RICERCA ITALIANA     

Programmi di ricerca simili:

• 1 - Progettazione, sintesi e proprietà biofarmacologiche di molecole attive come agenti antitumorali
• 2 - SINTESI E VALUTAZIONE DI NUOVI LIGANDI PER IL RECETTORE BENZODIAZEPINICO PERIFERICO UTILI PER IL CHIARIMENTO DEL SUO RUOLO FISIO-FARMACOLOGICO E DIAGNOSTICO
• 3 - SINTESI E CARATTERIZZAZIONE FARMACOLOGICA DI NUOVE MOLECOLE SELETTIVE PER IL RECETTORE BENZODIAZEPINICO PERIFERICO UTILI PER LA MODULAZIONE DELLA NEUROSTEROIDOGENESI, PER LA DIAGNOSI DI MALATTIE NEURODEGENERATIVE E PER IL DIREZIONAMENTO DI FARMACI ANTITUMORALI
• 4 - Progettazione, sintesi e valutazione biologica di inibitori enzimatici e di induttori dell'apoptosi utili come agenti antitumorali
• 5 - Apoptosi e terapia del cancro: caratterizzazione di nuovi meccanismi e nuove molecole modulatrici dell'apoptosi
• 6 - BERSAGLI MOLECOLARI PER NUOVE TERAPIE ANTINEOPLASTICHE ATTRAVERSO LO STUDIO DI PROTEINE-SEGNALE CELLULARI E VIRALI E DI INIBITORI SPECIFICI
• 7 - I membri della famiglia del TNF nella modulazione del differenziamento cellulare e dell'attività antitumorale
• 8 - Vie di trasduzione e modifiche traduzionali e post-traduzionali nella protezione dall'apoptosi: disegno di nuove strategie terapeutiche antitumorali.
• 9 - CONTROLLO DEL CICLO CELLULARE DA LIGANDI DI RECETTORI NUCLEARI
• 10 - Medulloblastoma: studio delle vie molecolari di sviluppo e progressione tumorale allo scopo di identificare approcci terapeutici innovativi

Classificazione scientifico-disciplinare

• Area scientifico disciplinare: Scienze chimiche
  • CHIMICA FARMACEUTICA
• Area scientifico disciplinare: Scienze biologiche
  • BIOCHIMICA
  • BIOLOGIA APPLICATA

Classificazione brevettuale

• CHEMISTRY; METALLURGY
  • BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF (biocides, pest repellants or attractants, or plant growth regulators, containing micro-organisms, viruses, microbial fungi, enzymes, fermentates or substances produced by or extracted from micro-organisms or animal material A01N63/00; food compositions A21, A23; medicinal preparations A61K; chemical aspects of, or use of materials for, bandages, dressings, absorbent pads or surgical articles A61L; fertilisers C05); PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS (preservation of living parts of humans or animals A01N1/02); MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (micro-biological testing media C12Q)
  • ORGANIC CHEMISTRY (such compounds as the oxides, sulfides, or oxysulfides of carbon, cyanogen, phosgene, hydrocyanic acid or salts thereof C01; products obtained from layered base-exchange silicates by ion-exchange with organic compounds such as ammonium, phosphonium or sulfonium compounds or by intercalation of organic compounds C01B33/44; macromolecular compounds C08; dyes C09; fermentation products C12; fermentation or enzyme-using processes to synthesise a desired chemical compound or composition or to separate optical isomers from a racemic mixture C12P; production of organic compounds by electrolysis or electrophoresis C25B3/00, C25B7/00)
    • HETEROCYCLIC COMPOUNDS
    • PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00)

Classificazione geografica

• Regione: Toscana

Bibliografia

-Baker SP et al.,. Development of novel irreversible ligands. Neuroprotocols, 1994,4: 66.
-Bernassau JM et al. A 3D Model of the Peripheral Benzodiazepine Receptor and its Implication in Intramitochondrial Cholesterol Transport. J. Mol. Graphics 1993,11, 236-244.
-Brauestrup C et al. Specific benzodiazepine receptors in rat brain characterized by high-affinity (3H) diazepam binding. Proc Natl Acad Sci USA 1977;74:3805-9.
-Brown RC, et al. Location-dependent role of the human glioma cell peripheral-type benzodiazepine receptor in proliferation and steroid biosynthesis. Cancer Lett. 2000,156:125-32.
-Casellas P, et al. Peripheral benzodiazepine receptors and mitochondrial function. Neurochim Int 2002, 40:475-86.
-Chelli B, et al. Peripheral-type benzodiazepine receptor ligands: mitochondrial permeability transition induction in rat cardiac tissue. Biochem Pharmacol 2001, 61:695-705.
-Chelli B, et al. Peripheral benzodiazepine receptor ligands : mitochondrial transmembrane potential depolarization and apoptosis induction in rat C6 glioma cells. Biochem Pharmacol 2004, in press.
-Cornu P, et al. Increase in omega 3 (peripheral-type benzodiazepine) binding site densities in different types of human brain tumours. A quantitative autoradiography study. Acta Neurochir 1992,119:146-52.
-De Souza EB, et al. Peripheral-type benzodiazepine receptors in endocrine organs: autoradiographic localization in rat pituitary, adrenal, and testis. Endocrinology. 1985, 116:567-73.
-Ehlert F.J et al.The use of irreversible ligands to inactivate receptor subtypes: 4-DAMP mustard and muscarinic receptors in smooth muscle. Life Sci1998, 62, 1659.
-Farges R et al. Site-Directed Mutagenesis of the Peripheral Benzodiazepine Receptor: Identification of Amino Acids Implicated in the Binding Site of Ro 5-4864. Mol. Pharmacol. 1994, 46, 1160-1167.
-Fennell DA, et al. Bcl-2 resistant mitochondrial toxicity mediated by the isoquinoline carboxamide PK11195 involves de novo generation of reactive oxygen species. Br J Cancer 2001;84:1397-404.
-Galiegue S, et al. The peripheral benzodiazepine receptor: a promising therapeutic drug target. Curr Med Chem 2003;10:1563-72.
-Garnier M, et al. Diazepam binding inhibitor is a paracrine/autocrine regulator of Leydig cell proliferation and steroidogenesis: action via peripheral-type benzodiazepine receptor and independent mechanisms. Endocrinology. 1993, 132:444-58.
-Gavish M, et al. Enigma of the peripheral benzodiazepine receptor. Pharmacol Rev 1999;51:619-40.
-Green DR, et al. Mitochondria and apoptosis. Science 1998;281:1309-12.
-Guo, P., et al. Targeted delivery of a peripheral benzodiazepine receptor ligand-gemcitabine conjugate to brain tumors in a xenograft model. Cancer Chemother Pharmacol 2001, 48:169-76.
-Hardwick M, et al. Peripheral-type benzodiazepine receptor (PBR) in human breast cancer: correlation of breast cancer cell aggressive phenotype with PBR expression, nuclear localization, and PBR-mediated cell proliferation and nuclear transport of cholesterol. Cancer Res. 1999; 59:831-42.
- Hengartner MO. The biochemistry of apoptosis. Nature. 2000;40:685-7.
-Hirsch T, et al. PK 11195, a ligand of the mitochondrial benzodiazepine receptor, facilitates the induction of apoptosis and reverses Bcl-2 mediated cytoprotection. Exp Cell Res 1998;241:426-34.
-Kessel, D., et al. The role of the peripheral benzodiazepine receptor in the apoptotic response to photodynamic therapy. Photochem Photobiol 2001, 74: 346-9.
-Kessel, D, et al. Pro-apoptotic interactions between XK469 and the peripheral benzodiazepine receptor. Cancer Lett 2001, 168: 141-4.
-Kroemer G, et al. The mitochondrial death/life regulator in apoptosis and necrosis. Annu Rev Physiol 1998;60:619-42.
-Kupczyk-Subotkowska, L., et al. Modulation of melphalan resistance in glioma cells with a peripheral benzodiazepine receptor ligand-melphalan conjugate. J Med Chem 1997, 40: 1726-30.
-Joseph-Liauzun, E. et al. Topological Analysis of the Peripheral Benzodiazepine Receptor in Yeast Mitochondrial Membrane Supports a Five-Transmembrane Structure. J. Biol. Chem. 1998, 273: 2146-2152.
-Lacaper JJ et al. Peripheral-type benzodiazepine receptor : structure and function of a cholesterol-binding protein in steroid and bile acid biosynthesis. Steroids 2003; 68: 569-85
-Lee DH, et al. Effects of peripheral benzodiazepine receptor ligands on proliferation and differentiation of human mesenchymal stem cells. J Cell Physiol. 2004;198:91-9.
-Maaser, K., et al., Overexpression of the peripheral benzodiazepine receptor is a relevant prognostic factor in stage III colorectal cancer. Clin Cancer Res 2002, 8: 3205-9.
-Maaser, K., et al. Specific ligands of the peripheral benzodiazepine receptor induce apoptosis and cell cycle arrest in human colorectal cancer cells. Br J Cancer 2001, 85: 1771-80.
-McEnery MW, et al. Isolation of the mitochondrial benzodiazepine receptor: association with the voltage-dependent anion channel and the adenine nucleotide carrier. Proc Natl Acad Sci USA 1992;89:3170-4.
-McGrath J.C. et al. Fluorescent ligands for the study of receptors. TiPS, 1996, 17: 393
-Miettinen H, et al. Expression of peripheral-type benzodiazepine receptor and diazepam binding inhibitor in human astrocytomas: relationship to cell proliferation. Cancer Res 1995;55: 2691-5.
-Papadopoulos V, et al. Peripheral benzodiazepine receptor in cholesterol transport and steroidogenesis. Steroids. 1997, 62:21-8.
-Pastorino JG, et al. The cytotoxicity of tumor necrosis factor depends on induction of the mitochondrial permeability transition. J Biol Chem 1996;271:2992-8.
-Primofiore G et al. N,N-Dialkyl-2-phenylindol-3-ylglyoxylamides. A new class of potent and selective ligands at the Peripheral Benzodiazepine Receptor, J Med Chem, Web Release Date: Feb 24,2004.
-Rossi L, et al. 2-phenylindol-3-ylglyoxylamide derivative, a new synthesized specific ligand of peripheral benzodiazepine receptor, induces mitochondrial trasmembrane potential dissipation and apoptosis in rat C6 glioma cells. J Neurosci Res,2004 submitted.
-Sridaran R, et al. GnRH agonist treatment decreases progesterone synthesis, luteal peripheral benzodiazepine receptor mRNA, ligand binding and steroidogenic acute regulatory protein expression during pregnancy.J Mol Endocrinol. 1999;22:45-54.
-Sutter, A. P., et al., (2002). Specific ligands of the peripheral benzodiazepine receptor induce apoptosis and cell cycle arrest in human esophageal cancer cells. Int J Cancer 102, 318-27.
-Thompson CB. Apoptosis in the pathogenesis and treatment of disease. Science 1995 ;267:1456-62.
-Wilker M. et al. Avidin-Biotin technology, In Methods in Enzimology, Abelson J.N. and Simon M.I., Eds; Academic Press; New York, 1990, Vol. 184, pp 3-13.
-Xia W, et al. Tumor selective G2/M cell cycle arrest and apoptosis of epithelial and hematological malignancies by BBL22, a benzazepine. -Proc Natl Acad Sci U S A 2000;97:7494-9.
-Yeliseev A. et al. TspO of Rhodobacter sphaeroides. J. Biol. Chem. 2000, 275:5657-67.
-Yeliseev, A. et al., Mammalian Mitochondrial Drug Receptor Functions as a Bacterial "Oxygen" Sensor. Proc. Natl. Acad. Sci. U.S.A. 1997, 94: 5101-6.
-Zilz A, et al. Developmental expression of the peripheral-type benzodiazepine receptor and the advent of steroidogenesis in rat adrenal glands. Endocrinology. 1999;140:859-64.
-Zisterer DM, et al. Pyrrolo-1,5-benzoxazepines induce apoptosis in HL-60, Jurkat, and Hut-78 cells: a new class of apoptotic agents. J Pharmacol Exp Ther 2000;293:48-59.
-Zoratti M and Szabo I. The mitochondrial permeability transition. Biochim Biophys Acta. 1995;1241:139-76.

Parole Chiave

RECETTORE PERIFERICO DELLE BENZODIAZEPINE; LIGANDI DI NUOVA SINTESI AL PBR; PROGETTAZIONE; APOPTOSI; POTENZIALE TRANSMEMBRANALE MITOCONDRIALE; CELLULE TUMORALI; STEROIDOGENESI; ANALISI ULTRASTRUTTURALE; MITOCONDRI