RICERCA ITALIANA     

Programmi di ricerca simili:

• 1 - MECCANISMI DI TRASMISSIONE DEL SEGNALE IN PAZIENTI E MODELLI ANIMALI CON IPERTENSIONE SODIO SENSIBILE
• 2 - Interactoma dei canali per il cloruro nel DCT: valutazione biofisica, biochimica, fisiopatologica e prospettive terapeutiche
• 3 - Meccanismi di regolazione del volume nel rene : nuovi emergenti aspetti molecolari
• 4 - Determinanti genetici ed endocrino-metabolici di ipertensione arteriosa nell'obesità addominale: valuatazione dell'handling renale del sodio e degli effetti del calo ponderale
• 5 - Canalopatie cardiache
• 6 - Studio degli effetti genomici dell'aldosterone in modelli cellulari ed in vivo.
• 7 - Aspetti biochimici e genetici del disturbo autistico.
• 8 - PRODUZIONE E CATABOLISMO DELLA BETA-AMILOIDE IN PAZIENTI CON MALATTIA DI ALZHEIMER E MILD COGNITIVE IMPAIRMENT: STUDI IN VITRO E MARKERS EX VIVO
• 9 - PEROSSIDAZIONE LIPIDICA, ATTIVAZIONE PIASTRINICA ED INFIAMMAZIONE ASSOCIATI A RIDOTTI LIVELLI DI LIPOPROTEINE AD ALTA DENSITA' (HDL)
• 10 - Intolleranza alle proteine con lisinuria: sviluppo ed analisi di un modello genetico murino di tipo condizionale e di modelli cellulari umani

Classificazione scientifico-disciplinare

• Area scientifico disciplinare: Scienze mediche
  • GENETICA MEDICA
  • MEDICINA INTERNA
  • MALATTIE DELL'APPARATO CARDIOVASCOLARE
  • NEFROLOGIA

Classificazione brevettuale

• HUMAN NECESSITIES
  • MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES (bringing into special physical form A61J [N: mechanical aspects]; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; compounds per se C01, C07, C08, C12N; soap compositions C11D; micro-organisms per se C12N) [C0203]

Classificazione geografica

• Regione: Lombardia

Bibliografia

1. Whelton, P. e. a. 1994. Textbook of hypertension, Swales J.D. ed. 11-21.
2. Hamet, P. et al. 1998. Hypertension: genes and environment. J Hypertens. 16:397-18.
3. Cowley, A. 1997. Genetic and nongenetic determinants of salt sensitivity and blood pressure. Am J Clin.Nutr. 65:587S-593S.
4. Grimm, R. 1997. Intersalt data. Collaborative efforts must be made to reduce sodium in diet. BMJ 315:87.
5. Guyton, A. et al. 1972. Arterial pressure regulation. Overriding dominance of the kidneys in long-term regulation and in hypertension. Am J Med. 52:584-94.
6. Dahl, L. et al. 1975. Primary role of renal homografts in setting chronic blood pressure levels in rats. Circ.Res. 36:692-6.
7. Cowley, A. et al. 1996. The role of the kidney in hypertension. JAMA 275:1581-89.
8. Paillard, M. 1997. Na+/H+ exchanger subtypes in the renal tubule: function and regulation in physiology and disease. Exp.Nephrol. 5:277-84.
9. Plata, C. et al. 1999. Isoforms of the Na-K-2Cl cotransporter in murine TAL II. Functional characterization and activation by cAMP. Am J Physiol 276:F359-66.
10. Gamba, G. 1999. Molecular biology of distal nephron sodium transport mechanisms. Kidney Int. 56:1606-22.
11. Rossier, B.1997. 1996 Homer Smith Award Lecture. Cum grano salis: the epithelial sodium channel and the control of blood pressure. J Am Soc.Nephrol. 8:980-92.
12. Bianchi, G. et al. 1975. Changes in renin, water balance and sodium balance during development of high blood pressure in genetically hypertensive rats. Circ Res 36,37,Suppl 1:153-61.
13. Bianchi, G. et al. 1986. A renal abnormality in the Milan hypertensive strain of rats and in humans predisposed to essential hypertension. J Hypertens.Suppl 4:S33-S36.
14. Tripodi, G. et al. 1996. Hypertension-associated point mutations in the adducin a and b subunits affect actin cytoskeleton and ion transport. J Clin Invest.97:2815-22.
14a. Manunta P. 1998. a-adducin polymorphisms and renal sodium handling in essential hypertensive patients. Kidney Int 53: 1471-78
14b. Cusi, D. et al. 1997. Polymorphism of a-adducin and salt sensitivity in patients with essential hypertension. Lancet 349:1353-57.
15. Capasso, G. et al. 2001. The development of genetic hypertension is associated with an up-regulation of the Na-K-2Cl mRNA and protein abundance along the thick asccending limbs of Henle's loop. J Am Soc.Nephrol. 12.
16. Rizzo, M. et al. 2003. Quantification of gene expression of the sodium transporters NHE3, NKCC2 and NCC along the tubular nephron segments: their role in the maintenance of genetic hypertension. Nephrol.Dial.Transplant. 18:W150.
17. Bleich, M. et al. 1990. The luminal K+ channel of the thick ascending limb of Henle's loop. Pflugers Arch. 415:449-60.
18. Steinmeyer, K. et al. 1998. Molecular physiology of renal chloride channels. Curr.Opin.Nephrol.Hypertens. 7:497-02.
19. Coppola, S. et al. 2000. Fisiologia, biologia e genetica molecolare dei canali ionici: implicazioni diagnostiche e rilevanza clinica. Giornale Italiano di Nefrologia 17:3-13.
20. Greger, R. 1985. Ion transport mechanisms in thick ascending limb of Henle's loop of mammalian nephron. Physiol Rev. 65:760-97.
21. Hoagland, K. et al. 2004. Elevated BSC-1 and ROMK Expression in Dahl Salt-Sensitive Rat Kidneys. Hypertension .
22. Ito, O. et al. 1999. Role of 20-HETE in elevating chloride transport in the thick ascending limb of Dahl SS/Jr rats. Hypertension 33:419-23.
23. Simon, D. et al. 1998. Mutations in Na(K)Cl transporters in Gitelman's and Bartter's syndromes. Curr.Opin.Cell Biol. 10:450-54.
24. Bartter, F. 1980. On the pathogenesis of Bartter's syndrome. Mineral Electrolyte Metab 3:61-5.
25. Estevez, R. et al. 2001. Barttin is a Cl- channel beta-subunit crucial for renal Cl- reabsorption and inner ear K+ secretion. Nature 414:558-61.
26. Birkenhager, R. et al. 2001. Mutation of BSND causes Bartter syndrome with sensorineural deafness and kidney failure. Nat.Genet. 29:310-14.
27. Canessa, C. et al. 1995. Expression cloning of the epithelial sodium channel. Kidney Int. 48:950-55.
28. Biner, H. et al. 2002. Human cortical distal nephron: distribution of electrolyte and water transport pathways. J Am Soc.Nephrol. 13:836-47.
29. Agre, P. et al. 2003. Aquaporin water channels: molecular mechanisms for human diseases. FEBS Lett. 555:72-8.
30. Kozono, D. et al. 2002. Aquaporin water channels: atomic structure molecular dynamics meet clinical medicine. J Clin.Invest 109:1395-99.
31. Morello, J. et al. 2001. Nephrogenic diabetes insipidus. Annu.Rev.Physiol 63:607-30.
32. Wang, D. et al. 1997. Hypotension in transgenic mice overexpressing human bradykinin B2 receptor. Hypertension 29:488-93.
33. Madeddu, P. et al. 1997. Cardiovascular phenotype of a mouse strain with disruption of bradykinin B2-receptor gene. Circulation 96:3570-78.
34. Alfie, M. et al. 1999. An enhanced effect of arginine vasopressin in bradykinin B2 receptor null mutant mice. Hypertension 33:1436-40.
35. Margolius, H. 1989. Tissue kallikreins and kinins: regulation and roles in hypertensive and diabetic diseases. Annu.Rev.Pharmacol.Toxicol. 29:343-64.
36. Levy, S. et al. 1977. Urinary kallikrein and plasma renin activity as determinants of renal blood flow. The influence of race and dietary sodium intake. J Clin.Invest 60:129-38.
37. Zinner, S. et al. 1976. Familial aggregation of urinary kallikrein concentration in childhood: relation to blood pressure, race and urinary electrolytes. Am J Epidemiol. 104:124-32.
38. Berry, T. et al. 1989. A gene for high urinary kallikrein may protect against hypertension in Utah kindreds. Hypertension 13:3-8.
39. Margolius, H. et al. 1972. Altered urinary kallikrein excretion in rats with hypertension. Circ.Res. 30:358-62.
40. Margolius, H. 1995. Theodore Cooper Memorial Lecture. Kallikreins and kinins. Some unanswered questions about system characteristics and roles in human disease. Hypertension 26:221-9.
41. Persu, A. et al. 1998. Genetic analysis of the beta subunit of the epithelial Na+ channel in essential hypertension. Hypertension 32:129-37.
42. Munroe, P. et al. 1998. Absence of linkage of the epithelial sodium channel to hypertension in black Caribbeans. Am J Hypertens. 11:942-5.
43. Poch, E. et al. 2000. Genetic variation of the gamma subunit of the epithelial Na+ channel and essential hypertension. Relationship with salt sensitivity. Am J Hypertens. 13:648-53.
44. Glorioso, N. et al. 2001. Interaction of alpha(1)-Na,K-ATPase and Na,K,2Cl-cotransporter genes in human essential hypertension. Hypertension 38:204-9.
45. Melander, O. et al. 2000. Genetic variants of thiazide-sensitive NaCl-cotransporter in Gitelman's syndrome and primary hypertension. Hypertension 36:389-94.
46. Song, Y. et al. 2001. Non-association of the thiazide-sensitive Na,Cl-cotransporter gene with polygenic hypertension in both rats and humans. J Hypertens. 19:1547-51.
47. Schork, N. et al. 2000. Single nucleotide polymorphisms and the future of genetic epidemiology. Clin.Genet. 58:250-64.
48. Brookes, A. 1999. The essence of SNPs. Gene 234:177-86.
49. Morris, R. et al. 2002. On the advantage of haplotype analysis in the presence of multiple disease susceptibility alleles. Genet.Epidemiol. 23:221-33.
50. Martin, E. et al. 2000. SNPing away at complex diseases: analysis of single-nucleotide polymorphisms around APOE in Alzheimer disease. Am J Hum.Genet. 67:383-94.
51. Bader, J. 2001. The relative power of SNPs and haplotype as genetic markers for association tests. Pharmacogenomics. 2:11-24.
52. Qian, D. et al. 2002. Minimum-recombinant haplotyping in pedigrees. Am J Hum.Genet. 70:1434-45.
53. Service, S. et al. 1999. Linkage-disequilibrium mapping of disease genes by reconstruction of ancestral haplotypes in founder populations. Am J Hum.Genet. 64:1728-38.
54. McKee, J. et al. 2000. Detection of Na(+) transporter proteins in urine. J Am Soc.Nephrol. 11:2128-32.
55. Kanno, K. et al. 1995. Urinary excretion of aquaporin-2 in patients with diabetes insipidus. N.Engl.J Med. 332:1540-45.

Parole Chiave

SODIO-SENSIBILITA'; CANALI AL SODIO; CANALI AL POTASSIO; CANALI AL CLORO; ACQUAPORINE; POLIMORFISMI A SINGOLO NUCLEOTIDE; APLOTIPI; RATTI MILANO; PROTEOMICA URINARIA