RICERCA ITALIANA     

FIRB simili:

• 1 - Sviluppo di microsistemi multifunzionali per analisi in diagnostica clinica e nel settore alimentare
• 2 - Sviluppo di microsistemi multisensoriali per applicazioni ambientali e agroalimentari
• 3 - NANOTECNOLOGIE E NANOSCIENZE ORGANICHE
• 4 - Microtecnologie per la telepresenza immersiva virtuale
• 5 - MIcrosistemi sensoriali per Applicazioni estreme ed Ostili (MIAO)
• 6 - Sviluppo di metodiche e approcci endovascolari per la diagnosi e la cura della patologia cerebrovascolare, ed esplorazione di nuove tecniche per l'esecuzione di interventi chirurgici a bassissima invasività con l'ausilio della guida robotica.
• 7 - Studio di microsistemi multifunzionali per determinazioni chimiche e biochimiche in matrici biologiche complesse
• 8 - Manipolazione di biomolecole, fluidi, sistemi e dati per la tecnologia Bio-chip
• 9 - Sviluppo di un Lab-on-a-chip basato su tecnologia microelettronica e sua validazione biotecnologica
• 10 - Nanotecnologie e nanodispositivi per la società dell'informazione

Classificazione scientifico-disciplinare

• Area scientifico disciplinare: Scienze chimiche
  • CHIMICA ANALITICA

Classificazione brevettuale

• CHEMISTRY; METALLURGY
  • BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS (immunoassay G01N33/53); COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES

Classificazione geografica

• Regione: Lombardia

Bibliografia

DNA MICROARRAYS

Watson et al., (1998), Curr. Opin. Biotechnol., 9, 609-614

Duggan et al., (1999), Nat. Gen., 21, S10-S14

Graves, (1999),Trends Biotechnol., 17, 127-134

Pollack et al., (1999), Nat. Gen., 23, 41-46

De Sauzieu et al., (1998), Nat. Biotechnol., 16, 45-48

Johnston, (1998), Curr. Biol., 8, 171-174

O’Donnell- Maloney et al., (1996), Genet. Anal., 12, 151-157

Matthews J.A. and Kricka L.J.,(1988), Anal.Biochem., 169, 1-25

Collins FS, Patrinos A, Jordan E, Chakravarti A, Gesteland R,"New goals for the U.S. Human Genome Project 1998-2003", 1998, Science, 282: 682-689

McCarthy JJ, Hilfiker R,"The use of single-nucleotide polymorphism maps in pharmacogenomics", 2000, Nat. Biotechnol, 18: 505-508

Proudnikov et al., (1998), Anal. Biochem., 259, 34-41

Chrisey et al., (1996), Nucleic Acid Res., 24, 3031-3039

Rasmussen et al., (1991), Anal. Biochem., 198, 138-142

Salo et al., (1999), Bioconjug. Chem., 10, 815-823

Beier and Hoheisel, (1999), Nucleic Acid Res., 27, 1970-1977

Cheung et al., Nat. Gen., 21, 15-19

Morozov e Morozova, (1999), Anal. Chem., 71, 3110-3117

Fodor et al., (1991), Science, 251: 767-773

Schena et al., (1996), Genome Res., 6, 639-645

Methods in Molecular Biology, vol. 162, 2001- Vol. I, Capillary Electrophresis of Nucleic acids, cap. 9, M. Chiari e M. Cretich, Capillary coating: choices for capillary Electrophoresis of DNA.

CE MICROCHIPS

Altria, K. Ed., Chromatographia CE series: Analysis of Nucleic Acids by Capillary Electrophoresis, Heller, C., (Ed)

Harrison, D.J., Fluri K, Seiler, K., Fan, Z., Effenhauser, C.S., Manz, A., Micromachining a miniaturized capillary electrophoresis-based chemical analysis system on a chip, Science, 1993, 261, 895-897.

Jacobson S.C., Ramsey, M., integrated microdevice for DNA restriction fragment analysis, Anal. Chem., 1996, 68, 720-723.

Kopp, M., de Mello A., J., Manz, A., Chemical amplification continuos-flow PCR on a chip, Science, 1998, 280, 1046-1047.

Manz, A., Becker, H., Eds., Microsystem Technology in Chemistry and Life Science, vol. 194 di Topics in Current Chemistry (Springer, Berlin, 1984)

Manz, A., Fettinger, J.C., Verpoorte, E., Indi, H., Widmer. H. M, Micromachining of microcrystalline silicon and glass for chemical analysis systems, Trends, Anal. Chem., 1991, 10, 144-148.

Petersen, K.E., Silicon as a mechanical material , Proc. IEEE 1982, 70, 420-457.

Jacobson, S.C., Koutny, L.B., Hergenroder R., Moore A.W., Ramsey, M., Microchip capillary electrophoresis with integrated postcolumn reactor, Anal. Chem., 1994, 66, 3472-3476.

Regnier, F., He, B., Lin, S., Busse, J., Chromatography and
electrophoresis on chips: critical elements of future integrated, microfluidic analytical systems for life science, Trends in
Biotechnology, 1999, 17, 101-106

Tavrow, L.S., Bart, S.F., Lang, J.H., Operational characteristics of microfabricated electric motors, Sensor and Actuators A, 1992, 35, 33-44.

Waters, L.C., Jacobson, S.C., Kroutchinina, N., Khandurina, J., Foote, R.S., Ramsey, J.M., Microchip device for cell lysis, multiplex PCR amplification, and electrophoretic sizing, Anal. Chem., 1998, 70, 158-162.

Wise K.D., Najafi, K., Microfabrication techniques for integrated sensors and microsystems , Science 1991, 254, 1335-1342.

SNE

Carella M, D’Ambrosio L, Totaro A: Mutation analysis of the HLA-H gene in Italian hemochromatosis patients. Am J Hum Genet 1997; 60: 828–382.

Feder JN, Gnirke A, Thomas W, Tsuchihashi Z, Ruddy DA, Basava A, et al.: A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis. Nat Genet. 1996 Aug;13(4):399-408.

Fortina P, Delgrosso K, Sakazume T, Santacroce R, Moutereau S, Su HJ, Graves D, McKenzie S, Surrey S.: Simple two-color array-based approach for mutation detection. Eur J Hum Genet. 2000; 8(11):884-94.

Gasparini P, Rabionet R, Barbujani G, Melchionda S, Petersen M, Brondum-Nielsen K, Metspalu A, Oitmaa E, Pisano M, Fortina P, Zelante L, Estivill X.: High carrier frequency of the 35delG deafness mutation in European populations. Genetic Analysis Consortium of GJB2 35delG. Eur J Hum Genet. 2000;8(1):19-23

Pastinen T, Kurg A, Metspalu A, Peltonen L, Syvanen A-C: Minisequencing: a specific tool for DNA analysis and diagnostics on oligonucleotide arrays. Genome Res 1997; 7: 606–614.

Southern E, Mir K, Shchepinov M: Molecular interactions on microarrays. Nat Genet 1999; 21(suppl 1): 5–9.

Tonisson N, Kurg A, Lohmussaar E, Metspalu A: Arrayed primer extension on the DNA chip: method and applications. In: Schena M (ed). Microarray Biochip Technology. BioTechniques Books: Natick, MA, 2000, pp 247–263.

Zelante L, Gasparini P, Estivill X, Melchionda S, D'Agruma L, Govea N, Mila M, Monica MD, Lutfi J, Shohat M, Mansfield E, Delgrosso K, Rappaport E, Surrey S, Fortina P.: Connexin26 mutations associated with the most common form of non-syndromic neurosensory autosomal recessive deafness (DFNB1) in Mediterraneans. Hum Mol Genet. 1997;6(9):1605-9.

NANOGEN MICROCHIPS

Edman CF, Raymond DE, Wu DJ, Tu E, Sosnowski RG, Butler WF, Nerenberg M, Heller M. Electric field directed nucleic acid hybridization on microchips. Nucl Ac Res 1997; 25(24):4907-4914.

Gilles PN, Wu DJ, Foster CB, Dillon PJ, Chanock SJ. Single nucleotide polymorphic discrimination by an electronic dot blot assay on a semiconductor microchips. Nat Biotechnol 1999; 17:365-370.

21-HYDROXYLASE DEFICIT

P. Carrera, A.M. Barbieri, M. Ferrari , P.G. Righetti, M. Perego, C. Gelfi. (1997). Rapid detection of 21-hydroxylase deficiency mutations by allele-specific in vitro amplification and capillary zone electrophoresis. CLINICAL CHEMISTRY. vol. 43(11), pp. 2121-2127.

STARGARDT MACULAR DISTROPHY

Allikmets R, Sing N, Sun H, Shroyer NF, Hutchinson A, Chidambaram A, Gerrard B, Baierd L, Stauffer D, Peiffer A, Rattner A, Smallwood P, Li Y, Anderson KL, Lewis RA, Nathans J, Leppert M, Dean M, Lupski JR. A photoreceptor cell-specific ATP-binding transporter gene (ABCR) is mutated in recessive Stargardt macular dystrophy. Nat Genet 15, 236-245 (1997)

SPAD

S.Cova, A.Longoni, and A.Andreoni:
"Towards picosecond resolution with single-photon avalanche diodes"
Rev. Sci. Instrum. 52, 408-412 (1981)

S.Cova, A.Longoni,and G.Ripamonti:
"Active-Quenching and Gating Circuits for Single-Photon Avalanche Diodes (SPADs)".
IEEE Trans. on Nucl. Sci. NS-29, 599-601, (1982)

T.A.Louis, G.Ripamonti, A.Lacaita
"Photoluminescence lifetime microscope spectrometer based on time-correlated single-photon counting with an avalanche diode detector"
Rev.Sci.Instrum. 61, 11-22 (1990)

A.Lacaita, M.Ghioni, F.Zappa, G.Ripamonti, S.Cova:
"Recent advances in the detection of optical photons with silicon photodiodes"
Nucl.Instr. and Meth., A326, 290-294 (1993)

A.Lacaita, S.Cova, C.Samori, M.Ghioni :
"Performance optimizationof active quenching circuits for picosecond timing with single-photon avalanche diodes"
Rev. Sci. Instrum., 66, 4289-4295 (1995)

S.Cova, M.Ghioni, A.Lacaita, C.Samori, F.Zappa:
"Avalanche photodiodes and quenching circuits for single photon -detection"
Appl. Optics., 35, 1956-1976 (1996)

M.Ghioni, S.Cova, F.Zappa, C.Samori
"Compact active quenching circuit for fast photon counting with avalanche photodiodes"
Rev. Sci. Instrum., 67, 3440-3448 (1996)

A. Spinelli, A. L. Lacaita
"Physics and Numerical Simulation of Single Photon Avalanche Diodes"
IEEE Trans. Electron Devices, 44, 1931-1943 (1997)

Zappa F.,Ghioni M.,Zappa R.,Drodofski U.
High-sensitivity photodetectors with on-chip pinhole for laser scanning microscopy
IEEE Trans. Electron Devices, 47, 1472 -1476 (2000)

Parole Chiave

MICROSISTEMI; DNA; MICROCHIP; CONTEGGIO DI FOTONI; ELETTROFORESI CAPILLARE; MALATTIE GENETICHE