RICERCA ITALIANA     

Programmi di ricerca simili:

• 1 - RECETTORI PURINERGICI E NEUROPROTEZIONE
• 2 - Neurotrasmissione glutamatergica: organizzazione strutturale della sinapsi, recettori e ruolo in fisiopatologia."
• 3 - RECETTORI PURINERGICI E NEUROPROTEZIONE
• 4 - Identificazione, espressione funzionale e caratterizzazione fisiopatologica di nuovi recettori purinici.
• 5 - Transcrittomica e proteomica dello scompenso cardiaco umano per l'individuazione di nuovi meccanismi patogenetici e biomarcatori: focus sui recettori purinergici P2
• 6 - Recettori legati alle proteine G: nuovi concetti sui meccanismi di trasduzione del segnale
• 7 - I recettori metabotropici del glutammato com "targets" di farmaci neuroprotettivi
• 8 - CONTROLLO DEL CICLO CELLULARE DA LIGANDI DI RECETTORI NUCLEARI
• 9 - Modulazione da parte di neurotrasmettitori della funzionalità di recettori AMPA: implicazioni sulla trasmissione sinaptica in condizioni fisiologiche e patologiche.
• 10 - Regolazione negativa del signalling di recettori oncogenici: implicazioni terapeutiche

Classificazione scientifico-disciplinare

• Area scientifico disciplinare: Scienze biologiche
  • FISIOLOGIA
  • FARMACOLOGIA
• Area scientifico disciplinare: Scienze mediche

Classificazione brevettuale

• CHEMISTRY; METALLURGY
  • BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF (biocides, pest repellants or attractants, or plant growth regulators, containing micro-organisms, viruses, microbial fungi, enzymes, fermentates or substances produced by or extracted from micro-organisms or animal material A01N63/00; food compositions A21, A23; medicinal preparations A61K; chemical aspects of, or use of materials for, bandages, dressings, absorbent pads or surgical articles A61L; fertilisers C05); PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS (preservation of living parts of humans or animals A01N1/02); MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (micro-biological testing media C12Q)
  • ORGANIC CHEMISTRY (such compounds as the oxides, sulfides, or oxysulfides of carbon, cyanogen, phosgene, hydrocyanic acid or salts thereof C01; products obtained from layered base-exchange silicates by ion-exchange with organic compounds such as ammonium, phosphonium or sulfonium compounds or by intercalation of organic compounds C01B33/44; macromolecular compounds C08; dyes C09; fermentation products C12; fermentation or enzyme-using processes to synthesise a desired chemical compound or composition or to separate optical isomers from a racemic mixture C12P; production of organic compounds by electrolysis or electrophoresis C25B3/00, C25B7/00)
    • PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00)
• HUMAN NECESSITIES
  • MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES (bringing into special physical form A61J [N: mechanical aspects]; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; compounds per se C01, C07, C08, C12N; soap compositions C11D; micro-organisms per se C12N) [C0203]

Classificazione geografica

• Regione: Lombardia

Bibliografia

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27. Flores-Hernandez J, Cepeda C, Hernandez-Echeagaray E, Calvert CR, Jokel ES, Fienberg AA, Greengard P, Levine MS 2002 Dopamine enhancement of NMDA currents in dissociated medium-sized striatal neurons: role of D1 receptors and DARPP-32. J Neurophysiol 88:3010

28. Fiorentini C, Rizzetti MC, Busi C, Bontempi S, Collo G, Spano P, Missale C. 2006 Loss of synaptic D1 dopamine/N-methyl-D-aspartate glutamate receptor complexes in L-DOPA-induced dyskinesia in the rat. Mol Pharmacol 69:805

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30. Bezard E, Ferry S, Mach U, Stark H, Leriche L, Boraud T, Gross C, Sokoloff P 2003 Attenuation of levodopa-induced dyskinesia by normalizing dopamine D3 receptor function. Nat Med 9:762

31. Saveanu A, Lavaque E, Gunz G, Barlier A, Kim S, Taylor JE, Culler MD, Enjalbert A, Jaquet P. 2002 Demonstration of enhanced potency of a chimeric somatostatin-dopamine molecule, BIM-23A387, in suppressing growth hormone and prolactin secretion from human pituitary somatotroph adenoma cells. J Clin Endocrinol Metab 87:5545

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33. Genedani S, Rasio G, Cortelli P, Antonelli F, Guidolin D, Galantucci M, Fuxe K, Agnati LF. 2004 Studies on homocysteine and dehydroepiandrosterone sulphate plasma levels in Alzheimer's disease patients and in Parkinson's disease patients. Neurotox Res 6:327

34. Agnati LF, Fuxe K, Torvinen M, Genedani S, Franco R, Watson S, Nussdorfer GG, Leo G, Guidolin D 2005 New methods to evaluate colocalization of fluorophores in immunocytochemical preparations as exemplified by a study on A2A and D2 receptors in Chinese hamster ovary cells. J Histochem Cytochem 53:941

35. Missale C, Nisoli E, Liberini P, Rizzonelli P, Memo M, Buonamici M, Rossi A, Spano PF. 1989 Repeated reserpine administration up-regulates the transduction mechanisms of D1 receptors without changing the density of [3H]-SCH 23390 binding. Brain Res 483:117
36. Missale C, Boroni F, Castelletti L, Dal Toso R, Gabellini N, Sigala S, Spano PF 1991 Lack of coupling of D2 receptors to adenylate cyclase in GH3 cells exposed to epidermal growth factor. J Biol Chem 266:23392
37. Memo M, Castelletti L, Missale C, Valerio A, Carruba MO, Spano PF 1986 Dopaminergic inhibition of prolactin release and calcium influx induced by neurotensin in anterior pituitary is independent of cyclic AMP. J Neurochem 47:1689
38. Schallert T, Fleming SM, Leasure JL, Tillerson JL and Bland ST 2000 CNS plasticity and assessment of forelimb sensorimotor outcome in unilateral rat models of stroke, cortical ablation, parkinsonism and spinal cord injury. Neuropharmacol 39:777
39. Torvinen M, Marcellino D, Canals M, Agnati L, Lluis C, Franco R, Fuxe K 2005 Adenosine A2A receptor and dopamine D3 receptor interactions: evidence of functional A2A/D3 heteromeric complexes. Mol Pharmacol 67:400

Parole Chiave

MOSAICI RECETTORIALI, RECETTORI DOPAMINERGICI, RECETTORI ADENOSINICI, RECETTORI GLUTAMATERGICI, DESENSITIZZAZIONE, TRAFFICO RECETTORIALE, GANGLI DELLA BASE, MODELLI ANIMALI DI MALATTIA DI PARKINSON, ETERODIMERIZZAZIONE