RICERCA ITALIANA     

Programmi di ricerca simili:

• 1 - Plasticita' ed evoluzione del genoma
• 2 - Plasticita’ delle regioni pericentromeriche nell’evoluzione e loro organizzazione tridimensionale nel nucleo
• 3 - GENOMICA FUNZIONALE DELL'ETEROCROMATINA IN DROSOPHILA MELANOGASTER
• 4 - RNAi, eterocromatina e controllo epigenetico dell'espressione genica e comportamento cromosomico
• 5 - Analisi di genomica funzionale e strutturale degli Equidi
• 6 - Evoluzione del genoma dei pesci ossei
• 7 - La dissezione molecolare delle filogenesi del cromosoma Y e del DNA mitocondriale: un requisito essenziale per gli studi di associazione con patologie complesse
• 8 - Genomica mitocondriale in diversi gruppi di Metazoi: evoluzione molecolare e strutturale ed utilità filogenetica del genoma mitocondriale
• 9 - Difetti di Imprinting Genomico nei disordini della crescita e tumori
• 10 - Caratterizzazione molecolare di cromosomi double minutes/homogeneously staining regions nei tumori solidi.

Classificazione scientifico-disciplinare

• Area scientifico disciplinare: Scienze biologiche
  • BIOLOGIA MOLECOLARE
  • GENETICA

Classificazione brevettuale

• CHEMISTRY; METALLURGY
  • BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS (immunoassay G01N33/53); COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF (biocides, pest repellants or attractants, or plant growth regulators, containing micro-organisms, viruses, microbial fungi, enzymes, fermentates or substances produced by or extracted from micro-organisms or animal material A01N63/00; food compositions A21, A23; medicinal preparations A61K; chemical aspects of, or use of materials for, bandages, dressings, absorbent pads or surgical articles A61L; fertilisers C05); PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS (preservation of living parts of humans or animals A01N1/02); MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (micro-biological testing media C12Q)

Classificazione geografica

• Regione: Puglia

Bibliografia

Armengol L., Pujana M. A., Cheung J., Scherer S. W., and Estivill X. (2003). Enrichment of segmental duplications in regions of breaks of synteny between the human and mouse genomes suggest their involvement in evolutionary rearrangements. Hum Mol Genet 12: 2201-8.

Ballarati L., Piccini I., Carbone L., Archidiacono N., Rollier A., Marozzi A., Meneveri R., and Ginelli E. (2002). Human genome dispersal and evolution of 4q35 duplications and interspersed LSau repeats. Gene 296: 21-7.

Barbouti A., Stankiewicz P., Nusbaum C., Cuomo C., Cook A., Hoglund M., Johansson B., Hagemeijer A., Park S. S., Mitelman F., Lupski J. R., and Fioretos T. (2004). The Breakpoint Region of the Most Common Isochromosome, i(17q), in Human Neoplasia Is Characterized by a Complex Genomic Architecture with Large, Palindromic, Low-Copy Repeats. Am J Hum Genet 74: 1-10.

Choo K. H. (2000). Centromerization. Trends Cell Biol 10: 182-8.

Choo K. H. A. (1997). Centromere DNA dynamics: latent centromeres and neocentromere formation. Am.J.Hum.Genet. 61: 1225-1233.

Giglio S., Broman K. W., Matsumoto N., Calvari V., Gimelli G., Neumann T., Ohashi H., Voullaire L., Larizza D., Giorda R., Weber J. L., Ledbetter D. H., and Zuffardi O. (2001). Olfactory receptor-gene clusters, genomic-inversion polymorphisms, and common chromosome rearrangements. Am J Hum Genet 68: 874-83.

Giglio S., Calvari V., Gregato G., Gimelli G., Camanini S., Giorda R., Ragusa A., Guerneri S., Selicorni A., Stumm M., Tonnies H., Ventura M., Zollino M., Neri G., Barber J., Wieczorek D., Rocchi M., and Zuffardi O. (2002). Heterozygous submicroscopic inversions involving olfactory receptor-gene clusters mediate the recurrent t(4;8)(p16;p23) translocation. Am J Hum Genet 71: 276-85.

Hirotsune S., Yoshida N., Chen A., Garrett L., Sugiyama F., Takahashi S., Yagami K., Wynshaw-Boris A., and Yoshiki A. (2003). An expressed pseudogene regulates the messenger-RNA stability of its homologous coding gene. Nature 423: 91-6.

Horvath J. E., Bailey J. A., Locke D. P., and Eichler E. E. (2001). Lessons from the human genome: transitions between euchromatin and heterochromatin. Hum Mol Genet 10: 2215-23.

Ikeno M., Grimes B., Okazaki T., Nakano M., Saitoh K., Hoshino H., McGill N. I., Cooke H., and Masumoto H. (1998). Construction of YAC-based mammalian artificial chromosomes. Nat Biotechnol 16: 431-9.

Leem S. H., Kouprina N., Grimwood J., Kim J. H., Mullokandov M., Yoon Y. H., Chae J. Y., Morgan J., Lucas S., Richardson P., Detter C., Glavina T., Rubin E., Barrett J. C., and Larionov V. (2004). Closing the gaps on human chromosome 19 revealed genes with a high density of repetitive tandemly arrayed elements. Genome Res 14: 239-246.

Lemke J., Claussen J., Michel S., Chudoba I., Muhlig P., Westermann M., Sperling K., Rubtsov N., Grummt U. W., Ullmann P., Kromeyer-Hauschild K., Liehr T., and Claussen U. (2002). The DNA-based structure of human chromosome 5 in interphase. Am J Hum Genet 71: 1051-9.

Luke S., Verma R. S., Conte R. A., and Mathews T. (1992). Molecular characterization of the secondary constriction region (qh) of human chromosome 9 with pericentric inversion. J Cell Sci 103 ( Pt 4): 919-23.

Moralli D., Vagnarelli P., Bensi M., De Carli L., and Raimondi E. (2001). Insertion of a loxP site in a size-reduced human accessory chromosome. Cytogenet Cell Genet 94: 113-20.

Park J. P., Wojiski S. A., Spellman R. A., Rhodes C. H., and Mohandas T. K. (1998). Human chromosome 9 pericentric homologies: implications for chromosome 9 heteromorphisms. Cytogenet Cell Genet 82: 192-4.

Piccini I., Ballarati L., Bassi C., Rocchi M., Marozzi A., Ginelli E., and Meneveri R. (2001). The structure of duplications on human acrocentric chromosome short arms derived by the analysis of 15p. Hum Genet 108: 467-77.

Politi V., Perini G., Trazzi S., Pliss A., Raska I., Earnshaw W. C., and Della Valle G. (2002). CENP-C binds the alpha-satellite DNA in vivo at specific centromere domains. J Cell Sci 115: 2317-27.

Raimondi E., Balzaretti M., Moralli D., Vagnarelli P., Tredici F., Bensi M., and De Carli L. (1996). Gene targeting to the centromeric DNA of a human minichromosome. Hum Gene Ther 7: 1103-9.

Rudd M. K., Mays R. W., Schwartz S., and Willard H. F. (2003). Human artificial chromosomes with alpha satellite-based de novo centromeres show increased frequency of nondisjunction and anaphase lag. Mol Cell Biol 23: 7689-97.

Schueler M. G., Higgins A. W., Rudd M. K., Gustashaw K., and Willard H. F. (2001). Genomic and genetic definition of a functional human centromere. Science 294: 109-15.

Stankiewicz P., Shaw C. J., Dapper J. D., Wakui K., Shaffer L. G., Withers M., Elizondo L., Park S. S., and Lupski J. R. (2003). Genome architecture catalyzes nonrecurrent chromosomal rearrangements. Am J Hum Genet 72: 1101-16.

Trazzi S., Bernardoni R., Diolaiti D., Politi V., Earnshaw W. C., Perini G., and Della Valle G. (2002). In vivo functional dissection of human inner kinetochore protein CENP-C. J Struct Biol 140: 39-48.

Ventura M., Mudge J. M., Palumbo V., Burn S., Blennow E., Pierluigi M., Giorda R., Zuffardi O., Archidiacono N., Jackson M. S., and Rocchi M. (2003). Neocentromeres in 15q24-26 map to duplicons which flanked an ancestral centromere in 15q25. Genome Res 13: 2059–2068.

Warburton P. E. (2001). Epigenetic analysis of kinetochore assembly on variant human centromeres. Trends Genet 17: 243-7.

Parole Chiave

RIPOSIZIONAMENTO DEL CENTROMERO; RIUSO DI REGIONI CENTROMERICHE LATENTI; EVOLUZIONE DEL CARIOTIPO; PRIMATI; SEQUENZE TELOMERICHE INTERSTIZIALI; DUPLICAZIONI E RIARRANGIAMENTI