RICERCA ITALIANA     

Programmi di ricerca simili:

• 1 - Caratterizzazione dei meccanismi molecolari e cellulari della sarcopenia.
• 2 - Ruolo della miostatina nella atrofia muscolare nei cani. Studio patogenetico e basi per lo sviluppo di approcci terapeutici
• 3 - Basi molecolari del deficit cellulare in miopatie primitive
• 4 - Meccanismi molecolari funzionali nella patogenesi delle miopatie primitive: verso nuovi approcci prognostici e terapeutici
• 5 - Meccanismi cellulari e molecolari coinvolti nel rimodellamento muscolare indotto da elettrostimolazione in soggetti giovani ed anziani.
• 6 - Meccanismi di regolazione della plasticità del muscolo scheletrico
• 7 - Studio dell'attività della neuregulina 1 e della ghrelina sul nervo periferico in rigenerazione e sul muscolo scheletrico denervato.
• 8 - NUOVI BERSAGLI PER LA PREVENZIONE E LA CURA DELLA ATROFIA MUSCOLARE IN CORSO DI NEOPLASIA
• 9 - Genomica funzionale e modulazione dell'espressione delle proteine di membrana nelle miopatie primitive
• 10 - Sfingosina 1-fosfato in muscolo scheletrico: suo metabolismo e contributo alla rigenerazione muscolare

Classificazione scientifico-disciplinare

• Area scientifico disciplinare: Scienze mediche
  • PATOLOGIA GENERALE
  • NEUROLOGIA
• Area scientifico disciplinare: Ingegneria industriale e dell'informazione
  • BIOINGEGNERIA INDUSTRIALE

Classificazione brevettuale

• HUMAN NECESSITIES
  • AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
  • MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES (bringing into special physical form A61J [N: mechanical aspects]; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; compounds per se C01, C07, C08, C12N; soap compositions C11D; micro-organisms per se C12N) [C0203]

Classificazione geografica

• Regione: Sicilia

Bibliografia

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Asakura A. Stem cells in adult skeletal muscle. Trends Cardiovasc. Med. 2003;13:123-128.
Carraro U. Long-term aneurally regenerated skeletal muscle fibers into heart: How long they could survive and grow by daily FES? Basic Appl Myol 2003;13:53-64.
Carraro U. Modulation of trophism and fiber type expression of denervated muscle by different patterns of electrical stimulation. Basic Appl Myol 2002;12:263-272.
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Cossu G., Molinaro M. Cell heterogeneity in the myosin lineage. Curr. Top. Dev. Biol. 1987;23:185-208.
Dona M, Sandri M, Rossini K, Dell'aica I, Podhorskaokolow M, Carraro U. Functional in vivo gene transfer into the myofibers of adult skeletal muscle. Biochem Biophys Res Commun 2003; 312:1132-1138.
Dubrovsky AL, Angelini C., Bonifati DM, Pegoraro E, Mesa L. Steroids in muscular dystrophy: where do we stand? Neuromuscul Disord 1998;8:380-384.
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Harris JB. Myotoxic phospholipases A2 and the regeneration of skeletal muscles. Toxicon 2003;42:933-945
Haslett JN, Sanoudou D, Kho AT, Bennett RR, Greenberg SA, Kohane IS, Beggs AH, Kunkel LM. Gene expression comparison of biopsies from Duchenne muscular dystrophy (DMD) and normal skeletal muscle. Proc Natl Acad Sci USA 2002;99:15000-15005.
Hawke T.J., Garry D.J. Myogenic satellite cells: physiology to molecular biology. J. Appl. Physiol. 2001;91:534-551.
Heslop L., Morgan J.E., Partridge T.A. Evidence for a myogenic stem cell that is exhausted in dystrophic muscle. J. Cell Sci. 2000;113:2299-2308.
Hutmacher DW. Scaffold design and fabrication technologies for engineering tissues: state of the art and future perspectives. J Biomater Sci Polym Ed 2001;12:107–124.
Kaliman P, Canicio J, Testar X, Palacin M, Zorzano A. Insulin-like growth factor-II, phosphatidylinositol 3-kinase, nuclear factor-kappaB and inducible nitric-oxide synthase define a common myogenic signaling pathway. J Biol Chem 1999;274:17437-17444.
Kern H, Hofer C, Forstner C, Vogelauer M, Richter W, Mayr W, Zanin ME, Rossini K, Carraro U. First sound evidence of muscle regeneration in recovery of function of human permanent denervated muscles by a long-lasting functional electrical stimulation (FES) training: Biopsy findings. Zdravniski Vestnik 2004, in press.
Kern H, Hofer C, Mödlin M, Forstner C, Mayr W, Richter W: Functional electrical stimulation (FES) of long-term denervated muscles in humans: Clinical observations and laboratory findings. Basic Appl Myol 2002;12:291-296.
Kern H, Hofer C, Strohhofer M, Mayr W, Richter W, Stohr H. Standing up with denervated muscles in humans using functional electrical stimulation. Artif Organs 1999;23:447-452.
Kumar A, Boriek AM. Mechanical stress activates the nuclear factor-kappaB pathway in skeletal muscle fibers: a possible role in Duchenne muscular dystrohy. FASEB J 2003;17:386-396.
Lee JI, Burckart GJ. Nuclear factor kappa B: important transcription factor and therapeutic target. J Clin Pharmacol 1998;38:981-993.
Levenberg S, Huang NF, Lavik E, Rogers AB, Itskovitz-Eldor J, Langer R. Differentiation of human embryonic stem cells on three-dimensional polymer scaffolds. Proc Natl Acad Sci U S A. 2003;100:12741-12746.
Melone MA, Peluso G, Petillo O, Galderisi U, Cotrufo R. Defective growth in vitro of Duchenne Muscular Dystrophy myoblasts: the molecular and biochemical basis. J Cell Biochem. 1999;76:118-132.
Melone MAB, Peluso G, Galderisi U, Petillo O, Jori FP, and Cotrufo R. c-Myc downregulation by Transforming Growth Factorβ (TGFβ) is required for activation of the p15Ink4b arrest pathway in DMD myoblasts Clin Neuropathol 2002;21:125.
Monici MC, Aguennouz M, Mazzeo A, Messina C, Vita G. Activation of nuclear factor-kappaB in inflammatory myopathies and Duchenne muscular dystrophy. Neurology 2003;60:993-997.
Musaro A, Giacinti C, Borsellino G, Dobrowolny G, Pelosi L, Cairns L, Ottolenghi S, Cossu G, Bernardi G, Battistini L, Molinaro M, Rosenthal N. Stem cell-mediated muscle regeneration is enhanced by local isoform of insulin-like growth factor 1. Proc Natl Acad Sci U S A 2004;101:1206-1210.
Neumann T, Hauschka SD, Sanders JE. Tissue engineering of skeletal muscle using polymer fiber arrays. Tissue Eng 2003;9:995-1003.
Oexle K, Kohlschütter A. Cause of progression in Duchenne muscular dystrophy: impaired differentiation more probable than replicative aging. Neuropediatrics 2001;32:123-129.
Petrini P, Farè S, Piva A, Tanzi MC. Design, synthesis and properties of polurethane hydrogels for tissue engineering, J Materials Sci – Materials in Medicne 2003;14:683-686.
Porter JD, Khanna S, Kaminski Hj et al. A chronic inflammatory response dominates the skeletal muscle molecular signature in dystrophin-deficient mdx mice. Hum Mol Genet 2002;11:63-272.
Qu-Petersen Z.Q., Deasy B., Jankowski R., Izekawa M., Cummins J., Pruchnic R., Mytinger J., Cao B.H., Gates C., Wernig A., Huard J. Identification of a novel population of stem cells in mice: potential for muscle regeneration. J. Cell Biol. 2002;157:851-864.
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Rossini K, Zanin ME, Podhorska-Okolow M, Carraro U: Stage and quantify regenerative myogenesis in FES-induced functional recovery of human long-term permanent denervated muscle. Basic Appl Myol 2002;12:277-286.
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Parole Chiave

MUSCOLO SCHELETRICO; RIGENERAZIONE MUSCOLARE; DISTROFIA MUSCOLARE DI DUCHENNE; INGEGNERIA DEL TESSUTI; TRAPIANTO MUSCOLARE; NF-KB