RICERCA ITALIANA     

Programmi di ricerca simili:

• 1 - Modelli dinamici dell'espressione genica e proteica in cellule progenitrici endoteliali nell'evoluzione del diabete
• 2 - Analisi delle mappe trascrizionali e delle variazioni di moduli funzionali nel corso del differenziamento mieloide umano normale
• 3 - Meccanismi della citochinesi: identificazione di nuovi geni coinvolti nel processo e nella sua regolazione
• 4 - Metodi statistici negli studi di biologia sistemica
• 5 - Eritropoiesi normale e patologica: caratterizzazione molecolare mediante tecnologie avanzate a resa elevata.
• 6 - Caratterizzazione molecolare dell'eritropoiesi:analisi post-genomica e funzionale del profilo di espressione proteica
• 7 - ANALISI DEI MECCANISMI DI SOPRAVVIVENZA CELLULARE DI EUCARIOTI MEDIANTE STRATEGIE DI PROTEOMICA
• 8 - Il repertorio delle lectine nei protocordati. Evoluzione dei meccanismi di riconoscimento e dell'immunità innata.
• 9 - Basi metaboliche e molecolari della sindrome di Down
• 10 - Dallo studio dell’espressione genica globale allo studio della virulenza di Mycobacterium tuberculosis

Classificazione scientifico-disciplinare

• Area scientifico disciplinare: Scienze biologiche
  • ECOLOGIA
  • BIOLOGIA APPLICATA
• Area scientifico disciplinare: Scienze matematiche e informatiche
  • INFORMATICA

Classificazione brevettuale

• CHEMISTRY; METALLURGY
  • BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS (immunoassay G01N33/53); COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF (biocides, pest repellants or attractants, or plant growth regulators, containing micro-organisms, viruses, microbial fungi, enzymes, fermentates or substances produced by or extracted from micro-organisms or animal material A01N63/00; food compositions A21, A23; medicinal preparations A61K; chemical aspects of, or use of materials for, bandages, dressings, absorbent pads or surgical articles A61L; fertilisers C05); PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS (preservation of living parts of humans or animals A01N1/02); MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (micro-biological testing media C12Q)

Bibliografia

Alexander S., Min J., Alexander H. (2006) Dictyostelium discoideum to human cells: pharmacogenetic studies demonstrate a role for sphingolipids in chemoresistance. Biochim. Biophys Acta 1760: 301-309.
Alexander S., Srinivasan S., Alexander H. (2003) Proteomics opens doors to the mechanisms of developmentally regulated secretion. Mol. Cell Proteomics. 2: 1156-1163.
Anderson N.L., Anderson N.G. (1998) Proteome and proteomic: new technologies, new concepts, and new words. Electrophoresis 19: 1853-1861
DeRisi, J.L., Iyer, V.R., Brown, P.O. (1997). Exploring the metabolic and genetic control of gene expression on a genomic scale. Science 278: 680-686.
Dondero F., Jonsson H., Rebelo M., Pesce G., Berti E., Pons G., Viarengo A. (2006) Cellular responses to environmental contaminants in amoebic cells of the slime mould Dictyostelium discoideum. Comp. Biochem. Physiol. C Toxicol. Pharmacol.
Echeverria D., Woods J.S., Heyer N.J., Rohlman D.S., Farin F.M., Bittner A.C. Jr., Li T., Garabedian C. (2005) Chronic low-level mercury exposure, BDNF polymorphism, and associations with cognitive and motor function. Neurotoxicol. Teratol. 6: 781-796
Falugi C., Amaroli A., Evangelisti V., Viarengo A., Corrado M.U. (2002) Cholinesterase activity and effects of its inhibition by neurotoxic drugs in Dictyostelium discoideum.
Chemosphere 48: 407-414.
Farbrother P., Wagner C., Na J., Tunggal B., Morio T., Urushihara H., Tanaka Y., Schleicher M., Steinert M., Eichinger L. (2006) Dictyostelium transcriptional host cell response upon infection with Legionella. Cell Microbiol. 8: 438-456.
Gasch A.P., Spellman P.T., Kao C.M., Carmel-Harel O., Eisen M.B., Storz G., Botstein D., Brown P.O. (2000) Genomic expression programs in the response of yeast cells to environmental changes. Mol. Biol. Cell. 11: 4241-4257.
Gerisch S.C.H. (1987) Cyclic AMP and other signals controlling cell development and differentiation in Dictyostelium. Annu. Rev. Biochem. 56: 853-79.
Katoch B., Begum R. (2003) Biochemical basis of the high resistance to oxidative stress in Dictyostelium discoideum. J Biosci. 28: 581-588.
Kessin R. H. 2001 Dictyostelium: evolution, cell biology, and the
development of multicellularity. Cambridge University Press.
Kültz D. (2003) Evolution of the cellular stress proteome: from monophyletic origin to ubiquitous function. J. of Experim. Biol. 206: 3119-3124.
Kuspa A., Loomis W.F. (1992) Tagging developmental genes in Dictyostelium by restriction enzyme-mediated integration of plasmid DNA. Proc. Natl. Acad. Sci. USA. 89: 803-807.
Lee T.I., Rinaldi N.J., Robert F., Odom D.T, Bar-Joseph Z., Gerber G.K., Hannett N.M., Harbison C.T., Thompson C.M., Simon I., et al., (2002) Transcriptional regulatory networks in Saccharomyces cerevisiae. Science 298: 799-804.
Martens H., Novotny J., Oberstrass J., Steck T.L., Postlethwait P. , Nellen W. (2002). RNAi in Dictyostelium: The Role of RNA-directed RNA Polymerases and Double-stranded RNase Molec. Biol. of Cell 2: 445-453.
Moggs J.G., Orphanides, G. (2003) Genomic analysis of stress response genes. Toxicology Letters 141: 149–153.
Parent C.A., Devreotes P.N. (1996) Constitutively active adenylyl cyclase mutant requires neither G proteins nor cytosolic regulators. J. Biol. Chem. 271: 18333-18336.
Qin L., Qiu P., Wang L., Li X., Tolias P., Partridge N.C. (2003) Gene expression profiles and transcription factors involved in PTH signaling in osteoblasts revealed by microarray and bioinformatics, J. Biol. Chem. 278: 19723-19731.
Qiu P., Ding W., Jiang Y., Greene J., Wang L. (2002) Computational analysis of composite regulatory elements, Mamm. Genome 13: 327-332.
Shaulsky G., Loomis W.F. (2002) Gene expression patterns in Dictyostelium using microarrays. Protist 153: 93-98.
Takeda K., Saito T., Tanaka T., Morio T., Maeda M., Tanaka Y., Ochiai H. (2003) A novel gene trap method using terminator-REMI and 3' rapid amplification of cDNA ends (RACE) in Dictyostelium. Gene 312: 321-333.
Trinklein N.D., Aldred S.J., Saldanha A.J., Myers R.M. (2003) Identification and functional analysis of human transcriptional promoters. Genome Res. 13: 308-312.
Van Driessche N., Shaw C., Katoh M., Morio T., Sucgang R., Ibarra M., Kuwayama H., Saito T., Urushihara H., Maeda M., Takeuchi I., Ochiai H., Eaton W., Tollett J., Halter J., Kuspa A., Tanaka Y., Shaulsky G. (2002) A transcriptional profile of multicellular development in Dictyostelium discoideum. Development 129: 1543-1552.
Van Driessche N., Demsar J., Booth E.O., Hill P., Juvan P., Zupan B., Kuspa A., Shaulsky G. (2005) Epistasis analysis with global transcriptional phenotypes. Nat. Genet. 37: 471-477.
Zischka H., Oehme F., Pintsch T., Ott A., Keller H., Kellermann J., Schuster S.C. (1999) Rearrangement of cortex proteins constitutes an osmoprotective mechanism in Dictyostelium. EMBO J. 18: 4241-4249.

Parole Chiave

ECOTOSSICOLOGIA, INQUINAMENTO, STRESS AMBIENTALE, ADATTAMENTO, GENOMICA AMBIENTALE, PROTEOMICA AMBIENTALE, BIOINFORMATICA, BIOMODELLISTICA, BIOLOGIA DEI SISTEMI COMPLESSI