RICERCA ITALIANA     

Programmi di ricerca simili:

• 1 - Basi genetiche dell’autoimmunità: studi in modelli naturali di aumentata suscettibilità
• 2 - Ricerca dei fattori genetici responsabili della suscettibilità al diabete autoimmune e comprensione delle loro conseguenze funzionali
• 3 - IDENTIFICAZIONE DI NUOVI GENI MALATTIA MEDIANTE ANALISI DEL TRASCRITTOMA (TOM: TRANSCRIPTOME OF MIM)
• 4 - DISSEZIONE DEI FATTORI GENETICI E COMPRENSIONE DEI MECCANISMI RESPONSABILI DEL DIABETE AUTOIMMUNE
• 5 - Geni dell'angiogenesi indotti da ipossia: fattori di suscettibilità nella Sclerosi Laterale Amiotrofica ?
• 6 - Patogenesi molecolare ed analisi sequenziale di interazioni cellulari e marcatori biologici di progressione di malattia e di resistenza al trattamento nella leucemia linfatica cronica
• 7 - Nuove acquisizioni sul carico mutazionale e sulle possibilità di monitoraggio citogenetico e molecolare delle displasie/neoplasie mieloidi
• 8 - Malattie lisosomiali. Basi molecolari, patogenesi e approcci terapeutici innovativi.
• 9 - Studio di biologia integrata ad alta produttività per l'analisi genetica della IgA nefropatia
• 10 - STUDI SUI FATTORI GENETICI ED IMMUNOLOGICI CHE REGOLANO IL DANNO TESSUTALE ED IL DECORSO CLINICO DELL'ARTRITE REUMATOIDE

Classificazione scientifico-disciplinare

• Area scientifico disciplinare: Scienze biologiche
• Area scientifico disciplinare: Scienze mediche
  • GENETICA MEDICA
  • MEDICINA INTERNA
  • GASTROENTEROLOGIA
  • ENDOCRINOLOGIA
  • REUMATOLOGIA

Classificazione brevettuale

• CHEMISTRY; METALLURGY
  • BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS (immunoassay G01N33/53); COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
• HUMAN NECESSITIES
  • AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
  • MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES (bringing into special physical form A61J [N: mechanical aspects]; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; compounds per se C01, C07, C08, C12N; soap compositions C11D; micro-organisms per se C12N) [C0203]

Classificazione geografica

• Regione: Lombardia

Bibliografia

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2. Jacobson DL, Gange SJ, Rose NR, Graham NM. Epidemiology and estimated population burden of selected autoimmune diseases in the United States. Clin Immunol Immunopathol 1997;84:223-243.
3. Invernizzi P, Miozzo M, Battezzati PM, Bianchi I, Grati FR, Simoni G, Selmi C, et al. Frequency of monosomy X in women with primary biliary cirrhosis. Lancet 2004;363:533-535.
4. Kaplan MM, Bianchi DW. Primary biliary cirrhosis: for want of an X chromosome? Lancet 2004;363:505-506.
5. Ranke MB, Saenger P. Turner's syndrome. Lancet 2001;358:309-314.
6. Davis CJ, Davison RM, Payne NN, Rodeck CH, Conway GS. Female sex preponderance for idiopathic familial premature ovarian failure suggests an X chromosome defect: opinion. Hum Reprod 2000;15:2418-2422.
7. Valiaho J, Riikonen P, Vihinen M. Novel immunodeficiency data servers. Immunol Rev 2000;178:177-185.
8. Becker KG, Simon RM, Bailey-Wilson JE, Freidlin B, Biddison WE, McFarland HF, Trent JM. Clustering of non-major histocompatibility complex susceptibility candidate loci in human autoimmune diseases. Proc Natl Acad Sci U S A 1998;95:9979-9984.
9. Barbesino G, Tomer Y, Concepcion ES, Davies TF, Greenberg DA. Linkage analysis of candidate genes in autoimmune thyroid disease. II. Selected gender-related genes and the X-chromosome. International Consortium for the Genetics of Autoimmune Thyroid Disease. J Clin Endocrinol Metab 1998;83:3290-3295.
10. Imrie H, Vaidya B, Perros P, Kelly WF, Toft AD, Young ET, Kendall-Taylor P, et al. Evidence for a Graves' disease susceptibility locus at chromosome Xp11 in a United Kingdom population. J Clin Endocrinol Metab 2001;86:626-630.
11. Jawaheer D, Seldin MF, Amos CI, Chen WV, Shigeta R, Monteiro J, Kern M, et al. A genomewide screen in multiplex rheumatoid arthritis families suggests genetic overlap with other autoimmune diseases. Am J Hum Genet 2001;68:927-936.
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13. Azuma T, Takei M, Yoshikawa T, Nagasugi Y, Kato M, Otsuka M, Shiraiwa H, et al. Identification of candidate genes for Sjogren's syndrome using MRL/lpr mouse model of Sjogren's syndrome and cDNA microarray analysis. Immunol Lett 2002;81:171-176.
14. Ridgway WM. The non obese diabetic (NOD) mouse: a unique model for understanding the interaction between genetics and T cell responses. Rev Endocr Metab Disord 2003;4:263-269.
15. L Groop. Diabetes mellitus: diagnosis, classification,
epidemiology and metabolic disturbances. In: Endocrinology and methabolism. A.Pinchera ed. McGraw-Hill 2001.Chapter 25.
16. The expert committee on the diagnosis and classification of diabetes mellitus. Report of the expert commitee on thediagnosis and classification of diabetis mellitus. Diabetes care 1997. 20:1183-1197.
17. TW Ladenson. Diagnosis of thyrotoxicosis in Werner and Ingbar's thyroid: a fundamental and clinical text.pag 685-690.
Diagnosis of hypothyroidism. pag.848-852. 8th edition.LE Braverman, RD Utiger 2000.
18. Baloch Z, Carayon P, Conte-Devolx B, Demers LM, Feldt-Rasmussen U, Henry JF, LiVosli VA, Niccoli-Sire P, John R, Ruf J, Smyth PP, Spencer CA, Stockigt JR. Guidelines Committee, National Academy of Clinical Biochemistry. Laboratory medicine practice guidelines. Laboratory support for the diagnosis and monitoring of thyroid disease. Thyroid 2003;13:3-126.
19. Lonzetti LS, Joyal F, Raynauld JP, Roussin A, Goulet JR, Rich E, Choquette D, Raymond Y, Senecal JL. Updating the American College of Rheumatology preliminary classification criteria for systemic sclerosis: addition of severe nailfold capillaroscopy abnormalities markedly increases the sensitivity for limited scleroderma. Arthritis Rheum. 2001;44:735-736.
20. Vitali C, BombardieriS, Jonsson R, Moutsopoulos HM, Alexander EL, Carsons SE, Daniels TE, Fox PC, Fox RI, Kassan SS, Pillemer SR, Talal N, Weisman MH; European Study Group on Classification Criteria for Sjogren's Syndrome. Classification criteria for Sjogren's syndrome: a revised version of the European criteria proposed by the American-European Consensus Group. Ann Rheum Dis. 2002;61:554-558.
21. Bohan A, Peter JB. Polymyositis and dermatomyositis.N Engl J Med. 1975 13;292:344-347.
22. Hochberg MC. Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 1997;40:1725.
23. Bossu P, Neumann D, Del Giudice E, Ciaramella A, Gloaguen I, Fantuzzi G, Dinarello CA, Di Carlo E, Musiani P, Meroni PL, Caselli G, Ruggiero P, Boraschi D.IL-18 cDNA vaccination protects mice from spontaneous lupus-like autoimmune disease. Proc Natl Acad Sci U S A. 2003;100:14181-6.
24. Amital H, Levi Y, Blank M, Barak V, Langevitz P, Afek A, Nicoletti F, Kopolovic J, Gilburd B, Meroni PL, Shoenfeld Y. Immunomodulation of murine experimental SLE-like disease by interferon-gamma. Lupus. 1998;7:445-54.
25. Nicoletti F, Zaccone P, Magro G, Barcellini W, Cavallaro V, Belli G, Cocuzza C, di Marco R, Meroni PL. The effects of thymopentin on the development of SLE-like syndrome in the MRL/lpr-lpr mouse. Scand J Immunol. 1994;40:549-56.
26. Nicoletti F, Zaccone P, Conget I, Gomis R, Moller C, Meroni PL, Bendtzen K, Trepicchio W, Sandler S. Early prophylaxis with recombinant human interleukin-11 prevents spontaneous diabetes in NOD mice. Diabetes. 1999;48:2333-9.
27. Nicoletti F, Di Marco R, Zaccone P, Magro G, Di Mauro M, Grasso S, Meroni PL. Endogenous interleukin-12 only plays a key pathogenetic role in non-obese diabetic mouse diabetes during the very early stages of the disease. Immunology 1999;97:367-70.
28. Nicoletti F, Zaccone P, Di Marco R, Magro G, Grasso S, MorroneS, Santoni A, Tempera G, Meroni PL, Bendtzen K. Effects of sodium fusidate in animal models of insulin-dependent diabetes mellitus and septic shock. Immunology 1995;85:645-50.
29. Nicoletti F, Di Marco R, Barcellini W, Magro G, Schorlemmer HU, Kurrle R, Lunetta M, Grasso S, Zaccone P, Meroni P. Protection from experimental autoimmune diabetes in the non-obese diabetic mouse with soluble interleukin-1 receptor. Eur J Immunol. 1994;24:1843-7.
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31. Sandstedt SA, Tucker PK. Evolutionary strata on the mouse X chromosome correspond to strata on the human X chromosome. Genome Res 2004;14:267-272.

Parole Chiave

MALATTIE AUTOIMMUNI; CROMOSOMI SESSUALI; TOPI MLR; TOPI NOD; SUSCETTIBILITA'GENETICA