RICERCA ITALIANA     

Programmi di ricerca simili:

• 1 - Analisi genomica della regolazione trascrizionale nella mielopoiesi umana normale: correlazione tra localizzazione dei geni, reti geniche e domini nucleari.
• 2 - Basi metaboliche e molecolari della sindrome di Down
• 3 - Patogenesi molecolare ed analisi sequenziale di interazioni cellulari e marcatori biologici di progressione di malattia e di resistenza al trattamento nella leucemia linfatica cronica
• 4 - Ruolo dei microRNA nel differenziamento cellulare e nella tumorigenesi
• 5 - Studio di biologia integrata ad alta produttività per l'analisi genetica della IgA nefropatia
• 6 - Sviluppo di un sistema integrato di risposte bio-molecolari per lo studio dell'adattamento di Dictyostelium discoideum a condizioni di stress ambientali.
• 7 - RETI GENETICO-MOLECOLARI NELLO SVILUPPO NEURALE: DAL DIFFERENZIAMENTO ALLA FUNZIONE
• 8 - Meccanismi della citochinesi: identificazione di nuovi geni coinvolti nel processo e nella sua regolazione
• 9 - Eritropoiesi normale e patologica: caratterizzazione molecolare mediante tecnologie avanzate a resa elevata.
• 10 - Il repertorio delle lectine nei protocordati. Evoluzione dei meccanismi di riconoscimento e dell'immunità innata.

Classificazione scientifico-disciplinare

• Area scientifico disciplinare: Scienze biologiche
  • BIOLOGIA MOLECOLARE
  • BIOLOGIA APPLICATA

Classificazione brevettuale

• CHEMISTRY; METALLURGY
  • BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF (biocides, pest repellants or attractants, or plant growth regulators, containing micro-organisms, viruses, microbial fungi, enzymes, fermentates or substances produced by or extracted from micro-organisms or animal material A01N63/00; food compositions A21, A23; medicinal preparations A61K; chemical aspects of, or use of materials for, bandages, dressings, absorbent pads or surgical articles A61L; fertilisers C05); PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS (preservation of living parts of humans or animals A01N1/02); MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (micro-biological testing media C12Q)

Classificazione geografica

• Regione: Emilia Romagna

Bibliografia

Akashi K et al. Transcriptional accessibility for genes of multiple tissues and hematopoietic lineages is hierarchically controlled during early hematopoiesis. Blood. 2003 Jan 15;101(2):383-9. Epub 2002 Sep 05.
Antonarakis SE et al. Cromosome 21 and Down Syndrome: from genomics to pathophysiology. Nat. Rev. Genet. 5: 725-738, 2004.
Barabasi AL, Oltvai ZN. Network Biology: understanding the cell’s functional organization. Nature Rev Gen. 5: 101-113, 2004.
Beer MA, Tavazole S. Predicting gene expression by sequence. Cell 117: 185-198, 2004.
Bourette RP, Rohrschneider LR. Early events in M-CSF receptor signaling. Growth Factors 17: 155-166, 2000.
Bruggeman FJ et al. Modular response analysis of cellular regulatory networks. J. Theor. Biol. 218: 507-520, 2002.
Caron H et al. The human transcriptome map: clustering of highly expressed genes in chromosomal domains. Science 291: 1289-1292, 2001.
Causier B. Studying the interactome with the yeast two-hybrid system and mass spectrometry. Mass Spectrom. Rev. 23: 350-367, 2004.
Chen CZ, Lodish HF. MicroRNAs as regulators of mammalian hematopoiesis. Seminars in Immunology 17: 155-165, 2005.
Cross MA, Enver T. The lineage commitment of haemopoietic progenitor cells. Curr. Opin. Gen. Dev. 7: 609-613, 1997.
Dillon N, Sabbattini P. Functional gene expression domains: defining the functional unit of eukaryotic gene regulation. BioEssays 22: 657-665, 2000.
Eckhardt F et al. Future potential of the human epigenome project. Expert Rev. mol. Diagn. 4: 609- 618, 2004.
Eisenberg E, Levanon EY. Human housekeeping genes are compact. Trends Genet. 19: 362-365, 2003.
Galperin MY. The molecular biology database collection: 2005 update. Nucleic Acid Res. 33: D5-D24, 2005.
Grewal SI, Moazed D. Heterochromatin and epigenetic control of gene expression. Science 301: 798-802, 2003.
Hartwell LHet al. From molecular to modular cell biology. Nature 402 (Suppl.): c47-c52, 1999.
Ideker T et al. A new approach to decoding life: Systems Biology. Annu. Rev. Genomics Hum. Genet. 2: 343-372, 2001.
International Human Genome Sequencing Consortium. Finishing the euchromatic sequence of human genome. Nature 431:931-945, 2004
Kampa D et al. Novel RNAs identified from an in-depth analysis of the transcriptome of human chromosomes 21 and 22. Genome Research 14: 331-342, 2004.
Kapranov P et al. Large-scale transcriptional activity in chromosomes 21 and 22. Science 296: 916-919, 2002.
Kitano H. Biological Robustness. Nature Rev. Genetics 5:826-837, 2004.
Kondo M et al. Biology of hematopoietic stem cells and progenitors: implications for clinical application. Annu Rev Immunol 2003; 21:759-806.
Kluger Y et al. A panorama of lineage-specific transcription in hematopoiesis. BioEssays 26: 1276-1287, 2004.
Lee JW, Lee SK. Mammalian two-hybrid assay for detecting protein-protein interactions in vivo. Methods Mol. Biol. 261: 327-336, 2004.
Lercher MJ et al. Clustering of housekeeping genes provides a unified model of gene order in the human genome. Nature Genetics 31:180-183, 2002.
Lian Z et al. Genomic and proteomic analysis of the myeloid differentiation program. Blood. 2001 Aug 1;98(3):513-24.
Li H, Wang W. Dissecting the transcription networks of a cell using computational genomics. Current Opinion in Genetics and Development 13: 611-616, 2003.
Li Q et al. Locus control region. Blood 100:3077-3086, 2002.
Lockhart DJ, Winzeler EA. Genomics, gene expression and DNA arrays. Nature 405: 827-836, 2000.
Manfredini R et al. The kinetic status of hemopoietic stem cells (HSC) sub-populations underlies a differential expression of genes involved in self-renewal, commitment and engraftment. Stem Cells 23: 496-506, 2005.
Metcalf D. The molecular control of cell division, differentiation commitment and maturationin haemopoietic cells. Nature 339: 27-30, 1989.
Ness SA, Engel JD. Vintage reds and whites: combinatorial transcription factor utilization in hematopoietic differentiation. Curr. Opin. Gen. Dev. 4: 718-724, 1994.
Orkin SH. Diversification of haematopoietic stem cells to specific lineages. Nat Rev Genet 1:57-64, 2000.
Resing KA, Ahn NG. Proteomics strategies for protein identification. FEBS Letters 579: 885-889, 2005.
Schomber T et al. Gene silencing by lentivirus-mediated delivery of siRNA in human CD34+ cells. Blood 103: 4511-4513, 2004.
Segal E et al. Module networks: identifying regulatory modules and their condition-specific regulators from gene expression data. Nature Genetics 34: 166-176, 2003.
Sieweke MH, Graf T. A transcription factor party during blood cell differentiation. Curr. Opin. Genet. Dev. 8: 545-551, 1998.
Stelling J et al. Robustness of cellular functions. Cell 118: 675-685, 2004
Tagliafico E et al. Gene expression profile of Vitamin D3 treated HL60 cells shows an incomplete molecular phenotypic conversion to monocytes. Cell Death Differ. 2002 Nov;9(11):1185-95.
Tenen DG et al. Transcription factors, normal myeloid development, and leukemia. Blood 1997; 90(2):489-519.
Versteeg R et al. The human transcriptome map reveals extremes in gene density, intron length, GC content, and repeat pattern for domains of highly and weakly expressed genes. Genome Research 13: 1998-2004, 2003.
Virtaneva K et al. Expression profiling reveals fundamental biological differences in acute myeloid leukemia with isolated trisomy 8 and normal cytogenetics. Proc. Natl. Acad. Sci. USA 98: 1124-1129, 2001.
Weeler DL et al. Database resources of the National Center for Biotechnology information. Nucleic Acids res. 33: D39-D45, 2005.
Ward AC et al. Regulation of granulopoiesis by transcription factors and cytokine signals. Leukemia 14: 973-990, 2000.
Yager TD et al. First comprehensive mapping of cartilage transcripts to the human genome. Genomics 84: 524-535, 2004.
Yamashita T et al. Genome-wide transcriptome mapping analysis identifies organ-specific gene expression patterns along human chromosomes. Genomics 84: 867-875, 2004.
Yu X et al. Lentiviral vectors with two independent internal promoters transfer high-level expression of multiple transgenes to human hematopoietic stem-progenitor cells. Mol Ther 2003; 7(6):827-838.
Xin L et al. A hypothesis for chromatin domain opening. BioEssays 25: 507-514, 2003.
Zhu H et al. Analysis of yeast protein kinases using protein chips. Nature Genetics 26: 283-289, 2000.

Parole Chiave

DIFFERENZIAMENTO; FATTORI TRASCRIZIONALI; PROFILO DI ESPRESSIONE GENICA; MAPPE TRASCRIZIONALI; MODULI FUNZIONALI; MICRO RNA; GENOMICA FUNZIONALE; BIOLOGIA COMPUTAZIONALE; PROMOTORI