RICERCA ITALIANA     

Programmi di ricerca simili:

• 1 - Ruolo della sfingosina-1-fosfato nell'infiammazione e nella iperresponsività delle vie aeree.
• 2 - RUOLO DEI RECETTORI ATTIVATI DALLE PROTEASI (PAR)- 1 e 2 NELL'INFIAMMAZIONE ED IN PROCESSI FIBROTICI AD ESSA CORRELATI.
• 3 - INTERAZIONI TRA I RECETTORI ATTIVATI DALLE PROTEASI (PAR-1 e PAR-2) ED I RECETTORI TOLL (TLR2 e TLR4) NELL'INFIAMMAZIONE POLMONARE: UN' ANALISI MOLECOLARE E FUNZIONALE
• 4 - CONTROLLO DEL CICLO CELLULARE DA LIGANDI DI RECETTORI NUCLEARI
• 5 - Ruolo degli endocannabinoidi nel differenziamento megacariocitico e nella funzionalità piastrinica
• 6 - RUOLO DEI MECCANISMI DI SEGNALE CELLULARE E DELLE SPECIE REATTIVE DELL'OSSIGENO E DELL'AZOTO NELL'INVECCHIAMENTO CELLULARE E NELLA CRESCITA NEOPLASTICA.
• 7 - Meccanismi di suscettibilità e di attivazione delle risposte tissutali e cellulari indotte dall'antigene nell'asma
• 8 - Le basi molecolari dell'insulino-resistenza e la loro rilevanza nella patogenesi delle alterazioni della parete vascolare.
• 9 - L'apoptosi nei processi immunitari ed infiammatori: caratterizzazione di meccanismi molecolari e cellulari finalizzata a interventi terapeutici innovativi.
• 10 - Ruolo dell'ATP extracellulare nella patogenesi delle neoplasie tiroidee e nella modulazione di vecchi e nuovi markers di malattia

Classificazione scientifico-disciplinare

• Area scientifico disciplinare: Scienze mediche
  • MALATTIE DELL'APPARATO RESPIRATORIO

Classificazione brevettuale

• CHEMISTRY; METALLURGY
  • BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF (biocides, pest repellants or attractants, or plant growth regulators, containing micro-organisms, viruses, microbial fungi, enzymes, fermentates or substances produced by or extracted from micro-organisms or animal material A01N63/00; food compositions A21, A23; medicinal preparations A61K; chemical aspects of, or use of materials for, bandages, dressings, absorbent pads or surgical articles A61L; fertilisers C05); PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS (preservation of living parts of humans or animals A01N1/02); MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (micro-biological testing media C12Q)
  • ORGANIC CHEMISTRY (such compounds as the oxides, sulfides, or oxysulfides of carbon, cyanogen, phosgene, hydrocyanic acid or salts thereof C01; products obtained from layered base-exchange silicates by ion-exchange with organic compounds such as ammonium, phosphonium or sulfonium compounds or by intercalation of organic compounds C01B33/44; macromolecular compounds C08; dyes C09; fermentation products C12; fermentation or enzyme-using processes to synthesise a desired chemical compound or composition or to separate optical isomers from a racemic mixture C12P; production of organic compounds by electrolysis or electrophoresis C25B3/00, C25B7/00)
    • PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00)
• HUMAN NECESSITIES
  • MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES (bringing into special physical form A61J [N: mechanical aspects]; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; compounds per se C01, C07, C08, C12N; soap compositions C11D; micro-organisms per se C12N) [C0203]

Classificazione geografica

• Regione: Liguria

Bibliografia

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2 John V. Fahy. Remodeling of the airway epithelium in asthma. Am J Respir Crit Care Med 2001;Vol 164: pp S46-S51

3 Peter K. Jeffery. Remodeling in asthma and chronic obstructive lung disease. Am J Respir Crit Care Med. 2001; 164: S28-S38

4 Milanese M, Crimi E, Scordamaglia A, Riccio, A Pellegrino R, Canonica GW, Brusasco V. On the functional consequences of bronchial basement membrane thickening. J Appl Physiol. 2001;91:1035-1040.

5 Niimi A, Matsumoto H, Takemura M, et al. Relationship or airway wall thickness to airway sensitivity and airway reactivity in asthma. Am J Respir Crit Care Med. 2003; 168: 983-988

6 Bousquet J, Vignola AM, Chanez P, et all. Airways remodeling in asthma: no doubt, no more? Int Arch Allergy Immunol. 1995; 107:211-4

7 Kanazawa H, Nomura S, Yoshikawa J. Role of microvascular permeability on physiologic differences in asthma and eosinophilic bronchitis. Am J Respir Crit Care Med. 2004; 169: 1125-30.Epub 2004

8 Gosens R, Zaagsma J, Grootte Bromhaar M, et all. Acetylcholine:a novel regulator of airway smooth muscle remodeling? Eur. J. Pharmacol 2004; 500: 193-201

9 Coulson FR, Fryer AD. Muscarinic acetylcholine receptor and aiway diseases. Pharmacol Ther. 2003; 98: 59-69

10 Gosens, R., Grootte Bromhaar, M.M., Tonkes, A., et all. Receptor-dependent regulation of airway smooth muscle phenotype. Br. J. Pharmacol 2004;141: 943-950

11 Gomez M., Sward K. Long termregulation of contractility and calcium current in smooth muscle. Am J Phhysiol 1997; 273: C1714-C1720

12 Liu H.W., Kassiri K.,Voros, A., et al. Galfaq-receptor coupled signaling induces RHO-dependent trscription of smooth muscle specific genes in cultured canine airway myocytes. Am J Respir Crit Care Med. 2002; 165: A670

13 Camoretti-Mercado,B., Liu, H.W., Halayko, A.J., et all. Physiological control of smooth muscle-specific gene expression through regulated nuclear translocation of serum response factor. J. Biol. Chem. 2000; 275: 30387-30393

14 Gosens, R., Nelemans, S.A.Hiemstra, M., et all. Insulin induces a hypercontractile airway smooth muscle phenotype. Eur. J. Pharmacol 2003; 481: 125-131

15 Mitchell, R.W., Halayko, A.J.,Kahraman, S., et all. Selective restoration of calcium coupling to muscarinic M(3) receptors in contractile cultured airway myocytes. Am. J. Physiol. 2000;278: L1091–L1100

16 Accomazzo MR, RovatiGE, Vigano T, et all. Leukotriene D4-induced activation of smooth- muscle cells from human bronchi is partly CA2+-independent. Am J Respir Crit Care Med. 2001; 163: 266-72

17 Suzuki Y, Asano K, Shiraishi Y, et al. Human bronchial smooth muscle cell proliferation via thromboxane A2 receptor. Prostaglandis, Leukotrienes and Essential Fatty Acids ,Elsevier 2004;71:375-382

18 Papadopoulos NG, Papi A, Psarras S, Johnston SL. Mechanism of rhinovirus induced asthma. Pediatric Respiratory Reviews. 2004;5:255-260.

19 Kotenko SV, Gallagher G, Baurin VV, et al. INF-lambdas mediate antiviral protection through a distinct II cytokine receptor complex. Nat Immunol 2003;4: 69-77.

20 Jacoby DB, Fryer AD. Interaction of viral infections with muscarinic receptors. Clin Exp Allergy. 1999;2suppl:59-64.

21 Amrani Y ,Moore PE, Hoffman R, et al. Interferon gamma modulates cysteinil leukotrienes receptor-1 expression and function in human airway myocytes. Am J Respir Crit Care Med 2001;164:2098-2101.

22 Song P Crimi E, Duan J, Rehder K, Brusasco V. Anti-inflammatory agents and allergen induced beta2 receptor dysfunction in isolated human bronchi. Am J Respir Crit Care Med 1998;158:1809-1814.

23 Proud D, Togias A, Naclerio RM, Crush SA, Norman PS, Lichtenstein LM. Kinins are generated in vivo following nasal airway challenge of allergic individuals with allergen. J Clin Invest 1983;72:1678-85.

24 Abraham WM, Burch RM, Farmer SG, Sielczak MW, Ahmed A, Cortes A. A bradykinin antagonist modifies allergen-induced mediator release and late bronchial responses in sheep. Am Rev Respir Dis 1991;143:787-96.

25 Folkerts G, Vlieger JW, de Vries A, Faas S, van Der Linde H, Engels F, de Jong JC, Verheyen FA, Van Heuven-Nolsen D, Nijkamp FP. Virus- and bradykinin-induced airway hyperresponsiveness in guinea pigs. Am J Respir Crit Care Med. 2000 May;161(5):1666-71.

26 Hoshino M, Nakamura Y, Hamid QA. Gene expression of vascular endothelial growth factor and its receptors and angiogenesis in bronchial asthma. J Allergy Clin Immunol 2001;107: 1034-8

27 Hoshino M, Takahashi M, Aoike N. Expression of vascular endothelial growth factor, basic fibroblast growth factor, and angiogenin immunoreactivity in asthmatic airways and its relationship to angiogenesis. J Allergy Clin Immunol 2001;107:295-301.

28 Altaf S. Kazi, Shidan Lotfi, Elena A. goncharova, et all. Vascular endothelial gowth factor- induced secretion of fibronectin is ERK dependent. AJP – Lung 2004; 286:539-545

29 Knox AJ, Corbett L, Stocks J, Holland E, Zhu YM, Pang L. Human airway smooth muscle cells secrete vascular endothelial growth factor: up-regulation by bradykinin via a protein kinase C and prostanoid-dependent mechanism. FASEB J. 2001 Nov;15(13):2480-8.)

Parole Chiave

RIMODELLAMENTO; MUSCOLO LISCIO BRONCHIALE; MEDIATORI INFIAMMATORI