RICERCA ITALIANA     

Programmi di ricerca simili:

• 1 - RECETTORI PURINERGICI E NEUROPROTEZIONE
• 2 - Identificazione, espressione funzionale e caratterizzazione fisiopatologica di nuovi recettori purinici.
• 3 - Transcrittomica e proteomica dello scompenso cardiaco umano per l'individuazione di nuovi meccanismi patogenetici e biomarcatori: focus sui recettori purinergici P2
• 4 - I recettori metabotropici del glutammato com "targets" di farmaci neuroprotettivi
• 5 - Studio dei mosaici recettoriali a livello dei gangli della base: implicazioni fisiopatologiche e terapeutiche
• 6 - CONTROLLO DEL CICLO CELLULARE DA LIGANDI DI RECETTORI NUCLEARI
• 7 - Agenti Attivi sul Sistema Nervoso Centrale: Moderni Approcci Chimico-Farmaceutici per la Modulazione e Caratterizzazione di Pathways Recettoriali
• 8 - Il sistema nocicettina/OFQ-recettore NOP: studi di base e clinici
• 9 - Interazioni neuroni-glia nei meccanismi di neurodegenerazione e neuroprotezione
• 10 - Regolazione negativa del signalling di recettori oncogenici: implicazioni terapeutiche

Classificazione scientifico-disciplinare

• Area scientifico disciplinare: Scienze biologiche
  • BIOCHIMICA
  • BIOLOGIA MOLECOLARE
  • BIOLOGIA APPLICATA
  • FARMACOLOGIA
• Area scientifico disciplinare: Scienze chimiche
  • CHIMICA FARMACEUTICA

Classificazione brevettuale

• CHEMISTRY; METALLURGY
  • BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF (biocides, pest repellants or attractants, or plant growth regulators, containing micro-organisms, viruses, microbial fungi, enzymes, fermentates or substances produced by or extracted from micro-organisms or animal material A01N63/00; food compositions A21, A23; medicinal preparations A61K; chemical aspects of, or use of materials for, bandages, dressings, absorbent pads or surgical articles A61L; fertilisers C05); PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS (preservation of living parts of humans or animals A01N1/02); MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (micro-biological testing media C12Q)
  • ORGANIC CHEMISTRY (such compounds as the oxides, sulfides, or oxysulfides of carbon, cyanogen, phosgene, hydrocyanic acid or salts thereof C01; products obtained from layered base-exchange silicates by ion-exchange with organic compounds such as ammonium, phosphonium or sulfonium compounds or by intercalation of organic compounds C01B33/44; macromolecular compounds C08; dyes C09; fermentation products C12; fermentation or enzyme-using processes to synthesise a desired chemical compound or composition or to separate optical isomers from a racemic mixture C12P; production of organic compounds by electrolysis or electrophoresis C25B3/00, C25B7/00)
    • PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00)

Classificazione geografica

• Regione: Lombardia

Bibliografia

Abbracchio MP & Burnstock G (1994). Purinoceptors: are there families of P2X and P2Y purinoceptors? Pharm. Ther. 64: 445-475.

Abbracchio MP & Ceruti S (2006). Roles of P2 receptors in glial cells: focus on astrocytes. Purinergic Signalling, in press.

Abbracchio MP et al. (2003). Characterization of the UDP-glucose receptor (re-named here the P2Y14 receptor) adds diversity to the P2Y receptor family. Trends Pharmacol. Sci. 24: 52-55.

Abbracchio MP et al. (2006). International Union of Pharmacology. Update of the P2Y G-protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy. Pharm. Rev., in press.

Adinolfi E et al. (2005) Basal activation of the P2X7 ATP receptor elevates mitochondrial calcium and potential, increases cellular ATP levels, and promotes serum-independent growth. Mol. Biol. Cell. 16: 3260-3272.

Amadio S et al. (2002). P2 receptor modulation and cytotoxic function in cultured CNS neurons. Neuropharmacol. 42: 489-501.

Banfi C et al. (2005). P2 receptors in human heart: upregulation of P2X6 in patients undergoing heart transplantation, interaction with TNFa and potential role in myocardial cell death. J. Mol. Cell. Cardiol. 39: 929-939.

Bouvier M. (2001). Oligomerization of G-protein-coupled transmitter receptors. Nat. Rev. Neurosci. 2: 274-286.

Brambilla R et al. (2002). Induction of COX-2 and reactive astrogliosis by P2Y receptors in rat cortical astrocytes is dependent on ERK1/2 but independent of calcium signaling. J. Neurochem. 83: 1285-1296.

Brambilla R et al. (2003). P2Y receptors in brain astroglial cells: identification of a gliotic P2Y receptor coupled to activation of a calcium-independent Ras/ERK1/2 pathway. Drug Dev. Res. 59: 161-170
<br />Buffo A et al. (2005). Expression pattern of the transcription factor Oligo2 in response to brain injuries: implications for neuronal repair. PNAS 102: 18183-18188.

Camaioni E et al. (1998). Deoxyadenosine-bisphosphate derivatives as potent antagonists at P2Y1 receptors. J Med Chem 41: 183-190.

Cavaliere F et al. (2002). Extracellular ATP and nerve growth factor intensify hypoglycemia-induced cell death in primary neurons: role of P2 and NGFRp75 receptors. J. Neurochem. 83: 1-10.

Cavaliere F et al. (2003). Extracellular ATP and neurodegeneration. Neurosci. 120: 85-98.

Cavaliere F et al. (2004). Role of the metabotropic P2Y(4) receptor during hypoglycemia: cross talk with the ionotropic NMDAR1 receptor. Exp. Cell. Res. 300: 149-158.

Cavaliere F et al. (2005). The metabotropic P2Y4 receptor participates in the commitment to differentiation and cell death of human neuroblastoma SH-SY5Y cells. Neurobiol. Dis. 18: 100-109.

Chorna NE et al. (2004). P2Y receptors activate neurprotective mechanisms in astrocytic cells. J. Neurochem. 91: 119-132.

Cristalli G et al. (2005). Effects of 5'-phosphate derivatives of 2-hexynyl adenosine and 2-phenylethynyl adenosine on responses of human platelets mediated by P2Y receptors. J. Med. Chem. 48: 2763-2766.

D’Ambrosi N et al. (2004). 2-ClATP exerts anti-tumoural actions not mediated by P2 receptors in neuronal and glial cell lines. Biochem. Pharmacol. 67: 621-630.

Davalos D et al. (2005). ATP mediates rapid microglial response to local brain injury in vivo. Nat. Neurosci. 8: 752-758.

Fredholm BB et al. (1994). Nomenclature and classification of purinoceptors. Pharm. Rev. 46: 143-156.

Heins N et al. (2002). Glial cells generate neurons: the role of the transcription factor Pax6. Nat. Neurosci. 5: 308-315, erratum in 5: 500.

Hibell AD et al. (2001). Complexity of measuring antagonist potency at P2X7 receptor orthologs. J. Pharmacol. Ther. 296: 947-957.

Jacobson KA &amp; Gao ZG (2006). Adenosine receptors as therapeutic targets. Nat. Rev. Drug Discov. 5: 247-264.

Jacobson KA et al. (2002). Purine and pyrimidine (P2) receptors as drug targets. J. Med. Chem. 45: 4057-4093.

Jacobson KA et al. (2004). Molecular recognition at purine and pyrimidine nucleotide (P2) receptors. Curr. Top. Med. Chem. 4: 671-686.

Khakh BS et al. (2001). International Union of Pharmacology. XXIV. Current status of the nomenclature and properties of P2X receptors and their subunits. Pharm. Rev. 53: 107-118.

Kim SG et al. (2003). Tumor necrosis factor alpha-induced apoptosis in astrocytes is prevented by the activation of P2Y6, but not P2Y4 nucleotide receptors. Biochem. Pharmacol. 65: 923-931.

Koizumi S et al. (2002). Mechanisms underlying the neuronal calcium sensor-1-evoked enhancement of exocytosis in PC12 cells. J. Biol. Chem. 277: 30315-30324.

Lazarowski ER et al. (2003). Release of cellular UDP-glucose as a potential exracellular signaling molecule. Mol. Pharmacol. 63: 1190-1197.

Mamedova LK et al. (2004). Diisothiocyanate derivatives as potent, insurmountable antagonists of P2Y6 nucleotide receptors. Biochem. Pharmacol. 67: 1763-1770.

Mazzola A et al. (2006). Uracil nucleotides protect murine HL-1 cardiomyocytes from cell-cycle changes and apoptotic/necrotic death induced by adenine nucleotides and tumor necrosis factor-alpha. Abstract submitted to the "8th International Symposium on Adenosine and Adenine Nucleotides", Ferrara, Italy (May 24th-28th).

Melani A et al. (1999). Striatal outflow of adenosine, excitatory amino acids, gamma-aminobutyric acid, and taurine in awake freely moving rats after middle cerebral artery occlusion: correlations with neurological deficit and histopathological damage. Stroke 30: 2448-2454.

Melani A et al. (2005). ATP extracellular concentrations are increased in the rat striatum during in vivo ischemia. Neurochem. Int. 47: 442-448.

Melani A et al. (2006). P2X(7) receptor modulation on microglial cells and reduction of brain infarct caused by middle cerebral artery occlusion in rat. J. Cereb. Blood Flow Metab. Epub ahead of print.

Mishra SK et al. (2006). Extracellular nucleotide signaling in adult neural stem cells: synergism with growth factor-mediated cellular proliferation. Development. 133: 675-684.

Nandanan E et al. (1999). Structure-activity relationships of bisphosphate nucleotide derivatives as P2Y1 receptor antagonists and partial agonists. J. Med. Chem. 42: 1625-1638.

Neary JT et al. (1996). Trophic actions of extrcellular nucleotides and nucleosides on glial and neuronal cells. Trends Neurosci. 19: 13-18.

Pelleg A &amp; Vassort G (2001). P2 receptors in the cardiovascular system. In: Abbracchio MP, Williams M, editors. Purinergic and pyrimidergic signalling II. Berlin: Springer; p. 73–100.

Sokolova E et al. (2004). Agonist-dependence of recovery from desensitization of P2X3 receptors provides a novel and sensitive approach for their rapid up or downregulation. Br. J. Pharmacol. 141: 1048-1058.

Volonté C et al. (2003). Extracellular ATP and neurodegeneration. Curr. Drug Targets CNS Neurol. Disord. 2: 403-412.

Wihlborg AK et al. (2006). Positive inotropic effects by uridine triphosphate (UTP) and uridine diphosphate (UDP) via P2Y2 and P2Y6 receptors on cardiomyocytes and release of UTP in man during myocardial infarction. Circ. Res. 98: 970-976.

Yitzhaki S et al. (2005). Involvement of uracil nucleotides in protection of cardiomyocytes from hypoxic stress. Biochem. Pharmacol. 69: 1215-1223.

Parole Chiave

RECETTORI P2 NEURONALI E GLIALI, NEURODEGENERAZIONE, NEUROPROTEZIONE, SINTESI DI NUOVI LIGANDI P2, RILASCIO CEREBRALE DI ATP E UTP IN CORSO DI ISCHEMIA, TRANS-ATTIVAZIONE DEI RECETTORI PER I FATTORI DI CRESCITA DA PARTE DI RECETTORI A G-PROTEINA P2Y, ISCHEMIA CEREBRALE, NEUROGENESI, STRUTTURA QUATERNARIA, OLIGOMERIZZAZIONE E DINAMICA RECETTORIALE DEI RECETTORI P2Y