RICERCA ITALIANA     

Programmi di ricerca simili:

• 1 - Dalla rigenerazione alla ricostruzione del muscolo scheletrico: meccanismi regolatori e applicazioni terapeutiche
• 2 - Genomica funzionale e modulazione dell'espressione delle proteine di membrana nelle miopatie primitive
• 3 - Meccanismi molecolari funzionali nella patogenesi delle miopatie primitive: verso nuovi approcci prognostici e terapeutici
• 4 - Caratterizzazione dei meccanismi molecolari e cellulari della sarcopenia.
• 5 - Ruolo della miostatina nella atrofia muscolare nei cani. Studio patogenetico e basi per lo sviluppo di approcci terapeutici
• 6 - Patogenesi molecolare delle malattie del motoneurone come tool per l’identificazione di nuovi approcci terapeutici biomolecolari e cellulari
• 7 - Meccanismi di regolazione della plasticità del muscolo scheletrico
• 8 - DISTROFIA MIOTONICA DI TIPO 1 E 2: DALLA PATOGENESI ALLO SVILUPPO DI PROTOCOLLI DI TERAPIA GENICA INNOVATIVI
• 9 - Meccanismi cellulari e molecolari coinvolti nel rimodellamento muscolare indotto da elettrostimolazione in soggetti giovani ed anziani.
• 10 - Segnali e dialogo fra cellule neuronali, gliali e muscolari nella sclerosi laterale amiotrofica

Classificazione scientifico-disciplinare

• Area scientifico disciplinare: Scienze biologiche
  • FISIOLOGIA
  • BIOLOGIA APPLICATA
  • ISTOLOGIA

Classificazione brevettuale

• CHEMISTRY; METALLURGY
  • BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF (biocides, pest repellants or attractants, or plant growth regulators, containing micro-organisms, viruses, microbial fungi, enzymes, fermentates or substances produced by or extracted from micro-organisms or animal material A01N63/00; food compositions A21, A23; medicinal preparations A61K; chemical aspects of, or use of materials for, bandages, dressings, absorbent pads or surgical articles A61L; fertilisers C05); PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS (preservation of living parts of humans or animals A01N1/02); MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (micro-biological testing media C12Q)
• HUMAN NECESSITIES
  • AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
  • MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES (bringing into special physical form A61J [N: mechanical aspects]; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; compounds per se C01, C07, C08, C12N; soap compositions C11D; micro-organisms per se C12N) [C0203]

Classificazione geografica

• Regione: Lazio

Bibliografia

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2. Blake, D.J., Weir, A., Newey, S.E., and Davies, K.E. (2002). Function and genetics of dystrophin and dystrophin-related proteins in muscle. Physiol Rev 82, 291-329.
3. Watchko, J.F., O'Day, T.L., and Hoffman, E.P. (2002). Functional characteristics of dystrophic skeletal muscle: insights from animal models. J Appl Physiol 93, 407-417.
4. Sampaolesi, M., Torrente, Y., Innocenzi, A., Tonlorenzi, R., D'Antona, G., Pellegrino, M.A., Barresi, R., Bresolin, N., De Angelis, M.G., Campbell, K.P., Bottinelli, R., and Cossu, G. (2003). Cell therapy of alpha-sarcoglycan null dystrophic mice through intra-arterial delivery of mesoangioblasts. Science 301, 487-492.
5. Cossu, G., and Bianco, P. (2003). Mesoangioblasts -- vascular progenitors for extravascular mesodermal tissues. Current Opinion in Genetics & Development 13, 537-542.
6. De Angelis, L., Berghella, L., Coletta, M., Cusella De Angelis, M.G., Lattanzi, L., Ponzetto, C., and Cossu, G. (1999). Skeletal myogenic progenitors originating from embryonic dorsal aorta co-express endothelial and myogenic markers and contribute to post-natal muscle growth and regeneration. Journal of Cell Biology 147, 869-878.
7. Minasi, M.G., Riminucci, M., De Angelis, L., Borello, U., Berarducci, B., Innocenzi, A., Caprioli, A., Sirabella, D., Baiocchi, M., De Maria, R., Boratto, R., Jaffredo, T., Broccoli, V., Bianco, P., and Cossu, G. (2002). The meso-angioblast: a multipotent, self-renewing cell that originates from the dorsal aorta and differentiates into most mesodermal tissues. Development 129, 2773-2783.
8. Wijmenga, C., Hewitt, J.E., Sandkuijl, L.A., Clark, L.N., Wright, T.J., Dauwerse, H.G., Gruter, A.M., Hofker, M.H., Moerer, P., Williamson, R., and et al. (1992). Chromosome 4q DNA rearrangements associated with facioscapulohumeral muscular dystrophy. Nat Genet 2, 26-30.
9. Wijmenga, C., Frants, R.R., Brouwer, O.F., Moerer, P., Weber, J.L., and Padberg, G.W. (1990). Location of facioscapulohumeral muscular dystrophy gene on chromosome 4. Lancet 336, 651-653.
10. van Geel, M., Dickson, M.C., Beck, A.F., Bolland, D.J., Frants, R.R., van der Maarel, S.M., de Jong, P.J., and Hewitt, J.E. (2002). Genomic analysis of human chromosome 10q and 4q telomeres suggests a common origin. Genomics 79, 210-217.
11. Meneveri, R., Agresti, A., Della Valle, G., Talarico, D., Siccardi, A.G., and Ginelli, E. (1985). Identification of a human clustered G + C-rich DNA family of repeats (Sau3A family). J Mol Biol 186, 483-489.
12. van Deutekom, J.C., Wijmenga, C., van Tienhoven, E.A., Gruter, A.M., Hewitt, J.E., Padberg, G.W., van Ommen, G.J., Hofker, M.H., and Frants, R.R. (1993). FSHD associated DNA rearrangements are due to deletions of integral copies of a 3.2 kb tandemly repeated unit. Hum Mol Genet 2, 2037-2042.
13. Lemmers, R.J., de Kievit, P., Sandkuijl, L., Padberg, G.W., van Ommen, G.J., Frants, R.R., and van der Maarel, S.M. (2002). Facioscapulohumeral muscular dystrophy is uniquely associated with one of the two variants of the 4q subtelomere. Nat Genet 32, 235-236.
14. Kissel, J.T. (1999). Facioscapulohumeral dystrophy. Semin Neurol 19, 35-43.
15. Winokur, S.T., Chen, Y.W., Masny, P.S., Martin, J.H., Ehmsen, J.T., Tapscott, S.J., van der Maarel, S.M., Hayashi, Y., and Flanigan, K.M. (2003). Expression profiling of FSHD muscle supports a defect in specific stages of myogenic differentiation. Hum Mol Genet 12, 2895-2907.
16. Gabellini, D., Green, M.R., and Tupler, R. (2002). Inappropriate gene activation in FSHD: a repressor complex binds a chromosomal repeat deleted in dystrophic muscle. Cell 110, 339-348.
17. Bickmore, W.A., and van der Maarel, S.M. (2003). Perturbations of chromatin structure in human genetic disease: recent advances. Hum Mol Genet 12 Spec No 2, R207-213.
18. Kurz, A., Lampel, S., Nickolenko, J.E., Bradl, J., Benner, A., Zirbel, R.M., Cremer, T., and Lichter, P. (1996). Active and inactive genes localize preferentially in the periphery of chromosome territories. J Cell Biol 135, 1195-1205.
19. Marshall, W.F. (2003). Gene expression and nuclear architecture during development and differentiation. Mech Dev 120, 1217-1230.
20. Mattout-Drubezki, A., and Gruenbaum, Y. (2003). Dynamic interactions of nuclear lamina proteins with chromatin and transcriptional machinery. Cell Mol Life Sci 60, 2053-2063.
21. Ostlund, C., and Worman, H.J. (2003). Nuclear envelope proteins and neuromuscular diseases. Muscle Nerve 27, 393-406.
22. Wilson, K.L. (2000). The nuclear envelope, muscular dystrophy and gene expression. Trends Cell Biol 10, 125-129.
23. Burke, B., and Stewart, C.L. (2002). Life at the edge: the nuclear envelope and human disease. Nat Rev Mol Cell Biol 3, 575-585.
24. Allamand, V., and Campbell, K.P. (2000). Animal models for muscular dystrophy: valuable tools for the development of therapies. Hum Mol Genet 9, 2459-2467.
25. Tews, D.S. (2002). Apoptosis and muscle fibre loss in neuromuscular disorders. Neuromuscul Disord 12, 613-622.
26. Mars, T., King, M.P., Miranda, A.F., Walker, W.F., Mis, K., and Grubic, Z. (2003). Functional innervation of cultured human skeletal muscle proceeds by two modes with regard to agrin effects. Neuroscience 118, 87-97.
27. Dorchies, O.M., Laporte, J., Wagner, S., Hindelang, C., Warter, J.M., Mandel, J.L., and Poindron, P. (2001). Normal innervation and differentiation of X-linked myotubular myopathy muscle cells in a nerve-muscle coculture system. Neuromuscul Disord 11, 736-746.
28. Wagner, S., Dorchies, O.M., Stoeckel, H., Warter, J.M., Poindron, P., and Takeda, K. (2003). Functional maturation of nicotinic acetylcholine receptors as an indicator of murine muscular differentiation in a new nerve-muscle co-culture system. Pflugers Arch 447, 14-22.

Parole Chiave

DISTROFIA MUSCOLARE; RIGENERAZIONE MUSCOLARE; CELLULE SATELLITI; CELLULE STAMINALI DEL MESODERMA