RICERCA ITALIANA     

Programmi di ricerca simili:

• 1 - Ruolo dei sistemi di ubiquitinazione e proteolisi nell'organizzazione cromatinica e nella trascrizione dei geni coinvolti nella biogenesi e funzione del ribosoma
• 2 - Proprieta’ strutturali e attivita’ funzionale di un complesso proteico modificante la cromatina nell’uomo
• 3 - Ruolo, Meccanismi molecolari e nuovi interattori delle proteine Prep/Meis/Pbx nello sviluppo embrionale.
• 4 - Dallo studio dell’espressione genica globale allo studio della virulenza di Mycobacterium tuberculosis
• 5 - Approccio multidisciplinare allo studio di fattori trascrizionali in Arabidopsis thaliana
• 6 - Ruolo fisiopatologico delle proteine HMGA nella trasmissione dei segnali ormonali e proliferativi.
• 7 - Studio dei meccanismi molecolari e del ruolo fisiopatologico delle proteine HMGA nella trasmissione e trasduzione dei segnali ormonali e proliferativi.
• 8 - Basi metaboliche e molecolari della sindrome di Down
• 9 - Dalla cromatina ai fattori di trascrizione: studio del meccanismi di regolazione trascrizionale in piante di interesse agrario
• 10 - Ruolo dei fattori HMGA nello sviluppo e differenziamento del sistema nervoso.

Classificazione scientifico-disciplinare

• Area scientifico disciplinare: Scienze biologiche
  • BIOCHIMICA
  • BIOLOGIA MOLECOLARE

Classificazione brevettuale

• CHEMISTRY; METALLURGY
  • BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS (immunoassay G01N33/53); COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF (biocides, pest repellants or attractants, or plant growth regulators, containing micro-organisms, viruses, microbial fungi, enzymes, fermentates or substances produced by or extracted from micro-organisms or animal material A01N63/00; food compositions A21, A23; medicinal preparations A61K; chemical aspects of, or use of materials for, bandages, dressings, absorbent pads or surgical articles A61L; fertilisers C05); PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS (preservation of living parts of humans or animals A01N1/02); MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (micro-biological testing media C12Q)

Classificazione geografica

• Regione: Puglia

Bibliografia

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2. Clayton, D.A. (1982) Replication of animal mitochondrial DNA Cell 28, 693-705.
3. Fish, J., Raule, N. and Attardi G. (2004) Discovery of a major D-loop replication origin reveals two modes of human mtDNA synthesis. Science 306, 2098-2101.
4. Yang, M.Y., Bowmaker, M., Reyes, A., Vergani, L., Angeli, P., Gringeri, Jacobs, H.T. and Holt, I.J. (2002) Biased incorporation of ribonucleotides on the mitochondrial L-strand accounts for apparent strand-asymmetric DNA replication. Cell 111, 495-505.
5. Taanman JW. (1999) The mitochondrial genome: structure, transcription, translation and
Replication. Biochim Biophys Acta 1410, 103-123.
6. Shadel GS (2004) Coupling the mitochondrial transcription machinery to human disease. Trends Genet. 20, 513-519.
7. Madsen, C.S., Ghivizzani, S.C., and Hauswirth, W.W. (1993) Protein binding to a single Termination Associated Sequence in the mitochondrial DNA D-loop region. Mol. Cell. Biol. 13, 2162-2171.
8. Falkenberg, M., Gaspari, M., Rantanen, A., Trifunovic, A., Larsson, N.-G. and Gustafsson, C. (2002) Mitochondrial transcription B1 and B2 activate transcription of human mtDNA. Nat. Genet. 31, 289-294.
9. McCulloch, V. and Shadel, G.S. (2003) Human mitochondrial transcription factor B1 interacts with the C-terminal activation region of h-mtTFA and stimulates transcription independently of its RNA methyltransferase activity. Mol. Cell. Biol. 23, 5816-5824.
10. Fernandez-Silva, P., Martinez-Azorin, F., Micol, V. and Attardi, G. (1997) The human mitochondrial transcription termination factor (mTERF) is a multizipper protein but binds to DNA as a monomer, with evidence pointing to intramolecular leucine zipper interactions. EMBO J. 16, 1066-1079.
11. Hess, J.F., Parisi, M.A., Bennett, J.L., and Clayton, D.A. (1991) Impairment of mitochondrial transcription termination by a point mutation associated with the MELAS subgroup of mitochondrial encephalomyopathies. Nature 351, 236-239.
12. Camasamudran, V., Fang, J.-K. And Avadhani, N.G. (2003) Transcription termination at the mouse mitochondrial H-strand promoter distal site requires an A/T rich sequence motif and sequence specific DNA binding proteins. Eur. J. Biochem. 270, 1128-1140.
13. Zeviani M, Carelli V. (2003) Mitochondrial disorders. Curr Opin Neurol. 16, 585-594.
14. Lamantea E, Tiranti V, Bordoni A, Toscano A, Bono F, Servidei S, Papadimitriou A, Spelbrink H, Silvestri L, Casari G, Comi GP, Zeviani M. (2002) Mutations of mitochondrial DNA polymerase gammaA are a frequent cause of autosomal dominant or recessive progressive external ophthalmoplegia. Ann Neurol. 52, 211-219.
15. Van Goethem G, Dermaut B, Lofgren A, Martin JJ, Van Broeckhoven C. (2001) Mutation of POLG is associated with progressive external ophthalmoplegia characterized by mtDNA deletions. Nat Genet. 28, 211-212.
16. Agostino A, Valletta L, Chinnery PF, Ferrari G, Carrara F, Taylor RW, Schaefer AM, Turnbull DM, Tiranti V, Zeviani M. (2003) Mutations of ANT1, Twinkle, and POLG1 in sporadic progressive external ophthalmoplegia (PEO). Neurology. 60, 1354-1356.
17. Kaukonen J, Juselius JK, Tiranti V, Kyttala A, Zeviani M, Comi GP, Keranen S, Peltonen L, Suomalainen A. (2000) Role of adenine nucleotide translocator 1 in mtDNA maintenance.
Science, 289, 782-785.
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Nucleosides Nucleotides Nucleic Acids. 23, 1217-1225.
19. Salviati L, Sacconi S, Mancuso M, Otaegui D, Camano P, Marina A, Rabinowitz S, Shiffman R, Thompson K, Wilson CM, Feigenbaum A, Naini AB, Hirano M, Bonilla E, DiMauro S, Vu TH. (2002) Mitochondrial DNA depletion and dGK gene mutations. Ann Neurol. 52, 311-317.
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21. Jacobs, H.T., Herbert, E.R. and Rankine, J. (1989) Sea urchin egg mitochondrial DNA contains a short displacement loop (D-loop) in the replication origin region. Nucleic Acids Res. 17, 8949-8965.
22. Elliot, D.J. and Jacobs, H.T. (1989) Mutually exclusive pathways for sea urchin mitochondrial rRNA and mRNA. Mol. Cell. Biol. 14, 7717-7730.
23. Cantatore, P., Roberti, M., Loguercio Polosa, P., Mustich, A. and Gadaleta, M.N. (1990) Mapping and characterization of Paracentrotus lividus mitochondrial transcripts: multiple and overlapping transcription units. Curr. Genet. 17, 235-245.
24. Roberti, M., Mustich, A., Gadaleta, M.N. and Cantatore, P. (1991) Identification of two homologous mitochondrial DNA sequences, which bind strongly and specifically to a mitochondrial protein of Paracentrotus lividus. Nucleic Acids Res. 19, 6249-6254.
25. Loguercio Polosa, P., Roberti, M., Mustich, A., Gadaleta, M.N. and Cantatore, P. (1994) Purification and characterization of a mitochondrial DNA-binding protein that binds to double-stranded and single-stranded sequences of Paracentrotus lividus mitochondrial DNA. Curr. Genet. 25, 350-356.
26. Loguercio Polosa, P., Roberti, M., Musicco, C., Gadaleta, M.N., Quagliariello, E. and Cantatore, P. (1999) Cloning and characterization of mtDBP, a DNA-binding protein which binds two distinct regions of sea urchin mitochondrial DNA. Nucleic Acids Res. 28, 1890-1899.
27. Fernandez-Silva, P., Loguercio Polosa, P., Roberti, M, Di Ponzio, B, Gadaleta, M.N., Montoya, J., and Cantatore, P. (2001) Sea urchin mtDBP is a two-faced transcription termination factor with a biased polarity depending on the RNA polymerase. Nucleic Acids Res. 29, 4736-4743.
28. Lewis, D.L., Farr, C.L., and Kaguni, L.S. (1995) Drosophila melanogaster mitochondrial DNA: completion of the nucleotide sequence and evolutionary comparisons. Insect Mol. Biol. 4, 263-278.
29. Berthier, F., Renaud, M., Alziari, S., and Durand, R. (1986) RNA mapping on Drosophila mitochondrial DNA precursors and template strands. Nucleic Acids Res. 14, 4519-4533.
30. Roberti, M., Loguercio Polosa, P., Bruni, F., Musicco, C., Gadaleta, M.N., and Cantatore, P. (2003) DmTTF, a novel mitochondrial transcription termination factor that recognises two sequences of Drosophila melanogaster mitochondrial DNA. Nucleic Acids Res. 31, 1597-1604.
31. Roberti, M., Fernandez Silva, P., Loguercio Polosa, P., Fernandez Vizara, E., Bruni, F., Deceglie, S., Montoya, J., Gadaleta, M.N., and Cantatore, P. (2005) In vitro termination activity of the Drosophila mitochondrial DNA-binding protein DmTTF. Biochem. Biophys. Res. Commun. 331, 357-362.

Parole Chiave

REPLICAZIONE DNA MITOCONDRIALE; TRASCRIZIONE DNA MITOCONDRIALE; DNA BINDING PROTEIN; MALATTIE MITOCONDRIALI; UOMO; DROSOPHILA