RICERCA ITALIANA     

Similar FIRB:

• 1 - HOST-TUMOR BALANCE IN THE THERAPY OF NEOPLASIAS: ROLE OF NF-kB
• 2 - Development of innovative molecules for the treatment of neurodegenerative and neuroinflammatory disease
• 3 - The ubiquitous Ca2+ signalling cascade: from molecules to functions
• 4 - Transgenic animal models for diseases of complex etiology.
• 5 - Multifocal combined approaches for gene therapy of Glioblastomas
• 6 - Molecular recognition and cell function
• 7 - Mechanisms regulating nervous system development and neural differentiation (PRONEURO)
• 8 - Deciphering cell identity and cell differentiation mechanisms in the postgenomic era by using three paradigmatic systems: breast, bone and lymphocytes
• 9 - Mechanisms of signal transduction and synaptic function: Development of molecular, cellular, and animal models.
• 10 - GENE EXPRESSION AND ACCUMULATION OF AGRICULTURALLY IMPORTANT PROTEINS IN THE PLANT CELL:TRANSCRIPTIONAL AND POST-TRANSCRIPTIONAL MECHANISMS

Scientific and education field classification

• Field: Scienze biologiche
  • BIOLOGIA MOLECOLARE

International Patent Classification

• CHEMISTRY; METALLURGY
  • BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF (biocides, pest repellants or attractants, or plant growth regulators, containing micro-organisms, viruses, microbial fungi, enzymes, fermentates or substances produced by or extracted from micro-organisms or animal material A01N63/00; food compositions A21, A23; medicinal preparations A61K; chemical aspects of, or use of materials for, bandages, dressings, absorbent pads or surgical articles A61L; fertilisers C05); PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS (preservation of living parts of humans or animals A01N1/02); MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (micro-biological testing media C12Q)

Geographical classification

• Region: Lazio

Bibliografia

Adrain C, Martin SJ. The mitochondrial apoptosome: a killer unleashed by the cytochrome seas. Trends Biochem Sci. 2001 26:390-7
Aznar S, Lacal JC. Searching new targets for anticancer drug design: the families of Ras and Rho GTPases and their effectors. Prog Nucleic Acid Res Mol Biol. 2001;67:193-234
Barber GN. Host defense, viruses and apoptosis. Cell Death Differ. 2001 Feb;8(2):113-26
Boya P, Roques B, Kroemer G. New EMBO members' review: viral and bacterial proteins regulating apoptosis at the mitochondrial level. EMBO J. 2001 20:4325-31
Budd RC. Activation-induced cell death. Curr Opin Immunol. 2001;13:356-62
Cecconi F. Apaf1 is no longer single. Cell Death Differ. 2001;8:773-5
Ciriolo MR, et al. Differential role of superoxide and glutathione in S-nitrosoglutathione-mediated apoptosis: a rationale for mild forms of familial amyotrophic lateral sclerosis associated with less active Cu,Zn superoxide dismutase mutants. J Neurochem. 2001;77:1433-43
Ciriolo MR, et al. Role of the electrostatic loop of Cu,Zn superoxide dismutase in the copper uptake process. Eur J Biochem. 2001;268:737-42
Ciriolo MR, et al. Cu,Zn-superoxide dismutase-dependent apoptosis induced by nitric oxide in neuronal cells. J Biol Chem. 2000 18;275:5065-72
De Laurenzi V, Melino G. Apoptosis. The little devil of death. Nature. 2000;406:135-6
De Laurenzi V, Melino G. Evolution of functions within the p53/p63/p73 family. Ann N Y Acad Sci. 2000;926:90-100
De Laurenzi V, Melino G. Gene disruption of tissue transglutaminase. Mol Cell Biol. 2001;21:148-55
Domen J. The role of apoptosis in regulating hematopoiesis and hematopoietic stem cells. Immunol Res. 2001;22:83-94
Evan GI, Vousden KH. Proliferation, cell cycle and apoptosis in cancer. Nature. 2001;411:342-8
Fortin A, et al. APAF1 is a key transcriptional target for p53 in the regulation of neuronal cell death. J Cell Biol
Garaci E, et al. Nerve growth factor is an autocrine factor essential for the survival of macrophages infected with HIV. Proc Natl Acad Sci U S A. 1999;96:14013-8
Garrido C, et al. Heat shock proteins: endogenous modulators of apoptotic cell death. Biochem Biophys Res Commun. 2001;286:433-42
Giammarioli AM, et al GD3 glycosphingolipid contributes to Fas-mediated apoptosis via association with ezrin cytoskeletal protein. FEBS Lett. 2001;506:45-50
Hengartner MO. Apoptosis: corralling the corpses. Cell. 2001;104:325-8
Henson PM, et al. The phosphatidylserine receptor: a crucial molecular switch? Nat Rev Mol Cell Biol. 2001;2:627-33
Herdegen T, Waetzig V. AP-1 proteins in the adult brain: facts and fiction about effectors of neuroprotection and neurodegeneration. Oncogene. 2001;20:2424-37
Ho MK, Wong YH.G(z) signaling: emerging divergence from G(i) signaling. Oncogene. 2001;20:1615-25
Huang Z. Bcl-2 family proteins as targets for anticancer drug design. Oncogene. 2000;19:6627-31
Hughes RE, Olson JM. Therapeutic opportunities in polyglutamine disease. Nat Med. 2001;7:419-23
Iannicola C, et al. Early alterations in gene expression and cell morphology in a mouse model of Huntington's disease. J Neurochem. 2000;75:830-9
Jiang M, et al. p53 binds the nuclear matrix in normal cells: binding involves the proline-rich domain of p53 and increases following genotoxic stress. Oncogene. 2001;20:5449-58
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Kowaltowski AJ, et al. Mitochondrial permeability transition and oxidative stress. FEBS Lett. 2001;495:12-5
Leist M, Jaattela M. Four deaths and a funeral: from caspases to alternative mechanisms. Nat Rev Mol Cell Biol. 2001;2:589-98
Martinou JC, Green DR. Breaking the mitochondrial barrier. Nat Rev Mol Cell Biol. 2001;2:63-7
Matarrese P, et al. Expression of P-170 glycoprotein sensitizes lymphoblastoid CEM cells to mitochondria-mediated apoptosis. Biochem J. 2001;355:587-95
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Melino G. The Sirens' song. Nature. 2001;412:23
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Moroni MC, et al. Apaf-1 is a transcriptional target for E2F and p53. Nat Cell Biol. 2001;3:552-8
Muller H, et al. E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis. Genes Dev. 2001;15:267-85
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Parlato S, et al. CD95 (APO-1/Fas) linkage to the actin cytoskeleton through ezrin in human T lymphocytes: a novel regulatory mechanism of the CD95 apoptotic pathway. EMBO J. 2000;19:5123-34
Perno CF, Cozzi-Lepri A, Balotta C, Forbici F, Violin M, Bertoli A, Facchi G, Pezzotti P, Cadeo G, Tositti G, Pasquinucci S, Pauluzzi S, Scalzini A, Salassa B, Vincenti A, Phillips AN, Dianzani F, Appice A, Angarano G, Monno L, Ippolito G, Moroni M, Monforte Ad. Secondary mutations in the protease region of human immunodeficiency virus and virologic failure in drug-naive patients treated with protease inhibitor-based therapy. J Infect Dis. 2001;184:983-91
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Pirkkala L, Nykanen P, Sistonen L. Roles of the heat shock transcription factors in regulation of the heat shock response and beyond. FASEB J. 2001;15:1118-31
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Stassi G, Di Liberto D, Todaro M, Zeuner A, Ricci-Vitiani L, Stoppacciaro A, Ruco L, Farina F, Zummo G, De Maria R. Control of target cell survival in thyroid autoimmunity by T helper cytokines via regulation of apoptotic proteins. Nat Immunol. 2000;1:483-8
Stassi G, Zeuner A, Di Liberto D, Todaro M, Ricci-Vitiani L, De Maria R. Fas-FasL in Hashimoto's thyroiditis. J Clin Immunol. 2001;21:19-23
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Zornig M, Hueber A, Baum W, Evan G. Apoptosis regulators and their role in tumorigenesis. Biochim Biophys Acta. 2001;1551, F1-F37

Keywords

apoptosis; cell cycle; neurodegeneration; infection and immunology; tumour cells; reactive oxygen species