Contenuto
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Fund for investing in fundamental research
italiano - inglese
Research Units
- Consiglio nazionale delle ricerche (CNR)
Istituto Internazionale di Genetica e Biofisica , NAPOLI (NA) - Universita' degli Studi di BARI
Dip. FARMACOLOGIA E FISIOLOGIA UMANA , BARI (BA) - Universita' degli Studi di MILANO-BICOCCA
Dip. BIOTECNOLOGIE E BIOSCIENZE , MILANO (MI) - Universita' degli Studi di PARMA
Dip. BIOLOGIA EVOLUTIVA E FUNZIONALE , PARMA (PR) - Universita' degli Studi di ROMA "La Sapienza"
Dip. BIOLOGIA CELLULARE E DELLO SVILUPPO , ROMA (RM) - Universita' degli Studi di TORINO
Dip. BIOLOGIA ANIMALE E DELL'UOMO , TORINO (TO) - CEINGE BIOTECNOLOGIE AVANZATE SCARL
Biologia molecolare , NAPOLI (NA) - IRCCS Fondazione S. Lucia
Neurologia sperimentale , ROMA (RM)
Similar FIRB:
- 1 - Mechanisms of signal transduction and synaptic function: Development of molecular, cellular, and animal models.
- 2 - The ubiquitous Ca2+ signalling cascade: from molecules to functions
- 3 - Deciphering cell identity and cell differentiation mechanisms in the postgenomic era by using three paradigmatic systems: breast, bone and lymphocytes
- 4 - Transgenic animal models for diseases of complex etiology.
- 5 - Signalling Proteomics (Signalomics): differential studies by novel strategies and technologies
- 6 - GENOTOPO: Mouse functional genomics
- 7 - HOST-TUMOR BALANCE IN THE THERAPY OF NEOPLASIAS: ROLE OF NF-kB
- 8 - Apoptotic mechanisms and their implications in human diseases
- 9 - Molecular recognition and cell function
- 10 - Functional interactions among synaptic proteins: physiopathology and potential therapeutic indications.
Scientific and education field classification
International Patent Classification
- CHEMISTRY; METALLURGY
- BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF (biocides, pest repellants or attractants, or plant growth regulators, containing micro-organisms, viruses, microbial fungi, enzymes, fermentates or substances produced by or extracted from micro-organisms or animal material A01N63/00; food compositions A21, A23; medicinal preparations A61K; chemical aspects of, or use of materials for, bandages, dressings, absorbent pads or surgical articles A61L; fertilisers C05); PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS (preservation of living parts of humans or animals A01N1/02); MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (micro-biological testing media C12Q)
- BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Geographical classification
- Region: Campania
Bibliografia
1) Vaage, S., et al. (1969). Adv. Anat. Embryol. Cell Biol., 41: 1-87.2) Altman, J., et al.. (1988) J. Comp. Neurol., 275: 346-377.
3) Figdor, M.C., et al. (1993). Nature, 363: 630-634.
4) Rubenstein, J.L.R., et al. (1998). Annu. Rev. Neurosci., 21: 445-477.
5) Lemaire, P., et al. (1996). Trends Genet., 12: 525-531.
6) Tam, P.P.L., et al. (1997) Mech. Dev., 68: 3-25.
7) Reichert , H., et al. (1999) Current Opinion in Neurobiology, 9: 589-595.
8) Simeone, A. (2000). TIG, 16: 237-240.
9) Ye, W., et al. (1998). Cell, 29: 755-66.
10) Perrone-Capano, C:, et al. (1996) BioEssays,18: 817-824.
11) di Porzio, U., et al. (1999) Dopaminergic Neuron Development pp. 196 AUSTIN TX: Neuroscience Intellingence Unit Landes Co.
12) Perrone-Capano C., et al. (2000) Neurosci. Biobehav. Rev., 24: 119-124.
13) Zetterstrom RH, et al. (1997) Science, 276:248-250.
14) Wagner J, et al. (1999) Nat Biotechnol., 17: 653-9.
15) Forman BM, et al. (1995) Cell,; 81:541-550.
16) Sakurada,K.,et al.(1999) Development, 126: 4017-4026.
17) Blitz IL, et al. (1995) Development, 121:993-1004.
18) Pannese M. et al. Development, 121:707-720.
19) Vignali R. (2000) Mech Dev., 96:3-13.
20) Finkelstein, R. et al. (1990) Genes Dev., 4: 1516-1527.
21) Patterson et al. (2000) Dev. Genes Evol., 210:140-144.
22) Malgaretti, N., et al. (1997). J. Biol. Chem., 272:17632-17639.
23) Garel, S., et al. (1997). Dev Dyn., 210:191-205.
24) Dubois, L., et al. (1998) in : Xenopus. Current Biology, 8:199-209.
25) Garel, S., et al. (1999) Development, 126: 5285-5294.
26) Pozzoli, O., et al. (2001) Developmental Biology, 233: 495-512.
27) Prasad, B. C., et al. (1998) Development, 125: 1561-8.
28) Garel, S., et al. (2000) Development, 127: 5297-307.
29) Jessen, K. R., et al. (1999) Trends in Neurosci., 22: 402-410.
30) Gennarini, G., et al. (1989) J. Cell. Biol., 109:775-88.
31) Furley, AJ., (1990) Cell, 61:157-70.
32) Gennarini G, et al. (1991) Neuron, 6:595-606.
33) Buttiglione, M., et al. (1996) Mol. Cell Neurosci., 8:53-69.
34) Sakurai, T., et al. (1997) J. Cell Biol., 136:907-18.
35) Peles, E., et al. (1998) Trends Biochem. Sci., 23:121-4.
36) Zeng, L, et al. (1999) J. Cell Biol., 147:707-14.
37) Faivre-Sarrailh, C., et al. (2000) J. Cell Biol., 149:491-502.
38) Rios, J.C., et al. (2000) J. Neurosci., 20:8354-64.
39) Berglund, E.O., et al. (1999) Neuron,. 24:739-50.
40) Boyle, M.E., et al. (2001) Neuron, 30:385-97.
41) Buttiglione, M., et al. (1998) J. Neurosci., 18:6853-70.
42) Fukamauchi, F., et al. (2001) Biochem. Biophys. Res. Commun., 281:220-6.
43) Tessier-Lavigne, M., & Goodman, C.S. (1996) Science, 274: 1123-1133.
44) Tamagnone, L., et al. (2000) Trends in Cell Biology, 10:377-385.
45) Luo, Y., et al. (1993) Cell, 75: 217-227.
46) Kolodkin, A.L., et al. (1993) Cell, 75:1389-1399.
47) Winberg, M.L., et al. (1998) Cell, 95: 903-916.
48) Pasterkamp, R.J., et al. (1998) Prog. Brain Res., 117:151-170.
49) Tamagnone, L., et al. (1999) Cell, 99: 71-80.
50) Maestrini, E., et al. (1996) Proc. Natl. Acad. Sci. U.S.A., 93:674-8.
51) Takahashi, T., et al. (1999) Cell, 99: 59-69.
52) Kolodkin, A.L., et al. (1993) Cell, 75:1389-1399.
53) Behar, O., et al. (1996) Nature, 383: 525-528.
54) Taniguchi, M., et al. (1997) Neuron, 19: 519-530.
55) Raper, J.A. (2000) Curr. Opin. Neurobiol., 10:88-94.
56) Ohta, K., et al. (1995) Neuron, 14:1189-1199.
57) Liu, B.P. & Strittmatter, S.M. (2001) Curr. Opin. Cell. Biol., 13:619-26.
58) Rice, D.S. & Curran, T. (1999) Genes Dev., 13:2758-73.
59) Bashaw, G.J., et al. (2000) Cell, 101:703-15.
60) Selkoe, D.J. (2001) Physiol. Rev., 81:741-66.
61) Fiore, F., et al. (1995) J. Biol. Chem., 270: 30853-30856.
62) Zambrano, N., et al. (1997) J. Biol. Chem., 272:6399-6405.
63) Borg, J.P., et al. (1996) Mol. Cell. Biol., 16:6229-41.
64) Howell, B.W., et al. (1999) Mol. Cell. Biol.,19:5179-88.
65) Matsuda, S., et al. (2001) J. Neurosci., 21:6597-607.
66) Ermekova, K.S., et al. (1997) J. Biol. Chem., 272: 32869-32877.
67) Zambrano, N., et al. (2001), J. Biol. Chem., 276:19787-92.
68) Zambrano, N., et al. (1998) J. Biol. Chem., 273:20128-20133.
69) Minopoli, G., et al. (2001) J. Biol. Chem., 276:6545-50.
70) Malosio, M.L., et al. (1997) J. Neuroscience, 17: 6717-6728.
71) Albertinazzi, C., et al. (1998) J. Cell Biol., 142: 815-825.
72) Di Cesare, A., et al. (2000) Nature Cell Biol., 2:521-530.
73) Manser, E., et al. (1998) Mol. Cell, 1:183– 192.
74) Turner, C.E., et al. (1999) J. Cell Biol., 145:851–863.
75) Daniels, R.H. and Bokoch, G.M. (1999) Trends Bioch. Sci., 24:350-355.
76) Matafora V., et al. (2001) J. Cell Sci. in press.
77) de Curtis I. (2001).EMBO Reports, 2:277-281.
78) D’Souza-Schorey, C., et al. (1995) Science 267:1175–1178.
79) Peters P.J., et al. (1995) J. Cell Biol.,128:1003–1017.
80) Kao S., et al. (2001) J. Biol. Chem., 276:18169-18177.
81) York, R.D., et al. (1998) Nature, 392:622-626.
82) Goi T, et al. (1999) Mol. Cell. Biol., 19:1731-1741.
83) Martegani, E., et al. (1992) EMBO J., 11:2151-2157.
84) Sturani E, et al. (1997) Exp. Cell Res., 235:117-123.
85) Tonini, R., et al. (1999) Eur. J. Neurosci., 11:959-966.
86) Gnesutta, N., et al. (2001) J. Biol. Chem., In press
87) Choi et al. (2001). Mol. Cell. Biol., 21:2695-2705.
88) Rusanescu, P., et al. (2001) Mol. Cell. Biol., 21:2650-2658.
89) Susen, K., et al. (1999). FEBS Lett . 463:231-4.
90) Colangelo, A.M., et al. (1994) Glia, 12: 117-127.
91) Pflug. B.R., et al. (2001) J. Neurosci. Res., 64:636-645.
Keywords
brain patterning; dopaminergic differentiation; connectivity; neural induction; oligomeric complexes; axonal growthMechanisms regulating nervous system development and neural differentiation (PRONEURO)
Consiglio Nazionale delle Ricerche (CNR)Abstract
The project proposed by the PRONEURO network deals with the identification and the characterization of the function of genes and cellular machineries, important in neural differentiation and brain development. It is in line with one of the objectives of the "Programma Strategico Neuroscienze" and it is aimed at a better understanding of the development of the nervous system (NS) and of the mechanisms that govern the biological features involved in this process. The project deals with scientific themes that are the object of the modern research in developmental neurobiology.The molecular machineries that will be the object of the proposed research have been chosen on the basis of the expertises of the research groups involved. In particular, all the groups belonging to PRONEURO have long experience in studies of the molecular bases of neural development and neuronal differentiation. Their work has been focused on neural induction and differentiation of specific neuronal phenotypes and glia, regionalization of the nervous system, neuritogenesis and sinaptogenesis, neuronal and glial migration and in functional studies of specific brain circuits.
The experimental plan is organized in various interconnected steps. The first step will be the determination of the temporal and spatial pattern of expression of genes (some of them will be identified during the course of the project) and of cascades of genes, essential in some crucial phases of the NS development. One>>>
Principal Investigator
UMBERTO DI PORZIO, Consiglio nazionale delle ricerche (CNR)Research Goal
This proposal addresses one of the specific objectives of the "Programma Strategico Neuroscienze" (Strategic Program Neuroscience), that is to provide a better understanding of the nervous system development and mechanisms governing biological processes in it.To this aim the scientific objectives of the proposal are:
i) to develop and/or to set-up new experimental systems and methodologies for the functional and structural characterization of molecular machineries involved in: a) patterning and differentiation; b) organization of connectivity; c) assonal growth and pathfinding; d) signal transduction and transcription regulation in neuronal development. These topics will be explored by using, among the others, DNA array analysis, mass-spectrometry based peptide fingerprint, in vivo manipulation of cultured cells.
ii) to develop animal models, obtained through genetic modification of mice or other animals, that contribute to the understanding molecular mechanisms underlying: a) the role of Otx2 in controlling dopaminergic fate, by analyzing different mouse models conditionally inactivating Otx2 at different efficiency in different areas of the midbrain; b) the role of Plexin B-1 in cell migration and growth of axonal extension, by generating and characterizing knock out or knock in mice in which the Plexin B-1 gene is inactivated or mutated; c) the differential expression of F3/contactin gene in distinct neuronal populations during development, by>>>
