RICERCA ITALIANA     

FIRB simili:

• 1 - Misfolding di proteine e patologie umane: studio della conversione patologica di proteine globulari in aggregati fibrillari e sviluppo di farmaci che inibiscano i processi di misfolding e aggregazione
• 2 - PROTEASI NELLA RISPOSTA CELLULARE NORMALE E PATOLOGICA: IDENTIFICAZIONE DEI SUBSTRATI ENDOGENI E DEI MECCANISMI MOLECOLARI INDOTTI
• 3 - ESPRESSIONE GENICA ED ACCUMULO DI PROTEINE D'INTERESSE AGRONOMICO NELLA CELLULA VEGETALE: MECCANISMI TRASCRIZIONALI E POST-TRASCRIZIONALI
• 4 - Sviluppo di Tecnologie Avanzate per lo Studio della Proteomica Differenziale del Segnale (Segnalo-Proteomica)
• 5 - Sviluppo di molecole innovative in grado di curare malattie neurodegenerative e neuroinfiammatorie.
• 6 - FOLDING E AGGREGAZIONE DI PROTEINE: METALLI E BIOMOLECOLE NELLE MALATTIE CONFORMAZIONALI
• 7 - Studio delle interazioni proteine-rame, proteine-proteine, proteine-acidi nucleici e proteine-lipidi a livello dei microdomini di membrana. Rilevanza per la comprensione delle "patologie da microdomini di membrana" come le malattie da prioni, la malattia di Alzheimer e le alterazioni del metabolismo lipidico.
• 8 - Riconoscimento molecolare e funzionalità cellulare
• 9 - Meccanismi di trasduzione del segnale e funzione sinaptica: sviluppo di modelli molecolari, cellulari ed animali
• 10 - MALATTIE NEURODEGENERATIVE COME CONSEGUENZA DI UN ALTERATO PROCESSAMENTO DI PROTEINE NEURONALI. MODELLI ANIMALI E DI COLTURE CELLULARI IN VITRO.

Classificazione scientifico-disciplinare

• Area scientifico disciplinare: Scienze chimiche
  • CHIMICA GENERALE E INORGANICA
• Area scientifico disciplinare: Scienze biologiche
  • BIOCHIMICA

Classificazione brevettuale

• CHEMISTRY; METALLURGY
  • ORGANIC CHEMISTRY (such compounds as the oxides, sulfides, or oxysulfides of carbon, cyanogen, phosgene, hydrocyanic acid or salts thereof C01; products obtained from layered base-exchange silicates by ion-exchange with organic compounds such as ammonium, phosphonium or sulfonium compounds or by intercalation of organic compounds C01B33/44; macromolecular compounds C08; dyes C09; fermentation products C12; fermentation or enzyme-using processes to synthesise a desired chemical compound or composition or to separate optical isomers from a racemic mixture C12P; production of organic compounds by electrolysis or electrophoresis C25B3/00, C25B7/00)
    • PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00)

Classificazione geografica

• Regione: Veneto

Bibliografia

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Parole Chiave

Microscopia a forza atomica (AFM); Cristallografia di proteine; NMR biomolecolare; Dinamica molecolare; Riconoscimento di biomolecole; Correlazioni struttura funzione nelle proteine