at the mitochondrial level. EMBO J. 2001 20:4325-31
Budd RC. Activation-induced cell death. Curr Opin Immunol. 2001;13:356-62
Cecconi F. Apaf1 is no longer single. Cell Death Differ. 2001;8:773-5
Ciriolo MR, et al. Differential role of superoxide and glutathione in S-nitrosoglutathione-mediated apoptosis: a rationale for mild forms of familial amyotrophic lateral sclerosis associated with less active Cu,Zn superoxide dismutase mutants. J Neurochem. 2001;77:1433-43
Ciriolo MR, et al. Role of the electrostatic loop of Cu,Zn superoxide dismutase in the copper uptake process. Eur J Biochem. 2001;268:737-42
Ciriolo MR, et al. Cu,Zn-superoxide dismutase-dependent apoptosis induced by nitric oxide in neuronal cells. J Biol Chem. 2000 18;275:5065-72
De Laurenzi V, Melino G. Apoptosis. The little devil of death. Nature. 2000;406:135-6
De Laurenzi V, Melino G. Evolution of functions within the p53/p63/p73 family. Ann N Y Acad Sci. 2000;926:90-100
De Laurenzi V, Melino G. Gene disruption of tissue transglutaminase. Mol Cell Biol. 2001;21:148-55
Domen J. The role of apoptosis in regulating hematopoiesis and hematopoietic stem cells. Immunol Res. 2001;22:83-94
Evan GI, Vousden KH. Proliferation, cell cycle and apoptosis in cancer. Nature. 2001;411:342-8
Fortin A, et al. APAF1 is a key transcriptional target for p53 in the regulation of neuronal cell death. J Cell Biol
Garaci E, et al. Nerve growth factor is an autocrine factor essential for the survival of macrophages infected with HIV. Proc Natl Acad Sci U S A. 1999;96:14013-8
Garrido C, et al. Heat shock proteins: endogenous modulators of apoptotic cell death. Biochem Biophys Res Commun. 2001;286:433-42
Giammarioli AM, et al GD3 glycosphingolipid contributes to Fas-mediated apoptosis via association with ezrin cytoskeletal protein. FEBS Lett. 2001;506:45-50
Hengartner MO. Apoptosis: corralling the corpses. Cell. 2001;104:325-8
Henson PM, et al. The phosphatidylserine receptor: a crucial molecular switch? Nat Rev Mol Cell Biol. 2001;2:627-33
Herdegen T, Waetzig V. AP-1 proteins in the adult brain: facts and fiction about effectors of neuroprotection and neurodegeneration. Oncogene. 2001;20:2424-37
Ho MK, Wong YH.G(z) signaling: emerging divergence from G(i) signaling. Oncogene. 2001;20:1615-25
Huang Z. Bcl-2 family proteins as targets for anticancer drug design. Oncogene. 2000;19:6627-31
Hughes RE, Olson JM. Therapeutic opportunities in polyglutamine disease. Nat Med. 2001;7:419-23
Iannicola C, et al. Early alterations in gene expression and cell morphology in a mouse model of Huntington's disease. J Neurochem. 2000;75:830-9
Jiang M, et al. p53 binds the nuclear matrix in normal cells: binding involves the proline-rich domain of p53 and increases following genotoxic stress. Oncogene. 2001;20:5449-58
Jochum W, et al. AP-1 in mouse development and tumorigenesis. Oncogene. 2001;20:2401-12
Kowaltowski AJ, et al. Mitochondrial permeability transition and oxidative stress. FEBS Lett. 2001;495:12-5
Leist M, Jaattela M. Four deaths and a funeral: from caspases to alternative mechanisms. Nat Rev Mol Cell Biol. 2001;2:589-98
Martinou JC, Green DR. Breaking the mitochondrial barrier. Nat Rev Mol Cell Biol. 2001;2:63-7
Matarrese P, et al. Expression of P-170 glycoprotein sensitizes lymphoblastoid CEM cells to mitochondria-mediated apoptosis. Biochem J. 2001;355:587-95
Mechta-Grigoriou F, et al. The mammalian Jun proteins: redundancy and specificity. Oncogene. 2001;20:2378-89
Melino G. The Sirens' song. Nature. 2001;412:23
Mollace V, et al. Oxidative stress and neuroAIDS: triggers, modulators and novel antioxidants. Trends Neurosci. 2001;24:411-6
Moroni MC, et al. Apaf-1 is a transcriptional target for E2F and p53. Nat Cell Biol. 2001;3:552-8
Muller H, et al. E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis. Genes Dev. 2001;15:267-85
Nemes Z,et al. Analysis of protein transglutamylation in apoptosis. Methods Cell Biol. 2001;66:111-33
Parlato S, et al. CD95 (APO-1/Fas) linkage to the actin cytoskeleton through ezrin in human T lymphocytes: a novel regulatory mechanism of the CD95 apoptotic pathway. EMBO J. 2000;19:5123-34
Perno CF, Cozzi-Lepri A, Balotta C, Forbici F, Violin M, Bertoli A, Facchi G, Pezzotti P, Cadeo G, Tositti G, Pasquinucci S, Pauluzzi S, Scalzini A, Salassa B, Vincenti A, Phillips AN, Dianzani F, Appice A, Angarano G, Monno L, Ippolito G, Moroni M, Monforte Ad. Secondary mutations in the protease region of human immunodeficiency virus and virologic failure in drug-naive patients treated with protease inhibitor-based therapy. J Infect Dis. 2001;184:983-91
Piredda L, Farrace MG, Lo Bello M, Malorni W, Melino G, Petruzzelli R, Piacentini M. Identification of 'tissue' transglutaminase binding proteins in neural cells committed to apoptosis. FASEB J. 1999;13:355-64
Pirkkala L, Nykanen P, Sistonen L. Roles of the heat shock transcription factors in regulation of the heat shock response and beyond. FASEB J. 2001;15:1118-31
Ranger AM, Malynn BA, Korsmeyer SJ. Mouse models of cell death. Nat Genet. 2001;28:113-8
Reed JC. Apoptosis-regulating proteins as targets for drug discovery. Trends Mol Med. 2001;7:314-9
Rossi L, De Martino A, Marchese E, Piccirilli S, Rotilio G, Ciriolo MR. Neurodegeneration in the animal model of Menkes' disease involves Bcl-2-linked apoptosis. Neuroscience. 2001;103:181-8
Ryan KM, Phillips AC, Vousden KH. Regulation and function of the p53 tumor suppressor protein. Curr Opin Cell Biol. 2001;13:332-7
Selliah N, Finkel TH. Biochemical mechanisms of HIV induced T cell apoptosis. Cell Death Differ. 2001;8:127-36
Senderowicz AM. Small molecule modulators of cyclin-dependent kinases for cancer therapy. Oncogene. 2000;19:6600-6
Shi Y. A structural view of mitochondria-mediated apoptosis. Nat Struct Biol. 2001;8:394-401
Stassi G, De Maria R. Response to 'Thyrocytes - not innocent bystanders in autoimmune disease' Nat Immunol. 2001;2:183
Stassi G, Di Liberto D, Todaro M, Zeuner A, Ricci-Vitiani L, Stoppacciaro A, Ruco L, Farina F, Zummo G, De Maria R. Control of target cell survival in thyroid autoimmunity by T helper cytokines via regulation of apoptotic proteins. Nat Immunol. 2000;1:483-8
Stassi G, Zeuner A, Di Liberto D, Todaro M, Ricci-Vitiani L, De Maria R. Fas-FasL in Hashimoto's thyroiditis. J Clin Immunol. 2001;21:19-23
Taylor WR, Stark GR. Regulation of the G2/M transition by p53. Oncogene. 2001;20:1803-15
Turkson J, Jove R. STAT proteins: novel molecular targets for cancer drug discovery. Oncogene. 2000;19:6613-26
Weber CH, Vincenz C. The death domain superfamily: a tale of two interfaces? Trends Biochem Sci. 2001;26:475-81
White MK, McCubrey JA. Suppression of apoptosis: role in cell growth and neoplasia. Leukemia. 2001;15:1011-21
Yu SP, Canzoniero LM, Choi DW. Ion homeostasis and apoptosis. Curr Opin Cell Biol. 2001;13:405-11
Zamzami N, Kroemer G. The mitochondrion in apoptosis: how Pandora's box opens. Nat Rev Mol Cell Biol. 2001;2:67-71
Zeuner A, Eramo A, Peschle C, De Maria R. Caspase activation without death. Cell Death Differ. 1999;6:1075-80
Zornig M, Hueber A, Baum W, Evan G. Apoptosis regulators and their role in tumorigenesis. Biochim Biophys Acta. 2001;1551, F1-F37

Parole Chiave

apoptosi; ciclo cellulare; neurodegenerazione; infezioni virali; tumori; specie reattive dell'ossigeno