RICERCA ITALIANA     

Programmi di ricerca simili:

• 1 - Medulloblastoma: studio delle vie molecolari di sviluppo e progressione tumorale allo scopo di identificare approcci terapeutici innovativi
• 2 - Cellule Staminali Cardiache Umane e loro potenziale rigenerativo
• 3 - Esocitosi in cellule neurosecernenti: dalla competenza alla regolazione
• 4 - Apoptosi e terapia del cancro: caratterizzazione di nuovi meccanismi e nuove molecole modulatrici dell'apoptosi
• 5 - Aspetti spaziotemporali nella fisiologia e patologia cellulare dei segnali mediati dai secondi messaggeri
• 6 - INTERRELAZIONI TRA LA PERMEABILITÀ IONICA DI MEMBRANA E LO STATO REDOX INTRACELLULARE NEI PROCESSI NEURODEGENERATIVI: AZIONE DEI PEPTIDI AMILOIDI IN CELLULE NEURONALI E GLIALI.
• 7 - Sviluppo di un sistema integrato AFM/MEA per la misura delle proprietà meccano-elettriche di cellule caridache e neuroni
• 8 - ANALISI DEI MECCANISMI DI SOPRAVVIVENZA CELLULARE DI EUCARIOTI MEDIANTE STRATEGIE DI PROTEOMICA
• 9 - I membri della famiglia del TNF nella modulazione del differenziamento cellulare e dell'attività antitumorale
• 10 - RUOLO DEL SEGNALE LIPIDICO NUCLEARE NEL PASSAGGIO G1/S DEL CICLO CELLULARE

Classificazione scientifico-disciplinare

• Area scientifico disciplinare: Scienze biologiche
  • FISIOLOGIA
  • BIOLOGIA MOLECOLARE
  • GENETICA

Classificazione brevettuale

• CHEMISTRY; METALLURGY
  • BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF (biocides, pest repellants or attractants, or plant growth regulators, containing micro-organisms, viruses, microbial fungi, enzymes, fermentates or substances produced by or extracted from micro-organisms or animal material A01N63/00; food compositions A21, A23; medicinal preparations A61K; chemical aspects of, or use of materials for, bandages, dressings, absorbent pads or surgical articles A61L; fertilisers C05); PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS (preservation of living parts of humans or animals A01N1/02); MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (micro-biological testing media C12Q)
• ELECTRICITY
  • BASIC ELECTRIC ELEMENTS
    • SEMICONDUCTOR DEVICES; ELECTRIC SOLID STATE DEVICES NOT OTHERWISE PROVIDED FOR (use of semiconductor devices for measuring G01; details of scanning-probe apparatus, in general G12B21/00; resistors in general H01C; magnets, inductors, transformers H01F; capacitors in general H01G; electrolytic devices H01G9/00; batteries, accumulators H01M; waveguides, resonators or lines of the waveguide type H01P; line connectors, current collectors H01R; stimulated emission devices H01S; electromechanical resonators H03H; loudspeakers, microphones, gramophone pick-ups or like acoustic electromechanical transducers H04R; electric light sources in general H05B; printed circuits, hybrid circuits, casings or constructional details of electric apparatus, manufacture of assemblages of electrical components H05K; use of semiconductor devices in circuits having a particular application, see the subclass for the application) [C0103]

Classificazione geografica

• Regione: Veneto

Bibliografia

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De Bruin K.A., Krassowska W. (1999) Modeling electroporation in a single cell. I. effects of field strength and rest potential. Biophys. J. 77:1213-1224

Esteban J.A., Shi S.H., Wilson C., Nuriya M., Huganir R.L., Malinow R. (2003) PKA phosphorylation of AMPA receptor subunits controls synaptic trafficking underlying plasticity. Nat Neurosci. 6:136-143

Goraya T.A., Cooper D.M. (2005) Ca(2+)-calmodulin-dependent phosphodiesterase (PDE1): Current perspectives.Cell Signal. 17:789-97

Gross G.W, Rieske E., Kreutzberg G.W., Meyer A. (1997) A new fixed-array multi-microelectrode system designed for long-term monitoring of extracellular single unit neuronal activity in vitro. Neurosci. Lett. 6:101-106

Guo-qiangBi and Mu-mingPoo. Synaptic Modifications in Cultured Hippocampal Neurons: Dependence on SpikeTiming ,Synaptic Strength, and Postsynaptic Cell Type. J. Neurosci. 1998,15, 18(24):10464–10472

Hui-zhong W.Tao, LiI.Zhang, Guo-qiang Bi,and Mu-ming Poo. (2000) Selective Presynaptic Propagation of Long-term Potentiation in Defined Neural Networks. J. Neurosci.20:3233–3243

Kandel E.R. (2001) The molecular biology of memory storage: a dialogue between genes and synapses. Science 294:1030-1038

Jimbo Y and Kawana A. (1992) Electrical stimulation and recording from cultured neurones using a planar electrode array. Bioelectrochem and Bioenergetics 29, 193-204

Laporte S.A., Oakley R.H., Caron M.G. (2001) Bringing Channels Closer to the Action! Science 2001 293:62-63

Miyawaki A., Llopis J., Heim R., McCaffery J.M., Adams J.A., Ikura M., Tsien R.Y. (1997) Fluorescent indicators for Ca2+ based on green fluorescent proteins and calmodulin. Nature 388:882-7

Mongillo M., McSorley T., Evellin S., Sood A., Lissandron V., Terrin A., Huston E., Hannawacker A., Lohse M.J., Pozzan T., Houslay M.D., Zaccolo M. (2004) Fluorescence resonance energy transfer-based analysis of cAMP dynamics in live neonatal rat cardiac myocytes reveals distinct functions of compartmentalized phosphodiesterases. Circ Res. 95:67-75

Neumann E., Kakorin S., Toensing K. (1999) Fundamentals of electroporative delivery of drugs and genes. Bioelectrochemistry and Bioenergetics 48:3-16

Pokorska A., Vanhoutte P., Arnold F.J., Silvagno F., Hardingham G.E., Bading H. (2003) Synaptic activity induces signalling to CREB without increasing global levels of cAMP in hippocampal neurons. J Neurochem. 84:447-52

Ryttsén F., Farre C., Brennan C., Weber S.G., Nolkrantz K., Jardemark K., Chiu D.T., Orwar O. (2000) Characterization of single-cell electroporation by using patc-clamp and fluorescence microscopy. Biophys. J. 79:1993-2001

Shaner N.C., Campbell R.E., Steinbach P.A., Giepmans B.N., Palmer A.E., Tsien R.Y. (2004) Improved monomeric red, orange and yellow fluorescent proteins derived from Discosoma sp. red fluorescent protein. Nat Biotechnol. 22 :1567-72

Vassanelli S., Bandiera L., Borgo M., Cellere G. (2004) Biochip Electroporator and its use in multi-site, single-cell electroporation. PCT Patent submitted

Vassanelli S., Fromherz P. (1998) Transistors Records of Excitable Neurons from Rat Brain. Applied Physics. 66:459-463

Voelker M. and Fromherz P. (2005) Signal Transmission from Individual Mammalian Nerve Cell to Field-Effect Transistor. Small 1:206-210

Wallrapp F., Vassanelli S., Vainonen-Ahlgren E., Fromherz P. "High-K Materials on Silicon for Stimulation of Nerve Cells", Polar Oxides: Properties, Characterization and Imaging, Symposium, Capri, Italy, June 8th - 11th , 2003

Weaver J.C. (1993) Electroporation: a general phenomenon for manipulating cells and tissues. J Cell Biochem. 51:426-35.

Wong W. and Scott J.D. AKAP signalling complexes: focal points in space and time. (2004) Nat Rev Mol Cell Biol. 5:959-70

Xia Z. and Storm D.R. (2005) The role of calmodulin as a signal integrator for synaptic plasticity. Nat Rev Neurosci. 6:267-76.

Zaccolo M., De Giorgi F., Cho Charles Y., Feng L., Knapp T,. Negulescu P.A,. Taylor S.S., Tsien R.Y. and Pozzan T. (2000) A genetically encoded, fluorescent indicator for cyclic AMP in living cells. Nature Cell Biology 2: 25-29

Zaccolo M., Pozzan T. (2002) Discrete microdomains with high concentration of cAMP in stimulated rat neonatal cardiac myocytes. Science. 295:1711-5.

Zhang J., Campbell R.E., Ting A.Y., Tsien R.Y. (2002) Creating new fluorescent probes for cell biology. Nat Rev Mol Cell Biol.3:906-18.

Parole Chiave

PLASTICITÀ SINAPTICA; IMAGING; ELETTROPORAZIONE DI SINGOLA CELLULA; AMP CICLICO; CALCIO