RICERCA ITALIANA     

Programmi di ricerca simili:

• 1 - Il ruolo della mioglobina nel muscolo umano: rapporto tra struttura molecolare e funzione delle diverse isoforme
• 2 - ADIPOSITA' E BILANCIO ENERGETICO:FATTORI ENDOCRINI, MECCANISMI CELLULARI ED ASPETTI FISIO-PATOLOGICI
• 3 - Danno cardio-vascolare precoce in bambini ed adolescenti obesi :la identificazione di markers di rischio metabolici e/o genetici rende possibile la diagnosi precoce e può migliorare la qualità della vita futura.
• 4 - METABOLISMO LOCALE ED ESPRESSIONE GENICA: NUOVE PROSPETTIVE IN CHIRURGIA
• 5 - Determinanti genetici e molecolari del ruolo della COX-2 nell'aterotrombosi.
• 6 - Studio degli effetti genomici dell'aldosterone in modelli cellulari ed in vivo.
• 7 - Meccanismi di regolazione della plasticità del muscolo scheletrico
• 8 - PEROSSIDAZIONE LIPIDICA, ATTIVAZIONE PIASTRINICA ED INFIAMMAZIONE ASSOCIATI A RIDOTTI LIVELLI DI LIPOPROTEINE AD ALTA DENSITA' (HDL)
• 9 - Caratterizzazione biochimica e molecolare dell'interazione Von Willebrand Factor e ADAMTS-13: nuove ipotesi sulla fisiopatogenesi delle malattie microangiopatiche trombotiche
• 10 - Benessere animale, salute, biodiversità: effetti del gene candidato NR31C (Recettore dei Glucocorticoidi) in avicoltura.

Classificazione scientifico-disciplinare

• Area scientifico disciplinare: Scienze biologiche
  • FISIOLOGIA
  • BIOCHIMICA
  • BIOLOGIA MOLECOLARE
• Area scientifico disciplinare: Scienze mediche

Classificazione brevettuale

• HUMAN NECESSITIES
  • MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • DIAGNOSIS; SURGERY; IDENTIFICATION (analysing biological material G01N, e.g. G01N33/48; obtaining records using waves other than optical waves, in general G03B42/00)
    • PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES (bringing into special physical form A61J [N: mechanical aspects]; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; compounds per se C01, C07, C08, C12N; soap compositions C11D; micro-organisms per se C12N) [C0203]
  • SPORTS; GAMES; AMUSEMENTS
    • APPARATUS FOR PHYSICAL TRAINING, GYMNASTICS, SWIMMING, CLIMBING, OR FENCING; BALL GAMES; TRAINING EQUIPMENT

Classificazione geografica

• Regione: Lombardia

Bibliografia

- Antonini E, M Brunori. “Hemoglobin and myoglobin in their reactions with ligands”. North Holland, Amsterdam, 1971.
- Borutaite V, GC Brown. Rapid reduction of nitric oxide by mitochondria, and reversible inhibition of mitochondrial respiration by nitric oxide. Biochem J. 315 :2 95-299, 1996.
- Brunori M. Nitric oxide moves myoglobin centre stage. Trends Biochem Sci 26: 209-210, 2001
- Cerretelli, P. Limiting factors to oxygen transport on Mount Everest. J Appl Physiol 40 : 658-667, 1976.
- Chen QH, Ge RL, Wang XZ, Chen HX, Wu TY, Kobayashi T, Yoshimura K Exercise performance of Tibetan and Han adolescents at altitude of 3,417 and 4,300 m. J Appl Physiol 83, 661-667, 1997.
- Cleeter MW, JM Cooper, VM Darley-Usmar, S Moncada, AH Schapira. Reversible inhibition of cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, by nitric oxide. FEBS Lett 354: 50-54, 1994.
- Dennell RW, Rendell HM, Hailwood E. Late Pliocene artifacts from Northern Pakistan. Curr Anthropol. 29, 495-498, 1988.
- Flögel U, MW Merx, A Godecke, UKM Decking, J Schrader. Myoglobin: A scavenger of bioactive NO. Proc Natl Acad Sci 98:735-740, 2001.
- Gelfi C, S De Palma, M Ripamonti, R Wait, I Eberini, A. Bajracharya, C Marconi, A Schneider, H Hoppeler, P Cerretelli. New aspects of altitude adaptation in Tibetans: a proteomic approach. FASEB J, publ online January 20, 2004
- Gelfi C., S. De Palma, P. Cerretelli, S. Begum, R. Wait. Two-dimensional protein map of human vastus lateralis muscle. Electrophoresis 24: 286-295, 2003.
- Gladwin Mt. JH Crawford, RP Patel. The biochemistry of nitric oxide, nitrite, and hemoglobin: role in blood flow regulation. Free Rad Biol Med. 36: 707-7171, 2004
- Grassi B., M. Marzorati, B. Kayser, M. Bordini, A. Colombini, M. Conti, C. Marconi, and P. Cerretelli. Peak blood lactate and blood lactate vs. work load during acclimatization to 5,050 m and in deacclimatization. J Appl Physiol 80: 685-692, 1996.
- Grassi B., S. Pogliaghi, V. Quaresima, M. Ferrari, C. Marconi, P. Cerretelli. Muscle oxygenation kinetics during exercise on- transitions in humans. J. Appl. Physiol. 95: 149-158, 2003
- Hoppeler H. and M. Vogt. Muscle tissue adaptations to hypoxia. J Exp Biol 204 : 3133-3139, 2001.
- Howald H., D. Pette, J.-A. Simoneau, A. Uber, H. Hoppeler, and P. Cerretelli. III. Effects of chronic hypoxia on muscle enzyme activities. Int. G. Sports Med. 11 (suppl. 1) : S10-S14, 1990.
- Jürgens KD, S Papadopoulos, T Peters, G Gros. Myogobin: just an oxygen store or also an oxygen transporter? News Physiol Sci. 15: 269-274, 2000
- Kreutzer U, Wang DS, T Jue. Observing the 1H NMR signal of the myoglobin Val-E11 in myocardium: An index of cellular oxygenation. Proc. Natl. Acad. Sci. 89: 4731-4733, 1992.
- Lawrie RA. The activity of the cytochrome system in muscle and its relation to myoglobin. Biochem J 55: 298-305, 1953
- Marconi C, M Marzorati, B Grassi, B Basnyat, A Colombini, B kaiser, P Cerretelli. Second generation Tibetan lowlanders acclimatize to high altitude more quickley than Caucasians. J. Physiol. (in press 2004).
- Masuda K, JY Choi, H Shimojo, S Katsuta. Maintenance of myoglobin concentration in human skeletal muscle after heavy resistance training. Eur J Appl Physiol 79: 347-352, 1999.
- Masuda K, K Okazaki, S Kumo, K Asano, H Shimojo, S Katsuta. Endurance training under 2500-m hypoxia does not increase myoglobin content in human skeletal muscle. Eur J Appl Physiol 85 : 486-490, 2001.
- Moncada S, JD Erusalimsky. Does nitric oxide modulate mitochondrial energy generation and apoptosis? Nat Rev Mol Cell Biol 3: 214-220, 2002
- Moore LG. Human genetic adaptation to high altitude. High Alt. Med. Biol. 2: 257-279, 2001.
- Niu W, Wu Y, Li B, Chen N, Song S (1995). Effects of long-term acclimatization in lowlanders migrating to high altitude: comparison with high altitude residents. Eur J Appl Physiol 71, 543-548.
- Reynafarje B. Myoglobin content and enzymatic activity of muscle and altitude adaptation. J Appl Physiol 17: 301-305, 1962
- Schlieper G, JH Kim, A. Molojavyi, C Jacoby, T Laussmann, U Flogel, A Godecke, J Schrader. Adaptation of the myoglobin knockout mouse to hypoxic stress. Am J Physiol 286: R786-R792, 2004.
- Sun SF, Droma TS, Zhang JG, Tao JX, Huang SY, McCullough RG, McCullough RE, Reeves CS, Reeves JT, Moore LG. Greater maximal O₂ uptakes and vital capacities in Tibetan than Han residents of Lhasa. Respir Physiol 79, 151-162, 1990.
- Vezzoli A, M Gussoni, F Greco, L Zetta, P Cerretelli. Quantitative analysis of anaerobic metabolism in resting anoxic muscle by 31P and 1H NMR spectroscopy. Bioch. Bioph. Acta (Bioenergetics) 1322 : 195-207, 1997.
- Vezzoli A, M Gussoni, F Greco, L Zetta, P Cerretelli. Temperature and pH dependence of energy balance by ³¹P- ¹H-MRS in anaerobic frog muscle. Bioch. Biophys. Acta (Bioenergetics) 1608, 163-170, 2004.
- Vezzoli A, M Gussoni, F Greco, L Zetta. Effects of temperature and extracellular pH on metabolites: kinetics of anaerobic metabolism in resting muscle by ³¹P and ¹H MRS. J Exp Biol 206, 3043-3052, 2003.
- Wittemberg JB, BA Wittemberg. Myoglobin function reassessed. J Exp Biol 206: 2011-2020, 2003.
- Witting PK, DJ Douglas, AG Mauk. Reaction of human myoglobin and nitric oxide. J Biol Chem 276: 3991-3998, 2001.
- Zhuang J, Droma T, Sutton JR, Groves BM, McCullough RE, McCullough RG, Sun S, Moore LG. Smaller alveolar-arterial O₂ gradients in Tibetan than Han residents of Lhasa (3658 m). Respir Physiol 103, 75-82, 1996.

Parole Chiave

MUSCOLO SCHELETRICO; MIOGLOBINA; OSSIDO NITRICO; IPOSSIA CRONICA; CINETICA DEGLI SCAMBI GASSOSI; SPETTROSCOPIA NEL VICINO INFRAROSSO; SPETTROSCOPIA DI RISONANZA MAGNETICA