RICERCA ITALIANA     

FIRB simili:

• 1 - Sviluppo di microsistemi multifunzionali per analisi in diagnostica clinica e nel settore alimentare
• 2 - Bioinformatica per la Genomica e la Proteomica
• 3 - Sviluppo di microsistemi multisensoriali per applicazioni ambientali e agroalimentari
• 4 - MICRO-SISTEMI PER DIAGNOSTICA GENETICA
• 5 - INTESA - INtegrazione TElematica SAnitaria per la continuità di cura della salute del cittadino
• 6 - Infrastruttura Telematica d'Area per la Continuità della Assistenza sanitaria - ITACA
• 7 - MIcrosistemi sensoriali per Applicazioni estreme ed Ostili (MIAO)
• 8 - PIATTAFORME ABILITANTI PER GRIGLIE COMPUTAZIONALI A ELEVATE PRESTAZIONI ORIENTATE A ORGANIZZAZIONI VIRTUALI SCALABILI
• 9 - Nuove Metodologie e tecnologie integrate per la documentazione e restauro dei complessi archeologici e monumentali mediterranei.
• 10 - NANOTECNOLOGIE E NANOSCIENZE ORGANICHE

Classificazione scientifico-disciplinare

• Area scientifico disciplinare: Ingegneria industriale e dell'informazione
  • ELETTRONICA
  • SISTEMI DI ELABORAZIONE DELLE INFORMAZIONI
  • BIOINGEGNERIA ELETTRONICA E INFORMATICA

Classificazione brevettuale

• CHEMISTRY; METALLURGY
  • BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF (biocides, pest repellants or attractants, or plant growth regulators, containing micro-organisms, viruses, microbial fungi, enzymes, fermentates or substances produced by or extracted from micro-organisms or animal material A01N63/00; food compositions A21, A23; medicinal preparations A61K; chemical aspects of, or use of materials for, bandages, dressings, absorbent pads or surgical articles A61L; fertilisers C05); PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS (preservation of living parts of humans or animals A01N1/02); MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (micro-biological testing media C12Q)

Classificazione geografica

• Regione: Lombardia

Bibliografia

DNA chip

1. Chee M et al. "Accessing genetic information with high density DNA arrays". Science 274:610-614 (1996)
2. Hacia J et al" Detection of Heterozygous Mutations in Brca1 Using High-Density Oligonucleotide Arrays and 2-Color Fluorescence Analysis" Nature Genetics 14:441-447 (1996)
3. Lockhart DJ et al “Expression Monitoring by Hybridization to High-Density Oligonucleotide Arrays” Nature Biotechnology 14 : 1675-1680 (1996)
4. Shoemaker-DD et al. “Quantitative Phenotypic Analysis of Yeast Deletion Mutants Using a Highly Parallel Molecular Bar-Coding Strategy” Nature Genetics 14: 450-456 (1996)
5. Mcgall-G et al. “Light-Directed Synthesis of High-Density Oligonucleotide Arrays Using Semiconductor Photoresists“ Proc. Natl. Acad USA 93:13555-13560 (1996)
6. Kozal-MJ et al “Extensive Polymorphisms Observed in HIV-1 Clade-B Protease Gene Using High-Density Oligonucleotide Arrays” Nature Medicine 2 :753-759 (1996)
7. “SPATIALLY-ADDRESSABLE IMMOBILIZATION OF OLIGONUCLEOTIDES AND OTHER BIOLOGICAL POLYMERS ON SURFACES” US PATENT NO.: 5,412,087
8. “METHOD AND APPARATUS FOR IMAGING A SAMPLE ON A DEVICE” US PATENT NO.: 5,578,832
9. “COMPUTER-AIDED ENGINEERING SYSTEM FOR DESIGN OF SEQUENCE ARRAYS AND LITHOGRAPHIC MASKS” US PATENT NO.: 5,593,839
10. “SURFACE-BOUND, UNIMOLECULAR, DOUBLE-STRANDED DNA” US PATENT NO.: 5,556,752
11. METHODS FOR MAKING A DEVICE FOR CONCURRENTLY PROCESSING MULTIPLE BIOLOGICAL CHIP ASSAYS” PATENT NO.: 5,545,531
12. M. Schena et al. "Parallel human genome analysis: Microarray-based expression monitoring of 1000 genes" Proc. Natl. Acad USA 93:10614-10619 1996
13. Yershov et al. "DNA analysis and diagnostics on oligonucleotide microchips” Proc. Natl. Acad USA 93:4913-4918 (1996)
14. Drmanac R et al. “DNA sequence determination by hybridization : A strategy for efficient large scale sequencing” Science 260 :1649-1652 1993
15. “METHOD OF SEQUENCING BY HYBRIDIZATION OF OLIGONUCLEOTIDE PROBES” US PATENT NO.: 5,525,464
16. METHOD OF SEQUENCING OF GENOMES BY HYBRIDIZATION OF OLIGONUCLEOTIDE PROBES” US PATENT NO.: 5,202,231
17. ACTIVE PROGRAMMABLE ELECTRONIC DEVICES FOR MOLECULAR BIOLOGICAL ANALYSIS AND DIAGNOSTICS” US PATENT NO.: 5,605,662


Protein chip
1.Yalow RS, Berson SA. Assay of plasma insulin in human subjects by immunological methods. Nature 1959; 184: 1648-9.
2. Ekins RP. The estimation of thyroxine in human plasma by an electrophoretic technique. Clin. Chim. Acta 1960; 5: 453-9.
3. Gosling GP. A decade of development in immunoassay methodology. Clin Chem 1990; 36: 1408-27.
4. Silzel JW, Cercek B, Dodson C, et al. Mass-sensing, multianalyte microarray immunoassay with imaging detection. Clin Chem 1998; 44: 2036-43.
5. Kricka LJ. Trends in immunoassay technologies. J Clin Immunoassay 1993; 16: 267-71.

Microluidica / Microfluidics

Jian HM, Schlick T, Vologodskii A; “Internal motion of supercoiled DNA: Brownian dynamics simulations of site juxtaposition”; J. Mol. Biol., 284 (2), pp 287-296, NOV 27 1998;
Accoto D., Carrozza M.C., Dario P. (2000). “Modelling of micropumps using unimorph piezoelectric actuator and balls valves”, J. Microm. Microeng. vol. 10, pp. 277-281;
Dario P., Croce N., Carrozza M.C., Varallo G. (1996). “A fluid handling system for a chemical microanalyzer”, J. Microm. Microeng. vol. 6, pp. 95-98.
Carrozza M.C., Menciassi A., Dario P., Tiezzi G. (1996), “Methods and Techniques for Cell Micromanipulation”, in Di Natale C., D’Amico A., Sensors and Microsystems. (pp. 346-350), Singapore: World Scientific Publishing Co. Pte. Ltd.
Miller G.A., Belosludtsev Y.Y., Murphy T.H., Garner H.R., “Transparent Electronically Controlled DNA Chips”, Biom. Microd., Vol. 2, No 3, pp. 215-220, June 2000;
Mastangelo C.H., Burns M.A., Burke D.T., “Microfabricated Devices for Genetic Diagnostics”, Proc. IEEE, vol. 86, No 8, pp. 1769-1787, August 1998;
Manz A., Effenhauser C.S., Burggraf N., Harrison D.J., Seiler K., Fluri K., “Electroosmotic pumping and electrophoretic separations for miniaturized chemical analysis systems”, J. Microm. Microeng., Vol. 4, pp. 257-265, 1994.

Analisi statistica dei dati

Alter, O., Brown, P.O., Botstein, D. (2000) P Natl Acad Sci USA., 97(18), 10101-10106.
Basset, D.E., Eisen, M.B., Boguski, M.S. (1999) Nat Genet, 21(Supplement), 51-55
Bicciato, S. (1999) Scuola Nazionale di Biofisica, Biofisica del DNA, Bressanone, Italia, 13-15 Settembre 1999
Bicciato, S., Di Bello, C. (2000) In Biondi, E., Grattarola, M., Magenes, G., Stefanelli, M., Tagliasco, V. Analisi e Modifica di Biomolecole e di Cellule, 123-141, Bologna, Patron, Italia
Bicciato, S., Toffolo, G.M. (2001) ESMTB School, Biology and Mathematics of Cells: Physiology, Kinetics and Evolution, Sigüenza, Spagna, 11-22 Giugno 2001
Butte, A.J., Tamayo, P., Slonim, D., Golub, T.R., Kohane, I.S. (2000) P Natl Acad Sci USA., 97(22), 12182-12186
Cline, E.I., Bicciato, S., Lingen, M.W. (2001) Nature Genetics Oncogenomics Conference:Dissecting Cancer through Genome Researc. 25-27 Gennaio 2001, Tucson, Arizona, USA.
DeRisi, J.L., Iyer, V.R., Brown, P.O. (1997) Science, 278(5338), 680-686
Fuhrman, S., Cunningham, M.J., Wen, X., Zweiger, G., Seihamer, J.J., Somogyi, R. (2000) Biosystems, 55, 5-14
Golub, T.R., Slonim, D.K., Tamayo, P., Huard, C., Gaasenbeek, M., Mesirov, J.P., Coller, H., Loh, M., Downing, J.R., Caligiuri, M.A., Bloomfield, C.D., Lander, E.S. (1999) Science, 286(5439), 531-537
Hasina, R., Hulett, K., Bicciato, S., Cline, E.I., Lingen, M.W. (2001) American Association for Cancer Research, 92nd Annual Meeting. 24-28 Marzo 2001. New Orleans, LA, USA.
Kamimura, R.T., Bicciato, S., Shimizu, H., Alford, J., Stephanopoulos, G.N. (2000a) Metabolic Engeneering, 2(3), 218-227
Kamimura, R.T., Bicciato, S., Shimizu, H., Alford, J., Stephanopoulos, G.N. (2000b) Metabolic Engeneering, 2(3), 228-238
Marx, J. (2000) Science, 289(5485), 1670-1672
Perou, C.M., Jeffrey, S.S., van de Rijn, M., Rees, C.A., Eisen, M.B., Ross, D.T., Pergamenschikov, A., Williams, C.F., Zhu, S.X., Lee, S.X., Lashkari, D., Shalon, D., Brown, P.O., Botstein, D. (1999) P Natl Acad Sci USA, 96, 9212—9217
Ross, DT., Scherf, U., Eisen, M.B., Perou, C.M., Rees, C., Spellman, P., et al (2000) Nat Genet, 24(3), 227-35
Sherlock, G., Hernandez-Boussard, T., Kasarskis, A., Binkley, G., Matese, J.C, Dwight, S.S., Kaloper, M, Weng, S., Jin, H., Ball, C.A., Eisen, M.B, Spellman, P.T., Brown, P.O, Botstein, D, Cherry, J.M. (2001) Nucleic Acids Research, 29(1), 152-155
Spellman, P.T., Sherlock, G., Iyer, V.R., Zhang, M., Anders, K., Eisen, M.B., Brown, P.O., Botstein, D., Futcher, B. (1998) Mol Biol Cell, 9, 3273-3297
Stephanopoulos, G.N., Kamimura, R.T., Rinaldi, C., Bicciato, S. (1999) Abstracts of papers of the American Chemical Society. 166-BIOT, 217
Tamayo, P., Slonim, D., Mesirov, J., Zhu, Q., Kitareewan, S., Dmitrovsky, E., Lander, E.S., Golub, T.R. (1999) P Natl Acad Sci USA., 96(6), 2907-2912

Parole Chiave

DNA chip; protein chip; micromatrici; microsistemi; microfluidica; analisi statistica