RICERCA ITALIANA     

Programmi di ricerca simili:

• 1 - Apoptosi e mitocondri: nuovi bersagli nelle malattie neoplastiche, degenerative ed immunologiche
• 2 - Meccanismi di danno e protezione nel miocardio ischemico
• 3 - Modulazione dei meccanismi di apoptosi in corso di risposta immunitaria/infiammatoria: studio delle interazioni tra citochine della famiglia del TNF per la caratterizzazione di meccanismi molecolari e cellulari funzionali alla identificazione di nuovi target per la terapia di malattie croniche degenerative.
• 4 - BERSAGLI MOLECOLARI PER NUOVE TERAPIE ANTINEOPLASTICHE ATTRAVERSO LO STUDIO DI PROTEINE-SEGNALE CELLULARI E VIRALI E DI INIBITORI SPECIFICI
• 5 - Il fattore di trascrizione NF-kB nella regolazione del differenziamento ed apoptosi del sistema immune.
• 6 - L'autofagia nell'omeostasi del sistema immunitario: ruolo nella patogenesi e nella progressione delle malattie autoimmuni
• 7 - L'apoptosi nei processi immunitari ed infiammatori: caratterizzazione di meccanismi molecolari e cellulari finalizzata a interventi terapeutici innovativi.
• 8 - L'alterazione dell'asse ipotalamo-ipofisi-gonadi (HPG) nella patogenesi della malattia di Alzheimer: meccanismi molecolari e correlazione con il colesterolo di membrana e l'organizzazione dei microdomini di membrana
• 9 - INTERRELAZIONI TRA LA PERMEABILITÀ IONICA DI MEMBRANA E LO STATO REDOX INTRACELLULARE NEI PROCESSI NEURODEGENERATIVI: AZIONE DEI PEPTIDI AMILOIDI IN CELLULE NEURONALI E GLIALI.
• 10 - Caratterizzazione molecolare dell'eritropoiesi:analisi post-genomica e funzionale del profilo di espressione proteica

Classificazione scientifico-disciplinare

• Area scientifico disciplinare: Scienze biologiche
  • BIOCHIMICA
  • BIOLOGIA MOLECOLARE
  • BIOLOGIA APPLICATA
• Area scientifico disciplinare: Scienze mediche
  • PATOLOGIA GENERALE

Classificazione brevettuale

• CHEMISTRY; METALLURGY
  • BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF (biocides, pest repellants or attractants, or plant growth regulators, containing micro-organisms, viruses, microbial fungi, enzymes, fermentates or substances produced by or extracted from micro-organisms or animal material A01N63/00; food compositions A21, A23; medicinal preparations A61K; chemical aspects of, or use of materials for, bandages, dressings, absorbent pads or surgical articles A61L; fertilisers C05); PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS (preservation of living parts of humans or animals A01N1/02); MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (micro-biological testing media C12Q)

Classificazione geografica

• Regione: Veneto

Bibliografia

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3. Klöhn PC, Soriano ME, Irwin W, Penzo D, Scorrano L, Bitsch A, Neumann HG & Bernardi P (2003) Early resistance to cell death and to onset of the mitochondrial permeability transition during hepatocarcinogenesis with 2-acetylaminofluorene. Proc Natl Acad Sci USA 100, 10014-10019.
4. Soriano ME, Nicolosi L & Bernardi P (2004) Desensitization of the permeability transition pore by cyclosporin A prevents activation of the mitochondrial apoptotic pathway and liver damage by tumor necrosis factor-alpha. J Biol Chem 279, 36803-36808.
5. Irwin WA, Bergamin N, Sabatelli P, Reggiani C, Megighian A, Merlini L, Braghetta P, Columbaro M, Volpin D, Bressan GM, Bernardi P & Bonaldo P (2003) Mitochondrial dysfunction and apoptosis in myopathic mice with collagen VI deficiency. Nat Genet 35, 267-271.
6. Cecconi F (1999) Apaf1 and the apoptotic machinery. Cell Death Diff 6, 1087-1098.
7. Bernardi P, Petronilli V, Di Lisa F & Forte M (2001) A mitochondrial perspective on cell death. Trends Biochem Sci 26, 112-117.
8. Mitchell P (1979) Keilin's respiratory chain concept and its chemiosmotic consequences. Science 206, 1148-1159.
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15. Migliaccio E, Giorgio M, Mele S, Pelicci G, Reboldi P, Pandolfi PP, Lanfrancone L & Pelicci PG (1999) The p66shc adaptor protein controls oxidative stress response and life span in mammals. Nature 402, 309-313.
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27. Milanesi E, Costantini P, Gambalunga A, Colonna R, Petronilli V, Cabrelle A, Semenzato G, Cesura AM, Pinard E & Bernardi P (2006) The mitochondrial effects of small organic ligands of BCL-2: Sensitization of BCL-2-overexpressing cells to apoptosis by a pyrimidine-2,4,6-trione derivative. J Biol Chem 281, 10066-10072.
28. Kokoszka JE, Waymire KG, Levy SE, Sligh JE, Cai J, Jones DP, MacGregor GR & Wallace DC (2004) The ADP/ATP translocator is not essential for the mitochondrial permeability transition pore. Nature 427, 461-465.
29. Krauskopf A, Eriksson O, Craigen WJ, Forte MA & Bernardi P (2006) Properties of the permeability transition in VDAC1-/- mitochondria. Biochim Biophys Acta in press.
30. Cesura AM, Pinard E, Schubenel R, Goetschy V, Friedlein A, Langen H, Polcic P, Forte MA, Bernardi P & Kemp JA (2003) The voltage-dependent anion channel is the target for a new class of inhibitors of the mitochondrial permeability transition pore. J Biol Chem 278, 49812-49818.
31. Baines CP, Kaiser RA, Purcell NH, Blair NS, Osinska H, Hambleton MA, Brunskill EW, Sayen MR, Gottlieb RA, Dorn GW, Robbins J & Molkentin JD (2005) Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death. Nature 434, 658-662.
32. Basso E, Fante L, Fowlkes J, Petronilli V, Forte MA & Bernardi P (2005) Properties of the permeability transition pore in mitochondria devoid of Cyclophilin D. J Biol Chem 280, 18558-18561.
33. Nakagawa T, Shimizu S, Watanabe T, Yamaguchi O, Otsu K, Yamagata H, Inohara H, Kubo T & Tsujimoto Y (2005) Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death. Nature 434, 652-658.
34. Schinzel AC, Takeuchi O, Huang Z, Fisher JK, Zhou Z, Rubens J, Hetz C, Danial NN, Moskowitz MA & Korsmeyer SJ (2005) Cyclophilin D is a component of mitochondrial permeability transition and mediates neuronal cell death after focal cerebral ischemia. Proc Natl Acad Sci USA 102, 12005-12010.
35. Baines CP, Song CX, Zheng YT, Wang GW, Zhang J, Wang OL, Guo Y, Bolli R, Cardwell EM & Ping P (2003) Protein kinase C epsilon interacts with and inhibits the permeability transition pore in cardiac mitochondria. Circ Res 92, 873-880.
36. Martindale JJ, Wall JA, Martinez-Longoria DM, Aryal P, Rockman HA, Guo Y, Bolli R & Glembotski CC (2005) Overexpression of mitogen-activated protein kinase kinase 6 in the heart improves functional recovery from ischemia in vitro and protects against myocardial infarction in vivo. J Biol Chem 280, 669-676.
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38. Ciechanover A (2005) Proteolysis: from the lysosome to ubiquitin and the proteasome. Nat Rev Mol Cell Biol 6, 79-87.
39. Amerik AY & Hochstrasser M (2004) Mechanism and function of deubiquitinating enzymes. Biochim Biophys Acta 1695, 189-207.

Parole Chiave

MITOCONDRI, MORTE CELLULARE, APOPTOSI, FARMACI, INIBITORI PROTEASOMA, RECETTORE T, TRANSIZIONE DI PERMEABILITÀ