RICERCA ITALIANA     

Programmi di ricerca simili:

• 1 - Neurotrasmissione glutamatergica: organizzazione strutturale della sinapsi, recettori e ruolo in fisiopatologia."
• 2 - Transcrittomica e proteomica dello scompenso cardiaco umano per l'individuazione di nuovi meccanismi patogenetici e biomarcatori: focus sui recettori purinergici P2
• 3 - Identificazione, espressione funzionale e caratterizzazione fisiopatologica di nuovi recettori purinici.
• 4 - Fisiologia e patologia dell'assemblaggio, del traffico e del "signaling" di proteine nel reticolo endoplasmico
• 5 - Studio dei mosaici recettoriali a livello dei gangli della base: implicazioni fisiopatologiche e terapeutiche
• 6 - Regolazione negativa del signalling di recettori oncogenici: implicazioni terapeutiche
• 7 - Studio delle interazioni molecolari tra integrina beta1, recettori di membrana e canali ionici tramite FRET e interferenza a RNA in cellule epiteliali ed endoteliali.
• 8 - Ruolo dell'oligomerizzazione dei recettori associati alle proteine G e rilevanza nella patologia umana
• 9 - Meccanismi molecolari coinvolti nel controllo delle alterazioni conformazionali di proteine formanti aggregati come bersagli di nuovi farmaci potenzialmente utili nella terapia delle sindromi neurodegenerative
• 10 - Progettazione, sintesi e valutazioni bio-farmacologiche preliminari di ligandi utili allo sviluppo di farmaci per le patologie neurodegenerative del S.N.C. - Un approccio multirecettoriale.

Classificazione scientifico-disciplinare

• Area scientifico disciplinare: Scienze biologiche
  • FISIOLOGIA
  • BIOCHIMICA
  • BIOLOGIA MOLECOLARE
  • FARMACOLOGIA
• Area scientifico disciplinare: Scienze mediche
  • ENDOCRINOLOGIA

Classificazione brevettuale

• CHEMISTRY; METALLURGY
  • ORGANIC CHEMISTRY (such compounds as the oxides, sulfides, or oxysulfides of carbon, cyanogen, phosgene, hydrocyanic acid or salts thereof C01; products obtained from layered base-exchange silicates by ion-exchange with organic compounds such as ammonium, phosphonium or sulfonium compounds or by intercalation of organic compounds C01B33/44; macromolecular compounds C08; dyes C09; fermentation products C12; fermentation or enzyme-using processes to synthesise a desired chemical compound or composition or to separate optical isomers from a racemic mixture C12P; production of organic compounds by electrolysis or electrophoresis C25B3/00, C25B7/00)
    • PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00)

Classificazione geografica

• Regione: Toscana

Bibliografia

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Parole Chiave

OLIGOMERIZZAZIONE; PROTEINE-G; BETA-ARRESTINE; RECETTORI ACCOPPIATI ALLE PROTEINE G; COMPARTIMENTALIZZAZIONE RECETTORIALE; CANALI GIRK E AL CALCIO; RAFT LIPIDICI; MICRODOMINI DI MEMBRANA; MODELLI COMPUTAZIONALI DI GPCR