RICERCA ITALIANA     

Programmi di ricerca simili:

• 1 - Lattobacilli geneticamente modificati come vaccino orale per la prevenzione del diabete mellito autoimmune
• 2 - IMMUNITA' INNATA E MALATTIA CELIACA
• 3 - Studio dei meccanismi etiopatogenetici nel pemfigo
• 4 - Eterogeneità del Diabete Tipo 2: Impatto del Fenotipo e del Genotipo sul Rischio Cardiovascolare.
• 5 - Regolazione della massa e della funzione beta-cellulare nel diabete mellito di tipo 2: meccanismi di danno e strategie riparative
• 6 - Modulazione dei meccanismi di apoptosi in corso di risposta immunitaria/infiammatoria: studio delle interazioni tra citochine della famiglia del TNF per la caratterizzazione di meccanismi molecolari e cellulari funzionali alla identificazione di nuovi target per la terapia di malattie croniche degenerative.
• 7 - Diabete, Iperglicemia ed Insulino-Resistenza: Meccanismi di disfunzione endoteliale e danno vascolare
• 8 - Interazioni fra Mycobacterium Avium Paratuberculosis ed ospite nella patogenesi della malattia di Crohn
• 9 - Nuovi modelli animali per lo studio dei meccanismi molecolari di malattia comuni a diabete mellito di tipo 2 e aterosclerosi
• 10 - Patogenesi molecolare della sclerodermia. Verso una diagnosi precoce ed una terapia mirata.

Classificazione scientifico-disciplinare

• Area scientifico disciplinare: Scienze mediche
  • GASTROENTEROLOGIA
  • PEDIATRIA GENERALE E SPECIALISTICA

Classificazione brevettuale

• HUMAN NECESSITIES
  • MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES (bringing into special physical form A61J [N: mechanical aspects]; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; compounds per se C01, C07, C08, C12N; soap compositions C11D; micro-organisms per se C12N) [C0203]

Classificazione geografica

• Regione: Campania

Bibliografia

1.Akerblom HK, Knip M. Putative environmental factors in type 1 diabetes. Diabetes Metab Rev 1998; 14: 31-67.
2. Perez-Bravo F, Carrasco E, Gutierrez-Lopez MD, Martinez MT, Lopez G, Garcia de los Rios M. Genetic predisposition and environmental factors leading to the development of insulin-dependent diabetes mellitus in Chilean children. J Mol Med 1996; 74: 105-109.
3. Cavallo MG, Fava SD, Monetini L, -casein in recent onsetBarone F, Pozzilli P. Cell-mediated immune response to insulin-dependent diabetes: implication for disease pathogenesis. Lancet 1996; 348: 926-928.
4. Paronen J, Klemetti P, Kantele JM, Savilhati E, Peerheentupa J, Akerblom HK, Vaarala O. Glutamate-decarboxylase-reactive peripheral blood lymphocytes from patients with IDDM express gut specific homing receptor 7-integrin. Diabetes 1997; 46: 583-588.4
5. Savilhati E, Ormala T, Saukkonen T, Sandini-Pohjavuori U, Kantele JM, Arato A, Ilonen J, Akerblom HK. Jejuna of patients with insulin-dependent diabetes mellitus (IDDM) show signs of immune activation. Clin Exp immunol 1999; 116:70-77.
6. Delovitch TL, Singh B. The nonobese diabetic mouse as a model of autoimmune diabetes: immune dysregulation gets the NOD (Review). Immunity 1997; 7: 727-738.
7. Rabinovitch A, Suarez-Pinzon WL, Sorensen O. Interleukin 12 mRNA expression in -cells destruction in NOD mice. J Autoimmunity 1996; 9:islet correlates with 645-651.
8. Wicker LS, Appel MC, Dotta F, pressey A, Miller J, Delarato NH, Fischer PA, Boltz RC Jr, Peterson LB. Autoimmune syndromes in major histocompatibility complex (MHC) congenic strains of nonobese diabetic (NOD) mice: the NOD MHC is dominant for insulitis and cyclophosphamide-induced diabetes. J Exp Med 1992; 176: 67-77.
9. Wicker LS, Todd JA, Peterson LB. Genetic control of autoimmune diabetes in the mouse. Ann Rev immunol 1995; 13: 179-200.
10. Yang X-D, Sytwu H-K, McDewitt HO, Michie SA. Involvement of integrin and mucosal addressin cell adhesion molecule-1 (MAdCAM-1) in the development of diabetes in nonobese diabetic mice. Diabetes 1997; 46: 1542-1547.
11. Hanninen A, Jaakkola I, Jalkanen S. Mucosal addressin is required for the development of diabetes in nonobese diabetic mice. J Immunol 1998; 160: 6018-6025.
12. Hanninen A, Salmi M, Simell O, Jalkanen S. Mucosa-associated (beta 7-integrinhigh) lymphocytes accumulate early in the pancreas of NOD mice and show aberrant recirculation behaviour. Diabetes 1996; 45: 173-180.
13. Hanninen A, Jaakkola I, Jalkanen S. High prevalence of diabetogenic lymphocytes in gut-associated lymphoid tissue of young NOD mice. Scand J Immunol 1996; 43: 735-738.
14. Elliot RB, Martin JM. Dietary protein: a trigger of insulin-dependent diabetes in the BB rat? Diabetologia 1984; 26: 297-299.
15. Scott FW, Cloutier EH, Kleeman R, Woerz-Pagenstert U, Rowsell P, Modler HW, Kolb H. Potential mechanisms by which certain foods promote or inhibit the development of spontaneous diabetes in BB rats: dosage, timimg, early effect on islet area, and switch in infiltrate from Th1 to Th2 cells. Diabetes 1997; 46: 589-598.
16. Scott FW, Marliss EB. Conference summary: Diet as an environmental factor in development of insulin-dependent diabetes mellitus. Can J physiol Pharmacol 1990; 69: 311-319.
17. Hoorfar J, Buschard K, Dagnes-Hansen F. Prophylactic nutritional modification of the incidence of diabetes in autoimmune nonobese (NOD) mice. Br J Nutr 1993; 69: 597-607.
18. Funda DA, Kaas A, Bock T, Tlaskalova-Hogenova, Bushard K. Gluten-free diet prevents diabetes in NOD mice. Diabetes Metab Res Rev 1999; 15:323-327.
19. Holmes GK. Coeliac disease and type 1 diabetes mellitus-the case for screening. Diabet Med 2001; 18: 169-177.
20. Goggins, M., and D. Kelleher. 1994. Celiac disease and other nutrient related injuries to the gastrointestinal tract. Am J Gastroenterol 89:S2.
21. Wieser, H. 1996. Relation between gliadin structure and coeliac toxicity. Acta Paediatr Suppl 412:3.
22. Schuppan, D., W. Dieterich, and E. O. Riecken. 1998. Exposing gliadin as a tasty food for lymphocytes [news; comment]. Nat Med 4:666.
23. O'Keeffe, J., K. Mills, J. Jackson, and C. Feighery. 1999. T cell proliferation, MHC class II restriction and cytokine products of gliadin-stimulated peripheral blood mononuclear cells (PBMC). Clin Exp Immunol 117:269.
24. Lundin, K. E., H. A. Gjertsen, H. Scott, L. M. Sollid, and E. Thorsby. 1994. Function of DQ2 and DQ8 as HLA susceptibility molecules in celiac disease. Hum Immunol 41:24.
25. Molberg, O., S. N. McAdam, R. Korner, H. Quarsten, C. Kristiansen, L. Madsen, L. Fugger, H. Scott, O. Noren, P. Roepstorff, K. E. Lundin, H. Sjostrom, and L. M. Sollid. 1998. Tissue transglutaminase selectively modifies gliadin peptides that are recognized by gut-derived T cells in celiac disease. Nat Med 4:713.
26. Picarelli, A., L. Maiuri, A. Frate, M. Greco, S. Auricchio, and M. Londei. 1996. Production of antiendomysial antibodies after in-vitro gliadin challenge of small intestine biopsy samples from patients with coeliac disease [see comments]. Lancet 348:1065.
27. J Immunol 2001;166:4170
28. N Engl J Med 2002;346:180.
29. N Engl J Med 2003;348:2517
30. Diabetologia 2001;44:151
31. Gastroenterology 1999;117:297
32. Clin Exp Immunol 2003;134:516
33. J Pediatr 2000;137:263.
34. Lancet 1996;347:369.
35. Circulation 2002;105:2611
36. Gut 1995;36:239
37. McIntosh, R. S., M. S. Asghar, P. F. Watson, E. H. Kemp, and A. P. Weetman. 1996. Cloning and analysis of IgG kappa and IgG lambda anti-thyroglobulin autoantibodies from a patient with Hashimoto's thyroiditis: evidence for in vivo antigen-driven repertoire selection. J Immunol 157:927.
38. Graus, Y. F., M. H. de Baets, P. W. Parren, S. Berrih-Aknin, J. Wokke, P. J. van Breda Vriesman, and D. R. Burton. 1997. Human anti-nicotinic acetylcholine receptor recombinant Fab fragments isolated from thymus-derived phage display libraries from myasthenia gravis patients reflect predominant specificities in serum and block the action of pathogenic serum antibodies. J Immunol 158:1919.
39. Finnern, R., J. M. Bye, K. M. Dolman, M. H. Zhao, A. Short, J. D. Marks, M. C. Lockwood, and W. H. Ouwehand. 1995. Molecular characteristics of anti-self antibody fragments against neutrophil cytoplasmic antigens from human V gene phage display libraries. Clin Exp Immunol 102:566.
40. Marks, J. D., H. R. Hoogenboom, A. D. Griffiths, and G. Winter. 1992. Molecular evolution of proteins on filamentous phage. Mimicking the strategy of the immune system. J Biol Chem 267:16007.
41. Myers MA, et al. 2003. A diabetes-related epitope of GAD65: a major diabetes-related conformational epitope on GAD65.Ann N Y Acad Sci. 1005:250-2.
42. Myers MA, et al. 2000. Conformational epitopes on the diabetes autoantigen GAD65 identified by peptide phage display and molecular modeling. J Immunol. 165:3830-8.
43. Schwartz HL, et al. 1999. High-resolution autoreactive epitope mapping and structural modeling of the 65 kDa form of human glutamic acid decarboxylase. J Mol Biol. 287:983-99.
44. Visintin, M., Tse, E., Axelson, H., Rabbitts, T. H., Cattaneo, A. (1999). Selection of antibodies for intracellular function using a two-hybrid in vivo system. Proc. Natl Acad. Sci. USA, 96, 11723-11728.
45. Tse E, Lobato NM, Forster A, Tanaka T, Chung GTY, Rabbitts TH.. J. Mol. Biol. 2002; 317, 85-94.
46. Auf der Maur A, et al.. J Biol Chem 2002; 277, 45075–45085.
47. C. Pupilli, et al. Diabetes 1999; 12: 2309-15.
48. Rabin DU, Pleasic SM, Palmer-Crocker R, Shapiro JA: 1992. Diabetes 41:183–186.
49. Kasimiotis H, et al. 2000. Diabetes. Apr;49(4):555-61.
50. Edwards BM, Main SH, Cantone KL, Smith SD, Warford A, Vaughan TJ. 2000. J Immunol Methods. 245:67-78

Parole Chiave

AUTOIMMUNITA'; IMMUNITA' MUCOSALE; CELIACHIA; DIABETE TIPO 1; LIBRERIE FAGICHE; TOPI NOD; GLIADINA; INFIAMMAZIONE MUCOSALE