RICERCA ITALIANA     

FIRB simili:

• 1 - Identificazione, purificazione, transdifferenziazione e banking di cellule staminali indirizzate verso fenotipi propri e non propri da utilizzare per riparazione tissutale
• 2 - Cellule staminali adulte pluripotenti per la ricostituzione tissutale in modelli di malattie degenerative
• 3 - Approcci combinati di terapia genica nel trattamento del glioblastoma
• 4 - www*.neuralstemcells.it (*where,when,why)
• 5 - Studio dell'identità cellulare e dei meccanismi di differenziazione cellulare nell'era della postegnomica utilizzando tre situazioni paradigmatiche: la mammella, l'osso e i linfociti
• 6 - BILANCIO OSPITE-TUMORE NELLA TERAPIA MEDICA DELLE NEOPLASIE: RUOLO DI NF-kB
• 7 - Impiego delle tecniche di ingegneria tissutale nello sviluppo di protesi vascolari cellularizzate
• 8 - L'ingegneria dei tessuti per la rigenerazione dei tessuti connettivi con particolare riferimento al tessuto osseo
• 9 - ESPANSIONE E DIFFERENZIAZIONE IN VITRO DI CELLULE STAMINALI CORDONALI E DA LIQUIDO AMNIOTICO DA UTILIZZARE NELL'INGEGNERIA TESSUTALE
• 10 - Determinazione dei meccanismi molecolari di trasduzione del segnale implicati nel controllo della proliferazione e differenziamento in cellule emopoietiche

Classificazione scientifico-disciplinare

• Area scientifico disciplinare: Scienze biologiche
• Area scientifico disciplinare: Scienze mediche
  • PATOLOGIA GENERALE
  • MALATTIE DEL SANGUE

Classificazione brevettuale

• CHEMISTRY; METALLURGY
  • BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF (biocides, pest repellants or attractants, or plant growth regulators, containing micro-organisms, viruses, microbial fungi, enzymes, fermentates or substances produced by or extracted from micro-organisms or animal material A01N63/00; food compositions A21, A23; medicinal preparations A61K; chemical aspects of, or use of materials for, bandages, dressings, absorbent pads or surgical articles A61L; fertilisers C05); PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS (preservation of living parts of humans or animals A01N1/02); MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (micro-biological testing media C12Q)

Classificazione geografica

• Regione: Friuli Venezia Giulia

Bibliografia

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Curr Opin Cell Biol 11:255-260, 1999.
Bassini A, Zauli G, Migliaccio G, Migliaccio AR, Pascuccio M, Pierpaoli S, Guidotti L, Capitani S, and Vitale M. Lineage-restricted expression of protein kinase C (PKC) isoforms in hematopoiesis. Blood 93:1178-1188, 1999.
Bjornson CRR, Rietze RL, Reynolds BA, Magli MC, Vescovi AL. Turning Brain into Blood: A Hematopoietic Fate Adopted by Adult Neural Stem Cells in Vivo Science 283:534-537, 1999.
Blau HM, Brazelton TR, Weimann JM. The evolving concept of a stem cell: entity or function ? Cell 105:829-841, 2001.
Cibelli JB, Stice SL, Golueke PJ, Kane JJ, Jerry J, Blackwell C, Ponce de Leon FA, Robl JM. Cloned transgenic calves produced from nonquiescent fetal fibroblasts. Science 280:1256-1258, 1998.
Clarke DL, Johansson CB, Wilbertz J, Veress B, Nilsson E, Karlström H, Lendahl U, Frisén J Generalized Potential of Adult Neural Stem Cells Science 288:1660-1663, 2000.
Cocco L, Martelli AM, Gilmour RS, Rhee SG, Manzoli FA. Nuclear phospholipase C and signaling. Biochim Biophys Acta 1530:1-14, 2001.
Di Pietro R, Secchiero P, Rana R, Gibellini D, Visani G, Bemis K, Zamai L, Miscia S, Zauli G. Ionizing radiation sensitizes erythroleukemic cells but not normal erythroblasts to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)--mediated cytotoxicity by selective up-regulation of TRAIL-R1. Blood 97:2596-2603, 2001.
De Maria R, Zeuner A, Eramo A, Domenichelli C, Bonci D, Grignani F, Srinivasula SM, Alnemri ES, Testa U, Peschle C. Negative regulation of erythropoiesis by caspase-mediated cleavage of GATA-1. Nature 401:489-493, 1999.
Dunnwald M, Tomanek-Chalkley A, Alexandrunas D, Fishbaugh J, and Bickenbach JR. Isolating a pure population of epidermal stem cells for use in tissue engineering. Exp Dermatol 10:45-54, 2001.
Earnshaw WC. Apoptosis. A cellular poison cupboard. Nature 397:387-389, 1999.
Eichmann A, Corbel C, Nataf V, Vaigot P, Breant C, Le Douarin NM. Ligand-dependent development of the endothelial and hemopoietic lineages from embryonic mesodermal cells expressing vascular endothelial growth factor receptor 2. Proc Natl Acad Sci U S A 94:5141-5146, 1997.
Ferrari G, Cusella-De Angelis G, Coletta M, Paolucci E, Stornaiuolo A, Cossu G, Mavilio F. Muscle Regeneration by Bone Marrow-Derived Myogenic Progenitors. Science 279:1528-1530, 1998.
Flake AW, Zanjani ED. In utero hematopoietic stem cell transplantation: ontogenic opportunities and biologic barriers. Blood. 94:2179-2191, 1999.
Goodell MA, Rosenzweig M, Kim H, Marks DF, DeMaria M, Paradis G, Grupp SA, Sieff CA, Mulligan RC, and Johnson RP. Dye efflux studies suggest that ematopoietic stem cells expressing low or undetectable levels of CD34 antigen exist in multiple species. Nat Med 3:1337-1345, 1997.
Hao Q, Thiemann F, Petersen D, Smogozewska E, Crooks G. Extended long-term culture reveals a highly quiescent and primitive human hematopoietic progenitor population. Blood 88:3306-3313, 1996
Haslauer M, Baltensperger K, Porzig H.Erythropoietin- and stem cell factor-induced DNA synthesis in normal human erythroid progenitor cells requires activation of protein kinase Calpha and is strongly inhibited by thrombin. Blood 94:114-126, 1999.
Hug H, Sarre TF. Protein kinase C isoenzymes: divergence in signal transduction? Biochem J 291:329-343, 1993.
Iscove NN, Nawa K. Hematopoietic stem cells expand during serial transplantation in vivo without apparent exhaustion. Curr Biol 7:805-808, 1997.
Jackson KA, Mi T, Goodell MA. Hematopoietic potential of stem cells isolated from murine skeletal muscle. PNAS 96:14482-14486, 1999.
Karin M New twists in gene regulation by glucocorticoid receptor: is DNA binding dispensable? Cell 93:487-490, 1998.
Lagasse E, Shizuru JA, Uchida N, Tsukamoto A, Weissman IL. Toward regenerative medicine. Immunity 14:425-436, 2001
Martelli AM, Capitani S, Neri LM. The generation of lipid signaling molecules in the nucleus. Prog Lipid Res. 38:273-308, 1999.
Medvinsky A, Dzierzak E. Definitive hematopoiesis is autonomously initiated by the AGM region. Cell 86:897-906, 1996
Migliaccio AR, Carta C, Migliaccio G. In vivo expansion of purified hematopoietic stem cells transplanted in nonablated W/Wv mice. Exp Hematol 27:1655-1666, 1999.
Myklebust JH, Smeland EB, Josefsen D, Sioud M. Protein kinase C-alpha isoform is involved in erythropoietin-induced erythroid differentiation of CD34(+) progenitor cells from human bone marrow. Blood 95:510-8, 2000.
Niho Y, Asano Y. Fas/Fas ligand and hematopoietic progenitor cells. Curr Opin Hematol 5:163-165, 1998.
Park JR. Cytokine regulation of apoptosis in hematopoietic precursor cells. Curr Opin Hematol 3:191-196, 1996.
Shaaban AF, Kim HB, Milner R, Flake AW. A kinetic model for the homing and migration of prenatally transplanted marrow. Blood 94:3251-3257, 1999.
Shalaby F, Ho J, Stanford WL, Fischer KD, Schuh AC, Schwartz L, Bernstein A, Rossant J. A requirement for Flk1 in primitive and definitive hematopoiesis and vasculogenesis. Cell 89:981-990, 1997.
Sutherland HJ, Lansdorp PM, Henkelman DH, Eaves AC, Eaves CJ. Functional characterization of individual human hematopoietic stem cells cultured at limiting dilution on supportive marrow stromal layers. Proc Natl Acad Sci U S A 87:3584-3588, 1990.
von Lindern M, Parren-van Amelsvoort M, van Dijk T, Deiner E, van den Akker E, van Emst-de Vries S, Willems P, Beug H, Lowenberg B.Protein kinase C alpha controls erythropoietin receptor signaling. J Biol Chem 275:34719-34727, 2000.
Weissman IL. Stem cells: units of development, units of regeneration, and units in evolution. Cell 100:157-168, 2000
Wilmut I, Schnieke AE, McWhir J, Kind AJ, Campbell KH. Viable offspring derived from fetal and adult mammalian cells. Nature 385:810-813, 1997.
Yoder MC, Hiatt K, Mukherjee P. In vivo repopulating hematopoietic stem cells are present in the murine yolk sac at day 9.0 postcoitus. Proc Natl Acad Sci U S A 94:6776-6780, 1997.
Zamai L, Secchiero P, Pierpaoli S, Bassini A, Papa S, Alnemri ES, Guidotti L, Vitale M, Zauli G. TNF-related apoptosis-inducing ligand (TRAIL) as a negative regulator of normal human erythropoiesis. Blood 95:3716-3724, 2000.
Zauli G, Valvassori L, Capitani S. Presence and characteristics of circulating megakaryocyte progenitor cells in human fetal blood. Blood 81:385-390, 1993.
Zauli G, Furlini G, Vitale M, Re MC, Gibellini D, Zamai L, Visani G, Borgatti P, Capitani S, La Placa M. A subset of human CD34+ hematopoietic progenitors express low levels of CD4, the high affinity receptor for human immunodeficiency virus-type 1. Blood 84:1896-1905, 1994.
Zauli G, Vitale M, Gibellini D, et al. Inhibition of purified CD34+ hematopoietic progenitor cells by HIV-1 or gp120 is mediated by endogenous TGF-b1. J Exp Med 183:99-108, 1996
Zauli G, Bassini A, Vitale M, Gibellini D, Celeghini C, Caramelli E, Pierpaoli S, Guidotti L, Capitani S. Thrombopoietin enhances the alpha IIb beta 3-dependent adhesion of megakaryocytic cells to fibrinogen through PI 3 kinase. Blood 89:883-895, 1997
Zauli G, Vitale M, Falcieri E, Gibellini D, Bassini A, Celeghini C, Columbaro M, Capitani S. In vitro senescence and apoptotic cell death of human megakaryocytes. Blood 90:2234-2243, 1997.
Zauli G, Gibellini D, Secchiero P, et al. The induction of megakaryocyte differentiation is accompanied by selective Ser133 phosphorylation of the transcription factor CREB in both HEL cell line and primary CD34+ cells. Blood 92:472-480, 1998.
Zauli G, Gibellini D, Secchiero P, Dutartre H, Olive D, Capitani S, Collette Y. Human immunodeficiency virus type 1 Nef protein sensitizes CD4(+) T lymphoid cells to apoptosis via functional upregulation of the CD95/CD95 ligand pathway. Blood 93:1000-1010, 1999.
Ziegler BL, Valtieri M, Porada GA, De Maria R, Muller R, Masella B, Gabbianelli M, Casella I, Pelosi E, Bock T, Zanjani ED, Peschle C. KDR receptor: a key marker defining hematopoietic stem cells. Science 285:1553-1558, 1999.

Parole Chiave

cellule staminali umane; espansione in vitro; angiogenesi; fattori di crescita; citochine inibitorie; bioreattori