RICERCA ITALIANA     

Programmi di ricerca simili:

• 1 - Il fattore di trascrizione NF-kB nella regolazione del differenziamento ed apoptosi del sistema immune.
• 2 - Mitocondri e morte cellulare: identificazione di nuovi bersagli terapeutici
• 3 - Studio dell’integrazione tra segnali extracellulari e controllo della proliferazione e differenziamento attraverso le modificazioni postraduzionali di fattori trascrizionali chiave.
• 4 - MECCANISMI REDOX DI SEGNALAZIONE CELLULARE COINVOLTI NELLA GENESI DI MALATTIE ASSOCIATE A STRESS OSSIDATIVO
• 5 - Dallo studio dell’espressione genica globale allo studio della virulenza di Mycobacterium tuberculosis
• 6 - Meccanismi di danno e protezione nel miocardio ischemico
• 7 - Identificazione di nuovi meccanismi molecolari dei glucocorticoidi nella regolazione di geni coinvolti nei processi infiammatori.
• 8 - Basi molecolari della citotossicità indotta dai diversi stati di aggregazione di beta amiloide: studio multidisciplinare in vitro, su colture cellulari e su modello animale.
• 9 - Medulloblastoma: studio delle vie molecolari di sviluppo e progressione tumorale allo scopo di identificare approcci terapeutici innovativi
• 10 - Accumulo e turnover proteine nelle piante

Classificazione scientifico-disciplinare

• Area scientifico disciplinare: Scienze biologiche
  • FISIOLOGIA VEGETALE
• Area scientifico disciplinare: Scienze agrarie e veterinarie
  • GENETICA AGRARIA

Classificazione brevettuale

• CHEMISTRY; METALLURGY
  • BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF (biocides, pest repellants or attractants, or plant growth regulators, containing micro-organisms, viruses, microbial fungi, enzymes, fermentates or substances produced by or extracted from micro-organisms or animal material A01N63/00; food compositions A21, A23; medicinal preparations A61K; chemical aspects of, or use of materials for, bandages, dressings, absorbent pads or surgical articles A61L; fertilisers C05); PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS (preservation of living parts of humans or animals A01N1/02); MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (micro-biological testing media C12Q)

Classificazione geografica

• Regione: Lombardia

Bibliografia

Apel K., Hirth H. (2004) ROS: metabolism, oxidative stress and signal transduction. Annu. Rev. Plant Biol. 55, 373-399.
Beligni MV., Lamattina L. (1998) Nitric oxide protects against cellular damage produced by methylviologen in potato plants. Nitric Oxide 3, 199-208.
Beligni MV., Lamattina L. (2002) Nitric oxide interferes with photo-oxidative stress by detoxifying ROS. Plant Cell Environ. 25, 737-748.
Bergo E.et al. (2003) Role of visible light in the recovery of photosystem ii structure and function from ultraviolet-B stress in higher plants. J. Exp. Bot. 54, 1665-1673.
Bethke PC.et al. (2004) Apoplastic synthesis of nitric oxide by plant tissues. Plant Cell 16,332-341.
Carimi F.et al. (2004) High levels of the cytokinin BAP induce PCD by acceleratine senescence. Plant Sci. 166, 963-969.
Carimi F.et al. (2005) NO signalling in cytokinin-induced programmend cell death. Plant Cell Env. 28, 1171-1178.
Cooney RV.et al. (1994) Light-mediated conversion of nitrogen dioxide to nitric oxide by carotenoid. Environmental Health Perspectives 102, 460-462.
Corpas FJ. et al. (2004) Cellular and subcellular localization of endogenous nitric oxide in young and senescent pea plants. Plant Physiol. 136, 2722-2733.
Dalle Donne I. et al. (2004) Proteins as biomarkers of oxidative/nitrosative stress in diseases. The contribution of redox proteomics. Mass Spect. Rev.24, 55-99.
Delledonne M. et al. (1998) Nitric oxide functions as a signal in plant disease resistance. Nature 394, 585-588.
Delledonne M.et al. (2001) Signal interactions between nitric oxide and reactive oxygen intermediates in the plant resistance response. Proc. Natl. Acad. Sci. USA 98, 13454-13459.
Delledonne M. (2005) NO news is good news for plant. Curr. Opin. Plant Biol. 8, 390-396.
Denninger JW., Marletta MA. (1999) Guanylate cyclase and the NO/cGMP signalling pathway. Biochim. Biophys. Acta 1411, 334-350.
de Pinto MC. et al. (2002) Changes in the antioxidant systems as part of the signaling pathway responsible for the programmed cell death activated by nitric oxide and reactive oxygen species in tobacco Bright-Yellow 2 cells. Plant Physiol. 130, 698-708.
Desikan R. et al. (2002) A new role for an old enzyme: nitrate reductase-mediated NO generation is required for abscisic acid-induced stomatal closure in Arabidopsis thaliana. Proc. Nat. Acad. Sci. 99, 16314-16318.
Donaldson L.et al. (2004) Salt and osmotic stress cause rapid increases in Arabidopsis thaliana cGMP levels. FEBS Letters. 569: 317–320.
Durner J., Klessig DF. (1999). Nitric oxide as a signal in plants. Curr. Opin. Plant Biol. 2, 369-374.
Feelisch M., Martin JF. (1995) The early role of nitric oxide in evolution. Trends Evol. Ecol. 10, 496-499.
Foyer CH., Noctor G. (2000) Oxygen processing in photosynthesis: regulation and signalling. New Phytol. 146, 359-388.
Guo FQ. et al.(2003) Identification of a plant nitric oxide synthase gene involved in hormonal signalling. Science 302, 100-103.
Guo FQ., Crawford NM. (2005) Arabidopsis nitric oxide synthase 1 is targeted to mitochondria and protects against oxidative damage and dark-induced senescence. Plant Cell 17, 3436-3450.
He Y.et al. (1998) Apoptosis, programmed cell death and the hypersensitive response. Eur. J. Plant Pathol. 104, 117-124.
Hess DT. et al. (2005) Protein S-nitrosylation: purview and parameters. Nature Mol Cell Biol. Reviews 6, 150-166.
Huang S. et al. (1997) Biochemical characterization and histochemical localization of nitric oxide synthase in the nervous system of the snail, Helix pomatia. J. Neurochem. 69, 2516-2528.
Huber SC., Hardin SC. (2004) Numerous posttranslational modifications provide opportunities for the intricate regulation of metabolic enzymes at multiple levels. Current Opinion Plant Biol. 7, 318-322.
Kaiser WM. (1976) The effect of hydrogen peroxide on CO2 fixation of isolated intact chloroplasts. Biochim. Biopys. Acta 440, 476-482.
Jaffrey SR. et al. (2001) Protein S-nitrosylation: a physiological signal for neuronal nitric oxide. Nature Cell Biol. 3, 193-197
Lamattina L.et al., (2003) Nitric oxide : the versatility of an extensive signal molecule. Ann. Rev. Plant Biol. 54, 109 136.
Lamb C., and Dixon RA. (1997) The oxidative burst in plant disease resistance, Ann. Rev. Plant Physiol. Plant. Mol. Biol., 48, 251-275
Leshem YY.et al. (1998) Evidence for the function of free radical gas nitric oxide (NO) as an endogenous maturation and senescence regulating factor in higher plants. Plant Physiol. Biochem. 36: 825-833.
Lindermayr C. et al. (2005) Proteomic identification of S-nitrosylated proteins in Arabidopsis. Plant Physiol. 137, 921-930.
Ludidi N., Gehring C. (2003) Identification of a novel protein with guanylyl cyclase activity in A.thaliana. J. Biol. Chem. 278, 6490–6494.
Mannick JB., Schonoff CM. (2002) Nitrosylation: the next phosphorylation? Arch. Biochem. Biophys. 408, 1-6.
Mano J. et al. (2001). Chloroplastic ascorbate peroxidase is the primary target of methylviologen-induced photooxidative stress in spinach leaves. Biochim. Biophys.Acta 1504, 275-287.
Martinez-Ruiz A., Lamas S. (2004) Detection and proteomic identification of S-nitrosylated proteins in endotheliai cells. Arch.Biochem. Biophys. 423, 192-199.
Murgia I.et al. (2002) Nitric oxide mediates iron-induced ferritin accumulation in Arabidopsis. Plant Journal 30, 521-528.
Murgia I. et al. (2004a) A. thaliana plants overexpressing thylakoidal ascorbate peroxidase show increased resistance to Paraquat-induced photooxidative stress and to NO-induced cell death. Plant Journal 38 940-953.
Murgia I. et al. (2004) Comparative effects of various nitric oxide donors on ferritin regulation, programmed cell death and cell redox state in plant cells. Journal of Plant Physiology 161, 777-783.
Nathan C. (1995) Natural resistance and nitric oxide. Cell 82, 873-876.
Planchet E,et al. (2005) Nitric oxide (NO) emission from tobacco leaves and cell suspensions. Plant Journal 41,732-743.
Polverari A. et al. (2003) Nitric oxide-mediated transcriptional changes in Arabidopsis thaliana. Mol. Plant Microbe Interact. 16, 1094-1105.
Rhee KY. et al. (2005) S-nitroso proteome of M. tuberculosis. Proc. Nat. Acad. Sci.102, 467-472.
Reggiani R. (1997) Alterations of levels of cyclic nucleotides in response to anaerobiosis in rice seedlings. Plant Cell physiol. 38, 740-742.
Romero-Puertas MC.et al. (2006) S-nitrosylation of peroxiredoxins during the plant hypersensitive disease resistance response augments peroxynitrite activity. Plant Cell, in press.
Shapiro AD. (2005) Nitric oxide signalling in plants. Vitamins and Hormones 22, 339-399.
Stamler JS.et al. (2001) Nitrosylation: the prototypic redox based signalling system. Cell 106, 675-683.
Stuehr JD. (1997) Structure-function aspects in the nitric oxide synthases. Annu. Rev. Pharmacol. Toxicol. 37, 339-359.
Takahashi S., Yamasaki H. (2002) Reversible inhibition of photophosphorylation in chloroplast by nitric oxide. FEBS Letters 512, 145-148.
Vacca RA.et al. (2004) Production of reactive oxygen species, alteration of cytosolic ascorbate peroxidase and impairment of mitochondrial metabolism are early events in heat shock-induced programmed cell death in tobacco Bright-Yellow 2 cells. Plant Physiol. 134, 1100-1112.
Wendehenne D. et al.2004) Nitric oxide: a new player in plant signalling and defence responses. Curr. Opin. Plant Biol. 7, 449-455.
Wojtaszek P. (2000) Nitric oxide in plants: to NO or not to NO. Phytochemistry 54,
Zeidler D. et al.(2004) Innate immunity in A. thaliana: lipolysaccharides activate nitric oxide synthase and induce defense genes. Proc. Nat. Acad. Sci. 101, 15811-15816.
Zemojtel T.et al. (2004) A novel conserved family of nitric oxide synthase? Trends Biochem Sci. 5, 224-226.
Zemojtel T.et al., (2006) Mammalian mitochondrial nitric oxide synthase: characterization of a novel candidate. FEBS Letters 580, 455-462.
Zottini M. et al. (2002) Nitric oxide affects plant mitochondrial functionality in vivo. FEBS Letters 515, 75-78.

Parole Chiave

OSSIDO NITRICO, PIANTE, MOLECOLE SEGNALE, STRESS BIOTICI ED ABIOTICI, SPECIE REATTIVE DELL'OSSIGENO