RICERCA ITALIANA     

FIRB simili:

• 1 - Identificazione, purificazione, transdifferenziazione e banking di cellule staminali indirizzate verso fenotipi propri e non propri da utilizzare per riparazione tissutale
• 2 - Cellule staminali adulte pluripotenti per la ricostituzione tissutale in modelli di malattie degenerative
• 3 - Ottimizzazione dell' espansione ex-vivo di cellule staminali e progenitori emopoietici umani
• 4 - Meccanismi di regolazione dello sviluppo del sistema nervoso e del differenziamento neurale (PRONEURO)
• 5 - ESPANSIONE E DIFFERENZIAZIONE IN VITRO DI CELLULE STAMINALI CORDONALI E DA LIQUIDO AMNIOTICO DA UTILIZZARE NELL'INGEGNERIA TESSUTALE
• 6 - L'ingegneria dei tessuti per la rigenerazione dei tessuti connettivi con particolare riferimento al tessuto osseo
• 7 - Studio dell'identità cellulare e dei meccanismi di differenziazione cellulare nell'era della postegnomica utilizzando tre situazioni paradigmatiche: la mammella, l'osso e i linfociti
• 8 - COMPARTIMENTALIZZAZIONE DELLA RISPOSTA IMMUNITARIA NELLA SCLEROSI MULTIPLA: IDENTIFICAZIONE DEI MECCANISMI PATOGENETICI COME BERSAGLIO DI UN INTERVENTO TERAPEUTICO MIRATO.
• 9 - Il trapianto cellulare come alternativa al trapianto d'organo: studio dei processi di crescita e differenziamento delle cellule staminali orientate verso fenotipi cardiovascolari.
• 10 - Approcci combinati di terapia genica nel trattamento del glioblastoma

Classificazione scientifico-disciplinare

• Area scientifico disciplinare: Scienze biologiche
  • BIOLOGIA MOLECOLARE
  • BIOLOGIA APPLICATA
  • ISTOLOGIA

Classificazione brevettuale

• CHEMISTRY; METALLURGY
  • BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF (biocides, pest repellants or attractants, or plant growth regulators, containing micro-organisms, viruses, microbial fungi, enzymes, fermentates or substances produced by or extracted from micro-organisms or animal material A01N63/00; food compositions A21, A23; medicinal preparations A61K; chemical aspects of, or use of materials for, bandages, dressings, absorbent pads or surgical articles A61L; fertilisers C05); PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS (preservation of living parts of humans or animals A01N1/02); MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (micro-biological testing media C12Q)

Classificazione geografica

• Regione: Lombardia

Bibliografia

Altman J (1970) Postnatal neurogenesis and the problem of neural plasticity In: Developmental Neurobiology (Himwich WA ed). Springfield 197

Alvarez-Buylla A (2000) The subventricular zone: source of neuronal precursors for brain repair Prog Brain Res 127:1

Alvarez-Buylla A (2001) A unified hypothesis on the lineage of neural stem cells Nat Rev Neurosci 2:287

Avilion AA, Nicolis SK, Pevny LH (joint first), Perez L, Vivian N, Lovell-Badge R. Multipotent cell lineages in early mouse development depend on SOX2 function, submitted, 2001

Bengzon J (1997) Apoptosis and proliferation of dentate gyrus neurons after single and intermittent limbic seizures Proc Natl Acad Sci USA 94:10432

Björklund A and Lindvall O (2000) Cell replacement therapies for central nervous system disorders Nat Neurosci 3:537

Bonfanti L (2001) Multipotent stem cells in the adult central nervous system. In: Stem Cells and CNS Development, The Humana Press 49

Bjornson CCR (1999) Turning brain into blood: adult neural stem cells adopt a hematopoietic fate in vivo Science 283:534

Brazelton TR (2000) From marrow to brain: expression of neuronal phenotypes in adult mice Science 290:1775

Brüstle O (1995) Host-guided migration allows targeted introduction of neurons into the embryonic brain Neuron 15:1275

Burrows RC (1997) Response diversity and the timing of progenitor cell maturation are regulated by developmental changes in EGFR expression in the cortex Neuron 19:251

Campbell K (1995) Regional incorporation and site-specific differentiation of striatal precursors transplanted to the embryonic forebrain ventricle Neuron 15:1259

Ciccolini F and Svendsen CN (1998) FGF-2 promotes acquisition of EGF responsiveness in mouse striatal precursor cells: identification of neural precursors responding to both EGF and FGF-2 J Neurosci 18:7869

Clarke D (2000) Generalized potential of adult neural stem cells Science 288:1660

Conover JC (2000) Disruption of Epf/ephrin signaling affects migration and proliferation in the adult subventricular zone Nat Neurosci 3:1091

Conti L (2001) Shc(s) signalling in differentiating neural progenitor cells Nat Neurosci 4:587

Craig CG (1996) In vivo growth factor expansion of endogenous subependymal neural precursor cell populations in the adult mouse brain J Neurosci 16:2649

Desai AR and McConnell SK (2000) Progressive restriction in fate potential by neural progenitors during cerebral cortical development. Development 127:2863

Doetsch F (2000) Subventricular zone astrocytes are neural stem cells in the adult mammalian brain Cell 97:703

Eglitis MA and Mezey E (1997) Hematopoietic cells differentiate into both microglia and macroglia in the brains of adult mice Proc Natl Acad Sci USA 94:4080

Fishell G (1995) Striatal precursors adopt cortical identities in response to local cues Development 121:803-12

Frantz GD and McConnell SK (1996) Restriction of late cerebral cortical progenitors to an upper layer fate Neuron 17:55

Gage FH (1998) Stem cells of the central nervous system Curr Opin Neurobiol 8:671

Gage FH (1995) Survival and differentiation of adult neuronal progenitor cells transplanted to the adult brain Proc Natl Acad Sci USA 92:11879

Galli R (2000) Skeletal myogenic potential of human and mouse neural stem cells Nat Neurosci 3:986

Gould E (1992) Adrenal hormones suppress cell division in the adult rat dentate gyrus J Neurosci 12:3642

Gritti A (1996) Multipotential stem cells from the adult mouse brain proliferate and self renew in response to basic fibroblast growth factor J Neurosci 16:1091

Jankovski A (1996) Neuronal precursors in the postnatal mouse cerebellum are fully committed cells: evidence from heterochronic transplantation Eur J Neurosci 8:2308

Jankovski A and Sotelo C (1996) Subventricular zone-olfactory bulb migratory pathway in the adult mouse: cellular composition and specificity as determined by heterochronic and heterotopic transplantation J Comp Neurol 371:376

Johansson CB (1999) Identification of a neural stem cell in the adult mammalian central nervous system Cell 96:25

Johe KK (1996) Single factors direct the differentiation of stem cells from the fetal and adult central nervous system Genes Dev 10:3129

Kirschenbaum (1994) In vitro neuronal production and differentiation by precursor cells derived from the adult human forebrain Cerebral Cortex 6:576

Kuhn HG (1997) Epidermal growth factor and fibroblast growth factor-2 have different effects of neural progenitors in the adult rat brain J Neurosci 17:5820

Lim DA (1997) Postnatal mouse subventricular zone neuronal precursors can migrate and differentiate within multiple levels of the developing neuraxis Proc Natl Acad Sci USA 94:14832

Lim DA and Alvarez-Buylla A (1999) Interaction between astrocytes and adult subventricular zone precursors stimulates neurogenesis Proc Natl Acad Sci USA 96:7526

Lundberg C (1997a) Conditionally immortalized neural progenitor cells grafted to the striatum exhibit site-specific neuronal differentiation and establish connections with the host globus pallidus Neurobiol Dis 3:33

Lundberg C (1997b) Survival, integration, and differentiation of neural stem cell lines after transplantation to the adult rat striatum Exp Neurol 145:342

Magavi SS (2000) Induction of neurogenesis in the cortex of adult mice Nature 403:951

Magrassi L (1996) Scattered pirary and conditionally immortalized neuroepithelial cells transplanted into the embryonic rat brain differentiate into neurons and glia Neurosci Res Com 18:175

Magrassi L (1998) Basal ganglia precursors found in aggregates following embryonic transplantation adopt a striatal phenotype in hetrotpic locations Development 125:2847

McKay RDG (1997) Stem cells in the central nervous system Science 276:66

Mezey E (2000) Turning blood into brain: cells bearing neuronal antigens generated in vivo from bone marrow Science 290:1779

Noctor SC (2001) Neurons derived from radial glial cells establish radial units in neocortex Nature 409:714

Olsson M (1997) Specification of mouse telencephalic and mid-hindbrain progenitors following heterotopic ultrasound-guided embryonic transplantation Neuron 19:761

Olsson M (1998) Incorporation of mouse neural progenitors transplanted in the rat embryonic forebrain is developmentally regulated and dependent on regional adhesive properties Eur J Neurosci 10:71

Qian X (1997) FGF2 concentration regulates the generation of neurons and glia from multipotent cortical stem cells Neuron 18:81-93

Rietze RL (2001) Purification of a pluripotent neural stem cell from the adult mouse brain Nature 412:690

Shihabuddin LS (1996) Selective hippocampal lesions differentially affect the phenotypic fate of transplanted neural progenitor cells Exp Neurol 139:61

Suhonen JO (1996) Differentiation of adult hippocampus-derived progenitors into olfactory neurons in vivo Nature 383:624

Studer L (1998) Transplantation of expanded mesencephalic precursors leads to recovery in parkinsonian rats Nat Neurosci 1:290

Takahashi M. et al (1998) Widespread integration and survival of adult-derived neural progenitor cells in the developing optic retina Mol Cell Neurosci 12:340

Temple S and Alvarez-Buylla A (1999) Stem cells in the adult mammalian central nervous system Curr Op Neurobiol 9:135

Vescovi AL (1993)bFGF regulates the proliferative fate of unipotent (neuronal) and bipotent (neuronal/astroglial) EGF-generated CNS progenitor cells Neuron 11:951

Vicario-Abejón C (1995) Cerebellar precursors transplanted to the neonate dentate gyrus express features characteristic of hippocampal neurons J Neurosci 15:6351

Zappone M, (2000) Sox2 regulatory sequences direct expression of a beta-geo transgene to telencephalic neural stem cells and precursors of the mouse embryo, revealing regionalization of gene expression in CNS stem cells. Development 127:2367

Parole Chiave

cellule staminali; neuroni; trapianto; homeobox; proliferazione; plasticita'