RICERCA ITALIANA     

Programmi di ricerca simili:

• 1 - Mitocondri e morte cellulare: identificazione di nuovi bersagli terapeutici
• 2 - L'apoptosi nei processi immunitari ed infiammatori: caratterizzazione di meccanismi molecolari e cellulari finalizzata a interventi terapeutici innovativi.
• 3 - Processi apoptotici nella differenziazione e degenerazione cellulare
• 4 - Meccanismi di danno e protezione nel miocardio ischemico
• 5 - MECCANISMI REDOX DI SEGNALAZIONE CELLULARE COINVOLTI NELLA GENESI DI MALATTIE ASSOCIATE A STRESS OSSIDATIVO
• 6 - RUOLO DEI LIPIDI NELLA REGOLAZIONE DI FUNZIONI CELLULARI
• 7 - Meccanismi cellulari e molecolari di morte e protezione neuronale
• 8 - RUOLO DEI MECCANISMI DI SEGNALE CELLULARE E DELLE SPECIE REATTIVE DELL'OSSIGENO E DELL'AZOTO NELL'INVECCHIAMENTO CELLULARE E NELLA CRESCITA NEOPLASTICA.
• 9 - NUOVE STRATEGIE FARMACOLOGICHE CON MOLECOLE DI ORIGINE NATURALE PER IL CONTENIMENTO DELLA NEURODEGENERAZIONE E LA PREVENZIONE DI PATOLOGIE NEURODEGENERATIVE.
• 10 - Medulloblastoma: studio delle vie molecolari di sviluppo e progressione tumorale allo scopo di identificare approcci terapeutici innovativi

Classificazione scientifico-disciplinare

• Area scientifico disciplinare: Scienze biologiche
  • BIOCHIMICA
  • BIOLOGIA MOLECOLARE
  • BIOLOGIA APPLICATA
• Area scientifico disciplinare: Scienze mediche
  • PATOLOGIA GENERALE

Classificazione brevettuale

• HUMAN NECESSITIES
  • MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES (bringing into special physical form A61J [N: mechanical aspects]; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; compounds per se C01, C07, C08, C12N; soap compositions C11D; micro-organisms per se C12N) [C0203]

Classificazione geografica

• Regione: Veneto

Bibliografia

1. Orrenius, S., Zhivotovsky, B., & Nicotera, P. (2003) Regulation of cell death: the calcium-apoptosis link. Nat. Rev. Mol. Cell. Biol., 4, 552-565.
2. Duchen, M.R., McGuinness, O., Brown, L.A., & Crompton, M. (1993) On the involvement of a cyclosporin A sensitive mitochondrial pore in myocardial reperfusion injury. Cardiovasc. Res., 27, 1790-1794.
3. Di Lisa, F., Menabò, R., Canton, M., Barile, M., & Bernardi, P. (2001) Opening of the mitochondrial permeability transition pore causes depletion of mitochondrial and cytosolic NAD+ and is a causative event in the death of myocytes in postischemic reperfusion of the heart. J. Biol. Chem., 276, 2571-2575.
4. Schinder, A.F., Olson, E.C., Spitzer, N.C., & Montal, M. (1996) Mitochondrial dysfunction is a primary event in glutamate neurotoxicity. J. Neurosci., 16, 6125-6133.
5. Sawa, A., Wiegand, G.W., Cooper, J., Margolis, R.L., Sharp, A.H., Lawler-JF, J., Greenamyre, J.T., Snyder, S.H., & Ross, C.A. (1999) Increased apoptosis of Huntington disease lymphoblasts associated with repeat length-dependent mitochondrial depolarization. Nat. Med., 5, 1194-1198.
6. Folbergrova, J., Li, P.A., Uchino, H., Smith, M.L., & Siesjo, B.K. (1997) Changes in the bioenergetic state of rat hippocampus during 2.5 min of ischemia, and prevention of cell damage by cyclosporin A in hyperglycemic subjects. Exp. Brain Res., 114, 44-50.
7. Ferrand-Drake, M., Friberg, H., & Wieloch, T. (1999) Mitochondrial permeability transition induced DNA-fragmentation in the rat hippocampus following hypoglycemia. Neuroscience, 90, 1325-1338.
8. Blandini, F. & Greenamyre, J.T. (1998) Prospects of glutamate antagonists in the therapy of Parkinson's disease. Fundam. Clin. Pharmacol., 12, 4-12.
9. Tatton, W.G., Chalmers, R.R., Rideout, H.J., & Tatton, N.A. (1999) Mitochondrial permeability in neuronal death: possible relevance to the pathogenesis of Parkinson' s disease. Parkinsonism and Related Disorders, 5, 221-229.
10. Klöhn, P.C., Soriano, M.E., Irwin, W., Penzo, D., Scorrano, L., Bitsch, A., Neumann, H.G., & Bernardi, P. (2003) Early resistance to cell death and to onset of the mitochondrial permeability transition during hepatocarcinogenesis with 2-acetylaminofluorene. Proc. Natl. Acad. Sci. USA, 100, 10014-10019.
11. Irwin, W.A., Bergamin, N., Sabatelli, P., Reggiani, C., Megighian, A., Merlini, L., Braghetta, P., Columbaro, M., Volpin, D., Bressan, G.M., Bernardi, P., & Bonaldo, P. (2003) Mitochondrial dysfunction and apoptosis in myopathic mice with collagen VI deficiency. Nat. Genet., 35, 267-271.
12. Cecconi, F. (1999) Apaf1 and the apoptotic machinery. Cell Death Diff., 6, 1087-1098.
13. Bernardi, P., Petronilli, V., Di Lisa, F., & Forte, M. (2001) A mitochondrial perspective on cell death. Trends Biochem. Sci., 26, 112-117.
14. Mitchell, P. (1979) Keilin's respiratory chain concept and its chemiosmotic consequences. Science, 206, 1148-1159.
15. Boveris, A. & Chance, B. (1973) The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen. Biochem. J., 134, 707-716.
16. Giulivi, C., Boveris, A., & Cadenas, E. (1995) Hydroxyl radical generation during mitochondrial electron transfer and the formation of 8-hydroxydesoxyguanosine in mitochondrial DNA. Arch. Biochem. Biophys., 316, 909-916.
17. Melov, S., Coskun, P., Patel, M., Tuinstra, R., Cottrell, B., Jun, A.S., Zastawny, T.H., Dizdaroglu, M., Goodman, S.I., Huang, T.T., Miziorko, H., Epstein, C.J., & Wallace, D.C. (1999) Mitochondrial disease in superoxide dismutase 2 mutant mice. Proc. Natl. Acad. Sci. U. S. A, 96, 846-851.
18. Wallace, D.C. (1999) Mitochondrial diseases in man and mouse. Science, 283, 1482-1488.
19. Lenaz, G. (1998) Role of mitochondria in oxidative stress and aging. Biochim. Biophys. Acta, 1366, 53-67.
20. Gardner, P.R. & Fridovich, I. (1991) Superoxide sensitivity of the Escherichia coli aconitase. J. Biol. Chem., 266, 19328-19333.
21. Bernardi, P. (1999) Mitochondrial transport of cations: Channels, exchangers and permeability transition. Physiol. Rev., 79, 1127-1155.
22. Migliaccio, E., Giorgio, M., Mele, S., Pelicci, G., Reboldi, P., Pandolfi, P.P., Lanfrancone, L., & Pelicci, P.G. (1999) The p66shc adaptor protein controls oxidative stress response and life span in mammals [see comments]. Nature, 402, 309-313.
23. Trinei, M., Giorgio, M., Cicalese, A., Barozzi, S., Ventura, A., Migliaccio, E., Milia, E., Padura, I.M., Raker, V.A., Maccarana, M., Petronilli, V., Minucci, S., Bernardi, P., Lanfrancone, L., & Pelicci, P.G. (2002) A p53-p66Shc signalling pathway controls intracellular redox status, levels of oxidation-damaged DNA and oxidative stress-induced apoptosis. Oncogene, 21, 3872-3878.
24. Kokoszka, J.E., Coskun, P., Esposito, L.A., & Wallace, D.C. (2001) Increased mitochondrial oxidative stress in the Sod2 (+/-) mouse results in the age-related decline of mitochondrial function culminating in increased apoptosis. Proc. Natl. Acad. Sci. U. S. A, 98, 2278-2283.
25. Kowaltowski, A.J., Castilho, R.F., & Vercesi, A.E. (1996) Opening of the mitochondrial permeability transition pore by uncoupling or inorganic phosphate in the presence of Ca2+ is dependent on mitochondrial-generated reactive oxygen species. FEBS Lett., 378, 150-152.
26. Cai, J. & Jones, D.P. (1998) Superoxide in apoptosis. Mitochondrial generation triggered by cytochrome c loss. J. Biol. Chem., 273, 11401-11404.
27. Henderson, C. & Brancolini, C. (2003) Apoptotic pathways activated by histone deacetylase inhibitors: implications for the drug-resistant phenotype. Drug Resist. Updat., 6, 247-256.
28. Scorrano, L., Ashiya, M., Buttle, K., Weiler, S., Oakes, S.A., Mannella, C.A., & Korsmeyer, S.J. (2002) A distinct pathway remodels mitochondrial cristae and mobilizes cytochrome c during apoptosis. Dev. Cell, 2, 55-67.
29. Scorrano, L., Oakes, S.A., Opferman, J.T., Cheng, E.H., Sorcinelli, M.D., Pozzan, T., & Korsmeyer, S.J. (2003) BAX and BAK Regulation of Endoplasmic Reticulum Ca2+: A Control Point for Apoptosis. Science, 300, 135.
30. Garcia-Ruiz, C., Colell, A., Mari, M., Morales, A., & Fernandez-Checa, J.C. (1997) Direct effect of ceramide on the mitochondrial electron transport chain leads to generation of reactive oxygen species. Role of mitochondrial glutathione. J. Biol. Chem., 272, 11369-11377.
31. Ardail, D., Popa, I., Alcantara, K., Pons, A., Zanetta, J.P., Louisot, P., Thomas, L., & Portoukalian, J. (2001) Occurrence of ceramides and neutral glycolipids with unusual long-chain base composition in purified rat liver mitochondria. FEBS Lett., 488, 160-164.
32. El Bawab, S., Roddy, P., Qian, T., Bielawska, A., Lemasters, J.J., & Hannun, Y.A. (2000) Molecular cloning and characterization of a human mitochondrial ceramidase. J Biol. Chem., 275, 21508-21513.
33. Birbes, H., El Bawab, S., Hannun, Y.A., & Obeid, L.M. (2001) Selective hydrolysis of a mitochondrial pool of sphingomyelin induces apoptosis. FASEB J., 15, 2669-2679.
34. Penzo, D., Tagliapietra, C., Colonna, R., Petronilli, V., & Bernardi, P. (2002) Effects of fatty acids on mitochondria: implications for cell death. Biochim. Biophys. Acta Bioenergetics, 1555, 160-165.
35. Wissing, D., Mouritzen, H., Egeblad, M., Poirier, G.G., & Jäättelä, M. (1997) Involvement of caspase-dependent activation of cytosolic phospholipase A2 in tumor necrosis factor-induced apoptosis. Proc. Natl. Acad. Sci. USA, 94, 5073-5077.
36. Scorrano, L., Penzo, D., Petronilli, V., Pagano, F., & Bernardi, P. (2001) Arachidonic acid is a potent inducer of cell death through the mitochondrial permeability transition. Implications for TNF apoptotic signaling. J. Biol. Chem., 276, 12035-12040.
37. Petronilli, V., Penzo, D., Scorrano, L., Bernardi, P., & Di Lisa F. (2001) The mitochondrial permeability transition, release of cytochrome c and cell death. Correlation with the duration of pore openings in situ. J. Biol. Chem., 276, 12030-12034.

Parole Chiave

MITOCONDRI; APOPTOSI; CASPASI; SPECIE REATTIVE; FARMACI ANTINEOPLASTICI; PROTEASOME INHIBITORS; RECETTORE T; MALATTIE MITOCONDRIALI; TRANSIZIONE DI PERMEABILITÀ