RICERCA ITALIANA     

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• 2 - Molecole innovative ad attività antiflogistica ed antitumorale prodotte con metodologie chimiche avanzate
• 3 - Approcci combinati di terapia genica nel trattamento del glioblastoma
• 4 - Metodologie Innovative di Risonanza Magnetica (RM) in Patologie Tumorali e Cardiovascolari
• 5 - Modulazione razionale dell'attività antitumorale di farmaci "classici" tramite intervento selettivo su specifiche cascate regolatorie
• 6 - Sviluppo di biotecnologie e di sistemi per il miglioramento della cura e del monitoraggio di tumori solidi mediante perfusione locoregionale
• 7 - BILANCIO OSPITE-TUMORE NELLA TERAPIA MEDICA DELLE NEOPLASIE: RUOLO DI NF-kB
• 8 - Sviluppo di molecole innovative in grado di curare malattie neurodegenerative e neuroinfiammatorie.
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• 10 - Il sistema di trasduzione del segnale Ca2+: dalle molecole alle funzioni

Classificazione scientifico-disciplinare

• Area scientifico disciplinare: Scienze mediche
  • PATOLOGIA GENERALE
  • MICROBIOLOGIA E MICROBIOLOGIA CLINICA
  • MALATTIE INFETTIVE

Classificazione brevettuale

• HUMAN NECESSITIES
  • MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES (bringing into special physical form A61J [N: mechanical aspects]; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; compounds per se C01, C07, C08, C12N; soap compositions C11D; micro-organisms per se C12N) [C0203]

Classificazione geografica

• Regione: Marche

Bibliografia

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2. R.F. Service. Drug delivery takes a deap breath. Science 1997, 277, 1199-1200.
3. The Use of Resealed Erythrocytes as Carriers and Bioreactors. M. Magnani and J.R. De Loach Eds. Advances in experimental medicine and biology. 1992 Plenum Press. New York.
4. Transformed erythrocyes, process for preparing the same, and their use in pharmaceutical compositions. M. Magnani, L. Rossi. 1991, European Patent application n. 91 401 602.7 EP 0517986B1.
5. Method of encapsulating biologically active agents within erythrocytes, and apparatus therefor. M. Magnani, I. Panzani, L. Bigi and A. Zanella. 1998, United States Patent application . n. 09/071005. Patent Number 6, 139, 836.
6. Red Blood Cells as Carriers for Drugs. J.R. De Loach and U. Sprandel Eds. Bibliotheca Haematologica n. 51, 1985. Karger Press, New York.
7. Carrier and Bioreactors red blood cells for drug delivery and targeting. J.R. De Loach and J.L. Way Eds. Advances in the Biosciencies. Vol. 92, 1994. Elsevier Science Ltd. Great Britain.
8. Eryhtrocytes as Drug Carriers in Medicine. U. Sprandel and J.L. Way Eds. 1997. Plenum Press, New York.
9. M. Magnani. Engineered erythrocytes for new biomedical applications. Biochimica in Italia. Anno I n. 1, 1994, 7-13.
10. M. Magnani, L. Rossi, M. D’Ascenzo, I. Panzani, L. Bigi et al. Erythrocyte engineering for drug delivery and targeting. Biotechnol. Appl. Biochem. 1998, 28, 1-6.
11. C. Ropars, G. Avenard, M. Chassaigne. Large-scale entrapment of drugs into resealed red blood cells using a continuous-flow dialysis system. In: R. Green, K.J. Widder, eds. Method in Enzymology. Vol. 149, Drug and enzyme targeting, Part B San Diego Acad. Press, 1987, 242-248.
12. A.De Flora, U. Benatti., L. Guida, E. Zocchi. Encapsulation of adriamycin in human erythrocytes. Proc. Natl. Acad. Sci. USA 1986, 83, 7029-7033.
13. E. Zocchi, M. Tonetti, C. Polvani, L. Guida, U. Benatti et al. Encapsulation of doxorubicin in liver targeted erythrocytes increases the therapeutic index of the drug in a murine metastatic model. Proc. Natl. Acad. Sci. USA 1989, 86, 2040-2044.
14. R.L. Juliano, H. Yoo. Aspects of the transport and delivery of antisense oligonucleotides. Curr. Opin. Mol. Ther. 2000, 2(3), 297-303.
15. S.A. Barker, D. Khossravi. Drug delivery strategies for the new Millenium. Drug Discov. Today 2001, 6(2), 75-77.
16. A.Becker, C. Hessenius, K. Licha, B. Ebert, U. Sukowski, W. Semmler, C. Grotzinger. Receptor-target optical imaging of tumors with near-infrered fluorescent ligands. Nature Biotech. 2001, 19, 327-331.
17. J.R. De Loach and C. Barton. Glutaraldehyde-treated carrier erythrocytes for organ targeting of methotrexate in dogs. Am. J. Vet. Res. 1971, 42, 1971-1974.
18. L. Chiarantini, R. Droleskey, M. Magnani, J.R. De Loach. In vitro targeting of erythrocytes to cytotoxic T-cells by coupling of Thy-1,2 monoclonal antibody. Biotech. Appl. Biochem. 1992, 15, 171-184.
19. M.M. Kay. Mechanism of removal of senescent cells by human macrophages in situ. Proc. Natl. Acad. Sci. USA 1975, 72, 3521-3525.
20. F. Turrini, P. Arese, J. Yuang, P.S. Low. Clustering of integral membrane proteins of the human erythrocyte membrane stimulated autologous IgG binding, complement deposition, and phagocytosis. J. Biol. Chem. 1991, 266, 23611-23617.
21. M. Magnani, L. Rossi, G. Brandi, G.F. Schiavano, M. Montroni et al. Targeting antiretroviral nucleoside analogues in phosphorylated form to macrophages: in vitro and in vivo studies. Proc. Natl. Acad. Sci. USA 1992, 89, 6477-6481.
22. L. Chiarantini, L. Rossi, A. Fraternale, M. Magnani. Modulation red blood cell survival by membrane protein clustering. Mol. Cell. Biochem. 1995, 144, 53-59.
23. L. Rossi, M. Bianchi and M. Magnani. Increased glusose metabolism by enzyme-loaded erythrocytes in vitro and in vivo normalization of hyperglycemia in diabetic mice. Biotech. Appl. Biochem. 1992, 15, 207-216.
24. M. Magnani, L. Rossi, M. Bianchi, G. Serafini, E. Zocchi, C. Ropars. Improved stability of 2,3-bisphosphoglycerate during storage of hexokinase-overloaded erythrocytes. Biotech. Appl. Biochem. 1989, 11, 439-444.
25. M. Magnani, M. Laguerre, L. Rossi, M. Bianchi, P. Ninfali, F. Mangani, C. Ropars. In vivo accelerated acetaldehyde metabolism using acetaldehyde dehydrogenase-loaded erythrocytes. Alcohol Alcoholism 1990, 25(6), 627-637.
26. R. Kravtzoff, I. Desbois, C. Doinel, P. Colombat, J.P. Lamaguere et al. Immunological response to L-asparaginase loaded into red blood cells. In: The Use of Resealed Erythrocytes as Carriers and Bioreactors, M. Magnani and J.R. De Loach eds. 1992, pp. 175-182, Plenum Press, New York.
27. A.Fraternale, A. Casabianca, L. Rossi, L. Chiarantini, G. Brandi, G. Aluigi, G.F. Schiavano, M. Magnani. Inhibition of murine AIDS by combination of AZT and dideoxycytidine 5’-triphosphate. J. AIDS 1996, 12, 164-173.
28. M. Magnani, L. Rossi, A. Fraternale, L. Silvotti, F. Quintavalla, G. Piedimonte, D. Matteucci, F. Baldinotti, M. Bendinelli. FIV infection of macrophages: in vitro and in vivo inhibition of dideoxycytidine5’-triphosphate. Veter. Immunol. And Immunopathol. 1995, 46,151-158.
29. M. Magnani, A. Casabianca, A. Fraternale, G. Brandi, S. Gessani, R. Williams, M. Giovine, G. Damonte, A. De Flora, U.Benatti. Synthesis and targeted delivery of an azidothymidine homodinucleotide conferring protection to macrophages against retroviral infection. Proc. Natl. Acad. Sci. USA1996, 93, 4403-4408.
30. M. Magnani, A. Casabianca, A. Fraternale, G. Brandi, L. Chiarantini, U. Benatti, S. Scarfì, E. Millo, A. De Flora. Inhibition of murine AIDS by a new azidothymidine homodinucleotide. J. AIDS 1998, 17, 189-195.
31. L. Rossi, G. Brandi, G.F. Schiavano, E. Balestra, E. Millo, S. Scarfì, G. Damonte, A. Gasparini, M. Magnani. C-F. Perno, U. Benatti, A. De Flora. Macrophage protection against human immunodeficiency virus or herpes simplex virus by red blood cell-mediated delivery of a heterodinucleotide of azidothymidine and acyclovir. AIDS Res. Hum. Retrovir. 1998, 14 (5), 435-444.
32. L. Rossi, G. Brandi, G.F. Schiavano, S. Scarfì, E. Millo, G. Damonte, U. Benatti, A. De Flora, M. Magnani. Heterodimer-loaded erythrocytes as bioreactors for slow delivery of the antiviral drug azidothymidine and the antimycobacterial drug ethambutol. AIDS Res. Hum. Retrovir. 1999, 15(4), 345-353.
33. L. Rossi, S. Serafini, L. Cappellacci, E. Balestra, G. Brandi, G.F. Schiavano, P. Franchetti, M. Grifantini, C-F. Perno, M. Magnani. Erythrocyte-mediated delivery of a new homodinucleotide active against human immunodeficiency virus and herpes simplex virus. J. Antimicr. Chem. 2001, 47, 819-827.
34. P. Franchetti, G.A. Sheikha, L. Cappellacci, S. Marchetti, M. Grifantini, E. Balestra, , Carlo-Federico Perno, U. Benatti, G. Brandi, L. Rossi, M. Magnani. A new acyclic heterodinucleotide active against human immunodeficiency virus and herpes simplex virus. Antiviral Research 2000, 47, 149-158.
35. A.De Flora, E. Zocchi, L. Guida, C. Polvani, U. Benatti. Conversion of encapsulated 5-fluoro-2’-deoxyuridine 5’-monophosphate to the antineoplastic drug 5-fluoro-2’-deoxyuridine in human erythrocytes. Proc. Natl. Acad. Sci. USA 1988, 85, 3145-
36. R. Green, J. Miller, W. Crosby. Enhancement of iron chelation by Desferrioxamine entrapped in red blood cells ghosts. Blood 1981, 57, 866-
37. F. Esposito, A.M. Santroni, A. Habinetzel, V. Grellani, A. Pessi, S. Lombardi, G. Falcioni, M. Brunori. Intraerythrocytic administration of a synthetic Plasmodium antigen elicits antibody response in mice, without carrier molecules or adjuvants. Int. J. Parasitol. 1990, 20, 1109-
38. C.Polvani,A. Gasparini, U. Benatti, A. De Flora, S. Silvestri, G. Volpini, L. Nencioni. Murine red blood cells as efficient carriers of three bacterial antigens for the production of specific and neutralizing antibodies. Biotech. Appl. Biochem. 1991, 14,347-

Parole Chiave

GLOBULI ROSSI; DRUG CARRIERS; SISTEMI PER DRUG TARGETING; MACROFAGI; NUOVI FARMACI; PROCESSO DI INCAPSULAMENTO CELLULARE