RICERCA ITALIANA     

Programmi di ricerca simili:

• 1 - Il colangiocarcinoma: approccio terapeutico basato su nuove acquisizioni di biologia cellulare e molecolare.
• 2 - Nuove conoscenze fisiopatologiche per nuove prospettive terapeutiche del colangiocarcinoma
• 3 - Sviluppo e progressione del carcinoma epatocellulare: meccanismi molecolari ed implicazioni terapeutiche
• 4 - CONTROLLO DEL CICLO CELLULARE DA LIGANDI DI RECETTORI NUCLEARI
• 5 - RUOLO DELLE CELLULE DENDRITICHE, DELLE CITOCHINE E DEGLI ORMONI STEROIDEI SESSUALI NELLA STORIA NATURALE DELLE MALATTIE EPATICHE CRONICHE
• 6 - Basi molecolari della tumorigenesi neuronale indotta da alterazioni dello sviluppo cellulare: ruolo di Hedgehog e pathways interattive.
• 7 - Meccanismi di leucemogenesi e terapia target nelle sindromi Mielodisplastiche e nelle Leucemie Acute Mieloidi
• 8 - Medulloblastoma: studio delle vie molecolari di sviluppo e progressione tumorale allo scopo di identificare approcci terapeutici innovativi
• 9 - Studio di nuovi meccanismi molecolari nel controllo della risposta fibrogenica
• 10 - Rapporto ospite parassita nelle infezioni da clamidie e spirochete: immunità naturale e metabolismo lipidico studiati con tecniche convenzionali e con DNA microarray

Classificazione scientifico-disciplinare

• Area scientifico disciplinare: Scienze mediche
  • GASTROENTEROLOGIA

Classificazione brevettuale

• CHEMISTRY; METALLURGY
  • BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF (biocides, pest repellants or attractants, or plant growth regulators, containing micro-organisms, viruses, microbial fungi, enzymes, fermentates or substances produced by or extracted from micro-organisms or animal material A01N63/00; food compositions A21, A23; medicinal preparations A61K; chemical aspects of, or use of materials for, bandages, dressings, absorbent pads or surgical articles A61L; fertilisers C05); PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS (preservation of living parts of humans or animals A01N1/02); MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (micro-biological testing media C12Q)
• HUMAN NECESSITIES
  • MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES (bringing into special physical form A61J [N: mechanical aspects]; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; compounds per se C01, C07, C08, C12N; soap compositions C11D; micro-organisms per se C12N) [C0203]

Classificazione geografica

• Regione: Veneto

Bibliografia

1. Wilson PD. (2004) Polycystic kidney disease. N Engl J Med, 350, 151-64.
2. Masyuk AI. (2003) Polycystic kidney disease. Hepatology, 38, 107A.
3. Nishio S. et al. Pkd1 regulates immortalized proliferation of renal tubular epithelial cells through p53 induction and JNK activation. J Clin Invest. 2005 Mar 3.
4.Piontek KB et al. A functional floxed allele of Pkd1 that can be conditionally inactivated in vivo. J Am Soc Nephrol. 2004 Dec;15(12):3035-43.
5.Lantinga-van Leeuwen IS. Et al. Common regulatory elements in the polycystic kidney disease 1 and 2 promoter regions. Eur J Hum Genet. 2005 Mar 16.
6.Qian Q, Li A, King BF, Kamath PS, Lager DJ, Huston J 3rd, Shub C, Davila S, Somlo S, Torres VE. Clinical profile of autosomal dominant polycystic liver disease. Hepatology. 2003 Jan;37(1):164-71.
7.Perrone RD, Grubman SA, Rogers LC, Lee DW, Moy E, Murray SL, Torres VE, Jefferson DM. Continuous epithelial cell lines from ADPKD liver cysts exhibit characteristics of intrahepatic biliary epithelium. Am J Physiol. 1995 Sep;269(3 Pt 1):G335-45.
8.Witzgall R. Polycystin-2-an intracellular or plasma membrane channel? Naunyn Schmiedebergs Arch Pharmacol. 2005 Mar 4.
9. Somlo S, Markowitz GS. (2000) The pathogenesis of autosomal dominant polycystic kidney disease: an update. Curr Opin Nephrol Hypertens, 9, 385-94.
10. Ward CJ, Hogan MC, Rossetti S, Walker D, Sneddon T, Wang X, Kubly V, Cunningham JM, Bacallao R, Ishibashi M, Milliner DS, Torres VE, Harris PC. (2002) The gene mutated in autosomal recessive polycystic kidney disease encodes a large, receptor-like protein. Nat Genet, 30, 259-69.
11. Masyuk TV, Huang BQ, Ward CJ, Masyuk AI, Yuan D, Splinter PL, Punyashthiti R, Ritman EL, Torres VE, Harris PC, LaRusso NF. Defects in cholangiocyte fibrocystin expression and ciliary structure in the PCK rat. Gastroenterology. 2003;125(5):1303-10.
12. Pazour GJ, Witman GB. The vertebrate primary cilium is a sensory organelle. Curr Opin Cell Biol 2003; 15:105-110.
13.Nauli SM. Polycystins and mechanosensation in renal and nodal cilia.Bioessays. 2004 Aug;26(8):844-56. Review.
14.Sutters M. Autosomal dominant polycystic kidney disease: molecular genetics and pathophysiology. J Lab Clin Med. 2003 Feb;141(2):91-101. Review.
15. Zerres K, Mucher G, Becker J, Steinkamm C, Rudnik-Schoneborn S, Heikkila P, Rapola J, Salonen R, Germino GG, Onuchic L, Somlo S, Avner ED, Harman LA, Stockwin JM, Guay-Woodford LM. Prenatal diagnosis of autosomal recessive polycystic kidney disease (ARPKD): molecular genetics, clinical experience, and fetal morphology. Am J Med Genet. 1998;76(2):137-44.
16. Merta M, Tesar V, Zima T, Jirsa M, Rysava R, Zabka J. Cytokine profile in ADPKD. Biochem Molec Biol Internat 1997; 41: 619-624.
17. Munemura C, Uemasu J, Kawasaki H. Epidermal growth factor and endothelin in cyst fluid from autosomal dominant polycystic kidney disease cases: possible evidence of heterogeneity in cystogenesis. Am J Kidney Dis 1994; 24: 561-568.
18. Gardner KJ, Burnside J, Elzinga L, Locksley R. Cytokines in fluids from polycystic kidneys. Kidney Int 1991; 39: 718-724.
19.Regulation and deregulation of cholangiocyte proliferation. D. Alvaro, A. Gigliozzi, and A. F. Attili. Journal of Hepatology 2000: 33: 333-340
20.D. Alvaro, et al. Estrogens stimulate proliferation of intrahepatic biliary epithelium in rats. Gastroenterology 2000, 119(6):1681-91.
21.Alvaro D, Alpini G, Onori P, Franchitto A, Glaser S, Le Sage G, Gigliozzi A, Vetuschi A, Morini S, Attili AF, Gaudio E. Effect of ovariectomy on the proliferative capacity of intrahepatic rat cholangiocytes. Gastroenterology. 2002 Jul;123(1):336-44.
22.Gabow P, Johnson A, Kaehny W, Manco-Johnson M, Duley I, Everson G. Risk factors for the development of hepatic cysts in autosomal dominant polycystic kidney disease. Hepatology 1990;11:1033-1037.
23.Sherstha R, McKinley C, Russ P, Scherzinger A, Bronner T, Showlater R, Everson GT. Postmenopausal estrogen therapy selectively stimulates hepatic enlargement in women with autosomal dominant polycystic kidney disease. Hepatology 1997;26:1282-1286.
24.Ramos A, Torres V, Holley K, Offord K, Rakela J, Ludwig J. The liver in autosomal dominant polycystic kidney disease: implications for pathogenesis. Arch Pathol Lab Med 1990;114:180-184.
25.Chen D. Estrogen induces expression of secretory leukocyte protease inhibitor in rat uterus. Biol Reprod. 2004 Aug;71(2):508-14
26. Desmet VJ. (1998) Ludwig symposium on biliary disorders--part I. Pathogenesis of ductal plate abnormalities. Mayo Clin Proc, 73, 80-9.
27. Bello-Reuss E, Holubec K, Rajaraman S. (2001) Angiogenesis in autosomal-dominant polycystic kidney disease. Kidney Int, 60, 37-45.
28. Jakkula M, Le Cras TD, Gebb S, Hirth KP, Tuder RM, Voelkel NF, Abman SH. (2000) Inhibition of angiogenesis decreases alveolarization in the developing rat lung. Am J Physiol Lung Cell Mol Physiol, 279, L600-7.
29. Tufro A, Norwood VF, Carey RM, Gomez RA. (1999) Vascular endothelial growth factor induces nephrogenesis and vasculogenesis. J Am Soc Nephrol, 10, 2125-34.
30. Holash J, Wiegand SJ, Yancopoulos GD. (1999) New model of tumor angiogenesis: dynamic balance between vessel regression and growth mediated by angiopoietins and VEGF. Oncogene, 18, 5356-62.
31. Matthew T. Nichols, Elsa Gidey, Tom Matzakos, Rolf Dahl, Greg Stiegmann , Raj J. Shah , Jared J. Grantham , J. Gregory Fitz , R. Brian Doctor. Secretion of cytokines and growth factors into autosomal dominant polycystic kidney disease liver cyst fluid. Hepatology 2004;40:836-846.
32.Kim H. et al. Siah-1 interacts with the intracellular region of polycystin-1 and affects its stability via the ubiquitin-proteasome pathway. J Am Soc Nephrol. 2004 Aug;15(8):2042-9.
33.Chauvet V, Mechanical stimuli induce cleavage and nuclear translocation of the polycystin-1 C terminus. J Clin Invest. 2004 Nov;114(10):1433-43.
34.Qian F. er al. Cleavage of polycystin-1 requires the receptor for egg jelly domain and is disrupted by human autosomal-dominant polycystic kidney disease 1-associated mutations. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16981-6.
35. Rosen LS. (2002) Clinical experience with angiogenesis signaling inhibitors: focus on vascular endothelial growth factor (VEGF) blockers. Cancer Control, 9, 36-44.
36. Torres VE, Wang X, Qian Q, Somlo S, Harris PC, Gattone VH, 2nd. (2004) Effective treatment of an orthologous model of autosomal dominant polycystic kidney disease. Nat Med, 10, 363-4.
37. Wu G, D'Agati V, Cai Y, Markowitz G, Park JH, Reynolds DM, Maeda Y, Le TC, Hou H, Jr., Kucherlapati R, Edelmann W, Somlo S. (1998) Somatic inactivation of Pkd2 results in polycystic kidney disease. Cell, 93, 177-88.
38. Saishin Y, Takahashi K, Seo MS, Melia M, Campochiaro PA. (2003) The kinase inhibitor PKC412 suppresses epiretinal membrane formation and retinal detachment in mice with proliferative retinopathies. Invest Ophthalmol Vis Sci, 44, 3656-62.
39. Takamoto T, Sasaki M, Kuno T, Tamaki N. (2001) Flk-1 specific kinase inhibitor (SU5416) inhibited the growth of GS-9L glioma in rat brain and prolonged the survival. Kobe J Med Sci, 47, 181-91.
40. Alvaro D, Alpini G, Onori P, Perego L, Svegliata Baroni G, Franchitto A, Baiocchi L, Glaser SS, Le Sage G, Folli F, Gaudio E. (2000) Estrogens stimulate proliferation of intrahepatic biliary epithelium in rats. Gastroenterology, 119, 1681-91.
41. Sherstha R, McKinley C, Russ P, Scherzinger A, Bronner T, Showalter R, Everson GT. (1997) Postmenopausal estrogen therapy selectively stimulates hepatic enlargement in women with autosomal dominant polycystic kidney disease. Hepatology, 26, 1282-6.
42. Gagliardi AR, Hennig B, Collins DC. (1996) Antiestrogens inhibit endothelial cell growth stimulated by angiogenic growth factors. Anticancer Res, 16, 1101-6.

Parole Chiave

FEGATO POLICISTICO; FATTORI ANGIOGENETICI; COLANGIOCITA; ESTROGENI; PROLIFERAZIONE