RICERCA ITALIANA     

Programmi di ricerca simili:

• 1 - RILASCIO DI GLUTAMMATO E MECCANISMI MOLECOLARI PRESINAPTICI NELLE MALATTIE PSICHIATRICHE CORRELATE ALLO STRESS E NELL'AZIONE DI FARMACI PSICOTROPI. RICERCA DI NUOVI BERSAGLI FARMACOLOGICI
• 2 - Antidepressivi e meccanismi molecolari di plasticità neuronale
• 3 - Stress del reticolo endoplasmico: un potenziale nuovo meccanismo di danno cellulare nel diabete.
• 4 - Neurotrasmissione glutamatergica: organizzazione strutturale della sinapsi, recettori e ruolo in fisiopatologia."
• 5 - Effetto della delezione condizionale del recettore Y1 per l'NPY nell'interazione funzionale tra recettore GABAA e l'NPY in condizioni di stress ed esposizione cronica all'etanolo
• 6 - Bersagli neurochimici e funzionali del recettore nicotinico centrale con particolare riferimento ai meccanismi glutamatergici e dopaminergici.
• 7 - Interazioni neuroni-glia nei meccanismi di neurodegenerazione e neuroprotezione
• 8 - Meccanismi cellulari e molecolari di morte e protezione neuronale
• 9 - STUDIO DEGLI EFFETTI PRODOTTI DALLO STRESS DURANTE L'ADOLESCENZA E LORO IMPLICAZIONI PSICOPATOLOGICHE
• 10 - Potenziale terapeutico di nuovi ligandi per il recettore di nocicettina/orfanina FQ

Classificazione scientifico-disciplinare

• Area scientifico disciplinare: Scienze biologiche
  • ANATOMIA COMPARATA E CITOLOGIA
  • BIOLOGIA APPLICATA
  • FARMACOLOGIA

Classificazione brevettuale

• CHEMISTRY; METALLURGY
  • BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS (immunoassay G01N33/53); COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
• HUMAN NECESSITIES
  • MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES (bringing into special physical form A61J [N: mechanical aspects]; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; compounds per se C01, C07, C08, C12N; soap compositions C11D; micro-organisms per se C12N) [C0203]

Classificazione geografica

• Regione: Lombardia

Bibliografia

1. Akbarian S et al. (2002) Brain-Derived Neurotrophic factor is essential for opiate-induced plasticity of noradrenergic neurons. J Neurosci 22:4153–4162
2. Altamura CA, et al. (1993) Plasma and platelet excitatory amino acids in psychiatric disorders. Am J Psychiatry 150:1731-1733.
3. Bagley J, Moghaddam B (1997) Temporal dynamics of glutamate efflux in the prefrontal cortex and in the hippocampus following repeated stress:effects of pretreatment with saline or diazepam. Neurosci 77:65-73.
4. Blier P, Abbott FV. (2001). Putative mechanisms of action of antidepressant drugs in affective and anxiety disorders and pain. J Psychiatry Neurosci. 26:37-43.
5. Bonanno G, Giambelli R, Raiteri L, Tiraboschi E, Zappettini S, Musazzi L, Raiteri M, Racagni G, Popoli M. (2005) Chronic antidepressants reduce depolarization-evoked glutamate release and protein interactions favoring formation of SNARE complex in hippocampus. J Neurosci. 25(13):3270-3279.
6. Bremner JD et al. (1996) Noradrenergic mechanisms in stress and anxiety: I. preclinical studies. Synapse 23:28-38
7. Castren E (2004) Neurotrophins as Mediators of Drug Effects on Mood, Addiction, and Neuroprotection. Mol Neurobiol 29:289–301
8. Castro SL, Zigmond MJ (2001) Stress-induced increase in extracellular dopamine in striatum: role of glutamatergic action via N-methyl-D-aspartate receptors in substantia nigra. Brain Res 901:47-54.
9. Chen WG et al. (2003) Upstream stimulatory factors are mediators of Ca2+-responsive transcription in neurons. J Neurosci 23:2572-2581
10. Cirelli C, Tononi G (2000) Differential expression of plasticity-related genes in waking and sleep and their regulation by the noradrenergic system. J Neurosci 20:9187–9194
11. Cole BJ, Robbins TW. (1992) Forebrain norepinephrine: role in controlled information processing in the rat. Neuropsychopharmacol 7:129-42
12.Dazzi L et al. (2002) Chronic treatment with imipramine or mirtazapine antagonizes stress- and FG7142-induced increase in cortical norepinephrine output in freely moving rats. Synapse. 43:70-7
13. Dazzi L et al. (2003) Antagonism of the stress-induced increase in cortical norepinephrine output by the selective norepinephrine reuptake inhibitor reboxetine. Eur J Pharmacol. 476:55-61
14. Dias BG et al. (2003) Differential regulation of brain derived neurotrophic factor transcripts by antidepressant treatments in the adult rat brain. Neuropharmacology 45:553-563
15. Drevets WC et al. (1997) Subgenual prefrontal cortex abnormalities in mood disorders. Nature 386:824-827.
16. Duman RS (2000) Neuronal plasticity and survival in mood disorders. Biol Psychiatry 48:732–739
17. Enrico P et al. (1998) The role of afferents to the ventral tegmental area in the handling stress-induced in the release of dopamine in the medial prefrontal cortex: a dual-probe microdialysis study in the rat brain. Brain Res 779:205-213.
18. Fox K, Henley J, Isaac J (1999) Experience-dependent development of NMDA receptor transmission. Nature Neurosci 2:297-299.
19. Holm PC et al. (2003) Crucial role of TrkB ligands in the survival and phenotypic differentiation of developing locus coeruleus noradrenergic neurons. Development 130:3535-3545
20. Jacobs BL et al. (1991) Single-unit and physiological analyses of brain norepinephrine function in behaving animals. Prog Brain Res 88:159-65
21. Kim JJ et al. (1996) Behavioral stress modifies hippocampal plasticity through N-methyl-D-aspartate receptor activation. Proc Natl Acad Sci U S A 93:4750-4753.
22. Kole MH et al. (2002) The antidepressant tianeptine persistently modulates glutamate receptor currents of the hippocampal CA3 commissural associational synapse in chronically stressed rats. Eur J Neurosci 16:807-816.
23. Levine ES et al. (1998) Brain-derived neurotrophic factor modulates hippocampal synaptic transmission by increasing N-methyl-D-aspartic acid receptor activity. Proc Natl Acad Sci USA 95:10235-10239
24. Liu QR et al. (2005) Human brain derived neurotrophic factor (BDNF) genes, splicing patterns, and assessments of associations with substance abuse and Parkinson's Disease. Am J Med Genet B Neuropsychiatr Genet. 134:93-103
25. Lowy MT et al. (1995) Effect of acute stress on hippocampal glutamate levels and spectrin proteolysis in young and aged rats. J Neurochem 65:268-274.
26. Margotti E et al. (2002) TrkB signalling controls the developmental expression of NMDA receptors in the rat visual cortex. Eur J Neurosci 16:1067-1074
27. McQuade R et al. (1999). Effect of novel environmental stimuli on rat behaviour and central noradrenaline function measured by in vivo microdialysis. Psychopharmacol 145:393-400
28. Moghaddam B. (2002) Stress activation of glutamate neurotransmission in the prefrontal cortex: implications for dopamine-associated psychiatry disorders. Biol Psychiatry 51:775-787.
29. Monyer H et al. (1994) Developmental and regional expression in the rat brain and functional properties of four NMDA receptors. Neuron 12: 529-540.
30. Ninan PT. 1999. The functional anatomy, neurochemistry and pharmacology of anxiety. J Clin Psychiatry 60:12-7
31. Numan S et al. (1998) Differential regulation of neurotrophin and Trk receptor mRNAs in catecholaminergic nuclei during chronic opiate treatment and withdrawal. J Neurosci 18:10700–10708
32. O'brien CP. (2005). Benzodiazepine use, abuse, and dependence. J Clin Psychiatry. 66 (Suppl 2):28-33.
33. Pittaluga A, Feligioni M, Longordo F, Tiraboschi E, Tardito D, Racagni G, Popoli M, Raiteri M. Glutamatergic receptors and noradrenaline release as selective targets of antidepressant treatments (submitted)
34. Pittaluga A, Raiteri M. (1990). Release-enhancing glycine-dependent presynaptic NMDA receptors exist on noradrenergic terminals of hippocampus. Eur J Pharmacol 191:231-4
35. Pittaluga A, Raiteri M. (1992) N-methyl-D-aspartic acid (NMDA) and non-NMDA receptors regulating hippocampal norepinephrine release. III. Changes in the NMDA receptor complex induced by their functional cooperation. J Pharmacol Exp Ther 263:327-33
36. Raiteri L, Raiteri M (2000) Synaptosomes still viable after 25 years of superfusion. Neurochem Res 25:1265-1274.
37. Raiteri M et al. (1974) A simple apparatus for studying the release of neurotransmitters from synaptosomes. Eur J Pharmacol 25:411-414.
38. Rasmussen K, Jacobs B. (1986). Single Unit activity of locus coeruleus neurons in freely moving cat. -II. Conditioning and pharmacological studies. Brain Res 371:335-44
39. Rickels K, Rynn M. (2002) 63 (Suppl 14):9-16.
40. Robbins TW, Everitt BJ. (1995). Central norepinephrine neurons and behavior. In: Bloom FE, Kupfer DJ, editors. Psychopharmacology: The Fourth Generation of Progress. New York: Raven Press. p. 363-72
41. Rocher C et al. (2004) Acute stress-induced changes in hippocampal/prefrontal circuits in rats: effects of antidepressants. Cereb Cortex 14:224-229
42. Rosario L, Abercrombie ED. (1999) Brain Res Bull 48:595-602
43. Russo-Neustadt AA et al. (2000) Neuroscience. 101:305-12.
44. Sanacora G et al. (2004) Arch Gen Psychiatry 61:705-713.
45. Shakesby AC et al. (2002) J Neurosci 22:3638-3644.
46. Shelton RC, Brown LL. (2001). J Clin Psychiatry. (62 Suppl 12):10-5.
47. Skolnick P (1999) Eur J Pharmacol 375:31-40.
48. Tabuchi A et al. (2002) J Biol Chem 277:35920-35931
49. Tao X et al. (2002) Neuron 33:383-395
50. Timmusk T et al. (1993) Neuron 10:475-89
51. Tongiorgi E et al. (2004) BDNF mRNA and protein are targeted to discrete dendritic laminae by events that trigger epileptogenesis. J Neurosci 24:6842-6852
52. Tsai ES et al. (2002) Basal forebrain cholinergic cell attachment and neurite outgrowth on organotypic slice cultures of hippocampal formation. Neuroscience 115:815-827
53. Wang JK et al. (1992) Presynaptic glutamate receptors regulate noradrenaline release from isolated nerve terminals. J Neurochem. 58:204-11
54. Watanabe Y et al. (1992) Stress induces atrophy of apical dendrites of hippocampal CA3 pyramidal neurons. Brain Res 588:341

Parole Chiave

ANSIA; STRESS; ANTIDEPRESSIVO; RILASCIO DI NORADRENALINA; RILASCIO DI GLUTAMMATO; PROTEINE SNARE; RECETTORE NMDA; MICRODIALISI; DRUG DISCOVERY