RICERCA ITALIANA     

FIRB simili:

• 1 - Epigenetica e cromatina
• 2 - Il riconoscimento molecolare nelle interazioni proteina-ligando, proteina-proteina e proteina superficie: sviluppo di approcci sperimentali e computazionali integrati per lo studio di sistemi di interesse farmaceutico
• 3 - PROTEASI NELLA RISPOSTA CELLULARE NORMALE E PATOLOGICA: IDENTIFICAZIONE DEI SUBSTRATI ENDOGENI E DEI MECCANISMI MOLECOLARI INDOTTI
• 4 - Genomica e Proteomica nello studio di funzioni cellulari complesse(GAP).
• 5 - Misfolding di proteine e patologie umane: studio della conversione patologica di proteine globulari in aggregati fibrillari e sviluppo di farmaci che inibiscano i processi di misfolding e aggregazione
• 6 - Meccanismi molecolari della morte cellulare e loro implicazione in patologia umana
• 7 - Identificazione di nuovi marcatori molecolari per la diagnosi e la prognosi del carcinoma renale con tecniche genomiche e proteomiche. (Possibile risultato atteso: Identificazione di nuovi marcatori diagnostici o prognostici di malattie).
• 8 - Sviluppo di molecole innovative in grado di curare malattie neurodegenerative e neuroinfiammatorie.
• 9 - Post genomica di leguminose foraggere
• 10 - Studio delle interazioni proteine-rame, proteine-proteine, proteine-acidi nucleici e proteine-lipidi a livello dei microdomini di membrana. Rilevanza per la comprensione delle "patologie da microdomini di membrana" come le malattie da prioni, la malattia di Alzheimer e le alterazioni del metabolismo lipidico.

Classificazione scientifico-disciplinare

• Area scientifico disciplinare: Scienze biologiche
  • BIOLOGIA MOLECOLARE
  • GENETICA

Classificazione brevettuale

• CHEMISTRY; METALLURGY
  • BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF (biocides, pest repellants or attractants, or plant growth regulators, containing micro-organisms, viruses, microbial fungi, enzymes, fermentates or substances produced by or extracted from micro-organisms or animal material A01N63/00; food compositions A21, A23; medicinal preparations A61K; chemical aspects of, or use of materials for, bandages, dressings, absorbent pads or surgical articles A61L; fertilisers C05); PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS (preservation of living parts of humans or animals A01N1/02); MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (micro-biological testing media C12Q)

Classificazione geografica

• Regione: Lombardia

Bibliografia

1 Bird AP, Wolffe AP (1999) Methylation-induced repression: belts, braces, and chromatin Cell 99:451-4

2 Wade PA (2001) Methyl CpG binding proteins: coupling chromatin architecture to gene regulation Oncogene 20:3166-73

3 Ehrlich KC (1993) Characterization of DBPm, a plant protein that binds to DNA containing 5-methylcytosine Biochim Biophys Acta 1172:108-16

4 Pitto L, Cernilogar F, Evangelista M, Lombardi L, Miarelli C, Rocchi P (2000) Characterization of carrot nuclear proteins that exhibit specific binding affinity towards conventional and non-conventional DNA methylation Plant Mol Biol 44:659-73

5 Finnegan EJ, Peacock WJ, Dennis ES (2000) DNA methylation, a key regulator of plant development and other processes Curr Op Gen Dev 10:217-223

6 Helin K (1998) Regulation of cell proliferation by the E2F transcription factors Curr Opin Genet Dev 8:28-35

7 Luo RX, Postino AA, Dean DC (1998) Rb interacts with histone deacetylase to repress transcription Cell 92:463-73

8 Robertson KD, Ait-Sit-Ali S, Yokochi T, Wade PA, Jones PL Wolffe AP (2000) DNMT1 forms a complex with Rb, E2F1 and HDCA1 and represses transcription from E2F-responsive promoters Nature Genet 25:338-342

9 Albani D, Mariconti L, Ricagno S, Pitto L, Moroni C, Helin K, Cella R (2000) DcE2F, a functional plant E2F-like transcriptional activator from D. carota J Biol Chem 275:19258-19267

10 Breviario D and Nick P. (2000) Review-article: Plant tubulins: a melting pot for basic questions and promising applications Trans Res 9:383-393

11 Cleveland, DW (1987) The multitubulin hyphotesis revisited: what have we learned? J Cell Biol 104:381-383

12 Goddard GH, Wick S. M., Silflow CD, Snustad DP (1994) Microtubule components of the plant cell cytoskeleton Plant Physiol 104:1-6

13 Villemur, R, Joyce CM, Haas NA, Goddard RH, Kopczak SD, HusseyPJ, Snustad DP, Silflow CD (1992) a-tubulin gene family of maize (Z. mays) J Mol Biol 227:81-96

14 Villemur, R, Haas, N.A., Joyce, C. M., Snustad, D.P. and Silflow, C.D. (1994) Characterization of four new b-tubulin genes and their expression during male flower development in maize (Z. mays) Plant Mol Biol 24:295-315

15 Kornberg RD, Lorch Y (1999) Twenty-five years of the nucleosome, fundamental particle of the eukaryotic chromosome Cell 98:285-294

16 Struhl K (1998) Histone acetylation and transcriptional regulatory mechanisms Genes Dev 12:599-606

17 Lusser A, Kolle D, Loidl P (2001) Histone acetylation: lesson from the plant kingdom Trends Plant Sci 6:59-65

18 Rossi V, Hartings H, Motto M (1998) Identification and characterisation of an RPD3 homologoue from maize (Z. mays L.) that is able to complement an rpd3 null mutant of S. cerevisiae Mol Gen Genet 258:288-296

19 Rossi V, Varotto S, Locatelli S, Lanzanova C, Lauria M, Zanotti E, Hartings H, Motto M (2001) The maize WD-repeat gene ZmRbAp1 encodes a member of the MSI/RbAp sub-family and is differentially expressed during endosperm development Mol Genet Genom 265:576-584

20 Herrick G, Seger, J (1999). Imprinting and paternal genome elimination in insects Results Probl Cell Differ 25:41-71

21 Sleutels F, Barlow DP, Lyle R (2000) The uniqueness of the imprinting mechanism Curr Opin Genet Dev. 10:229-233

22 Alleman M, Doctor J (2000) Genomic imprinting in plants: observations and evolutionary implications Plant Mol Biol 43:147-161

23 Lund G, Messing J, Viotti A (1995). Endosperm-specific demethylation and activation of specific alleles of -tubulin genes of Z. mays Mol Gen Genet 246:716-722

24 Lund G, Ciceri P, Viotti A (1995). Maternal-specific demethylation and expression of specific alleles of zein genes in the endosperm of Z. mays. Plant J 8:571-581

25 Yadegary R, Kinoshita T, Lotan O, Cohen G, Katz A, Choi Y, Nakashima K, Harada JJ, Goberg RB, Fisher RL, Ohad N (2000) Mutations of the FIE and Mea genes that interact polycomb proteins cause parent-oforigin effects on seed development by distinct mechanisms. Plant Cell 12:2367-2382

26 Sturaro M, Viotti A (2001). Methylation of the Opaque2 box in zein genes is parent-dependent and affects O2 DNA binding activity in vitro. Plant Mol Biol 46:549-560

27 Stevens FJ and Argon Y (1999) Protein folding in the ER. Semin Cell Devel Biol 10:443-454

28 Pedrazzini E, Giovinazzo G, Bielli A, de Virgilio M, Frigerio L, Pesca M, Faoro F, Bollini R, Ceriotti A, Vitale A (1997) Protein quality control along the route to the plant vacuole. Plant Cell 9:1869-1880

29 Ellgaard, L and Helenius, A (2001) ER quality control: towards an understanding at the molecular level Curr Opin Cell Biol 13, 431-437

30 Vitale A, Denecke J (1999) The endoplasmic reticulum - Gateway of the secretory pathway Plant Cell 11:615-628

31 Miernik JA (1999) Protein folding in the plant cell Plant Physiol 121:695-703

32 Gething M-J (1999) Role and regulation of the ER chaperone BiP. Semin Cell Devel Biol 10:465-472

33 Pedrazzini E, Giovinazzo G, Bollini R, Ceriotti A, Vitale A (1994) Binding of BiP to assembly-defective protein in plant cells. Plant J 5:103-110

34 Shewry PR and Tatam AS. (1997) Disulphide bonds in wheat gluten proteins J Cereal Sci 25, 207-227

35 Ferrari DM and Soling HD (1999) The protein disulphide-isomerase family: unravelling a string of folds. Biochem. J. 339: 1-10

36 Ciaffi M., Dominici L., Tanzarella O.A. and Porceddu E. (1999). Chromosomal assignement of gene sequences coding for protein disulphide isomerase (PDI) in wheat. Theor Appl Genet 98:405-410.

37 Ciaffi M, Paolacci A.R., Dominici L., Tanzarella O.A. and Porceddu E. (2001) Molecular characterization of gene sequences coding for protein disulfide isomerase (PDI) in durum wheat (T. turgidum ssp. durum). Gene 265:147-156

38 Galili G, Shimoni Y, Giorini-Silfen S, Levanony H, Altschuler Y, and Shani N (1996) Wheat storage proteins: assembly, transport and deposition in protein bodies Plant Physiol Biochem 34, 245-252

39 Wrigley C (1996) Giant proteins with flour power. Nature 381:738-739.

40 Payne PI, Nighttingale MA, Krattinger AF, Holt, LM (1987) The relationship between the HMW glutenin subunit composition and the bread-making quality of British grown wheat varieties J Sci Food Agric 38:51-65

41 Torrent M, Alvarez I, Geli MI, Dalcol I, Ludevid D (1997) Lysine-rich modified (-zein accumulates in protein bodies of transiently transformed maize endosperms Plant Mol Biol 34:139

42 Bagga S, Adams HP, Rodriguez FD, Kemp JD, Sengupta-Gopalan C (1997) Coexpression of the maize -zein and beta zein genes results in stable accumulation of -zein in endoplasmic reticulum-derived protein bodies formed by beta zein Plant Cell 9:1683-1696

43 Duranti M, Scarafoni A, Gius C, Negri A, Faoro F (1994) Heat-induced synthesis and tunicamycin-sensitive secretion of the putative storage glycoprotein conglutin gamma from mature lupin seeds Eur J Biochem 222:387-393

44 Scarafoni A, Di Cataldo A, Vassilevskaia TD, Bekman EP, Rodrigues-Pousada C, Ceciliani F, Duranti M (2001) Cloning, sequencing and expression in the seeds and radicles of two Lupinus albus g-conglutin genes Biochim Biophys Acta 1519:147-151

45 Kazutoshi M (2000) Tripartite management of unfolded proteins in the endoplasmic reticulum. Cell 101:451-454

46 Ng DTW, Spear ED, Walter P (2000) The unfolded protein respone regulates multiple aspects of secretory and membrane protein biogenesis and endoplasmic reticulum quality control J Biol Chem 150:77-88

47 Patil C, Walter P (2001) Intracellularsignaling from the endoplasmic reticulum to the nucleus: the unfoldede protein response in yeast and mammals Curr Op in Cell Biol 13:349-356


48 Travers KJ, Patil CK, Wodicka L, Lockhart DJ, Weissman JS, Walter P (2000) Functional and genomic analysis reveal an essential coordination between the unfolded protein response and ER-associated degradation Cell 101:249-258

49 Sparvoli F, Faoro F, Daminati M G, Ceriotti A, Bollini R (2000) Misfolding and aggregation of vacuolar glycoproteins in plant cells Plant J 24:825-836

Parole Chiave

Sequenze geni regolatrici di piante; Rimodellamento della cromatina; Attivatori e repressori trascrizionali; Proteine della via di secrezione; Modificazioni post-traduzionali di proteine vacuolari; Accumulo di proteine di alto valore biologico