RICERCA ITALIANA     

FIRB simili:

• 1 - Profili di espressione genica nell'iniziazione e progressione tumorale: correlazione con indicatori prognostici e terapeutici
• 2 - Vaccini ricombinanti per la prevenzione e la cura del cancro
• 3 - Identificazione ed analisi funzionale delle alterazioni molecolari e geniche che caratterizzano i tumori della mammella ormono-responsivi
• 4 - BILANCIO OSPITE-TUMORE NELLA TERAPIA MEDICA DELLE NEOPLASIE: RUOLO DI NF-kB
• 5 - Modulazione razionale dell'attività antitumorale di farmaci "classici" tramite intervento selettivo su specifiche cascate regolatorie
• 6 - Modelli transgenici per malattie ad eziologia complessa
• 7 - Approcci combinati di terapia genica nel trattamento del glioblastoma
• 8 - COMPARTIMENTALIZZAZIONE DELLA RISPOSTA IMMUNITARIA NELLA SCLEROSI MULTIPLA: IDENTIFICAZIONE DEI MECCANISMI PATOGENETICI COME BERSAGLIO DI UN INTERVENTO TERAPEUTICO MIRATO.
• 9 - Geni murini, fenotipi e malattie umane - MousePHD
• 10 - Molecole innovative ad attività antiflogistica ed antitumorale prodotte con metodologie chimiche avanzate

Classificazione scientifico-disciplinare

• Area scientifico disciplinare: Scienze mediche
  • PATOLOGIA GENERALE

Classificazione brevettuale

• CHEMISTRY; METALLURGY
  • BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF (biocides, pest repellants or attractants, or plant growth regulators, containing micro-organisms, viruses, microbial fungi, enzymes, fermentates or substances produced by or extracted from micro-organisms or animal material A01N63/00; food compositions A21, A23; medicinal preparations A61K; chemical aspects of, or use of materials for, bandages, dressings, absorbent pads or surgical articles A61L; fertilisers C05); PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS (preservation of living parts of humans or animals A01N1/02); MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (micro-biological testing media C12Q)

Classificazione geografica

• Regione: Liguria

Bibliografia

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2. Elgert, K. D., Alleva, D. G., and Mullins, D. W. 1998. Tumor-induced immune dysfunction: the macrophage connection. Journal of Leukocyte Biology 64:275.
3. Varesio, L., I. Espinoza-Delgrado, L. Gusella, G.W. Cox, G. Melillo, T. Musso, and M.C. Bosco. 1995. Role of Cytokines in the Activation of Monocytes. In Human Cytokines:Their Role in Disease and Therapy. B.B. Aggarwal and R.K. Puri, eds. Blackwell Science, New York, p. 55.
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6. Di Napoli, M.R., Calderon, C.L., and Lopez, D. 1996. The altered tumoricidal capacity of macrophages isolated from tumor-bearing mice is related to reduced expression of inducible nitric oxide syntase gene. J. Exp. Med.:183:1323.
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8. Elgert, K. D., Alleva, D. G., and Mullins, D.W. 1998. Tumor-induced immune dysfunction: the macrophage connection. Journal of Leukocyte Biology 64:275.
9. Sica, A. Saccani, A., Bottazzi, B., Polentarutti, N., Vecchi, A., Van Damme, J., Mantovani, A. 2000. Autocrine Production of IL-10 Mediates Defective IL-12 Production and NF-kB Activation in Tumor-Associated Macrophages. J.Immunol. 164:762
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12. Maxwell, P. H., Dachs, G. U., Gleadle, J. M., Nicholls, L. G., Harris, A. L., Stratford, I. J., Hankinson, O., Pugh, C. W., and Ratcliffe, P. J. 1997. Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influence both angiogenesis and tumor growth. Proc.Natl.Acad.Sci. 94:8104
13. Graeber, T. G., Osmanian, C., Jacks, T., Housman, D. E., Koch, C. J., Lowe, S. W., and Giaccia, A. J. 1996. Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours. Nature 379:88.
14. Brizel, D. M., Scully, S. P., Harrelson, J. M., Layfield, L. J., Bean, J. M., Prosnitz, L. R., and Dewhirst, M. W. 1996. Tumor oxygenation predicts the likelyhood of distant metastases in human soft tissue sarcoma. Cancer Res. 56:941.
15. Desbaillets, I., Diserens, AC., de Tribolet, N., Hamou, MF., and Van Meir, E. G. 1997. Upregulation of Interleukin 8 by Oxygen-deprived Cells in Glioblastoma Suggests a Role in Leukocyte Activation, Chemotaxis, and Angiogenesis. The J. Exp.Med.186:1201.
1. Negus, R. P. M., Turner, L., Burke, F., and Balkwill, F. R. 1998. Hypoxia down-regulates MCP-1 expression: implications for macrophage distribution in tumors. J.Leuk.Biol. 63:758
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19. Melillo, G., Taylor, L., Brooks, A., Cox, G. W., and Varesio, L. 1996. Regulation of inducible nitric oxide synthase expression in IFN-gamma-treated murine macrophages cultured under hypoxic conditions. J.Immunol. 157:2638.
20. Doherty TM, Seder RA, Sher A.1996.Induction and regulation of IL-15 expression in murine macrophages. J. Immunol. 156:735,
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22. Badolato R, Negro Ponzi A, Millesimo M, Notarangelo LD, Musso T. 1997. Interleukin-15 (IL-15) induces IL-8 and moncyte chemotactic protein 1 production in human monocytes. Blood 90:2804.
23. Purin AJ, Razeghi P, Fantuzzi G, Dinarello CA. 1998. Interleukin-18 enhances lipopolysaccharide-induced interferon-gamma production in human whole blood cultures. J. Infect.Dis. 178:1830.
24. Munder M, Mallo M, Eichmann K, Modollel M. 2000. Murine macrophagessecrete interferon gamma upon combined stimulation with interleukin (IL)-12 and IL-18: A novel pathway of autocrine macrophage activation. J. Exp. Med. 187:2103.
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Parole Chiave

Macrofagi; Ipossia; Tumori; Chemochine; Citochine immunoregolatorie; Immunosoppressione