RICERCA ITALIANA     

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Classificazione scientifico-disciplinare

• Area scientifico disciplinare: Scienze mediche
  • GENETICA MEDICA
  • REUMATOLOGIA

Classificazione brevettuale

• CHEMISTRY; METALLURGY
  • BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS (immunoassay G01N33/53); COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
• HUMAN NECESSITIES
  • MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES (bringing into special physical form A61J [N: mechanical aspects]; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; compounds per se C01, C07, C08, C12N; soap compositions C11D; micro-organisms per se C12N) [C0203]

Classificazione geografica

• Regione: Lazio

Bibliografia

Bongi SM, Porfirio B, Rombola G, Palasciano A, Beneforti E, Bianucci G. Shared-epitope HLA-DRB1 alleles and sex ratio in Italian patients with rheumatoid arthritis. Joint Bone Spine. 2004 Jan;71(1):24-8.

Clark AG, Jordan JM, Vilim V, Dragomir AD, Luta G, Kraus VB. Serum cartilage oligomeric matrix protein reflects osteoarthritis presence and severity. Arthr Reum 1999, 42: 2356-2364.


Forslind K, Eberhardt k, Jonsson A, Saxne T. Inceased serum concentrations of cartilage oligomeric matrix protein. A prognostic marker in early rheumatoid arthritis. Br J Rheumatol 1992, 31: 593-598.

Huizinga T. Genetics in rheumatoid arthritis. Curr Rheumatol Rep. 2002 Jun;4(3):195-200.

MacGregor AJ, Snieder H, Rigby AS, Koskenvuo M, Kaprio J, Aho K, Silman AJ. Characterizing the quantitative genetic contribution to rheumatoid arthritis using data from twins. Arthritis Rheum. 2000 Jan;43(1):30-7.

Mansson B, Carey D, Alini M, Ionescu M, Rosemberg LC, Poole AR, Heinegard D, Saxne T. Cartilage and bone metabolism in rheumatoid arthritis. Differences between rapid and slow progression of disease identified by serum markers of cartilage metabolism. J Clin Invest 1995, 95: 1071-1077.

Mannson B, Geborek P, Saxne T. Cartilage and bone macromolecules in knee joint synovial fluid in rheumatoid arthritis: relation to development of knee or hip joint destruction. Ann Rheum Dis 1997, 56: 21-96.

Marti C, Neihart M, Gerber T, Hauser N, Michel BA, Hauselmann HJ. Cartilage Oligomerix matrix Protein (COMP): Die Rolle eines nichtkollagenen Knorpel-Matrix-Proteins als Marker der Krankenheitsaktivitat und Gelenkzerstorung bei Patienten mit rheumatoider Arthritis und Arthrose. Z Rheumatol 1999, 58: 79-87.

Neidhart M, Hauser N, Paulsson M, DiCesare PE, Michel BA, Hauselmann HJ. Small fragments of cartilage oligomeric matrix protein insynovial fluid and serum as markers for cartilage degradation. BR J Rheumatol 1997, 36: 1151-1160

Petersson IF, Boegard T, Svensson B, Heinegard D, Saxne T. Changes in cartilage and bone metabolism identified by serum markers in early osteoarthritis of the knee joint. Br J Rheumatol 1998, 37: 46-50.

Recklies AD, Baillargeon L, White C. Regulation of cartilage oligomeric matrix protein synthesis in human synovial cells and articular chondrocytes. Arthritis Rheum 1998, 41: 997-1006.
Seldin MF, Amos CI, Ward R, Gregersen PK. The genetics revolution and the assault on rheumatoid arthritis. Arthritis Rheum 1999; 42: 1071-9.
Silman AJ, Pearson JE. Epidemiology and genetics of rheumatoid arthritis. Arthritis Res. 2002;4 Suppl 3:S265-72.

Vos K, Visser H, Schreuder GM, de Vries RR, Zwinderman AH, Breedveld FC, Hazes JM, Zanelli EH. Human leukocyte antigen-DQ and DR polymorphisms predict rheumatoid arthritis outcome better than DR alone. Hum Immunol. 2001 Nov;62(11):1217-25.


- Alessandri C, Bombardieri M, Del Papa N, Cinquini M, Magrini L, Tincani A, Valesini G Decrease of anti-cyclic citrullinated peptide antibodies and rheumatoid factor following anti-TNF therapy (infliximzb) in rheumatoid arthritis is associated with clinical improvement.
Ann. Rhaum Dis 63: 1218-21; 2004

- Kroot EJ, De Jong BA, Van Leeuwed MA, Swnkels H, Van den Hoogen FH, Van't Hof MA, Van de Putte LB, Van Rijswijk MH, Van Venrooij WJ & Van Riel PL: The prognostic value of anti cyclic citrullinated peptide antibody in patients with recent-onset rheumatoid arthritis. Arthritis Rheum 2000, 43: 1831-1835.

- Lugering A, Schmidt M, Lugering N, Pauels HG, Domschke W, Kucharzik T. Infliximab induces apoptosis in monocytes from patients with chronic active Crohn's disease by using a caspase-dependent pathway. Gastroenterology 2001;121:1145-57

- Masson-Bessière C, Sebbag M, Durieux JJ, Nogueira L, Vincent C, Girbal-Neuhauser E, Durroux R, Cantagrel A & Serre G : In the rheumatoid pannus, anti-filaggrin autoantibodies are produced by local plasma cells and constitute a higher proportion of IgG
than in synovial fluid and serum. Clin Exp Immunol 2000, 119: 544-552.

- Masson-Bessière C, Sebbag M Girbal-Neuhauser E, Nogueira L, Vincent C, Senshu T & Serre G: The major synovial targets of the rheumatoid arthritis-specific antifilaggrin autoantibodies are deiminated forms of the a- and b-chains of fibrin. J Immunol 2001, 166:4177-4184.

- Nielen MMJ, Van Schaardenburg D, Reesink HWR, Van de Stadt RJ, Schellekens GA, Visser
H, de Jong BAW, van den Hoogen FHJ, Hazes JMW, Breedveld FC, van Venrooij WJ: The diagnostic properties of rheumatoid arthritis antibodies recognizing a cyclic citrullinated peptide. Arthritis Rheum 2000, 43:155-163

- Reparon-Schuijt CC, van Esch WJE, van Kooten C, Schellekens GA, de Jong BAW, von Venrooij WJ, Breedveld FC, Verweij CL: Secretion of anti-citrulline-containing peptide antibody by B lymphocytes in rheumatoid arthritis.
Arthritis Rheum 2001, 44:41-47

- Schellekens GA, de Jong BAW, van den Hoogen FHJ, van de Putte LBA: Citrulline is an essential constituent of antigenic determinants recognized by rheumatoid arthritis-specific autoantibodies. J Clin Invest 1998, 101:273-281.

- Schellekens GA, Visser H, de Jong BAW, van den Hoogen FHJ, Hazes JMW, Breedveld FC, van Venrooij WJ: The diagnostic properties of rheumatoid arthritis antibodies recognizing a cyclic citrullinated peptide. Arthritis Rheum 2000, 43:155-163

- Shiozawa S, Hayashi S, Tsukamoto Y, Goko H, Kawasaki H, Wada T, Shimizu K, Yasuda N, Kamatani N, Takasugi K, Tanaka Y, Shiozawa K & Imura S: Identification of the gene loci that predispose to rheumatoid arthritis. Int Immunol 1998, 10: 1891-1895.

- Suzuki A, Yamada R, Chang X, Tokuhiro S, Sawada T, Suzuki M, Nagasaki M.,Nakajama-Hamada M, Kawaida R, Ono M, Ohtsuki M, Furukawa H, Yoshino S, Yukioka M, Tohma S, Matsubara T, Wakitani S, Teshima R, Nishioka Y, Sekine A, Iida A, Takahashi A, Tsunoda T, Nakamura Y & Yamamoto K: Functional haplotypes of PAD14, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritits. Nat Genet 2003, 34: 395-402.


- Vossenaar ER, Smeets TMJ, Kraan MC , Raats JM, van Venrooij WJ, Tak PP The Presence of Citrullinated Proteins Is Not Specific for Rheumatoid Synovial Tissue. Arthr. Rheum. 2004b; 50: 3485-3494

Parole Chiave

REUMATOLOGIA; ARTRITE REUMATOIDE; AUTOANTICORPI; FATTORI REUMATOIDI; ANTI-CCP; COMP; GENI; HLA; APOPTOSI