RICERCA ITALIANA     

FIRB simili:

• 1 - Studio dell'identità cellulare e dei meccanismi di differenziazione cellulare nell'era della postegnomica utilizzando tre situazioni paradigmatiche: la mammella, l'osso e i linfociti
• 2 - GENOTOPO:Genomica funzionale del topo
• 3 - Modelli transgenici per malattie ad eziologia complessa
• 4 - Meccanismi di regolazione dello sviluppo del sistema nervoso e del differenziamento neurale (PRONEURO)
• 5 - Riconoscimento molecolare e funzionalità cellulare
• 6 - BILANCIO OSPITE-TUMORE NELLA TERAPIA MEDICA DELLE NEOPLASIE: RUOLO DI NF-kB
• 7 - Il sistema di trasduzione del segnale Ca2+: dalle molecole alle funzioni
• 8 - Metodologie per l'individuazione e lo sviluppo di molecole in grado di interferire specificamente con bersagli critici per la terapia di malattie
• 9 - Molecole innovative ad attività antiflogistica ed antitumorale prodotte con metodologie chimiche avanzate
• 10 - Nuovi strumenti biotecnologici e post-genomici utilizzabili per la rivascolarizzazione dei tessuti nelle malattie ischemiche.

Classificazione scientifico-disciplinare

• Area scientifico disciplinare: Scienze biologiche
  • BIOLOGIA MOLECOLARE
• Area scientifico disciplinare: Scienze mediche
  • GENETICA MEDICA

Classificazione brevettuale

• CHEMISTRY; METALLURGY
  • BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF (biocides, pest repellants or attractants, or plant growth regulators, containing micro-organisms, viruses, microbial fungi, enzymes, fermentates or substances produced by or extracted from micro-organisms or animal material A01N63/00; food compositions A21, A23; medicinal preparations A61K; chemical aspects of, or use of materials for, bandages, dressings, absorbent pads or surgical articles A61L; fertilisers C05); PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS (preservation of living parts of humans or animals A01N1/02); MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (micro-biological testing media C12Q)

Classificazione geografica

• Regione: Lazio

Bibliografia

WP2:
Donohue PJ, Shapira H, Mantey SA, Hampton LL, Jensen RT, Battey JF.
Brain Res Mol Brain Res 54: 152-60, 1998.

Drees BL. Curr Opin Chem Biol. 3: 64-70, 1999.

Kuhn R, Schwenk F. Curr Opin Immunol. 9: 183-8, 1997.

Imai et al., Cell, 105: 891–902, 2001.

Marazziti,D., Golini,E., Gallo,A., Lombardi,M.S., Matteoni,R. and Tocchini-Valentini,G.P. Genomics 45: 68-77, 1997.

Marazziti, D., Gallo, A., Golini, E., Matteoni, R. and Tocchini-Valentini, G.P. Genomics 53: 315-324, 1998.

Rajewsky K, Gu H, Kuhn R, Betz UA, Muller W, Roes J, Schwenk F.
J Clin Invest. 98: 600-3, 1996.

Zeng Z, Su K, Kyaw H, Li Y. Biochem Biophys Res Commun. 233:
559-67,1997.


WP2:
1. S.H. Mui, R. Hindges, G. Lemke and S. Bertuzzi (2001). The homeodomain protein Vax2 patterns the dorsoventral and nasotemporal axes of the eye. Submitted to Nature

2. S. Bertuzzi, R. Hindges, S.H. Mui, D.D.M. O'Leary and G. Lemke (1999). The homeodomain protein Vax1 is required for axon guidance and major tract formation in the developing forebrain. Genes Dev. 13:3092-105

3. S. Bertuzzi, F.D. Porter, A. Pitts, M. Kumar, A. Agulnick, C. Wassif and H. Westphal (1999). Characterization of Lhx9, a novel LIM/homeobox gene expressed by the pioneer neurons in the mouse cerebral cortex. Mech. Dev. 80: 193-198

4. H.Z. Sheng*, S. Bertuzzi*, M. Taira, I.B. Dawid and H. Westphal (1997). Expression of murine Lhx5 suggests a role in forebrain specification. Dev. Dyn. 208: 266-277. * Co-first authors

5. F. Bozzi, S. Bertuzzi, D. Strina, C. Giannetto, P. Vezzoni, A. Villa (1996). The exon-intron structure of human LHX1 gene. Biochem. Byophys Res. Comm. 229:494-497

6. S. Bertuzzi, H.Z. Sheng, N.G. Copeland, D.J. Gilbert, N.A. Jenkins, M. Taira, I.B. Dawid and H. Westphal (1996). Molecular cloning, structure, and chromosomal localization of the mouse LIM/homeobox gene Lhx5. Genomics 36: 234-239

7. H. Sheng, A.B. Zhadanov, B. Mosinger, T. Fujii, S. Bertuzzi, A. Grinberg, E.J. Lee, S.P. Huang, K.A. Mahon and H. Westphal (1996). The LIM homeobox gene Lhx3 is essential for the specification and proliferation of pituitary cell lineages. Science 272: 1004-1007

8. A.B. Zhadanov, S. Bertuzzi, M. Taira, I.B. Dawid and H. Westphal (1995). Expression pattern of the murine LIM class homeobox gene Lhx3 in subsets of neural and neuroendocrine tissues. Dev. Dyn. 202:354-364


WP3:
1. A.F. Muro, M. Caputi, R. Pariyarath, F. Pagani, E. Buratti, F.E. Baralle
"Regulation of fibronectin EDA exon alternative splicing: possible role of RNA secondary structure"
Mol. Cell. Biol., 19: 2657-2671 (1999)
2. M. Niksic, M. Romano, E. Buratti, F. Pagani and F.E. Baralle
"Functional analysis of cis-acting elements regulating the alternative splicing of human CFTR exon 9"
Hum. Mol. Gen., 8: 2339-2349 (1999)
3. M. Baralle, L. Vergenes, A.F. Muro, M.M. Zakin, F.E. Baralle and A. Ochoa.
"Regulation of the human Apolipoprotein AIV gene expression in transgenic mice"
FEBS Letters, 445: 45-52, 1999
4. A.F. Muro, M.L. Marro, S.Gajovic, F. Porro, L. Luzzatto and F.E. Baralle
"Mild spherocytic hereditary elliptocytosis and altered levels of a- and g-adducins in b- adducin-deficient mice"
Blood, 95: 3978-3985 (2000)
5. E. Buratti, T. Dörk, E. Zuccato, F. Pagani, M. Romano and F.E. Baralle
"Nuclear Factor TDP-43 and SR proteins promote in vitro and in vivo CFTR exon 9 skipping"
EMBO J., 20: 1774-1784 (2001)


WP4:
1. Granucci, F., C.Vizzardelli, N. Pavelka, S. Feau, M. Persico, E. Virzi, G. Moro, M. Rescigno and P. Ricciardi-Castagnoli (2001). Inducible IL-2 production by dendritic cells revealed by global gene expression analysis. Nature Immunology 2:882-888.
2. Granucci, F., C.Vizzardelli, E. Virzi, M. Rescigno and P. Ricciardi-Castagnoli (2001). Transcriptional reprogramming of dendritic cells by differentiation stimuli. Eur. J. Immunol. 31:2539-2546.
3. Panoutsakopoulou, V., M.E. Sanchirico, K.M. Huster, M. Jansson, F. Granucci, D.J. Shim, K.W. Wucherpfennig and H. Cantor (2001). Analysis of the relationship between viral infection and autoimmune disease. Immunity 15:134-147.
4. Rescigno, M., M. Urabano, B. Valzasina, M. Francolini, G. Rotta, R. Bonasio, F. Granucci and P. Ricciardi-Castagnoli (2001). Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria. Nature Immunology 2:361-367.
5. Granucci, F., F.P. Di Tota, G. Raimondi, S. Citterio, M. Rescigno M. and P. Ricciardi-Castagnoli (2000). Autoreactive isotype-specific T cells determine B cell frequency. Eur. J. Immunol. 31:215-224.



WP4:
RAVIZZA T; MONETA D; BOTTAZZI B; PERI G; GARLANDA C.; HIRSCH E; GRAYSON JR; MANTOVANI A; VEZZANI A
(2001). Dynamic induction of the long pentraxin PTX3 in CNS after limbic seizures: evidence for a protective role in
seizure-induced neurodegeneration NEUROSCIENCE. (vol. 105 pp. 43-53)
2.
HIRSCH E; KATANAEV VL; GARLANDA C.; AZZOLINO O; PIROLA L; SILENGO L; SOZZANI S; MANTOVANI A; ALTRUDA F;
WYMANN MP (2000). Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation SCIENCE.
(vol. 287 pp. 1049-1053)
3.
ALLAVENA P; BIANCHI G; SIRONI M; GARLANDA C.; VECCHI A; MANTOVANI A (2000). Cytokine regulation of
endothelial cells
In BALKWILL F Cytokine Cell Biology. pp. 87-101 LONDON: Oxford University Press (UNITED KINGDOM)
4.
GARLANDA C.; DEJANA E (1997). Heterogeneity of Endothelial Cells: specific markers ARTERIOSCLEROSIS
THROMBOSIS AND VASCULAR BIOLOGY. (vol. 17 pp. 1193-1202)
5.
GARLANDA C.; PARRAVICINI C; SIRONI M; DE ROSSI M; WAINSTOK DE CALMANOVICI R; CAROZZI F; BUSSOLINO F;
COLOTTA F; MANTOVANI A; VECCHI A (1994). Progressive growth in immunodeficient mice and host cell recruitment
by mouse endothelial cells transformed by polyoma middle-sized T antigen: implications for the pathogenesis of
opportunistic vascular tumors. PROC. NATL. ACAD. SCI. USA.. (vol. 91 pp. 7291-7295)



WP5:
1. COCEANI F.; ACKERLEY C.; SEIDLITZ E.; KELSEY L. (2001). Function of cyclooxygenase-1 and cyclooxygenase-2 in
the ductus arteriosus from foetal lamb: differential development and change by oxygen and endotoxin. BRITISH
JOURNAL OF PHARMACOLOGY. (vol. 132 pp. 241-251)
2.
COCEANI F.; LIU Y.A.; SEIDLITZ E.; KELSEY L.; KUWAKI T.; ACKERLEY C.; YANAGISAWA M. (1999). Endothelin-A
receptor is necessary for oxygen constriction but not closure of the ductus arteriosus. AMERICAN JOURNAL OF
PHYSIOLOGY. (vol. 277 pp. H1521-H1531)
3.
THEIS J.G.W.; TOYODA O.; COCEANI F. (1998). Effect of endothelium removal on prostaglandin and nitric oxide function
in pulmonary resistance arteries in the lamb. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY. (vol. 76
pp. 182-187)
4.
COCEANI F.; KELSEY L.; SEIDLITZ E.; MARKS G.S.; MCLAUGHLIN B.E.; VREMAN H.J.; STEVENSON D.K.; RABINOVITCH
M.; ACKERLEY C. (1997). Carbon monoxide formation in the ductus arteriosus in the lamb:implications for the
regulation of muscle tone. BRITISH JOURNAL OF PHARMACOLOGY. (vol. 120 pp. 599-608)
5.
WANG Y.; COE Y.; TOYODA O.; COCEANI F. (1995). Involvement of endothelin-1 in the hypoxic pulmonary
vasoconstriction in the lamb JOURNAL OF PHYSIOLOGY. (vol. 482 pp. 421-434)



WP6:
Levi, G., Topilko, P., Schneider-Maunoury, S., Lasagna M., Mantero, S., Cancedda, R. and Charnay P. (1996) Defective bone formation in Krox-20 mutant mice. Development 122, 113-120.

Otto, F., Thornell, A.P., Crompton, T., Denzel, A., Gilmour, K.C., Rosewell, I.R., Stamp, G.W., Beddington, R.S. Mundlos, S., Olsen, B. and Owen, M. (1997). Cbai, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development. Cell 89, 765-771.

Acampora, D., Merlo G., Paleari, L., Zerega, B., Postiglione, M.P., Mantero, S., Bober, E., Barbieri, O., Simeone, A., and Levi, G. (1999) Cranifacial, vastibular and bone defects in mice lacking the Distal-less related gene Dlx5. Development 126, 3795-3809.

Parole Chiave

genomica funzionale; ceppi mutanti di topo; analisi fenotipica; patologia e farmacologia molecolare; archivio dei ceppi mutanti; banche dati dei ceppi mutanti