RICERCA ITALIANA     

Programmi di ricerca simili:

• 1 - Problemi emergenti di antibiotico-resistenza e virulenza in batteri patogeni Gram-positivi e Gram-negativi.
• 2 - Geni di resistenza nei microrganismi patogeni Gram-positivi e Gram-negativi: caratterizzazione molecolare, funzionale e loro trasferimento orizzontale.
• 3 - Meccanismi molecolari di attività antimicrobica e di resistenza in microrganismi gram positivi
• 4 - Meccanismi molecolari ed effetti biologici della resistenza agli antibiotici in cocchi e bacilli Gram-positivi
• 5 - STUDIO DEI MECCANISMI MOLECOLARI DI ATTIVITA'/RESISTENZA DI SOSTANZE ANTIMICROBICHE
• 6 - Basi genetiche e fisiologiche della resistenza a peronospora nella vite (Vitis spp.)
• 7 - Variabilità genetica e analisi funzionale di ceppi di Streptococcus thermophilus di interesse industriale
• 8 - La resistenza agli antiparassitari in Artropodi di interesse agrario: studi su diffusione, meccanismi e basi genetico-molecolari
• 9 - PATOGENESI E TERAPIA DELLE MALATTIE DA INFEZIONE
• 10 - Una visione d'insieme sullo studio dei determinanti di resistenza e virulenza in batteri patogeni isolati in nosocomio ed in strutture extra-ospedaliere.

Classificazione scientifico-disciplinare

• Area scientifico disciplinare: Scienze mediche
  • MICROBIOLOGIA E MICROBIOLOGIA CLINICA

Classificazione brevettuale

• CHEMISTRY; METALLURGY
  • BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS (immunoassay G01N33/53); COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF (biocides, pest repellants or attractants, or plant growth regulators, containing micro-organisms, viruses, microbial fungi, enzymes, fermentates or substances produced by or extracted from micro-organisms or animal material A01N63/00; food compositions A21, A23; medicinal preparations A61K; chemical aspects of, or use of materials for, bandages, dressings, absorbent pads or surgical articles A61L; fertilisers C05); PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS (preservation of living parts of humans or animals A01N1/02); MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (micro-biological testing media C12Q)

Classificazione geografica

• Regione: Marche

Bibliografia

1. Hacker J, Carniel E. 2001. Ecological fitness, genomic islands and bacterial pathogenicity. A Darwinian view of the evolution of microbes. EMBO Rep 2:376-81.
2. Dobrindt U, Hochhut B, Hentschel U, Hacker J. 2004. Genomic islands in pathogenic and environmental microorganisms. Nat Rev Microbiol 2:414-24.
3. Lipsitch M. 2001. Bacterial population genetics and disease. Science 292:59-60.
4. Brüssow H, Canchaya C, Hardt CW. 2004. Phages and the evolution of bacterial pathogens: from genomic rearrangements to lysogenic conversion. Microbiol Mol Biol Rev 68:560-602.
5. Canchaya C, Fournous G, Brüssow H. 2004. The impact of prophages on bacterial chromosomes. Mol Microbiol 53:9-18.
6. Banks DJ, Beres SB, Musser JM. 2002. The fundamental contribution of phages to GAS evolution, genome diversification and strain emergence. Trends Microbiol 10:515-21.
7. Cunningham MW. 2000. Pathogenesis of group A streptococcal infections. Clin Microbiol Rev 13:470-511.
8. Facinelli B, Spinaci C, Magi G, Giovanetti E, Varaldo PE. 2001. Association between erythromycin resistance and ability to enter human respiratory cells in group A streptococci. Lancet 358:30-3.
9. Leclercq R. 2002. Mechanisms of resistance to macrolides and lincosamides: nature of the resistance elements and their clinical implications. Clin Infect Dis 34:482-92.
10. Santagati M, Iannelli F, Oggioni MR, Stefani S, Pozzi G. 2000. Characterization of a genetic element carrying the macrolide efflux gene mef(A) in Streptococcus pneumoniae. Antimicrob Agents Chemother 44:2585-7.
11. Gay K, Stephens DS. 2001. Structure and dissemination of a chromosomal insertion element encoding macrolide efflux in Streptococcus pneumoniae. J Infect Dis 184:56-65.
12. Del Grosso M, Iannelli F, Messina C, Santagati M, Petrosillo N, Stefani S, Pozzi G, Pantosti A. 2002. Macrolide efflux genes mef(A) and mef(E) are carried by different genetic elements in Streptococcus pneumoniae. J Clin Microbiol 40:774-8.
13. Montanari MP, Mingoia M, Cochetti I, Varaldo PE. 2003. Phenotypes and genotypes of erythromycin-resistant pneumocicci in Italy. J Clin Microbiol 41:428-31.
14. Giovanetti E, Brenciani A, Lupidi R, Roberts MC, Varaldo PE. 2003. Presence of the tet(O) gene in erythromycin- and tetracycline-resistant strains of Streptococcus pyogenes and linkage with either the mef(A) or the erm(A) gene. Antimicrob Agents Chemother 47:1935-40.
15. Brenciani A, Ojo KK, Monachetti A, Menzo S, Roberts MC, Varaldo PE, Giovanetti E. 2004. Distribution and molecular analysis of mef(A)-containing elements in tetracycline-susceptible and resistant Streptococcus pyogenes clinical isolates with efflux-mediated erythromycin resistance. J Antimicrob Chemother 54:991-8.
16. Santagati M, Iannelli F, Cascone C, Campanile F, Oggioni MR, Stefani S, Pozzi G. 2003. The novel conjugative transposon Tn1207.3 carries the macrolide efflux gene mef(A) in Streptococcus pyogenes. Microb Drug Resist 9:243-7.
17. Banks DJ, Porcella SF, Barbian KD, Martin JM, Musser JM. 2003. Structure and distribution of an unusual chimeric genetic element encoding macrolide resistance in phylogenetically diverse clones of group A Streptococcus. J Infect Dis 188:1898-908.
18. Montanari MP, Cochetti I, Mingoia M, Varaldo PE. 2003. Phenotypic and molecular characterization of tetracycline- and erythromycin-resistant strains of Streptococcus pneumoniae. Antimicrob Agents Chemother 47:2236-41.
19. Del Grosso M, Scotto d'Abusco A, Iannelli F , Pozzi G, Pantosti A. 2004. Tn2009, a Tn916-like element containing mef(E) in Streptococcus pneumoniae. Antimicrob Agents Chemother 48:2037-42.
20. Giovanetti E, Brenciani A, Vecchi M, Manzin A, Varaldo PE. 2005. Prophage association of mef(A) elements encoding efflux-mediated erythromycin resistance in Streptococcus pyogenes. J Antimicrob Chemother 55:445-51.
21. Moellering RC Jr. 2003. Community-acquired methicillin-resistant Staphylococcus aureus: no longer confined to the inpatient arena. Infect Dis Spec Ed 6:63-67.
22. Deresinski S. 2005. Methicillin-resistant Staphylococcus aureus: an evolutionary, epidemiologic, and therapeutic odyssey. Clin Infect Dis 40:562–73.
23. Frère JM. 1995. beta-Lactamases and bacterial resistance to antibiotics. Mol Microbiol 16:385-95.
24. Bush K, Jacoby GA, Medeiros AA. 1995. A functional classification scheme for beta-lactamases and its correlation with molecular structure. Antimicrob Agents Chemtoher 39:1211-33.
25. Bush K. 1998. Metallo-beta-lactamases: a class apart. Clin Infect Dis 27 Suppl 1:S48-S53.
26. Bonnet R. 2004. Growing group of extended-spectrum beta-lactamases: the CTX-M enzymes. Antimicrob Agents Chemtoher 48:1-14.
27. Rossolini GM, Riccio ML, Cornaglia G, Pagani L, Lagatolla C, Selan L, Fontana R. 2000. Carbapenem-resistant Pseudomonas aeruginosa with acquired blaVIM metallo-beta-lactamase determinants, Italy. Emerg Infect Dis 6:312-3.
28. Riccio ML, Pallecchi L, Docquier JD, Cresti S, Catania MR, Pagani L, Lagatolla C, Cornaglia G, Fontana R, Rossolini GM. 2005. Clonal relatedness and conserved integron structures in epidemiologically unrelated Pseudomonas aeruginosa strains producing the VIM-1 metallo-beta-lactamase from different Italian hospitals. Antimicrob Agents Chemother 49:104-10.
29. Alvarez M, Tran JH, Chow N, Jacoby GA. 2004. Epidemiology of conjugative plasmid-mediated AmpC beta-lactamases in the United States. Antimicrob Agents Chemother 48:533-7.
30. Bou G, Oliver A, Martinez-Beltran J. 2000. OXA-24, a novel class D beta-lactamase with carbapenemase activity in an Acinetobacter baumannii clinical strain. Antimicrob Agents Chemtoher 44:1556-61.
31. Poirel L, Heritier C, Tolun V, Nordmann P. 2004. Emergence of oxacillinase-mediated resistance to imipenem in Klebsiella pneumoniae. Antimicrob Agents Chemtoher 48:15-22.
32. Recchia GD, Hall RM. 1995. Gene cassettes: a new class of mobile element. Microbiology 141:3015-27.
33. Riccio ML, Franceschini N, Boschi L, Caravelli B, Cornaglia G, Fontana R, Amicosante G, Rossolini GM. 2000. Characterization of the metallo-β-lactamase determinant of Acinetobacter baumannii AC-54/97 reveals the existence of blaIMP allelic variants carried by gene cassettes of different phylogeny. Antimicrob Agents Chemother 44:1229-35.
34. Zarrilli R, Crispino M, Bagattini M, Barretta E, Di Popolo A, Triassi M, Villari P. 2004. Molecular epidemiology of sequential outbreaks of Acinetobacter baumannii in an intensive care unit shows the emergence of carbapenem resistance. J Clin Microbiol 42:946-53.
35. Gombac F, Riccio ML, Rossolini GM, Lagatolla C, Tonin E, Monti-Bragadin C, Lavenia A, Dolzani L. 2002. Molecular characterization of integrons in epidemiologically unrelated clinical isolates of Acinetobacter baumannii from Italian hospitals reveals a limited diversity of gene cassette arrays. Antimicrob Agents Chemother 46:3665-8.
36. Nemec A, Dolzani L, Brisse S, van den Broek P, Dijkshoorn L 2004. Diversity of aminoglycoside resistance genes and their association with class 1 integrons among strains of pan-European A. baumannii clones. J Med Microbiol 531:233-40.
37. van Dessel H, Dijkshoorn L, van der Reijden T, Bakker N, Paauw A, van den Broek P, Verhoef J, Brisse S. 2004. Identification of a new geographically widespread multiresistant Acinetobacter baumannii clone from European hospitals. Res Microbiol 155:105-12.
38. Spence RP, van der Reijden TJ, Dijkshoorn L, Towner KJ. 2004. Comparison of Acinetobacter baumannii isolates from United Kingdom hospitals with predominant Northern European genotypes by amplified-fragment length polymorphism analysis. J Clin Microbiol 42:832-4.
39. EARSS (European Antimicrobial Resistance Surveillance System). 2004. EARSS report 2004. RIVM, Bilthoven, The Netherlands.
40. Tran JH, Jacoby GA. 2002. Mechanism of plasmid-mediated quinolone resistance. PNAS 99:5638-42.
41. Poole K. 2001. Multidrug efflux pumps and antimicrobial resistance in Pseudomonas aeruginosa and related organisms. J Mol Microbiol Biotechnol 3:255-64.

Parole Chiave

MICROBIOLOGIA; PATOGENI GRAM-POSITIVI; PATOGENI GRAM-NEGATIVI; ANTIBIOTICO-RESISTENZA; VIRULENZA; FITNESS BATTERICA; INFEZIONI COMUNITARIE E OSPEDALIERE; β -LATTAMASI; ELEMENTI GENETICI MOBILI