RICERCA ITALIANA     

Similar FIRB:

• 1 - Tissue Engineering for regeneration of connective tissues and, in particular, its application to bone repair.
• 2 - Pluripotent adult stem cells for tissue reconstitution in models of degenerative diseases
• 3 - HOST-TUMOR BALANCE IN THE THERAPY OF NEOPLASIAS: ROLE OF NF-kB
• 4 - Apoptotic mechanisms and their implications in human diseases
• 5 - Identification, purification, transdifferentiation and banking of stem cells committed towards self and non-self phenotypes, to be used for tissue repair
• 6 - FUNCTIONAL ANALYSIS OF THE DISEASE GENES INVOLVED IN THE MAINTENANCE OF GENOME INTEGRITY
• 7 - Multifocal combined approaches for gene therapy of Glioblastomas
• 8 - Deciphering cell identity and cell differentiation mechanisms in the postgenomic era by using three paradigmatic systems: breast, bone and lymphocytes
• 9 - Rational modulation of the activity of antitumor drugs by selective interference with regulatory pathways
• 10 - www*.neuralstemcells.it (*where,when,why)

Scientific and education field classification

• Field: Scienze mediche
  • PATOLOGIA GENERALE
  • ANATOMIA PATOLOGICA

International Patent Classification

• CHEMISTRY; METALLURGY
  • BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF (biocides, pest repellants or attractants, or plant growth regulators, containing micro-organisms, viruses, microbial fungi, enzymes, fermentates or substances produced by or extracted from micro-organisms or animal material A01N63/00; food compositions A21, A23; medicinal preparations A61K; chemical aspects of, or use of materials for, bandages, dressings, absorbent pads or surgical articles A61L; fertilisers C05); PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS (preservation of living parts of humans or animals A01N1/02); MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (micro-biological testing media C12Q)
• HUMAN NECESSITIES
  • MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES (bringing into special physical form A61J [N: mechanical aspects]; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; compounds per se C01, C07, C08, C12N; soap compositions C11D; micro-organisms per se C12N) [C0203]

Geographical classification

• Region: Lazio

Bibliografia

- Austin L, Bower JJ, Bennett TM, Lynch GS, Kapsa R, White JD, Barnard W, Gregorevic P, Byrne E: Leukemia inhibiting factor Ameliorates muscle fiber degeneration in the mdx mouse. Muscle Nerve 23(11): 1700-5, 2000.
- Azzouz M, Hottinger A, Paterna JC, Zurn AD, Aebischer P, Bueler H. Increased motoneuron survival and improved neuromuscolar function in transgenic ALS mice after intraspinal injection of an adeno-associated virus encoding Bcl-2. Hum Mol Genet 9(5):803-11, 2000.
- Barlucchi L, Leri A, Dostal DE, Fiordaliso F, Tada H, Hintze TH, Kajstura J, Nadal-Ginard B, Anversa P. Canine ventricular myocytes possess a renin-angiotensin system that is upregulated with heart failure. Circ Res. 2001 Feb 16;88(3):298-304.
- Baulieu EE, Schumacher M. Progesterone as a neuroactive neurosteroid, with special reference to the effect of progesterone on myelination. Steroids, 65(10-11):605-12, 2000.
- Beltrami AP, Urbanek K, Kajstura J, Yan SM, Finato N, Bussani R, Nadal-Ginard B, Silvestri F, Leri A, Beltrami CA, Anversa P: Evidence that human cardiac myocytes divide after myocardial infarction. NEJM, 344:1750-1757, 2001.
- Bjorklund A, Lindvall O. Self-repair in the brain. Nature, 405:951-5, 2000.
- Bjorklund A. Cell replacement strategies for neurodegenerative disorders. Novartis Found Symp, 231:7-15, 2000.
- Blaveri K, Heslop L, Yu DS, Rosenblatt JD, Gross JG, Pertridge TA, Morgan JE: Patterns of repair of dystrophic mouse muscle:Studies on isolated fibers. Dev Dyn 216(3):244-56, 1999.
- Chinni C, De Niese MR, Tew DJ, Jenkins AL, Bottomley SP, Mackie EJ: Thrombin, a survival factor for cultured myoblasts. J Biol Chem, 274:9169-9174, 1999
- Clark RS, Kochanek PM, Watkins SC, Chen M, Dixon CE, Seidberg NA, Melick J, Loeffert JE, Nathaniel PD, Jin KL, Graham SH. Caspase-3 mediated neuronal death after traumatic brain injury in rats. J Neurochem, 74(2):740-53, 2000.
- Cohn RD and Campbell KP: Molecular Basis of Muscular Dysthophies. Muscle Nerve, 23:1456-1471, 2000.
- CONDORELLI G, RONCARATI R, ROSS J, PISANI A, STASSI G, TODARO M, TROCHA S, DRUSCO A, GU Y, RUSSO MA, FRATI G, JONES SP, LEFER DJ, NAPOLI C, AND CROCE CM. Heart-targeted overexpression of caspase-3 in mice increases infarct size and depresses cardiac function.
Proc Natl Acad Sci USA, 98:9977-9982, 2001
- Frustaci A, Perrone GA, Gentiloni N, Russo MA:
REVERSIBLE DILATED CARDIOMYOPATHY DUE TO GROWTH HORMONE DEFICIENCY.
Am J Cli Pathol, 97:503-511, 1992.
- Frustaci A, Gentiloni N and Russo MA:
Growth hormone in the treatment of dilated cardiomyopathy.
NEJM, 335:672-674, 1996.
- FRUSTACI A., CHIMENTI C., RICCI R., NATALE L, RUSSO M.A., DESNICK RJ. (2001). Galactose infusion therapies improves cardiac function in the cardiac of Fabry's disease. Two year experience ov chaperone-mediated enzyme enhancement.
New Engl J Med, 345:24-32, 2001
- Granholm AC. Oestrogen and nerve-growth factor-neuroprotection and repair in Alzheimer's disease. Expert Opin Investig Drugs, 9(4):685-94, 2000.
- Guttridge DC, Mayo MW, Madrid LW, Wang CY, Baldwin AS: NFkB-induced loss of MyoD mRNA: possible role in muscle decay and cachexia. Science, 289:2293-2294, 2000.
- Izumo S, Lompre AM, Matsuoka R, Koren G, Schwartz K, Nadal-Ginard B, Mahdavi V. Myosin heavy chain messenger RNA and protein isoform transitions during cardiac hypertrophy. Interaction between hemodynamic and thyroid hormone-induced signals. J Clin Invest. 1987 Mar;79(3):970-7.
- Izumo S, Nadal-Ginard B, Mahdavi V. Protooncogene induction and reprogramming of cardiac gene expression produced by pressure overload. Proc Natl Acad Sci U S A. 1988 Jan;85(2):339-43.
- Kajstura J, Fiordaliso F, Andreoli AM, Li B, Chimenti S, Medow MS, Limana F, Nadal-Ginard B, Leri A and Anversa P: IGF-1 overexpression inhibits the development of diabetic cardiomyopathy and angiotensin II- mediated oxidative stress. Diabetes 50(6): 1414-1424, 2001.
- Keirsteadt HS. Stem cell transplantation into the central nervous system and the control of differentiation. J Neurosci Res, 63(3):233-6, 2001.
- Koenig HL, Gong WH, Pelissier P. Role of progesterone in peripheral nerve repair. Rev Reprod, 5(3):189-99, 2000.
- Lee Y, Nadal-Ginard B, Mahdavi V, Izumo S. Myocyte-specific enhancer factor 2 and thyroid hormone receptor associate and synergistically activate the alpha-cardiac myosin heavy-chain gene. Mol Cell Biol. 1997 May;17(5):2745-55.
- Leri A, Liu Y, Wang X, Kajstura J , Malhotra A, Meggs LG, Anversa P. Overexpression of insulin-like growth factor-1 attenuates the myocyte renin-angiotensin system in transgenic mice. Circ Res 84(7):752-62, 1999.
- Li Q, Li B, Leri A, Jana KP, Liu Y, Kajstura J , Baserga R, Anversa P. Overexpression of insulin-like growth factor-1 in mice protects from myocyte death after ifarction, attenuating ventricular dilation, wall stress, and cardiac hypertrophy. J Clin Invest 100(8):1991-9, 1997.
- Lompre AM, Nadal-Ginard B, Mahdavi V. Expression of the cardiac ventricular alpha- and beta-myosin heavy chain genes is developmentally and hormonally regulated. J Biol Chem. 1984 May 25;259(10):6437-46.
- Mattson MP. Neuroprotective signaling and the aging brain: take away my food and let me run. Brain Res, 886(1-2):47-53, 2000.
- McKoy G, Ashley W, Mander J, Yang SY, Williams N, Russell B, Goldspink: Expression of IGF-1 splice variants and structural genes in rabbit skeletal muscle induced by stretch and stimulation. J Physol, 516:583-592, 1999.
- Miller KJ, Thaloor D, Matteson S, Pavlath GK: Hepatocyte growth factor affects satellite cell activation and differentiation in regenerating skeletal muscle. Am J Physiol cell physiol 278(1): 174-81, 2000.
- Munz B, Wiedman M, Lochmuller H, Werner S: Cloning of novel injury-regulated genes. Implications for an important role of the muscle-specific protein skNAC inmuscle repair. J Biol Chem, 274(19):13305-10,1999.
- Nadal-Ginard B, Mahdavi V. Molecular basis of cardiac performance. Plasticity of the myocardium generated through protein isoform switches. J Clin Invest. 1989 Dec;84(6):1693-700. Review.
- Orlic D, Kajstura J, Chimenti S, Limana F, Jakoniuk I, Quaini F, Nadal-Ginard B, Bodine DM, Leri A, Anversa P. Mobilized bone marrow cells repair the infarcted heart, improving function and survival. Proc Natl Acad Sci U S A. 2001 Aug 28;98(18):10344-9.
- Perry VH, Anthony DC. Axon damage and repair in multiple sclerosis. Philos Trans R Soc Lond B Biol Sci, 354(1390):1641-7, 1999.
- Russell SD, Cambon N, Nadal-Ginard B, Whalen RG. Thyroid hormone induces a nerve-Independent precocious expression of fast myosin heavy chain mRNA in rat hindlimb skeletal muscle. J Biol Chem. 1988 May 5;263(13):6370-4.
- Sakai T, Johnson KJ, Murozono M, Sakai K, Magnuson MA, Wieloch T, Cronberg T, Isshiki A, Erickson HP, Fassler R. Plasm fibronectin supports neuronal survival and reduces brain injury following transient focal cerebral ischemia but is not essential for skin-wound healing and hemostasis. Nat Med, 7(3):324-30, 2001.
- Scolding N. Therapeutic strategies in multiple sclerosis. II.Long-term repair. Philos Trans R Soc Lond B Biol Sci, 354(1390):1711-20, 1999.
- Thaloor D, Miller KJ, Gephart J, Mitchell PO, Pavlath GK: Systemic administration of the NFkB inhibitor curcumin stimulates muscle regeneration after traumatic injury. Am J Physiol, 277:C320-329, 1999.
- Walsh CA: Neuroscience in the post-genome era: an overview. Trends in Neurosciences, 24:363-363, 2001.
- Yamashit K, Kajstura J ,Discher DJ, Wasserlauf BJ, Bishopric NH, Anversa P, Webster KA: Reperfusion-activated Akt kinase prevents apoptosis in transgenic mouse heart overexpressing Insulin-like Growth Factor-1. Circ Res, 88:609-614, 2001.
- Zhu YZ, Chimon GN, Zhu YC, Lu Q, Li B, Hu HZ, Yap EH, Lee HS, Wong PT. Expression of angiotensin II AT2 receptor in the acute phase of stroke in rats. Neuroreport 11(6):1191-4, 2000.

Keywords

Molecular repair; Myocardial failure; Skeletal muscle myopathies; Neurodegenerative diseases; Repair signalling; Repair DNA microarrays