RICERCA ITALIANA     

FIRB simili:

• 1 - Identificazione, purificazione, transdifferenziazione e banking di cellule staminali indirizzate verso fenotipi propri e non propri da utilizzare per riparazione tissutale
• 2 - Cellule staminali adulte pluripotenti per la ricostituzione tissutale in modelli di malattie degenerative
• 3 - INGEGNERIA TISSUTALE: SVILUPPO DI NUOVE STRATEGIE PER LA RIGENERAZIONE DEL PARODONTO E DELL'OSSO ALVEOLARE MEDIANTE CELLULE MESENCHIMALI DI DERIVAZIONE EMATOPOIETICA NELL'ANIMALE E NELL'UOMO. VALUTAZIONE DEGLI EFFETTI SISTEMICI.
• 4 - Impiego delle tecniche di ingegneria tissutale nello sviluppo di protesi vascolari cellularizzate
• 5 - ESPANSIONE E DIFFERENZIAZIONE IN VITRO DI CELLULE STAMINALI CORDONALI E DA LIQUIDO AMNIOTICO DA UTILIZZARE NELL'INGEGNERIA TESSUTALE
• 6 - Ottimizzazione dell' espansione ex-vivo di cellule staminali e progenitori emopoietici umani
• 7 - Approcci combinati di terapia genica nel trattamento del glioblastoma
• 8 - Studio dell'identità cellulare e dei meccanismi di differenziazione cellulare nell'era della postegnomica utilizzando tre situazioni paradigmatiche: la mammella, l'osso e i linfociti
• 9 - www*.neuralstemcells.it (*where,when,why)
• 10 - Identificazione delle vie di signaling implicate nella riparazione molecolare e nel recupero funzionale di cellule post-mitotiche (miocardiociti, miociti scheletrici e neuroni). Studio pre-clinico e clinico.

Classificazione scientifico-disciplinare

• Area scientifico disciplinare: Scienze mediche
  • PATOLOGIA GENERALE
  • ANATOMIA PATOLOGICA

Classificazione brevettuale

• CHEMISTRY; METALLURGY
  • BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY (installation for fermenting manure A01C3/02; preservation of living parts of humans or animals A01N1/02; physical or chemical apparatus in general B01; malting or mashing apparatus C12C1/00; brewing apparatus C12C13/00; fermentation apparatus for wine C12G; apparatus for preparing vinegar C12J1/10)
• HUMAN NECESSITIES
  • AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS

Classificazione geografica

• Regione: Liguria

Bibliografia

1. Martin, I., V.P. Shastri, R.F. Padera, J. Yang, A.J. Mackay, R. Langer, G. Vunjak-Novakovic, and L.E. Freed. 2001. Selective differentiation of mammalian bone marrow stromal cells cultured on three-dimensional polymer foams. J Biomed Mater Res. 55:229-235.
2. Quarto, R., M. Mastrogiacomo, R. Cancedda, S.M. Kutepov, V. Mukhachev, A. Lavroukov, E. Kon, and M. Marcacci. 2001. Repair of large bone defects with the use of autologous bone marrow stromal cells. N Engl J Med. 344:385-386.
3. Mankani, M.H., S.A. Kuznetsov, B. Fowler, A. Kingman, and P.G. Robey. 2001. In vivo bone formation by human bone marrow stromal cells: effect of carrier particle size and shape. Biotechnol Bioeng. 72:96-107.
4. Theise, N.D., S. Badve, R. Saxena, O. Henegariu, S. Sell, J.M. Crawford, and D.S. Krause. 2000. Derivation of hepatocytes from bone marrow cells in mice after radiation-induced myeloablation. Hepatology. 31:235-240.
5. Muraglia, A., R. Cancedda, and R. Quarto. 2000. Clonal mesenchymal progenitors from human bone marrow differentiate in vitro according to a hierarchical model. J Cell Sci. 113:1161-1166.
6. Sanchez-Ramos, J., S. Song, F. Cardozo-Pelaez, C. Hazzi, T. Stedeford, A. Willing, T.B. Freeman, S. Saporta, W. Janssen, N. Patel, D.R. Cooper, and P.R. Sanberg. 2000. Adult Bone Marrow Stromal Cells Differentiate into Neural Cells in Vitro. Exp Neurol. 164:247-256.
7. Li, Y., M. Chopp, J. Chen, L. Wang, S.C. Gautam, Y.X. Xu, and Z. Zhang. 2000. Intrastriatal transplantation of bone marrow nonhematopoietic cells improves functional recovery after stroke in adult mice. J Cereb Blood Flow Metab. 20:1311-1319.
8. Kuznetsov, S.A., M.H. Mankani, and P.G. Robey. 2000. Effect of serum on human bone marrow stromal cells: ex vivo expansion and in vivo bone formation. Transplantation. 70:1780-1787.
9. Chen, J., Y. Li, and M. Chopp. 2000. Intracerebral transplantation of bone marrow with BDNF after MCAo in rat. Neuropharmacology. 39:711-716.
10. Banfi, A., A. Muraglia, B. Dozin, M. Mastrogiacomo, R. Cancedda, and R. Quarto. 2000. Proliferation kinetics and differentiation potential of ex vivo expanded human bone marrow stromal cells: Implications for their use in cell therapy. Exp Hematol. 28:707-715.
11. Kon, E., A. Muraglia, A. Corsi, P. Bianco, M. Marcacci, I. Martin, A. Boyde, I. Ruspantini, P. Chistolini, M. Rocca, R. Giardino, R. Cancedda, and R. Quarto. 2000. Autologous bone marrow stromal cells loaded onto porous hydroxyapatite ceramic accelerate bone repair in critical-size defects of sheep long bones. J Biomed Mater Res. 49:328-337.
12. Woodbury, D., E.J. Schwarz, D.J. Prockop, and I.B. Black. 2000. Adult rat and human bone marrow stromal cells differentiate into neurons. J Neurosci Res. 61:364-370.
13. Cancedda, R., P. Castagnola, F.D. Cancedda, B. Dozin, and R. Quarto. 2000. Developmental control of chondrogenesis and osteogenesis. Int J Dev Biol. 44:707-714.
14. Chopp, M., X.H. Zhang, Y. Li, L. Wang, J. Chen, D. Lu, M. Lu, and M. Rosenblum. 2000. Spinal cord injury in rat: treatment with bone marrow stromal cell transplantation [In Process Citation]. Neuroreport. 11:3001-3005.
15. Aubin, J.E. 1999. Osteoprogenitor cell frequency in rat bone marrow stromal populations: role for heterotypic cell-cell interactions in osteoblast differentiation [In Process Citation]. J Cell Biochem. 72:396-410.
16. Boyde, A., A. Corsi, R. Quarto, R. Cancedda, and P. Bianco. 1999. Osteoconduction in large macroporous hydroxyapatite ceramic implants: evidence for a complementary integration and disintegration mechanism. Bone. 24:579-589.
17. Galotto, M., G. Berisso, L. Delfino, M. Podesta, L. Ottaggio, S. Dallorso, C. Dufour, G.B. Ferrara, A. Abbondandolo, G. Dini, A. Bacigalupo, R. Cancedda, and R. Quarto. 1999. Stromal damage as consequence of high-dose chemo/radiotherapy in bone marrow transplant recipients. Exp Hematol. 27:1460-1466.
18. Marcacci, M., E. Kon, S. Zaffagnini, R. Giardino, M. Rocca, A. Corsi, A. Benvenuti, P. Bianco, R. Quarto, I. Martin, A. Muraglia, and R. Cancedda. 1999. Reconstruction of extensive long-bone defects in sheep using porous hydroxyapatite sponges. Calcif Tissue Int. 64:83-90.
19. Liu, P., B.O. Oyajobi, R.G. Russell, and A. Scutt. 1999. Regulation of osteogenic differentiation of human bone marrow stromal cells: interaction between transforming growth factor-beta and 1,25(OH)(2) vitamin D(3) In vitro. Calcif Tissue Int. 65:173-180.
20. Chiang, G.G., H.L. Rubin, V. Cherington, T. Wang, J. Sobolewski, C.A. McGrath, A. Gaffney, S. Emami, N. Sarver, P.H. Levine, J.S. Greenberger, and D.R. Hurwitz. 1999. Bone marrow stromal cell-mediated gene therapy for hemophilia A: in vitro expression of human factor VIII with high biological activity requires the inclusion of the proteolytic site at amino acid 1648 [In Process Citation]. Hum Gene Ther. 10:61-76.
21. Lopes, M.A., F.J. Monteiro, and J.D. Santos. 1999. Glass-reinforced hydroxyapatite composites: fracture toughness and hardness dependence on microstructural characteristics. Biomaterials. 20:2085-2090.
22. Pri-Chen, S., S. Pitaru, F. Lokiec, and N. Savion. 1998. Basic fibroblast growth factor enhances the growth and expression of the osteogenic phenotype of dexamethasone-treated human bone marrow- derived bone-like cells in culture. Bone. 23:111-117.
23. Oreffo, R.O., F.C. Driessens, J.A. Planell, and J.T. Triffitt. 1998. Effects of novel calcium phosphate cements on human bone marrow fibroblastic cells. Tissue Eng. 4:293-303.
24. Heidel, S.M., C.J. Czuprynski, and C.R. Jefcoate. 1998. Bone marrow stromal cells constitutively express high levels of cytochrome P4501B1 that metabolize 7,12-dimethylbenz[a]anthracene. Mol Pharmacol. 54:1000-1006.
25. Muraglia, A., I. Martin, R. Cancedda, and R. Quarto. 1998. A nude mouse model for human bone formation in unloaded conditions. Bone. 22:131S-134S.
26. Casabona, F., I. Martin, A. Muraglia, P. Berrino, P. Santi, R. Cancedda, and R. Quarto. 1998. Prefabricated engineered bone flaps: an experimental model of tissue reconstruction in plastic surgery. Plast Reconstr Surg. 101:577-581.
27. Takai, H., M. Kanematsu, K. Yano, E. Tsuda, K. Higashio, K. Ikeda, K. Watanabe, and Y. Yamada. 1998. Transforming growth factor-beta stimulates the production of osteoprotegerin/osteoclastogenesis inhibitory factor by bone marrow stromal cells. J Biol Chem. 273:27091-27096.
28. Siedlecki, C.A., and R.E. Marchant. 1998. Atomic force microscopy for characterization of the biomaterial interface. Biomaterials. 19:441-454.
29. Roingeard, F., C. Binet, J.C. Lecron, D. Truglio, P. Colombat, and J. Domenech. 1998. Cytokines released in vitro by stromal cells from autologous bone marrow transplant patients with lymphoid malignancy. Eur J Haematol. 61:100-108.
30. Martin, I., R. Quarto, B. Dozin, and R. Cancedda. 1997. Producing prefabricated tissues and organs via tissue engineering. IEEE Eng Med Biol Mag. 16:73-80.
31. Martin, I., B. Dozin, R. Quarto, R. Cancedda, and F. Beltrame. 1997. Computer-based technique for cell aggregation analysis and cell aggregation in in vitro chondrogenesis. Cytometry. 28:141-146.
32. Martin, I., A. Muraglia, G. Campanile, R. Cancedda, and R. Quarto. 1997. Fibroblast growth factor-2 supports ex vivo expansion and maintenance of osteogenic precursors from human bone marrow. Endocrinology. 138:4456-4462.
33. Quarto, R., G. Campanile, R. Cancedda, and B. Dozin. 1997. Modulation of commitment, proliferation, and differentiation of chondrogenic cells in defined culture medium. Endocrinology. 138:4966-4976.
34. Quarto, R., D. Thomas, and C.T. Liang. 1995. Bone progenitor cell deficits and the age-associated decline in bone repair capacity. Calcif Tissue Int. 56:123-129.
35. Tanaka, H., R. Quarto, S. Williams, J. Barnes, and C.T. Liang. 1994. In vivo and in vitro effects of insulin-like growth factor-I (IGF-I) on femoral mRNA expression in old rats. Bone. 15:647-653.

Parole Chiave

Medicina rigenerativa; Cellule staminali da adulto; Biomateriali; Bioreattori; Ingegneria dei tessuti; Osteorigenerazione