RICERCA ITALIANA     

Programmi di ricerca simili:

• 1 - Nuove strategie immunomodulatorie nella Malattia di Graves: ruolo delle chemochine e delle cellule T regolatorie
• 2 - I linfociti T gamma/delta come effettori della risposta immune nelle malattie tumorali: meccanismi di attivazione ed applicazioni cliniche
• 3 - Il sistema GITR/GITRL nelle malattie a patogenesi autoimmunitaria/infiammatoria: un bersaglio per la terapia farmacologica
• 4 - Studi genetici ed immunologici in gruppi etnici dell'Africa occidentale con diversa suscettibilità alla malaria
• 5 - Identificazione, analisi molecolare ed attività funzionale di recettori di membrana e fattori citoplasmatici coinvolti nella crescita e differenziamento di cellule di leucemia linfatica cronica B: impatto sulla prognosi clinica.
• 6 - L'AIDS come malattia del ciclo cellulare: studi clinici e sperimentali su primati infetti da SIV.
• 7 - RUOLO DI AGENTI INFETTIVI E DELL'INFIAMMAZIONE CORRELATA ALLA RISPOSTA IMMUNITARIA ADATTATIVA NELLA PATOGENESI DELLE SINDROMI CORONARICHE ACUTE
• 8 - Patogenesi molecolare ed analisi sequenziale di interazioni cellulari e marcatori biologici di progressione di malattia e di resistenza al trattamento nella leucemia linfatica cronica
• 9 - Modulazione dei meccanismi di apoptosi in corso di risposta immunitaria/infiammatoria: studio delle interazioni tra citochine della famiglia del TNF per la caratterizzazione di meccanismi molecolari e cellulari funzionali alla identificazione di nuovi target per la terapia di malattie croniche degenerative.
• 10 - Il fenomeno della cross-presentazione ed i segnali immunomodulatori nella genesi di patologie infettive ed autoimmuni

Classificazione scientifico-disciplinare

• Area scientifico disciplinare: Scienze mediche
  • PATOLOGIA GENERALE
  • PATOLOGIA CLINICA
  • MEDICINA INTERNA

Classificazione brevettuale

• CHEMISTRY; METALLURGY
  • BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS (immunoassay G01N33/53); COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
  • ORGANIC CHEMISTRY (such compounds as the oxides, sulfides, or oxysulfides of carbon, cyanogen, phosgene, hydrocyanic acid or salts thereof C01; products obtained from layered base-exchange silicates by ion-exchange with organic compounds such as ammonium, phosphonium or sulfonium compounds or by intercalation of organic compounds C01B33/44; macromolecular compounds C08; dyes C09; fermentation products C12; fermentation or enzyme-using processes to synthesise a desired chemical compound or composition or to separate optical isomers from a racemic mixture C12P; production of organic compounds by electrolysis or electrophoresis C25B3/00, C25B7/00)
    • PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00)
• HUMAN NECESSITIES
  • MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES (bringing into special physical form A61J [N: mechanical aspects]; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; compounds per se C01, C07, C08, C12N; soap compositions C11D; micro-organisms per se C12N) [C0203]

Classificazione geografica

• Regione: Emilia Romagna

Bibliografia

1. Franceschi C, Monti D, Sansoni P, Cossarizza A. The immunology of exceptional individuals: the lesson of centenarians. Immunol Today. 1995 Jan;16(1):12-6.
2. Franceschi C, Bonafe M, Valensin S. Human immunosenescence: the prevailing of innate immunity, the failing of clonotypic immunity, and the filling of immunological space. Vaccine. 2000 Feb 25;18(16):1717-20.
3. Jamieson BD, Douek DC, Killian S, Hultin LE, Scripture-Adams DD, Giorgi JV, Marelli D, Koup RA, Zack JA. Generation of functional thymocytes in the human adult.Immunity. 1999 May;10(5):569-75.
4. Globerson A. T lymphocytes and aging. Int Arch Allergy Immunol. 1995 Aug;107(4):491-7.
5. Rabin RL, Roederer M, Maldonado Y, Petru A, Herzenberg LA, Herzenberg LA. Altered representation of naive and memory CD8 T cell subsets in HIV-infected children. J Clin Invest. 1995 May;95(5):2054-60.
6. Fagnoni FF, Vescovini R, Passeri G, Bologna G, Pedrazzoni M, Lavagetto G, Casti A, Franceschi C, Passeri M, Sansoni P. Shortage of circulating naive CD8(+) T cells provides new insights on immunodeficiency in aging. Blood. 2000 May 1;95(9):2860-8.
7. Luciani F, Valensin S, Vescovini R, Sansoni P, Fagnoni F, Franceschi C, Bonafe M, Turchetti G. Luciani F, Valensin S, Vescovini R, Sansoni P, Fagnoni F, Franceschi C, Bonafe M, Turchetti G. A stochastic model for CD8(+)T cell dynamics in human immunosenescence: implications for survival and longevity. J Theor Biol. 2001 Dec 21;213(4):587-97.
8. Fagnoni FF, Vescovini R, Mazzola M, Bologna G, Nigro E, Lavagetto G, Franceschi C, Passeri M, Sansoni P. Expansion of cytotoxic CD8+ CD28- T cells in healthy ageing people, including centenarians.
Immunology. 1996 Aug;88(4):501-7.
9. Mackall CL, Fleisher TA, Brown MR, Andrich MP, Chen CC, Feuerstein IM, Magrath IT, Wexler LH, Dimitrov DS, Gress RE. Distinctions between CD8+ and CD4+ T-cell regenerative pathways result in prolonged T-cell subset imbalance after intensive chemotherapy. Blood. 1997 May 15;89(10):3700-7.
10. Caruso A, Licenziati S, Canaris AD, Cantalamessa A, Fiorentini S, Ausenda S, Ricotta D, Dima F, Malacarne F, Balsari A, Turano A. Contribution of CD4+, CD8+CD28+, and CD8+CD28- T cells to CD3+ lymphocyte homeostasis during the natural course of HIV-1 infection. J Clin Invest. 1998 Jan 1;101(1):137-44.
11. Fagnoni FF, Lozza L, Zibera C, Zambelli A, Ponchio L, Gibelli N, Oliviero B, Pavesi L, Gennari R, Vescovini R, Sansoni P, Da Prada G, Robustelli Della Cuna G. T-cell dynamics after high-dose chemotherapy in adults: elucidation of the elusive CD8+ subset reveals multiple homeostatic T-cell compartments with distinct implications for immune competence. Immunology. 2002 May;106(1):27-37.
12. Effros RB, Pawelec G. Replicative senescence of T cells: does the Hayflick Limit lead to immune exhaustion? Immunol Today. 1997 Sep;18(9):450-4.
13. Posnett DN, Vissinga CS, Pambuccian C, Wei S, Robinson MA, Kostyu D, Concannon P. Level of human TCRBV3S1 (V beta 3) expression correlates with allelic polymorphism in the spacer region of the recombination signal sequence. J Exp Med. 1994 May 1;179(5):1707-11.
14. Khan N, Shariff N, Cobbold M, Bruton R, Ainsworth JA, Sinclair AJ, Nayak L, Moss PA.Cytomegalovirus seropositivity drives the CD8 T cell repertoire toward greater clonality in healthy elderly individuals. J Immunol. 2002 Aug 15;169(4):1984-92.
15. Olsson J, Wikby A, Johansson B, Lofgren S, Nilsson BO, Ferguson FG.Age-related change in peripheral blood T-lymphocyte subpopulations and cytomegalovirus infection in the very old: the Swedish longitudinal OCTO immune study. Mech Ageing Dev. 2000 Dec 20;121(1-3):187-201.
16. Tarazona R, Solana R, Ouyang Q, Pawelec G. Basic biology and clinical impact of immunosenescence. Exp Gerontol. 2002 Jan-Mar;37(2-3):183-9.
17. Lechner F, Cuero AL, Kantzanou M, Klenerman P. Studies of humanantiviral CD8+ lymphocytes using class I peptide tetramers. Rev Med Virol. 2001 Jan-Feb;11(1):11-22.
18. Gamadia LE, Rentenaar RJ, Baars PA, Remmerswaal EB, Surachno S, Weel JF, Toebes M, Schumacher TN, ten Berge IJ, van Lier RA. Differentiation of cytomegalovirus-specific CD8(+) T cells in healthy and immunosuppressed virus carriers. Blood. 2001 Aug 1;98(3):754-61.
19. Appay V, Rowland-Jones SL. Premature ageing of the immune system: the cause of AIDS? Trends Immunol. 2002 Dec;23(12):580-5.
20. Smyth MJ, Godfrey DI. NKT cells and tumor immunity--a double-edged sword. Nat Immunol. 2000 Dec;1(6):459-60.
21. Terabe M, Matsui S, Noben-Trauth N, Chen H, Watson C, Donaldson DD, Carbone DP, Paul WE, Berzofsky JA. NKT cell-mediated repression of tumor immunosurveillance by IL-13 and the IL-4R-STAT6 pathway. Nat Immunol. 2000 Dec;1(6):515-20.
22. Franceschi C, Valensin S, Fagnoni F, Barbi C, Bonafe M. Biomarkers of immunosenescence within an evolutionary perspective: the challenge of heterogeneity and the role of antigenic load. Exp Gerontol. 1999 Dec;34(8):911-21.
23. Mondello C, Petropoulou C, Monti D, Gonos ES, Franceschi C, Nuzzo F. Telomere length in fibroblasts and blood cells from healthy centenarians. Exp Cell Res. 1999 Apr 10;248(1):234-42.
24. Cawthon RM, Smith KR, O'Brien E, Sivatchenko A, Kerber RA. Association between telomere length in blood and mortality in people aged 60 years or older. Lancet, 2003; 361: 393-395.
25. Ershler WB, Keller ET. Age-associated increased interleukin-6 gene expression, late-life diseases, and frailty. Annu Rev Med. 2000;51:245-70.
26. Giuliani N, Sansoni P, Girasole G, Vescovini R, Passeri G, Passeri M, Pedrazzoni M. Serum interleukin-6, soluble interleukin-6 receptor and soluble gp130 exhibit different patterns of age- and menopause-related changes. Exp Gerontol. 2001 Mar;36(3):547-57.
27.Harris TB, Ferrucci L, Tracy RP, Corti MC, Wacholder S, Ettinger WH Jr, Heimovitz H, Cohen HJ, Wallace R.Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly. Am J Med. 1999 May;106(5):506-12. Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly. Am J Med. 1999 May;106(5):506-12.
28. Franceschi C, Bonafe M, Valensin S, Olivieri F, De Luca M, Ottaviani E, De Benedictis G. Inflamm-aging. An evolutionary perspective on immunosenescence. Ann N Y Acad Sci. 2000 Jun;908:244-54.
29. Sansoni P, Cossarizza A, Brianti V, Fagnoni F, Snelli G, Monti D, Marcato A, Passeri G, Ortolani C, Forti E, et al. Lymphocyte subsets and natural killer cell activity in healthy old people and centenarians.
Blood. 1993 Nov 1;82(9):2767-73.
30. Levy SM, Herberman RB, Lee J, Whiteside T, Beadle M, Heiden L, Simons A. Persistently low natural killer cell activity, age, and environmental stress as predictors of infectious morbidity. Nat Immun Cell Growth Regul. 1991;10(6):289-307.
31. Bonafe M, Olivieri F, Cavallone L, Giovagnetti S, Mayegiani F, Cardelli M, Pieri C, Marra M, Antonicelli R, Lisa R, Rizzo MR, Paolisso G, Monti D, Franceschi C. A gender--dependent genetic predisposition to produce high levels of IL-6 is detrimental for longevity. Eur J Immunol. 2001 Aug;31(8):2357-61.
32. Lio D, Scola L, Crivello A, Colonna-Romano G, Candore G, Bonafe M, Cavallone L, Franceschi C, Caruso C. Gender-specific association between -1082 IL-10 promoter polymorphism and longevity. Genes Immun. 2002 Feb;3(1):30-3.
33. Lio D, Mario Pes G, Carru C, Listi; F, Ferlazzo V, Candore G, Colonna-Romano G, Ferrucci L, Deiana L, Baggio G, Franceschi C, Caruso C. Association between the HLA-DR alleles and longevity: a study in Sardinian population. Exp Gerontol. 2003 Mar;38(3):313-318.

Parole Chiave

IMMUNOSENESCENZA; CMV; TETRAMERI; CD8+ VIRUS-SPECIFICI; CITOCHINE INTRACELLULARI; TELOMERI; PROFILO DI RISCHIO IMMUNOLOGICO