RICERCA ITALIANA     

Programmi di ricerca simili:

• 1 - Meccanismi cellulari e molecolari di morte e protezione neuronale
• 2 - Ruolo fisiopatologico di poli(ADPR)polimerasi (PARP) e sue implicazioni terapeutiche.
• 3 - Caratterizzazione molecolare dell'eritropoiesi:analisi post-genomica e funzionale del profilo di espressione proteica
• 4 - EICOSANOIDI E MONOSSIDO DI AZOTO NEL DANNO ISCHEMICO CEREBRALE E NELLA RISOLUZIONE DELLA RISPOSTA INFIAMMATORIA AD ESSO ASSOCIATA
• 5 - RUOLO DEI LIPIDI NELLA REGOLAZIONE DI FUNZIONI CELLULARI
• 6 - Studi struttura-funzione sulle neurotrofine e loro precursori nella funzione presinaptica, nella epilettogenesi e nella neurogenesi adulta
• 7 - Proprieta’ strutturali e attivita’ funzionale di un complesso proteico modificante la cromatina nell’uomo
• 8 - Sviluppo e progressione del carcinoma epatocellulare: meccanismi molecolari ed implicazioni terapeutiche
• 9 - Meccanismi di danno e protezione nel miocardio ischemico
• 10 - Mitocondri e morte cellulare: identificazione di nuovi bersagli terapeutici

Classificazione scientifico-disciplinare

• Area scientifico disciplinare: Scienze biologiche
  • FARMACOLOGIA

Classificazione brevettuale

• CHEMISTRY; METALLURGY
  • BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF (biocides, pest repellants or attractants, or plant growth regulators, containing micro-organisms, viruses, microbial fungi, enzymes, fermentates or substances produced by or extracted from micro-organisms or animal material A01N63/00; food compositions A21, A23; medicinal preparations A61K; chemical aspects of, or use of materials for, bandages, dressings, absorbent pads or surgical articles A61L; fertilisers C05); PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS (preservation of living parts of humans or animals A01N1/02); MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (micro-biological testing media C12Q)

Classificazione geografica

• Regione: Toscana

Bibliografia

1. Annunziato L, Pignataro G, Di Renzo GF (2004) Pharmacology of brain Na+/Ca2+ exchanger: from molecular biology to therapeutic perspectives. Pharmacol Rev 56: 633-654.
2. Benveniste H, Drejer J, Schousboe A, Diemer N (1984) Elevation of extracellular concentrations of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis. J Neurochem 43: 1369-1374.
3. Bickler PE, Fahlman CS (2004) Moderate increases in intracellular calcium activate neuroprotective signals in hippocampal neurons. Neuroscience 127: 673-683.
4. Campbell KJ, Perkins ND (2004) Post-translational modification of RelA(p65) NF-kappaB. Biochem Soc Trans 32: 1087-1089.
5. Canitano A, Papa M, Boscia F, Castaldo P, Sellitti S, Taglialatela M, Annunziato L (2002) Brain distribution of the Na+/Ca2+ exchanger-encoding genes NCX1, NCX2, and NCX3 and their related proteins in the central nervous system. Ann N Y Acad Sci 976: 394-404.
6. Carty SM, Greenleaf AL (2002) Hyperphosphorylated C-terminal repeat domain-associating proteins in the nuclear proteome link transcription to DNA/chromatin modification and RNA processing. Mol Cell Proteomics 1: 598-610.
7. Chan PH (1996) Role of oxidants in ischemic brain damage. Stroke 27: 1124-1129.
8. Chiarugi A (2002) Poly(ADP-ribose) polymerase: killer or conspirator? The 'suicide hypothesis' revisited. Trends Pharmacol Sci 23: 122-129.
9. Chiarugi A, Moskowitz MA (2003) Poly(ADP-ribose) polymerase-1 activity promotes NF-kappaB-driven transcription and microglial activation: implication for neurodegenerative disorders. J Neurochem 85: 306-317.
10. Choi DW (1992) Excitotoxic cell death. J Neurobiol 23: 1261-1276.
11. Cunningham LA, Wetzel M, Rosenberg GA (2005) Multiple roles for MMPs and TIMPs in cerebral ischemia. Glia 50: 329-339.
12. De Keyser J, Sulter G, Luiten PG (1999) Clinical trials with neuroprotective drugs in acute ischaemic stroke: are we doing the right thing? Trends Neurosci 22: 535-540.
13. Devuyst G, Bogousslavsky J (1999) Recent progress in drug treatment for acute stroke. J Neurol Neurosurg Psychiatry 67: 420-425.
14. Ginsberg MD (2003a) Adventures in the pathophysiology of brain ischemia: penumbra, gene expression neuroprotection. Stroke 34: 223.
15. Ginsberg MD (2003b) Adventures in the pathophysiology of brain ischemia: penumbra, gene expression, neuroprotection: the 2002 Thomas Willis Lecture. Stroke 34: 214-223.
16. Grilli M, Pizzi M, Memo M, Spano PF (1996) Neuroprotection by Aspirin and Sodium salicylate through blockade of NF-kB activation. Science 274: 1983-1985.
17. Gu Z, Cui J, Brown S, Fridman R, Mobashery S, Strongin AY, Lipton SA (2005) A highly specific inhibitor of matrix metalloproteinase-9 rescues laminin from proteolysis and neurons from apoptosis in transient focal cerebral ischemia. J Neurosci 25: 6401-6408.
18. Horstmann S, Kalb P, Koziol J, Gardner H, Wagner S (2003) Profiles of matrix metalloproteinases, their inhibitors, and laminin in stroke patients: influence of different therapies. Stroke 34: 2165-2170.
19. Klenova E, Ohlsson R (2005) Poly(ADP-ribosyl)ation and epigenetics. Is CTCF PARt of the plot? Cell Cycle 4: 96-101.
20. Kraus WL, Lis JT (2003) PARP goes transcription. Cell 113: 677-683.
21. Kun E, Bauer PI (2001) Cell biological functions of PARP I: an overview. Ital J Biochem 50: 15-18.
22. Lesiuk H, Sutherland G, Peeling J, Butler K, Saunders J (1991) Effect of U74006F on forebrain ischemia in rats. Stroke 22: 896-901.
23. Lipton SA, Rosenberg PA (1994) Excitatory amino acids as a final common pathway for neurological disorders. N Engl J Med 330: 613-622.
24. Lombardi G, Moroni F (1992) GM1 ganglioside reduces ischemia-induced excitatory amino acid output: a microdialysis study in the gerbil hippocampus. Neurosci Lett 134: 171-174.
25. Meldrum B, Garthwaite J (1990) Excitatory amino acid neurotoxicity and neurodegenerative disease. Trends Pharmacol Sci 11: 379-387.
26. Meller R, Cameron JA, Torrey DJ, Clayton CE, Ordonez AN, Henshall DC, Minami M, Schindler CK, Saugstad JA, Simon RP (2006) Rapid degradation of Bim by the ubiquitin-proteasome pathway mediates short-term ischemic tolerance in cultured neurons. J Biol Chem 281: 7429-7436.
27. Moroni F, Attucci S, Cozzi A, Meli E, Picca R, Scheideler MA, Pellicciari R, Noe C, Sarichelou I, Pellegrini-Giampietro DE (2002) The novel and systemically active metabotropic glutamate 1 (mGlu1) receptor antagonist 3-MATIDA reduces post-ischemic neuronal death. Neuropharmacology 42: 741-751.
28. Moroni F, Lombardi G, Thomsen C, Leonardi P, Attucci S, Peruginelli F, Albani Torregrossa S, Pellegrini-Giampietro DE, Luneia R, Pellicciari R (1997) Pharmacological characterization of 1-aminoindan-1,5-dicarboxylic acid (AIDA), a potent mGluR1 antagonist. J Pharmacol Exp Ther 281: 721-729.
29. Nicoletti F, Bruno VM, Copani A, Casabona G, Knopfel T (1996) Metabotropic glutamate receptors: a new target for the therapy of neurodegenerative disorders? Trends Neurosci 19: 267-271.
30. Oliver FJ, Menissier-de Murcia J, Nacci C, Decker P, Andriantsitohaina R, Muller S, de la RG, Stoclet JC, de Murcia G (1999) Resistance to endotoxic shock as a consequence of defective NF-kappaB activation in poly (ADP-ribose) polymerase-1 deficient mice. EMBO J 18: 4446-4454.
31. Pellegrini-Giampietro DE, Cherici G, Alesiani M, Carlà V, Moroni F (1990) Excitatory amino acid release and free radical formation may cooperate in the genesis of ischemia-induced neuronal damage. J Neurosci 10: 1035-1041.
32.Pellegrini-Giampietro DE, Cozzi A, Peruginelli F, Leonardi P, Meli E, Pellicciari R, Moroni F (1999) 1-Aminoindane-1,5dicarbossilic acid and (s)-(+)-2-(3'-carboxybiciclo[1.1.1]pentyl)-glycine, two mGlu 1 receptor-preferring antagonists, reduce neuronal death in in vitro and in vivo models of cerebral ischemia. Eur J Neurosci 11: 3637-3647.
33. Pilitsis JG, Diaz FG, O'Regan MH, Phillis JW (2001) Inhibition of Na(+)/H(+) exchange by SM-20220 attenuates free fatty acid efflux in rat cerebral cortex during ischemia-reperfusion injury. Brain Res 913: 156-158.
34. Pizzi M, Sarnico I, Boroni F, Benarese M, Steimberg N, Mazoleni G, Dietz GP, Bahr M, Liou HC, Spano PF (2005) NF-kappaB factor c-Rel mediates neuroprotection elicited by mGlu5 receptor agonists against amyloid beta-peptide toxicity. Cell Death Differ 12: 761-772.
35. Poirier GG, de Murcia G, Jongstra-Bilen J, Niedergang C, Mandel P (1982) Poly(ADP-ribosyl)ation of polynucleosomes causes relaxation of chromatin structure. Proc Natl Acad Sci U S A 79: 3423-3427.
36. Rapizzi E, Fossati S, Moroni F, Chiarugi A (2004) Inhibition of poly(ADP-ribose) glycohydrolase by gallotannin selectively up-regulates expression of proinflammatory genes. Mol Pharmacol 66: 890-898.
37. Romanic AM, White RF, Arleth AJ, Ohlstein EH, Barone FC (1998) Matrix metalloproteinase expression increases after cerebral focal ischemia in rats: inhibition of matrix metalloproteinase-9 reduces infarct size. Stroke 29: 1020-1030.
38. Schneider A, Martin-Villalba A, Weih F, Vogel J, Wirth T, Schwaninger M (1999) NF-kappaB is activated and promotes cell death in focal cerebral ischemia. Nat Med 5: 554-559.
39. Schurr A, Payne RS, Tseng MT, Gozal E, Gozal D (2001) Excitotoxic preconditioning elicited by both glutamate and hypoxia and abolished by lactate transport inhibition in rat hippocampal slices. Neurosci Lett 307: 151-154.
40. Siesjo BK, Agardh CD, Bengtsson F (1989) Free radicals and brain damage. Cerebrovasc Brain Metab Rev 1: 165-211.
41. Uberti D, Belloni M, Grilli M, Spano PF, Memo M (1998) Induction of tumor-suppressor phosphoprotein p53 in the apoptosis of cultured rat cerebellar neurones triggered by excitatory amino acids. Eur J Neurosci 10: 246-254.
42. Weir CJ, Kaste M, Lees KR (2004) Targeting neuroprotection clinical trials to ischemic stroke patients with potential to benefit from therapy. Stroke 35: 2111-2116.
43. Ziegler M, Oei SL (2001) Bioessays 23: 543-548.

Parole Chiave

NEUROFARMACOLOGIA, ICTUS, MODELLI DI NEUROPATOLOGIA, NEURODEGENERAZIONE, MORTE NEURONALE, NEUROPROTEZIONE, ECCITOTOSSICITÀ