RICERCA ITALIANA     

Similar FIRB:

• 1 - PROTEASES IN NORMAL AND PATHOLOGICAL CELL RESPONSES. IDENTIFICATION OF ENDOGENOUS SUBSTRATES AND INDUCED MOLECULAR MECHANISMS.
• 2 - Mechanisms of signal transduction and synaptic function: Development of molecular, cellular, and animal models.
• 3 - The ubiquitous Ca2+ signalling cascade: from molecules to functions
• 4 - Molecular recognition and cell function
• 5 - Molecular recognition in protein-ligand, protein-protein and protein-surface interactions: development of integrated experimental and computational approaches to the study of systems of pharmaceutical interest.
• 6 - Development of innovative molecules for the treatment of neurodegenerative and neuroinflammatory disease
• 7 - Mechanisms regulating nervous system development and neural differentiation (PRONEURO)
• 8 - Functional interactions among synaptic proteins: physiopathology and potential therapeutic indications.
• 9 - Genomics And Proteomics in the analysis of complex cellular functions.(GAP)
• 10 - Apoptotic mechanisms and their implications in human diseases

Scientific and education field classification

• Field: Scienze biologiche
  • BIOCHIMICA
  • BIOLOGIA MOLECOLARE
• Field: Ingegneria industriale e dell'informazione
  • ELETTRONICA

International Patent Classification

• CHEMISTRY; METALLURGY
  • BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY (installation for fermenting manure A01C3/02; preservation of living parts of humans or animals A01N1/02; physical or chemical apparatus in general B01; malting or mashing apparatus C12C1/00; brewing apparatus C12C13/00; fermentation apparatus for wine C12G; apparatus for preparing vinegar C12J1/10)
  • ORGANIC CHEMISTRY (such compounds as the oxides, sulfides, or oxysulfides of carbon, cyanogen, phosgene, hydrocyanic acid or salts thereof C01; products obtained from layered base-exchange silicates by ion-exchange with organic compounds such as ammonium, phosphonium or sulfonium compounds or by intercalation of organic compounds C01B33/44; macromolecular compounds C08; dyes C09; fermentation products C12; fermentation or enzyme-using processes to synthesise a desired chemical compound or composition or to separate optical isomers from a racemic mixture C12P; production of organic compounds by electrolysis or electrophoresis C25B3/00, C25B7/00)
    • PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00)

Geographical classification

• Region: Campania

Bibliografia

1. Mochly-Rosen D, Kauvar LM. (1998) Adv Pharmacol 44:91-145
2. Hartwell LH et al., (1999) Nature 402:C47-52
3. Soskic V, Nyakatura E, Roos M, Muller-Esterl W, Godovac-Zimmermann J. (1999) J Biol Chem 274:8539-8545.
4. Soskic V, Gorlach M, Poznanovic S, Boehmer FD, Godovac-Zimmermann J. (1999) Biochemistry 38:1757-1764
5. Venter JC et al. (2001) Science 291,1304-1351
6. Zhou H, Watts JD, Aebersold R. (2001) Nat Biotechnol. 19, 375-378.
7. Oda Y, Nagasu T, Chait BT. (2001) Nat Biotechnol. 19, 379-382.
8. Rattenholl A, Ruoppolo M, Flagiello A, Monti M, Vinci F, Marino G, Lilie H, Schwarz E, Rudolph R. (2001) J Mol Biol 305:523-33
9. Scaloni A, Miraglia N, Orru S, Amodeo P, Motta A, Marino G, Pucci P. (1998) J Mol Biol. 277:945-58
10. Ferranti P, Malorni A, Marino G, Pucci P, Goodwin GH, Manfioletti G, Giancotti V. (1992) J Biol Chem. 267:22486-9
11. Pinna LA, Meggio F (1997) Progress in Cell Cycle Research, vol. 3 (Meijer L, Guidet S and Philippe M eds) Plenum Press , New York, USA, pp 77-97
12. Marin O, Meggio F, Sarno S, Cesaro L, Pagano MA, Pinna LA (1999) J. Biol. Chem. 274, 29260-29265
13. Modesti A, Bini L, Carraresi L, Magherini F, Liberatori S, Pallini V, Manao G, Pinna LA, Raugei G, Ramponi G (2001) Electrophoresis 22, 576-585
14. Chiarugi P, Cirri P, Taddei L, Giannoni E, Camici G, Manao G, Raugei G, Ramponi G (2000) J Biol Chem. 275:4640-6 and references therein
15. Paoli P, Giannoni E, Pescitelli R, Camici G, Manao G, Ramponi G. J Biol Chem. 2001, in press.
16. Caselli A, Taddei ML, Manao G, Camici G, Ramponi G. J Biol Chem. (2001) 276, 18849-54
17. Cesareni G et al in preparation
18. Reichsteiner M., Hoffman L., and Dubiel W., (1993) J. Biol. Chem. 268, 6065-6068
19. Baumeister, W. And Lupas A. (1997) Curr. Opin. Struct. Biol. 7, 273-278
20. Glotzer M., Murray A.W., Krschner M.W. (1991) Nature 349, 132-138
21. Scheffner M., Werness B.A., Hiubregtse J.M. et al. (1990) Cell 63, 1129-1136
22. Hicke L., Riezman H. (1996) Cell 84, 277-287
23. Rock KL, Gramm C., Rothstein L, et al. (1994) Cell 78, 761-771
24. Treier M., Staszewski L.M. Bohmann D. (1994) Cell 78. 787-798
25. Palombella V.J., Rando O.J., Goldberg A.L., and Maniatis T. (1994) Cell 78, 773-785
26. Plaksin D., Baeuerle P.A., Eisenbach L. (1993) J. Exp. Med 177, 1651-1662
27. Yaron A., Hatzubai A., Davis M., Lavon I., Amit S., et al., (1998) Nature 396, 590-594
28. Bedford FK, Kittler JT, Muller E, Thomas P, Uren JM, Merlo D, Wisden W, Triller A, Smart TG, Moss SJ. (2001) Nat Neurosci 4, 908-916
29. Magnani M, Crinelli R, Bianchi M, Antonelli A. (2000) Curr Drug Targets. 1, 387-399 and references therein.
30. Lesort M, Tucholski J, Miller ML, Johnson GV. (2000) Prog Neurobiol 61, 439-463
31. 31.Candi E, Oddi S, Terrinoni A, Paradisi A, Ranalli M, Finazzi-Agro' A, Melino G. (2001) J. Biol. Chem. 276,35014-23
32. Piacentini M, Rodolfo C, Farrace MG, Autuori F. (2000) Int J Dev Biol. 44, 655-662
33. Esposito C, Mariniello L, Cozzolino A, Amoresano A, Orru S, Porta R. (2001) Biochemistry 40,4966-7
34. Curtis DR et al., (1968) Exp Brain Res 6:1-18
35. Becker CM,(1992) Handbook of Exp. Pharmacol. 102:539-575
36. DeLorey TM, Olsen RW, (1992) J. Biol. Chem., 267:16747-16750
37. Sassoè Pognetto M & Fritschy JM (2000) Eur J Neurosci 12:2205-2210
38. Chen L et al., (2000) PNAS 97:11557-11562
39. Moss SJ, Smart TG (2001) Nat Rev Neurosci 2:240-250
40. Cockcroft VB et al., Mol. Neurobiol., 4:129-169, 1992.
41. Bode H, et al., (1986) Curr Topics Dev Biol 20:257-280
42. Westfall JA (1987) In: Nervous systems in Invertebrates. (MA Ali, Ed), pp. 3-28. Plenum Press, New York
43. Pierobon P et al., (1995) Life Sci., 56:1485-1497
44. Concas A et al.,(1998) Neuroscience, 85:979-988
45. Pierobon P et al., Eur. J. Neurosci., in press (2001)
46. Bamber BA et al., (1999) J Neurosci 19:5348-5359
47. Ortells MO, Lunt GG. (1995) Trends Neurosci 18:121-127.
48. Ye, W, et al (1998) Cell, 29:755-66
49. Perrone-Capano, C:, et al (1996) BioEssays,18:817-824
50. di Porzio, U, et al (1999) Dopaminergic Neuron Development pp 196 AUSTIN TX, Neuroscience Intellingence Unit Landes Co
51. Perrone-Capano C, et al (2000) Neurosci Biobehav Rev, 24:119-124
52. Zetterstrom RH, et al (1997) Science, 276:248-250
53. Wagner J, et al (1999) Nat Biotechnol, 17:653-9
54. Forman BM, et al (1995) Cell, 81541-550
55. Barone A (1995) Nucl. Phys. B (Proc. Suppl.), vol. 44 p.654
56. Twerenbold D et al (1995) Appl.Phys.Lett. vol. 68 p.3503 and (1998) Nature vol. 391 p.672;
M. Frank et al. (1996) Rapid Commun. Mass Spectrom. Vol.10 p.3503.
57. Twerenbold (1996) Nucl.Instr. and Meth. Vol.A370 p. 253

Keywords

Proteomics; Signal transduction; Post-translational modifications; Protein-protein interaction; Mass spectrometry; Cryogenic detectors