RICERCA ITALIANA     

Programmi di ricerca simili:

• 1 - Formulazione di Nuovi Materiali Polimerici Bioattivi per Applicazioni nel Settore dell'Ingegneria Tissutale
• 2 - Influenza del materiale e della sua micro e nanostrutturazione sul differenziamento di cellule staminali adulte e sulla risposta infiammatoria
• 3 - Strutture bioattive per il controllo della differenziazione delle cellule staminali: apllicazioni nell'ingegnerizzazione del tessuto neuronale e muscolare.
• 4 - Progettazione integrata di sistemi biomimetici nanostrutturati autoorganizzanti per applicazioni nei settori del rilascio mirato di farmaci e dell'ingegneria tissutale
• 5 - PROGETTAZIONE E REALIZZAZIONE DI SCAFFOLDS NANOSTRUTTURATI ORGANICI, INORGANICI E IBRIDI, DA UTILIZZARE IN MEDICINA RIGENERATIVA COME SUBSTRATI PER IL DIFFERENZIAMENTO DI CELLULE STAMINALI
• 6 - Progettazione e Sintesi di Silsesquiossani Poliedrici Multifunzionali per Compositi Polimerici Innovativi Termicamente Stabili
• 7 - Sintesi e caratterizzazione di ibridi organo-inorganici preparati con la tecnica sol-gel per la realizzazione di scaffolds per l'ingegneria dei tessuti craniofacciali.
• 8 - Interfacce bio-elettroniche ottenute mediante polimeri conduttori nanostrutturati funzionalizzati
• 9 - Biomeccanica e biomimetica: un approccio integrato per la validazione funzionale dell'utilizzo dei materiali nanostrutturati nelle riabilitazioni implantoprotesiche
• 10 - Nanovettori nella terapia anticancro

Classificazione scientifico-disciplinare

• Area scientifico disciplinare: Scienze chimiche
  • SCIENZA E TECNOLOGIA DEI MATERIALI POLIMERICI
  • FONDAMENTI CHIMICI DELLE TECNOLOGIE
  • FARMACEUTICO TECNOLOGICO APPLICATIVO
• Area scientifico disciplinare: Scienze biologiche
  • BIOLOGIA MOLECOLARE
• Area scientifico disciplinare: Scienze mediche
• Area scientifico disciplinare: Scienze agrarie e veterinarie

Classificazione brevettuale

• CHEMISTRY; METALLURGY
  • ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON (manufacture or treatment of artificial threads, fibres, bristles or ribbons D01 [C9410]
    • POLYSACCHARIDES; DERIVATIVES THEREOF (polysaccharides containing less than six saccharide radicals attached to each other by glycosidic linkages C07H; fermentation or enzyme-using processes C12P19/00; sugar industry C13; production of cellulose D21) [C9805]
• HUMAN NECESSITIES
  • MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agent employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toilet purposes A61K; preparation of ozone C01B13/10)
    • PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES (bringing into special physical form A61J [N: mechanical aspects]; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; compounds per se C01, C07, C08, C12N; soap compositions C11D; micro-organisms per se C12N) [C0203]

Classificazione geografica

• Regione: Toscana

Bibliografia

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3. D. Cunliffe, S. Pennadam, C. Alexander, Synthetic and Biological Polymers Merging the Interface, European Poly. J. 40, 5-25 (2003)

4. H. Shin, S. Jo, A.G. Mikos, Biomimetic Materials for Tissue Engineering, Biomaterials, 24, 4353-4364 (2003)

5. A.R. Boccaccini and J. J. Blaker, Bioactive Composite Materials for Tissue Engineering Scaffolds Expert, Rev. Med. Devices 2, 303-317 (2005)

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10. N. Koechlin, M. Pisam, P. Poujeol, M. Tanc, A. Rambourg, Conversion of a Rabbit Proximal Convoluted Tubule into a Cell Monolayer Ultrastructure Study of a Cell Differentiation and Redifferentation, Eur. J. Cell. Biol. 54, 224-236 (1991)

11. W.W. Minuth, J. Aigner, B. Kubat, S. Kloth, Improved Differentiation of Renal Tubular Epithelium in Vitro: Potential for Tissue Engineering, Exp. Nephrol. 5, 10-17 (1997)

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19. C.G. Gebelein, C.E. Carraher Eds. Bioactive Polymeric Systems. An Overview, Plenum Press, NY, USA (1985)

20. J.M. Anderson, S.W. Kim Eds. Advances in Drug Delivery Systems, Elsevier, Amsterdam, NL (1986)

21. P. Tyle, B.P. Ram, Eds. Targeted Therapeutic Systems, Marcel Dekker Publ., New York, NY-USA (1990)

22. D. Hoffman, L. Wahaberg, P. Aebscher, NGF Released from Polymer Materix Prevents Loss of Chat Expression in Basal Forebrain Neurons following a fimbrea-formix Lesion, Exp. Newal., 110, 39-44 (1990)

23. M.J. Mahoney, W.M. Saltzman, Transplantation of Brain Cells Assembled around a Programmable Synthetic Microenvironment, Nature Biotech., 19, 934-939 (2001)

24. C.G. Craig, In Vivo Growth Factor Expansion of Endogenous Subeperdimal Neural Precursor Cell Populations in the Adult Mouse Brain, J. Neurosci. 16, 2649-2658 (1996)

25. W.M. Saltzman, W.L. Olbricht, Building Drug Delivery into Tissue Engineering, Mat. Rev. Drug Discovery, 1, 177-186 (2002)

26. S. Lien, H.B. Lowman, Therapeutic Peptides, Trends in Biotech., 21, 556-562 (2003)

27. W.L. Fodor, Tissue Engineering and Cell Based Therapies from the Bench to the Clinic: The Potential to Replace, Repair and Regenerate, Reprod. Biol. Endocrinol. 1, 102, 1-6 (2003)

28. Wai-Yee Yeong, Chee-Kai Chua, Kah-Fai Leomg and M. Chandrasekaran, Rapid Prototyping in Tissue Engineering: Challenges and Potential, Trends in Biotech., 22, 643-652 (2004)



REFERENCES RELEVANT TO THE WORK DONE BY THE RESEARCH UNITS INVOLVED IN THE PROJECT

R. Toth, M. Ferrone, S. Miertus, E. Chiellini, M. Fermeglia, S. Pricl, Structure and Energetics of Biocompatible Polymer Nanocomposite Systems: A Molecular Dynamics Study Biomacromolecules, in press (2006)

S. Moscato, M.G. Cascone, L. Lazzeri, S. Danti, L. Matii, A. Dolfi and N. Bernardini, Morphological Features of Ovine Embrionic Fibroblasts Cultured on Different Bioactive Scaffolds, J. Biomed. Mater. Res. 76A, 214 (2006)

L. Lazzeri, M.G. Cascone, S. Donati, L.P. Serino, S. Moscato, N. Bernardini, PLLA/gelatine Sponge-Like Scaffolds: Morphological and Biological Characterization, J. Mater. Sci. Mater. Med. in press (2006)

R. Barbucci, G. Leone, S. Lamponi, Thixotrophy Property of Hydrogels to Evaluate the Cell Growing on the inside of the Material Bulk (Amber effect), J.Biomed. Mater. Res: part B Appl Biomat., 76B, 33-40 (2006)

L. Lazzeri, M.G. Cascone, S. Quiriconi, L. Morabito, P. Giusti, Biodegradable Hollow Microfibers to Produce Bioactive Scaffolds, Poly. Int. 54, 101-107 (2005) <br />
F. Signori, R. Solaro, E. Chiellini, Micelles from New Biodegradable Amphiphilic Block Copolymers Containing PEG and PLC, J. Contr. Rel., 101, 379-381 (2005)

P. Ferruti, S. Bianchi, E. Ranucci, F Chiellini., A.M. Piras, Novel Agmatine-Containing Poly(Amidoamine) Hydrogels As Scaffolds For Tissue Engineering. Biomacromol. 6, 2229-2235 (2005)

P. Ferruti, S. Bianchi, E. Ranucci, F. Chiellini, V. Caruso, Novel poly(amido-amine)-based Hydrogels as Scaffolds for Tissue Engineering, Macromol. Biosci., 5, 613-622 (2005)

L. Tondelli, M. Ballestri, A. Cazzato, F. Federici, L. Magnani, K. Sparnacci, M. Laus, Adsorption/release Behaviour of Oligonucleotides on Polymeric core-shell Microspheres, J. Control. Rel. 101, 355-356 (2005)

V. Bertini, F. Buffoni, G. Ignesti, N. Picci, S. Trombino, F. Iemma, S. Alfei, M. Pocci, F. Lucchesini, A. De Munno, Alkylamino Derivatives of 4-aminomethylpyridine as Inhibitors of Copper Containing Amine Oxidases, J. Med. Chem., 48, 664 (2005)

V. Bertini, F. Lucchesini, M. Pocci, S. Alfei, Soluble and Insoluble Polymeric 1,3-dithiane Reagents for the Synthesis of Aldehydes from Alkyl Halides, Tetrahedron, 61, 9519 (2005)

A. Fioravanti, L. Cantarini, F. Chiellini, D. Manca, E. Paccagnini, R. Marcolongo, G. Collodel, Effect of Hyaluronic Acid (MW 500-730 kDa) on Proteoglycan and Nitric Oxide Production in Human Osteoarthritic Chondrocyte Cultures Exposed to Hydrostatic Pressure, Osteoarthritis Cartilage,13, 688-96 (2005)

R. Barbucci, G. Leone, M. Monici, D. Pantalone, M. Fini, R. Giardino, The Effect of Amidic Moieties on Polysaccharides: Evaluation of the Physico-Chemical and Biological Properties of Amidic Carboxymethylcellulose (CMCA) in the Form of Linear Polymer and Hydrogel, J. Mater. Chem., 22, 2234-2241 (2005)

D. Pasqui, A. Rossi, R. Barbucci, S. Lamponi, R. Gerli, E. Weber, Hyaluronan and Sulphated Hyaluronan Micropatterns: Effect of Chemical and Topographic Cues on Lymphatic Endothelial Cell Alignment and Proliferation, Lymphology, 38, 50-65 2005

E. Bergamini, R. Bizzarri, G. Cavallini, B. Cerbai, E. Chiellini, A. Donati, Z. Gori, A. Manfrini, I. Patentini, F. Signori, I. Tamburini, Ageing and Oxidative Stress: a Role for Dolicol in the Antioxidant Machinary of Cell Membranes?, J. Alzh. Dis., 6, 129-135 (2004)

A.M. Bianucci, I. Massarelli, F. Chiellini, C. Eidelman, E. Chiellini, Design of Hugly Specified Ligands of Fibrins for Therapeutics Applications, J. Biomat. Sci. Poly. Ed. 15, 1203-1222 (2004)

S. Danti, M.G. Cascone, L. Lazzeri, S. Moscato, N. Bernardini, A. Dolfi, Viability, Growth and Cell Function Evaluation of Cells inside Sponge-like Scaffolds Based on PLLA and Agarose, J. Appl. Biomater. Biomech, 2, 205 (2004)

R. Bizzarri, F. Chiellini, C.K. Ober, W.M. Saltmann, R. Solaro, E. Chiellini, Malolactonate Polymers and Copolymers for Biomedical Applications, Macromol. Symp., 197, 303-314 (2003)

Parole Chiave

BIOMATERIALI, IDROGELI, INGEGNERIA TISSUTALE, NANOPARTICELLE, POLIMERI BIODEGRADABILI, FEGATO BIOARTIFIALE, CARTILAGINE, OSSO, SUPPORTI BIOATTIVI